scholarly journals CHEMICAL AND PHARMACOLOGICAL EVOLUTION OF SOME SYNTHESIZED CHALCONES AND HETROCYCLIC COMPOUNDS

2021 ◽  
Vol 9 (07) ◽  
pp. 747-771
Author(s):  
Geeta N Lodhi ◽  
Amit Nayak
Keyword(s):  
Medicinal Chemistry ◽  
Pharmaceutical Chemistry ◽  
Hydroxyl Group ◽  
Pharmaceutical Drugs ◽  
Open Chain ◽  
Blue Green Algae ◽  
Slime Moulds ◽  
Generic Term ◽  
Quality Aspects ◽  
Anti Fungal

Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. With centuries medicinal chemistry had emerged as a magnanimous field of science getting a facelift from the available natural compounds for synthesis of newer and complex molecules possessing medicinal activity while the transit from the earth to a synthetically furnished laboratory. Medicinal chemistry or pharmaceutical chemistry is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Chalconesis a generic term given to compounds bearing the 1,3-diarylprop2-en-1-one, which can be functionlized in the propane chain by the presence of olefinic, keto and/or hydroxyl group. Chalcones belongs to the flavonoid family. Chemically chalcones consisted of open chain flavonoids in which the two aromaticrings are joined by a three carbon a,ß-unsaturated carbonyl system (Dhar, 1981). Microorganisms are a heterogeneous group of several distinct classes of living beings. They were classified under third kingdom, theProstita. Based on differences in cellular organization and biochemistry, the kingdom prostita has been divided into two groups, Prokaryotes and Eukaryotes. Bacteria and blue green algae are prokaryotes while fungi, other algae, slime moulds and protozoa are eukaryotes. Anti-fungal drugs are among the most frequently prescribed preparations because of their fungal activity. They are widely used for the treatment of the fungal diseases such as Candidiasis and Apergillosis. These agents prevent from fungal infection. Anti-oxidant drugs are among the most frequently prescribed preparations prevent Oxidation.

scholarly journals CHEMICAL AND PHARMACOLOGICAL EVOLUTION OF SOME SYNTHESIZED CHALCONES AND HETROCYCLIC COMPOUNDS

2021 ◽  
Vol 9 (07) ◽  
pp. 772-795
Author(s):  
Geeta N. Lodhi ◽  
Amit Nayak
Keyword(s):  
Medicinal Chemistry ◽  
Pharmaceutical Chemistry ◽  
Hydroxyl Group ◽  
Pharmaceutical Drugs ◽  
Open Chain ◽  
Blue Green Algae ◽  
Slime Moulds ◽  
Generic Term ◽  
Quality Aspects ◽  
Anti Fungal

Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. With centuries medicinal chemistry had emerged as a magnanimous field of science getting a facelift from the available natural compounds for synthesis of newer and complex molecules possessing medicinal activity while the transit from the earth to a synthetically furnished laboratory. Medicinal chemistry or pharmaceutical chemistry is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Chalconesis a generic term given to compounds bearing the 1,3-diarylprop2-en-1-one, which can be functionlized in the propane chain by the presence of olefinic, keto and/or hydroxyl group. Chalcones belongs to the flavonoid family. Chemically chalcones consisted of open chain flavonoids in which the two aromaticrings are joined by a three carbon a,ß-unsaturated carbonyl system (Dhar, 1981). Microorganisms are a heterogeneous group of several distinct classes of living beings. They were classified under third kingdom, theProstita. Based on differences in cellular organization and biochemistry, the kingdom prostita has been divided into two groups, Prokaryotes and Eukaryotes. Bacteria and blue green algae are prokaryotes while fungi, other algae, slime moulds and protozoa are eukaryotes. Anti-fungal drugs are among the most frequently prescribed preparations because of their fungal activity. They are widely used for the treatment of the fungal diseases such as Candidiasis and Apergillosis. These agents prevent from fungal infection. Anti-oxidant drugs are among the most frequently prescribed preparations prevent Oxidation.

