scholarly journals Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2735 ◽  
Author(s):  
Syed Amir Ashraf ◽  
Abd Elmoneim O. Elkhalifa ◽  
Arif Jamal Siddiqui ◽  
Mitesh Patel ◽  
Amir Mahgoub Awadelkareem ◽  
...  
Keyword(s):  
Healthy Lifestyle ◽  
Therapeutic Potential ◽  
Good Health ◽  
Hydroxyl Group ◽  
Medicinal Mushroom ◽  
Health And Wellbeing ◽  
Medicinal Fungus ◽  
Bioactive Component ◽  
Wide Range ◽  
Anti Fungal

Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. Cordyceps contains various bioactive components, out of which, cordycepin is considered most vital, due to its utmost therapeutic as well as nutraceutical potential. Moreover, the structure similarity of cordycepin with adenosine makes it an important bioactive component, with difference of only hydroxyl group, lacking in the 3′ position of its ribose moiety. Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health. In this review, effort has been made to bring altogether the possible wide range of cordycepin’s nutraceutical potential along with its pharmacological actions and possible mechanism. Additionally, it also summarizes the details of cordycepin based nutraceuticals predominantly available in the market with expected global value. Moreover, this review will attract the attention of food scientists, nutritionists, pharmaceutical and food industries to improve the use of bioactive molecule cordycepin for nutraceutical purposes with commercialization to aid and promote healthy lifestyle, wellness and wellbeing.

scholarly journals Harmine and its derivatives: Biological activities and therapeutic potential in human diseases

2018 ◽  
Vol 13 (3) ◽  
pp. 203 ◽  
Author(s):  
Maria Javeed ◽  
Azhar Rasul ◽  
Ghulam Hussain ◽  
Farhat Jabeen ◽  
Bilal Rasool ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Biological Profile ◽  
Bioactive Component ◽  
Wide Range ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Molecular Mechanism Of Action ◽  
Reported Data

<p>This review article aims to provide an update on the sources, pharmaco-logical and biological profile of a β-carboline alkaloid, harmine which is a major bioactive component of various plants mainly Peganum harmala. Harmine’s wide range of pharmacological properties has been well-documented as anti-cancer, anti-inflammatory, anti-oxidant, neuroprotective, anti-depressant, and antimicrobial. Although reported data suggests a multifunctional pharmacological role of harmine but farther experimentation on its molecular mechanism of action, synthetic chemistry approaches, and preclinical studies are yet obligatory to fully uncover its pharmacological efficacy.</p>

Isoform-Selective PI3K Inhibitors for Various Diseases

2020 ◽  
Vol 20 (12) ◽  
pp. 1074-1092 ◽  
Author(s):  
Rammohan R.Y. Bheemanaboina
Keyword(s):  
Intracellular Signaling ◽  
Kinase Inhibitors ◽  
Therapeutic Potential ◽  
Type I ◽  
Selective Inhibitors ◽  
Pi3k Inhibitors ◽  
Wide Range ◽  
Lipid Kinases ◽  
Isoform Selectivity

Phosphoinositide 3-kinases (PI3Ks) are a family of ubiquitously distributed lipid kinases that control a wide variety of intracellular signaling pathways. Over the years, PI3K has emerged as an attractive target for the development of novel pharmaceuticals to treat cancer and various other diseases. In the last five years, four of the PI3K inhibitors viz. Idelalisib, Copanlisib, Duvelisib, and Alpelisib were approved by the FDA for the treatment of different types of cancer and several other PI3K inhibitors are currently under active clinical development. So far clinical candidates are non-selective kinase inhibitors with various off-target liabilities due to cross-reactivities. Hence, there is a need for the discovery of isoform-selective inhibitors with improved efficacy and fewer side-effects. The development of isoform-selective inhibitors is essential to reveal the unique functions of each isoform and its corresponding therapeutic potential. Although the clinical effect and relative benefit of pan and isoformselective inhibition will ultimately be determined, with the development of drug resistance and the demand for next-generation inhibitors, it will continue to be of great significance to understand the potential mechanism of isoform-selectivity. Because of the important role of type I PI3K family members in various pathophysiological processes, isoform-selective PI3K inhibitors may ultimately have considerable efficacy in a wide range of human diseases. This review summarizes the progress of isoformselective PI3K inhibitors in preclinical and early clinical studies for anticancer and other various diseases.

scholarly journals Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Kieran Joyce ◽  
Georgina Targa Fabra ◽  
Yagmur Bozkurt ◽  
Abhay Pandit
Keyword(s):  
Tissue Engineering ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Biological Assessment ◽  
Cross Linking ◽  
Natural Polymers ◽  
Drug Delivery Device ◽  
Biomedical Device ◽  
Wide Range ◽  
Bioactive Potential

AbstractBiomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, and more. There is an increasing trend in tissue engineering to use natural substrates, such as macromolecules native to plants and animals to improve the biocompatibility and biodegradability of delivered materials. At the same time, these materials have favourable mechanical properties and often considered to be biologically inert. More importantly, these macromolecules possess innate functions and properties due to their unique chemical composition and structure, which increase their bioactivity and therapeutic potential in a wide range of applications. While much focus has been on integrating these materials into these devices via a spectrum of cross-linking mechanisms, little attention is drawn to residual bioactivity that is often hampered during isolation, purification, and production processes. Herein, we discuss methods of initial material characterisation to determine innate bioactivity, means of material processing including cross-linking, decellularisation, and purification techniques and finally, a biological assessment of retained bioactivity of a final product. This review aims to address considerations for biomaterials design from natural polymers, through the optimisation and preservation of bioactive components that maximise the inherent bioactive potency of the substrate to promote tissue regeneration.

scholarly journals Workplace Healthy Lifestyle Determinants and Wellbeing Needs across the Preconception and Pregnancy Periods: A Qualitative Study Informed by the COM-B Model

2021 ◽  
Vol 18 (8) ◽  
pp. 4154
Author(s):  
Seonad K. Madden ◽  
Claire A. Blewitt ◽  
Kiran D. K. Ahuja ◽  
Helen Skouteris ◽  
Cate M. Bailey ◽  
...  
Keyword(s):  
Healthy Lifestyle ◽  
Intervention Development ◽  
Health Behavior Change ◽  
Overweight And Obesity ◽  
Specific Reference ◽  
Lifestyle Behaviors ◽  
Policy Makers ◽  
Health And Wellbeing ◽  
Healthy Lifestyle Behaviors ◽  
And Control

Overweight and obesity present health risks for mothers and their children. Reaching women during the key life stages of preconception and pregnancy in community settings, such as workplaces, is an ideal opportunity to enable health behavior change. We conducted five focus groups with 25 women aged between 25 and 62 years in order to investigate the determinants of healthy lifestyle behaviors, weight management, and wellbeing needs during the preconception and pregnancy periods in an Australian university workplace. Discussions explored women’s health and wellbeing needs with specific reference to workplace impact. An abductive analytical approach incorporated the capability, opportunity, and motivation of behavior (COM-B) model, and four themes were identified: hierarchy of needs and values, social interactions, a support scaffold, and control. Findings highlight the requirement for greater organization-level support, including top-down coordination of wellbeing opportunities and facilitation of education and support for preconception healthy lifestyle behaviors in the workplace. Interventionists and organizational policy makers could incorporate these higher-level changes into workplace processes and intervention development, which may increase intervention capacity for success.

scholarly journals Human Rights in the Least Developed Countries of Asia: An Index for Quantifying Sustainable Development Goal 3 (Good Health and Wellbeing)

2021 ◽  
Vol 18 (9) ◽  
pp. 4747
Author(s):  
Karen G. Añaños Bedriñana ◽  
José Antonio Rodríguez Martín ◽  
Fanny T. Añaños
Keyword(s):  
Sustainable Development ◽  
Maternal Education ◽  
Good Health ◽  
Developed Countries ◽  
Least Developed Countries ◽  
Sustainable Development Goal ◽  
Distance Method ◽  
Development Goal ◽  
Health And Wellbeing ◽  
The Impact

This paper aims to measure disparities among the variables associated with Sustainable Development Goal (SDG) 3 defined by the United Nations (UN) in the least developed countries (LDCs) of Asia. In the terms of the UN Conference on Trade and Development, LDCs are countries with profound economic and social inequalities. The indicator was constructed using a set of variables associated with SDG3: Good Health and Wellbeing. Applying Pena’s DP2 distance method to the most recent data available (2018) enables regional ordering of Asia’s LDCs based on the values of these variables. The index integrates socioeconomic variables that permit examination of the impact of each individual indicator to determine territorial disparities in terms of the partial indicators of SDG3. “Maternal education,” “Proportion of women who make their own informed decisions regarding sexual relations, contraceptive use, and reproductive health care,” and “Gender parity index in primary education” are the most important variables in explaining spatial disparities in good health and wellbeing in the LDCs of Asia.

scholarly journals Reinterpreting the SDGs: Taking Animals into Direct Consideration

