Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosterone

Plastic production is prominently increasing and its pollution is an emerging environmental global health concern. This study aimed to investigate the occurrence of pre-diabetes and type 2 diabetes mellitus (T2DM) among nonsmoking plastic industry workers. Three hundred and forty volunteers male plastic industry workers were interviewed after medical history and examination; finally, 278 nonsmoking plastic industry workers were selected. The mean age for the participants was 38.03 ± 10.86 years and body mass index was 25.52 ± 3.15 (kg/m)2. The plastic industry workers had been exposed to plastic plant pollution for 8 hr daily, 6 days in a week. Subjects with glycated hemoglobin (HbA1c) less than 5.7% were considered non-diabetics; HbA1c 5.7%–6.4% were pre-diabetics; and subjects with HbA1c greater than 6.4% were considered diabetics. In plastic industry workers, the prevalence of pre-diabetes was 176 (63.30%) and T2DM was 66 (23.74%); however, 36 (12.95%) plastic plant workers were normal. The prevalence of pre-diabetes and T2DM among plastic industry workers was significantly increased with duration of working exposure in plastic industry ( p = .0001). Exposure to plastic plant pollution is associated with the prevalence of pre-diabetes and T2DM among plastic industry workers. The prevalence was associated with the duration of working exposure in plastic industry. The occupational and environmental health executives must take priority steps to minimize the plastic plant pollution from plastic industries to reduce the occurrence of pre-diabetes and T2DM among the plastic industrial workers and save the men’s health in industries.

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Green tea consumption and risk of type 2 diabetes in Chinese adults: the Shanghai Women’s Health Study and the Shanghai Men’s Health Study

International Journal of Epidemiology ◽

10.1093/ije/dyy173 ◽

2018 ◽

Vol 47 (6) ◽

pp. 1887-1896 ◽

Cited By ~ 10

Author(s):

Xiaona Liu ◽

Wanghong Xu ◽

Hui Cai ◽

Yu-Tang Gao ◽

Honglan Li ◽

...

Keyword(s):

Type 2 Diabetes ◽

Women’S Health ◽

Women's Health ◽

Green Tea ◽

Men’S Health ◽

Health Study ◽

Men's Health ◽

Tea Consumption ◽

Chinese Adults

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Men's Health, Low Testosterone, and Diabetes Individualized

The Diabetes Educator ◽

10.1177/0145721708327143 ◽

2008 ◽

Vol 34 (5_suppl) ◽

pp. 97S-112S ◽

Cited By ~ 5

Author(s):

Donna Rice ◽

Robert E. Brannigan ◽

R. Keith Campbell ◽

Shari Fine ◽

Leonard Jack ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Sexual Health ◽

The United States ◽

Men’S Health ◽

Men's Health ◽

Testosterone Therapy ◽

Testosterone Levels ◽

Low Testosterone

Testosterone plays a critical role in male reproductive and metabolic functioning. Serum testosterone levels decrease with age, and low testosterone is associated with a variety of comorbidities, including insulin resistance, type 2 diabetes, obesity, metabolic syndrome, and cardiovascular disease. Men with type 2 diabetes have been shown to have significantly lower testosterone levels than men without diabetes. Several forms of testosterone replacement therapy (eg, oral, injectable, buccal, transdermal preparations) are available for use in the United States. The primary goals of testosterone therapy are to restore physiologic testosterone levels and reduce the symptoms of hypogonadism. Testosterone therapy may be a viable option in some men with diabetes and low testosterone; however, clinicians must be aware of contraindications to therapy (eg, prostate cancer and male breast cancer), implement appropriate monitoring procedures, and ensure that patient expectations are realistic regarding treatment outcome. Data suggest that testosterone therapy may have a positive effect on bones, muscles, erythropoiesis and anemia, libido, mood and cognition, penile erection, cholesterol, fasting blood glucose, glycated hemoglobin, insulin resistance, visceral adiposity, and quality of life. Sexual health may be a window into men's health; thus, more effective communication strategies are needed between clinicians and men with diabetes to ensure that sexual health topics are adequately addressed. Diabetes educators can play a key role in screening for low testosterone, providing relevant information to patients, and increasing clinician awareness of the need to address men's sexual health and implement appropriate strategies. Multidisciplinary care and individualized treatment are needed to optimize outcome.

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Men's health after COVID-19 in patients with type 2 diabetes mellitus and hypogonadism

Endocrinology: News, Opinions, Training ◽

10.33029/2304-9529-2021-10-4-25-32 ◽

2021 ◽

Vol 10 (4) ◽

pp. 25-32

Author(s):

D.I. Esaulenko ◽

◽

E.R. Rozhivanova ◽

V.A. Zakurdaev ◽

R.V. Rozhivanov ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Men’S Health ◽

Men's Health

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Antioxidative Properties and Inhibition of Key Enzymes Relevant to Type-2 Diabetes and Hypertension by Essential Oils from Black Pepper

Advances in Pharmacological Sciences ◽

10.1155/2013/926047 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 14

Author(s):

Ganiyu Oboh ◽

Ayokunle O. Ademosun ◽

Oluwatoyin V. Odubanjo ◽

Ifeoluwa A. Akinbola

Keyword(s):