Frontiers in Medicinal Chemistry 2015: Meet the Experts of MedChem near the Cradle of Medicinal and Pharmaceutical Chemistry

ChemMedChem ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. 1267-1271
Author(s):  
Christof Wegscheid-Gerlach ◽  
Hans-Dieter Gerber ◽  
Wibke E. Diederich
Keyword(s):  
Medicinal Chemistry ◽  
Pharmaceutical Chemistry

Benzimidazole: A Milestone in the Field of Medicinal Chemistry

2020 ◽  
Vol 20 (7) ◽  
pp. 532-565 ◽  
Author(s):  
Mahesh S. Vasava ◽  
Manoj N. Bhoi ◽  
Sanjay K. Rathwa ◽  
Divya J. Jethava ◽  
Prachi T. Acharya ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Benzimidazole Derivatives ◽  
Drug Candidate ◽  
Pharmacological Activities ◽  
Drug Candidates ◽  
The Future ◽  
Anti Inflammatory ◽  
Anti Fungal ◽  
Derivatives Of ◽  
Anti Hiv

In the last 2-3 decades, the broad research in the application of benzimidazole derivatives made it important for mankind. Many scientists have worked on benzimidazole derivatives and they found that this compound has a diverse role in the field of medicinal chemistry. Few benzimidazole derivatives are currently in the market as a drug candidate against various diseases. Moreover, the benzimidazole derivatives exhibit pharmacological activities such as anti-tuberculosis, anti-malarial, antihistamine, antimicrobial, antiviral, antidiabetic, anticancer, anti-fungal, anti-inflammatory, analgesic, anti-HIV, etc. In this review, we have summarized various derivatives of benzimidazole which have been prepared by many researchers to understand the chemistry as well as diverse pharmacological activities. These findings may lead the scientists who are working in the field of medicinal chemistry to the development of benzimidazole based drug candidates in the future.

A Mini Review on Recent Advancements in the Therapeutic Potentials of Benzothiazoles

2019 ◽  
Vol 16 ◽  
Author(s):  
Rubina Bhutani ◽  
Garima Kapoor ◽  
Dharam Pal Pathak ◽  
Asif Husain ◽  
Ravi Kant ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Therapeutic Potential ◽  
Pharmaceutical Chemistry ◽  
Biological Potential ◽  
Heterocyclic Derivatives ◽  
Anti Inflammatory ◽  
Clinical Drugs

: Among the various fused heterocyclic rings, benzothiazole and its analogues have been explored broadly in search of newer therapeutic medicinal agents. The benzothiazole scaffold has been associated with huge biological potential like anticancer, antidiabetic, anti-inflammatory, anti-tubercular, antiviral, anti-convulsant etc. The occurrence of benzothiazole core in various compounds proves its value in the sphere of pharmaceutical chemistry. The connected research and developments in benzothiazole based chemistry become an active topic for medicinal scientists. A large number of benzothiazole and its heterocyclic derivatives are available in the market and used for the treatment of as clinical drugs have been extensively used in practice to treat diverse types of ailments with high therapeutic potential. This review presents the latest therapeutic developments of benzothiazole containing compounds in the medicinal chemistry.

Anti-Bacterial and Anti-Fungal Study of Schiff Bases and their Metal Co (II)& Zn (II) Complexes

2021 ◽  
Vol 27 (2) ◽  
Author(s):  
Dileep Sharma ◽  
S.C. Agarwal
Keyword(s):  
Plant Growth ◽  
Metal Complexes ◽  
Plant Growth Regulators ◽  
Schiff Bases ◽  
Aromatic Aldehyde ◽  
Growth Regulators ◽  
Chemical Species ◽  
Pharmaceutical Chemistry ◽  
Industrial Chemistry ◽  
Anti Fungal