2021 ◽  
Vol 13 (2) ◽  
pp. 843
Author(s):  
Olle Torpman ◽  
Helena Röcklinsberg
Keyword(s):  
Sustainable Development ◽  
United Nations ◽  
Sustainable Development Goals ◽  
Good Health ◽  
Clean Water ◽  
Water And Sanitation ◽  
Agenda 2030 ◽  
Health And Wellbeing ◽  
Development Goals ◽  
Zero Hunger

The United Nations Agenda 2030 contains 17 sustainable development goals (SDGs). These goals are formulated in anthropocentric terms, meaning that they are to be achieved for the sake of humans. As such, the SDGs are neglecting the interests and welfare of non-human animals. Our aim in this paper was to ethically evaluate the assumptions that underlie the current anthropocentric stance of the SDGs. We argue that there are no good reasons to uphold these assumptions, and that the SDGs should therefore be reconsidered so that they take non-human animals into direct consideration. This has some interesting implications for how we should understand and fulfil the pursuit of sustainability in general. Most noticeably, several SDGs—such as those regarding zero hunger (SDG 2), good health and wellbeing (SDG 3), clean water and sanitation (SDG 6)—should be achieved for animals as well. Moreover, the measures we undertake in order to achieve the SDGs for humans must also take into direct account their effects on non-human animals.

Mechanistic Study on Gold(I)-Catalyzed Unsaturated Spiroketalization Reaction

2022 ◽  
Vol 19 ◽  
Author(s):  
Kamlesh Sharma
Keyword(s):  
Activation Barrier ◽  
Ring Formation ◽  
Hydroxyl Group ◽  
Mechanistic Study ◽  
Protecting Group ◽  
Wide Range ◽  
Oxocarbenium Ion ◽  
Metal Catalyzed ◽  
Insight Into ◽  
Mechanism Of The Reaction

Abstract: The mechanism of metal-catalyzed spiroketalization of propargyl acetonide is explored by employing DFT with the B3LYP/6-31+G(d) method. Acetonide is used as a regioselective regulator in the formation of monounsaturated spiroketal. The energies of transition states, intermediates, reactants and products are calculated to provide new insight into the mechanism of the reaction. The energetic features, validation of the observed trends in regioselectivity are conferred in terms of electronic indices via FMO analysis. The presence of acetonide facilitates a stepwise spiroketalization as it masks the competing nucleophile, and thus hydroxyl group present, exclusively acts as a nucleophile. The vinyl gold intermediate 3 is formed from 2 via activation barrier TS1. This is the first ring formation, which is 6-exo-dig cyclization. The intermediate 3 is converted into allenyl ether 4, which isomerizes to the intermediate oxocarbenium ion 5 via activation barrier TS2. The intermediate 5 cyclizes to 6 via TS3. This is the second ring formation. The intermediate 6 on protodeauration turns into 6,6-monounsaturated spiroketal 7. It is concluded that acetonide as a protecting group serves the purpose, and thus a wide range of spiroketals can be prepared, regioselectivity.

Targeted chemical nucleases have a wide range of untapped applications in biological fields, including gene therapy

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Metal Complex ◽  
Dna Cleavage ◽  
Therapeutic Potential ◽  
Chemical Reactivity ◽  
Major Groove ◽  
Sequence Recognition ◽  
Wide Range ◽  
Chemical Nucleases

A feasible alternative to state-of-the-art enzymatic nucleases was created by regulating the cleavage activity of metal complexes using (covalent or non-covalent) homing agents. Targeted AMNs, unlike enzymatic nucleases, break DNA by an oxidative mechanism and can therefore permanently knock off genes. Compared to larger enzymatic nucleases, the modest size of the metal complex may aid cellular transfection. Furthermore, the painstaking construction of the sequence-specific probe permits a metal complex to be directed to dsDNA's minor or major groove. To direct the chemical reactivity of several small-molecule compounds to dsDNA's minor groove, covalently bonded polyamide samples were used. PNA and DNA were also used to construct antisense and antigen hybrids, with Watson–Crick or Hoogsteen base pairing with major groove nucleobases giving sequence recognition. Click chemistry created chimeric AMN-TFOs with desirable focused effects and negligible off-target cleavage. Clip-Phen-modified TFOs, 230 polypyridyl-modified TFOs, 232 and intercalating phenanthrene-modified TFOs are three contemporary instances of copper AMN–TFOs. All three systems have distinct advantages in maintaining the desired 2:1 phenthroline/copper ratio for DNA cleavage (clip-Phen TFOs), caging the copper center and facilitating efficient ROS-mediated strand scission (polypyridyl-modified TFO) and improving triplex stability (polypyridyl-modified TFO) (phenanthrene-TFOs). Cerium (IV)/EDTA complexes, recently shown to bind and hydrolytically cleave ssDNA/dsDNA junctions and used in conjunction with PNA to successfully introduce genome changes in vitro and in vivo, are another important class of targeted chemical nucleases. The chemical reactivity and wide flexibility of metal complex design, combined with their coupling to sequence specific samples for directed applications, show that these compounds have a wide range of untapped applications in biological fields such as chemotherapy, protein engineering, DNA footprinting, and gene editing. Parallel advancements in cell and tissue targeting will be essential to maximise their therapeutic potential, either by using specific ligands or creating new targeting modalities.

