scholarly journals ROLE OF FUNCTIONALIZED GUAR GUM IN SOLID DISPERSION OF NON-STEOIDAL ANTI-INFLAMMATORY DRUG

2021 ◽  
Vol 9 (08) ◽  
pp. 1057-1067
Author(s):  
S. P Alane ◽  
◽  
A.B. Velhal ◽  
V.K Redasani ◽  
◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Guar Gum ◽  
Chemical Interaction ◽  
Current Investigation ◽  
Wide Scope ◽  
Dsc Studies ◽  
Ich Guidelines ◽  
Dissolution Behaviour ◽  
Dispersion Technique

The current investigation was developed to study the role of functionalized guar gum as carrier in solid dispersion of iboprofen. The solid dispersion technique using aminated guar gum would be an effective approach for increasing the solubility and increasing dissolution behaviour of ill fathomable medicament than the native guar gum. The results of FTIR and DSC studies confirmed that there is no chemical interaction or no incompatability between the drug and excipients. The invitro dissolution study was performed for the the prepared formulations. Based on the results SD3 was shown highest drug release 99.41% within 24hrs. Stabiliy study was conducted as per ICH guidelines and the falloutsrevealed that there is no physical or chemical change.it may be concluded that solubility of ibuprofen can br improved by using functionalized guar gum in the solid dispersion, which provides a wide scope for the therapeutic efficiency.

EVALUATION OF TRIBULUS TERRESTRIS MUCILAGE AS BINDER IN TABLET FORMULATIONS

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (07) ◽  
pp. 10-17
Author(s):  
V. A Arsul ◽  
◽  
S. Lahoti ◽  
P. K Sharma ◽  
B. Shrivastava
Keyword(s):  
Guar Gum ◽  
Chemical Interaction ◽  
Wet Granulation ◽  
Content Uniformity ◽  
Tribulus Terrestris ◽  
Stability Studies ◽  
Granulation Process ◽  
Ich Guidelines ◽  
Tablet Formulations ◽  
Model Drug

The aim of this study is to develop an economic and effective natural excipient that can be used as an alternative in formulation of tablets. Tribulus terrestris (Zygophyllaceae) is a herbaceous weed native throughout India and mucilage is derived from the freshly dried and coarsely powdered leaves. phytochemical and physiochemical characteristics of mucilage were studied. Mucilage was used in 5 different concentrations (10, 15, 20, 25, and 30% w/V). Metoprolol tartrate was used as model drug for formulation. The DSC and FTIR of drug and mucilage indicate no chemical interaction. The properties were compared with guar gum (GRAS excipient). The granules were prepared by wet granulation process and evaluated. Tablets were prepared and evaluated for disintegration, dissolution and content uniformity and was subjected to stability studies as per ICH guidelines. It was concluded that lower concentration of mucilage can be used as binder. The higher concentration shows sustained release and can be considered as alternative release retardant.

scholarly journals Solubility and Dissolution Enhancement of Ebastine by Surface Solid Dispersion Technique

2021 ◽  
Vol 30 (1) ◽  
pp. 122-132
Author(s):  
Lna S. Hussein ◽  
Eman B. H. Al-Khedairy
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Water Solubility ◽  
Chemical Interaction ◽  
Drug Carrier ◽  
Dissolution Enhancement ◽  
Duration Of Action ◽  
Drug Content ◽  
Percentage Yield ◽  
Dispersion Technique

