scholarly journals The Association of TNF-α Promoter Polymorphisms with Genetic Susceptibility to Cervical Cancer in a Chinese Han Population

2022 ◽  
Vol Volume 15 ◽  
pp. 417-427
Author(s):  
Jia Yang ◽  
Yingying Wang ◽  
Shao Zhang ◽  
Yu Li ◽  
Chuanyin Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Genetic Susceptibility ◽  
Chinese Han Population ◽  
Promoter Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Tnf Α

scholarly journals The association of TNF-α promoter polymorphisms with genetic susceptibility to cervical cancer in a Chinese Han population

2021 ◽  
Author(s):  
Jia Yang ◽  
Yingying Wang ◽  
Zhiling Yan ◽  
Chuanyin Li ◽  
Shuyuan Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chinese Han Population ◽  
Control Group ◽  
Chinese Han ◽  
Han Population ◽  
Cancer Group ◽  
Tnf Α

Abstract Background The Tumour necrosis factor-α (TNF-α) gene plays an important role in the host immune response. Recent studies have found that TNF-α also plays an important role in cancer. Polymorphism of the TNF-α promoter region is considered to influence its transcription and be a risk factor for tumorigenesis. In the current study, we evaluated the role of TNF-α promoter region polymorphisms in susceptibility to cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). Methods A total of 2,732 subjects, including 1,173 healthy controls, 579 patients with CIN and 980 patients with cervical cancer in a Chinese Han population, were selected for the current study. Five SNPs in the TNF-α promoter, rs1799964 (C > T), rs800630 (A > C), rs1799724 (C > T), rs1800629 (A > G) and rs361525 (A > G), were selected and genotyped using TaqMan Assays. The association of these SNPs with cervical cancer was evaluated among healthy controls and CIN and cervical cancer patients. Results The frequency distribution of rs1800629 and rs361525 alleles was significantly different between the cervical cancer group and the control group (P = 0.009 and P = 0.002). The A alleles of rs1800629 and rs361525 were found to be a protective factor (OR = 0.722; 95%CI = 0.564–0.923) and a risk factor (OR = 1.693; 95%CI = 1.205–2.378) for cervical cancer, respectively. In comparison of different pathological types of cervical cancer group and the control group, the distribution of allele frequencies of rs1800629 and rs361525 was significantly different between the squamous cell carcinoma and control groups (P = 0.002 and P < 0.001). The A alleles of rs1800629 and rs361525 were protective (OR = 0.659; 95%CI = 0.502–0.864) and risk (OR = 1.868; 95%CI = 1.317–2.648) factors for cervical squamous cell carcinoma, respectively. Conclusion rs1800629 and rs361525 in the TNF-α promoter are associated with susceptibility to cervical cancer and squamous cell carcinoma in the Chinese Han population.

scholarly journals The association between apolipoprotein A1-C3-A5 gene cluster promoter polymorphisms and risk of ischemic stroke in the northern Chinese Han population

2017 ◽  
Vol 45 (6) ◽  
pp. 2042-2052 ◽  
Author(s):  
Yanzhe Wang ◽  
Fang Liu ◽  
Lei Li ◽  
Shumin Deng ◽  
Zhiyi He
Keyword(s):  
Ischemic Stroke ◽  
Gene Cluster ◽  
Apolipoprotein A1 ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Promoter Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Northern Chinese

Objective Given its effects on lipid metabolism, the apolipoprotein A1-C3-A5 ( APOA1-C3-A5) gene cluster is thought to play an important role in ischemic stroke pathogenesis. Here, we evaluated whether the APOA1-C3-A5 cluster is associated with ischemic stroke in the northern Chinese Han population. Methods This case–control study analyzed 812 patients with ischemic stroke and 844 healthy controls with regard to four APOA1-C3-A5 cluster promoter single nucleotide polymorphisms (SNPs), rs670, rs2854116, rs2854117, and rs662799, using the SNaPshot Multiplex sequencing assay. Potential associations among ischemic stroke, genotyping, and allele frequencies were assessed. Results APOA1 rs670 CT/TT genotypes, APOA5 rs662799 AG/GG genotypes, and the APOC3 rs2854116 CC genotype were associated with an increased risk of ischemic stroke according to multivariate logistic analysis after adjusting for confounding factors. A significantly increased risk for ischemic stroke was also identified among high-risk haplotypes (C-C-T-A and T-T-C-A) for rs670–rs2854116–rs2854117–rs662799. Conclusion This study showed that rs670, rs2854116, and rs662799 SNPs of the APOA1-C3-A5 cluster are associated with ischemic stroke in the northern Chinese Han population.

Genetic polymorphisms in MMP 2, 3, 7, and 9 genes and the susceptibility and clinical outcome of cervical cancer in a Chinese Han population

Tumor Biology ◽  
2015 ◽  
Vol 37 (4) ◽  
pp. 4883-4888 ◽  
Author(s):  
Beibei Xie ◽  
Zhen Zhang ◽  
Hui Wang ◽  
Zhaojie Chen ◽  
Yongsheng Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Clinical Outcome ◽  
Genetic Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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