Type 2 Diabetes ◽

Essential Oil ◽

Enzyme Activities ◽

Phenolic Content ◽

Antioxidant Properties ◽

Black Pepper ◽

Converting Enzyme ◽

Piper Guineense ◽

Key Enzymes

The antioxidant properties and effect of essential oil of black pepper (Piper guineense) seeds onα-amylase,α-glucosidase (key enzymes linked to type-2 diabetes), and angiotensin-I converting enzyme (ACE) (key enzyme linked to hypertension) were assessed. The essential oil was obtained by hydrodistillation and dried with anhydrous Na2SO4, and the phenolic content, radical [1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) and nitric oxide (NO)] scavenging abilities as well as the ferric reducing antioxidant property (FRAP) and Fe2+-chelating ability of the essential oil were investigated. Furthermore, the effect onα-amylase,α-glucosidase, and ACE enzyme activities was also investigated. The characterization of the constituents was done using GC. The essential oil scavenged DPPH*, NO*, and ABTS* and chelated Fe2+.α-Pinene,β-pinene, cis-ocimene, myrcene, allo-ocimene, and 1,8-cineole were among the constituents identified by GC. The essential oil inhibitedα-amylase,α-glucosidase, and ACE enzyme activities in concentration-dependent manners, though exhibiting a stronger inhibition ofα-glucosidase thanα-amylase activities. Conclusively, the phenolic content, antioxidant activity, and inhibition ofα-amylase,α-glucosidase, and angiotensin-1 converting enzyme activities by the essential oil extract of black pepper could be part of the mechanism by which the essential oil could manage and/or prevent type-2 diabetes and hypertension.

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Interaction of Some Commercial Teas with Some Carbohydrate Metabolizing Enzymes Linked with Type-2 Diabetes: A Dietary Intervention in the Prevention of Type-2 Diabetes

Advances in Preventive Medicine ◽

10.1155/2014/534082 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Ganiyu Oboh ◽

Omodesola O. Ogunruku ◽

Funke O. Ogidiolu ◽

Adedayo O. Ademiluyi ◽

Bukola C. Adedayo ◽

...

Keyword(s):

Type 2 Diabetes ◽

Ascorbic Acid ◽

Antioxidant Activities ◽

Antioxidant Properties ◽

Inhibitory Effect ◽

Total Phenol ◽

Total Phenol Content ◽

Reducing Ability ◽

Significant Difference

This study is aimed at assessing the inhibitory effect of teas on key enzymes (α-amylase andα-glucosidase) linked with type-2 diabetes and their antioxidant properties. Four samples of three brands were used; infusions of green tea (GT), 2 brands of black tea (BT), and a formulated herbal preparation for diabetes (ADT) (white tea,Radix Puerariae,Radix ophiopogonis, hawthorn berry, Chinese yam, and fragrant Solomon seal rhizome) were prepared and subsequently analyzed for their total phenol, ascorbic acid contents, antioxidant properties (2,2-Azizobis (3-Ethylbenzo-Thiazoline~6-sulfonate) “ABTS” scavenging ability and ferric reducing antioxidant property), and inhibition of pancreatic-α-amylase and intestinal-α-glucosidasein vitro. The study revealed that GT had the highest total phenol content, ascorbic acid content, ABTS* scavenging ability, and ferric reducing ability. Furthermore, all the teas inhibited Fe2+and sodium nitroprusside induced lipid peroxidation in pancreas, with GT having the highest inhibitory effect. Conversely, there was no significant difference (P>0.05) in the inhibitory effects of the teas onα-amylase andα-glucosidase. The antidiabetic property of the teas could be attributed to their inhibitory effect on carbohydrate hydrolyzing enzymes implicated in diabetes and their antioxidant activities.

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Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?

Redox Report ◽

10.1080/13510002.2017.1324381 ◽

2017 ◽

Vol 23 (1) ◽

pp. 1-24 ◽

Cited By ~ 12

Author(s):

Siu Wai Choi ◽

Cyrus K. Ho

Keyword(s):

Type 2 Diabetes ◽

Diabetes Management ◽

Antioxidant Properties ◽

Antioxidant Therapy

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Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery

Antioxidants ◽

10.3390/antiox10010081 ◽

2021 ◽

Vol 10 (1) ◽

pp. 81

Author(s):

Jinjoo Lee ◽

Seungjin Noh ◽

Suhyun Lim ◽

Bonglee Kim

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Side Effects ◽

Protein Kinase ◽

Plant Extracts ◽

Antioxidant Properties ◽

Acid Oxidation ◽

Amino Terminal ◽

Chronic Hyperglycemia

Type 2 diabetes mellitus (T2DM) is one of the largest public health problems worldwide. Insulin resistance-related metabolic dysfunction and chronic hyperglycemia result in devastating complications and poor prognosis. Even though there are many conventional drugs such as metformin (MET), Thiazolidinediones (TZDs), sulfonylureas (SUF), dipeptidyl peptidase 4 (DPP-4) inhibitors, glucagon like peptide 1 (GLP-1) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, side effects still exist. As numerous plant extracts with antidiabetic effects have been widely reported, they have the potential to be a great therapeutic agent for type 2 diabetes with less side effects. In this study, sixty-five recent studies regarding plant extracts that alleviate type 2 diabetes were reviewed. Plant extracts regulated blood glucose through the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. The anti-inflammatory and antioxidant properties of plant extracts suppressed c-Jun amino terminal kinase (JNK) and nuclear factor kappa B (NF-κB) pathways, which induce insulin resistance. Lipogenesis and fatty acid oxidation, which are also associated with insulin resistance, are regulated by AMP-activated protein kinase (AMPK) activation. This review focuses on discovering plant extracts that alleviate type 2 diabetes and exploring its therapeutic mechanisms.

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