Ebastine (EBS) is a non-sedating antihistamine with a long duration of action. This drug has predominantly hydrophobic property causing a low solubility and low bioavailability. Surface solid dispersions (SSD) is an effective technique for improving the solubility and dissolution rate of poorly soluble drugs by using hydrophilic water insoluble carriers. The present study aims to enhance the solubility and dissolution rate of EBS by using surface solid dispersion technique. Avicel® PH101, Avicel® PH 102, croscarmellose sodium(CCS) and sodium starch glycolate(SSG) were used as water insoluble hydrophilic carriers. The SSD formulations of EBS were prepared by the solvent evaporation method in different drug:  carrier weight ratios and evaluated for their percentage yield, drug content , water solubility, dissolution study in 0.1 N HCl, crystal lattice using powder  X-ray diffraction (PXRD) and Fourier Transform Infrared Spectroscopy (FTIR) for determination the drug-carrier interaction. Most of the prepared SSD formulas showed improvement of drug solubility. The best result was obtained with formula SSD16 (EBS:CCS 1:15) that showed high percentage yield (98.5%), high drug content (98.39%) and 8.2 fold increase in solubility compared to solubility of pure drug with improved dissolution rate. The drug was converted to amorphous form without chemical interaction with the carrier.

scholarly journals SOLUBILITY AND DISSOLUTION ENHANCEMENT OF PIOGLITAZONE USING SOLID DISPERSION TECHNIQUE

2017 ◽  
pp. 186-193
Author(s):  
Bhushan A. Bhairav ◽  
Lalit R. Jagtap ◽  
R. B. Saudagar
Keyword(s):  
Solid Dispersion ◽  
Chemical Interaction ◽  
Physicochemical Characteristics ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Hydrophobic Drug ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Dispersion Technique ◽  
Poorly Water Soluble Drug

Objective: To design the study to improve the solubility and hence enhance the dissolution of hydrophobic drug Pioglitazone in order to increase its bioavailability.Methods: Solid dispersion of Pioglitazone using carriers Poloxomer 188 and HPβCD was formulated in different ratios by microwave induced fusion method. In particular, the Microwave technology has been considered in order to prepare an enhanced release dosage form for poorly water soluble drug Pioglitazone. Statistical Analysis: Their physicochemical characteristics and solubility were compared to the corresponding dispersions and marketed drug. Drug and polymer were further characterized by FTIR.Results: The results of FTIR revealed that no chemical interaction between the drug and the polymer exist.Conclusion: All the formulations showed a marked increase in drug release with the increase in the concentration of Poloxomer 188 and HPβCD. 

IN VITRO CHARACTERISTICS OF MODIFIED PULSINCAP FORMULATION WITH MESALAMINE FOR ULCERATIVE COLITIS TREATMENT

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (03) ◽  
pp. 35-43
Author(s):  
H. C Vadlamudi ◽  
◽  
Raju Y Prasanna ◽  
Y. B Rubia ◽  
J. Vulava ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethyl Cellulose ◽  
Guar Gum ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Phase Solubility ◽  
Natural Polymers ◽  
Dsc Studies ◽  
Dispersion Technique

The present work aims at fabricating the colon specific drug delivery of mesalamine (MES) by modified pulsincap technique and using natural polysaccharides. Mesalamine being poorly water soluble drug, solubility has been increased by solid dispersion technique using natural polymers such as guar gum (GG), hupu gum (HG) and xanthan gum (XG). Solid dispersions were prepared by kneading method at 1:1, 1:2 and 1:3 weight ratios (drug:polymer). The solid dispersions were characterized by FTIR, DSC studies and evaluated for practical yield, drug content. Saturation solubility, pH dependent solubility, phase solubility studies and dissolution studies were carried out. The solubility of the formulated solid dispersions was high when compared to pure drug. The order of drug release from the solid dispersions prepared by different gums are as follows GG>HG>XG and different ratio exhibited release as 1:3>1:2>1:1. The optimized solid dispersions have been exploited in the formulation of pulsincaps. Bodies were made insoluble by formaldehyde treatment. Solid dispersions of mesalamine were filled in the bodies. Guar gum (GG) was used as hydrogel plug. Sealing of body and cap was done using ethyl cellulose. Ethyl cellulose coating was employed on pulsincaps to ensure the capsule empties from the stomach intact. The pulsincaps were assessed for their dissolution profiles. Percent MES release from pulsincaps prepared with pure MES, MES-GG, MES-HG and MES-XG solid dispersions were found to be 63.22, 96.25, 94.90 and 93.05 respectively. Our studies have shown very effective and desirable mesalamine release profiles by pulsincap formulations at simulated colon pH condition, which can enable the drug delivery specifically at colon segment.