scholarly journals Older Adults’ Perception of Their Needs in Tehran: A Cry for Emotional and Social Support

2016 ◽  
Vol 9 (2) ◽  
pp. 134
Author(s):  
Sima Ghasemi ◽  
Nastaran Keshavarz Mohammadi ◽  
Farahnaz Mohammadi Shahboulaghi ◽  
Ali Ramezankhani
Keyword(s):  
Social Support ◽  
Older Adult ◽  
Meaning In Life ◽  
Healthy Lifestyle ◽  
Social Needs ◽  
Health Needs ◽  
Social Health ◽  
Structured Interviews ◽  
Instrumental Social Support ◽  
Wide Range

<p><strong>INTRODUCTION: </strong>Background and purpose: Human’s longevity has increased with advances in health and better management of communicable diseases. Therefore, the number of older adult is increasing in developed and developing countries. A glimpse at studies reveals that identifying elderly’s health needs has been mainly based on the experts’ understanding, while older adult themselves have rarely expressed their own opinions. This study aimed to better understand Tehran, Iran elderly’s perception of their own health needs.</p><p><strong>METHODS: </strong>In this qualitative study, with purposeful sampling, data was collected by conducting deep semi-structured interviews with elderlies aged 60-84 years, residing at their private houses. After 19 interviews, the data achieved saturation. The content of the interviews was analyzed through content-analysis approach.<strong></strong></p><p><strong>RESULTS: </strong>Data analyses led to extracting main categories of needs in different domains. The main health needs in physical health domain included: having a healthy lifestyle, independence and safety. Regarding elders’ mental health, coping with their aging, inner tranquility; regarding their spiritual health, the need to have a meaning in life and faithfulness in religion were identified as main groups of needs. And the most important among their main social health needs were the needs for emotional and social support, social involvement and instrumental social support. <strong></strong></p><p><strong>CONCLUSION: </strong>Although, a wide range of physical, mental and social needs were raised, some were more important. Fulfilling the emotional needs in social health had the highest frequency among the needs expressed by the contributors. Following that with a notable difference were the frequencies of having a healthy lifestyle, independence and inner tranquility. This means that attempts to address elderly health needs should avoid focusing mainly or even only on disease related needs and serious attention should be paid to their emotional and social needs.</p>

scholarly journals A therapeutic community as a relevant and efficient ecclesial model in African Christianity

2016 ◽  
Vol 72 (4) ◽  
Author(s):  
Matsobane Manala
Keyword(s):  
South African ◽  
Good Health ◽  
Healing Ministry ◽  
Black African ◽  
African Christianity ◽  
Health And Wellbeing ◽  
Reformed Church ◽  
Healing Community ◽  
African Worldview ◽  
Health And Healing

This article sets forth the argument that Christian ministry in Africa must become socially and culturally informed and constructed or else it will not touch the African soul and thus remain superficial. Black African people aspire above everything else to experience fullness of life and wellbeing here and now, as demonstrated by their greetings that are actually an enquiry into each other’s health and an expression of the wish for the other’s good health and wellbeing. The mainline churches that operate in Africa should embrace the scripturally sound Christian healing ministry in obedience to Christ’s commission to preach the gospel and heal the sick, if they are to prosper. Hence, this article discusses the following eight points, namely, (1) good health and healing as Africans’ important aspiration, (2) healing as the work of God and thus of the church, (3) the imperative of serious consideration of and respect for the African worldview, (4) membership decline and mainline churches’ loss of influence, (5) rethinking church in African Christianity, (6) the need for the black African church to adopt a therapeutic or healing community ecclesial model in order to position itself strategically to cater for the holistic needs of African (South African) church members and surrounding communities, (7) the rationale of the healing ministry in today’s Reformed Church in Africa and (8) the recommended healing ministry. The article closes with a few concluding statements and advice

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