Synthesis of Schiff bases from different types of aromatic aldehyde and 3-amino-2- napthol-4-sulphonic acid and then prepared the Co (II), Zn (II) complexes. Metal complexes of Schiff bases have occupied a central role in the development of coordination Chemistry. A number of verities of stable chemical species have been synthesized, containing transition metal and multifarious ligand. Metal complexes of Schiff base shows the strong anti fungicidal, anti bacterial activity, anti viral infection, anticancer, herbicides, plant growth regulators and anti covulsants . Metal complexes also find a wide applications in the field of industrial chemistry, analytical chemistry, pharmaceutical chemistry, agricultural chemistry and bioorganic chemistry. Recently hetrocyclic such as 2 ‘al’ pyrrol, 2 ‘al’ furan, 2 ‘al’ thiophen and aromatic aldehyde, there metal Zn (II), Co (II) complexes have also gained a focal position in bioinorganic field and frequently used as antifungal, plant growth regulators and anticancer.

scholarly journals Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2735 ◽  
Author(s):  
Syed Amir Ashraf ◽  
Abd Elmoneim O. Elkhalifa ◽  
Arif Jamal Siddiqui ◽  
Mitesh Patel ◽  
Amir Mahgoub Awadelkareem ◽  
...  
Keyword(s):  
Healthy Lifestyle ◽  
Therapeutic Potential ◽  
Good Health ◽  
Hydroxyl Group ◽  
Medicinal Mushroom ◽  
Health And Wellbeing ◽  
Medicinal Fungus ◽  
Bioactive Component ◽  
Wide Range ◽  
Anti Fungal

Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. Cordyceps contains various bioactive components, out of which, cordycepin is considered most vital, due to its utmost therapeutic as well as nutraceutical potential. Moreover, the structure similarity of cordycepin with adenosine makes it an important bioactive component, with difference of only hydroxyl group, lacking in the 3′ position of its ribose moiety. Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health. In this review, effort has been made to bring altogether the possible wide range of cordycepin’s nutraceutical potential along with its pharmacological actions and possible mechanism. Additionally, it also summarizes the details of cordycepin based nutraceuticals predominantly available in the market with expected global value. Moreover, this review will attract the attention of food scientists, nutritionists, pharmaceutical and food industries to improve the use of bioactive molecule cordycepin for nutraceutical purposes with commercialization to aid and promote healthy lifestyle, wellness and wellbeing.

Structure–sweetness relationships for fructose analogs. Part III. 3-Deoxy-D-erythro-hexulose (3-deoxy-D-fructose): composition in solution and evaluation of sweetness

1995 ◽  
Vol 73 (10) ◽  
pp. 1639-1644 ◽  
Author(s):  
Walter A. Szarek ◽  
Robert J. Rafka ◽  
Te-Fang Yang ◽  
Olivier R. Martin
Keyword(s):  
Complex Mixture ◽  
Structural Features ◽  
Sweet Taste ◽  
Hydroxyl Group ◽  
Solution Composition ◽  
Pyranose Form ◽  
Keto Form ◽  
Open Chain ◽  
Tautomeric Forms ◽  
Essential Function

As part of continuing studies on the structural features responsible for the intense sweetness of D-fructose, 3-deoxy-D-erythro-hexulose (3-deoxy-D-fructose, 1) was prepared, its solution composition was determined, and its taste was evaluated. In aqueous solution, 3-deoxy-D-fructose exists as a complex mixture of five tautomeric forms in which the β-D-pyranose form is preponderant (52.5% at 22 °C) and the α-D-pyranose form is the least abundant (5%). Quite remarkable is the behavior of the open-chain keto form of 1: its content increases from 7.5% at 22 °C, to 36% at 82 °C, and to 47% at 97 °C, making this form the preponderant one at high temperatures. 3-Deoxy-D-fructose was found to be sweet, albeit probably not as sweet as D-fructose. The hydroxyl group at C-3 is thus not an essential function of the glycophore of D-fructose. The significance of this result is discussed in relation to the evidence already available and the divergent theories that have been proposed to explain the origin of the sweet taste of D-fructose. Keywords: 3-deoxy-D-erythro-hexulose (3-deoxy-D-fructose), sweetness, solution composition.

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