PERILAKU DISOLUSI KETOPROFEN DAN INDOMETASIN FARNESIL TERSALUT GEL KITOSAN-GOM GUAR

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Purwantiningsih Sugita ◽  
Bambang Srijanto ◽  
Budi Arifin ◽  
Fithri Amelia ◽  
Mahdi Mubarok
Keyword(s):  
Room Temperature ◽  
Guar Gum ◽  
Tween 80 ◽  
Chitosan Solution ◽  
In Vitro Dissolution ◽  
Dissolution Profile ◽  
Magnetic Stirrer ◽  
Dissolution Behaviour ◽  
Shrimp Shell Waste

Chitosan, a modification of shrimp-shell waste, has been utilized as microcapsule. However, it’s fragile gel property needs to be strengthened by adding glutaraldehyde (glu) and natural hydrocolloid guar gum (gg). This research’s purposes were to study dissolution behaviour of ketoprofen and infar through optimum chitosan-guar gum microcapsule. Into 228.6 mL of 1.75% (w/v) chitosan solution in 1% (v/v) acetic acid,38.1 mL of gg solution was added with concentration variation of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules and 0.05, 0.19, and 0.33% (w/v) for infar microcapsules, and stirred with magnetic stirrer until homogenous. Afterwards, 7.62mL of glu was added slowly under stirring, with concentrations varied: 3, 3.5, and 4% (v/v) for ketoprofen microcapsules, and 4, 4.5, and 5% (v/v) for infar microcapsules. All mixtures were shaked for 20 minutes for homogenization. All mixtures wereshaked for 20 minutes for homogenization. Into each  microcapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added, whereas solution of 100 mg of in 250 mL of 96% ethanol was added into each microcapsule mixture for infar. Every mixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Everymixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. The data of [gg], [glu], and medicine’s content from each microcapsule were treated with Minitab 14 software to obtain optimum [gg] and [glu] for microencapsulation. The dissolution behaviour of optimum ketoprofen and infar microcapsules were investigated. The result of optimization by using Minitab Release 14 software showed that among the microcapsule compositions of [gg] and [glu] were 0.35% (w/v) and 3.75% (v/v), respectively, optimum to coat ketoprofen, whereas [gg] and [glu] of 0.05% (w/v) and4.00% (v/v), respectively, optimum to coat infar, at constant chitosan concentration (1.75% [w/v]). In vitro dissolution profile showed that chitosan-guar gum gel microcapsule was more resistant in intestinal pH condition (rather basic) compared with that in gastric pH (very acidic).

Solubility Enhancement of Poorly Water-Soluble Antifungal Drug Acyclovir by Nanocrystal Formulation Approach

2018 ◽  
Vol 11 (2) ◽  
pp. 4036-4042
Author(s):  
Prakash Goudanavar ◽  
Ankit Acharya ◽  
Vinay C.H
Keyword(s):  
Chemical Interaction ◽  
Research Work ◽  
Antiviral Drug ◽  
In Vitro Release ◽  
Oral Route ◽  
Water Soluble ◽  
Precipitation Method ◽  
Dsc Studies ◽  
Ft Ir

Administration of an antiviral drug, acyclovir via the oral route leads to low and variable bioavailability (15-30%). Therefore, this research work was aimed to enhance bioavailability of acyclovir by nanocrystallization technique. The drug nanocrystals were prepared by anti-solvent precipitation method in which different stabilizers were used. The formed nanocrystals are subjected to biopharmaceutical characterization including solubility, particle size and in-vitro release. SEM studies showed nano-crystals were crystalline nature with sharp peaks. The formulated drug nanocrystals were found to be in the range of 600-900nm and formulations NC7 and NC8 showed marked improvement in dissolution velocity when compared to pure drug, thus providing greater bioavailability. FT-IR and DSC studies revealed the absence of any chemical interaction between drug and polymers used. 

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