The role of brief intervention in achieving and maintaining abstinence in patients with alcoholic liver disease

Objective of the study. prove the effectiveness of brief psychological intervention (BPI) conducted by an internist in achieving and maintaining abstinence in patients with alcoholic liver disease (ALD).Materials and methods. A total of 65 patients were included in the study: 29 patients in the BPI group and 36 in the historical control group. A comparative analysis of the frequency of achievement and maintenance of abstinence and analysis of factors associated with these parameters were conducted.Results of the study. The frequency of achieving abstinence was significantly higher in the BPI group compared with the control group after 6, 9, 12 and 24 months from the date of inclusion in the study (p <0.001, p = 0.002, p = 0.001, p = 0.017, respectively; criterion χ2). The frequency of failures to achieve abstinence in the CPC group was significantly lower than in the control group after 6 months and in general for the entire observation period (p = 0.004, p = 0.005, respectively; criterion χ2). Provision of BPIs for 12 months after alcohol-induced decompensation serves as a factor that is reliably associated with achieving total abstinence within 24 months (p = 0.001, criterion χ2). Decompensated cirrhosis of the liver serves as factors independently associated with failures to achieve abstinence within 24 months after alcohol-induced illness (OS: 10.72 [95% CI 2.17–52.81]; p = 0.004) and the absence of BPI after discharge from the hospital (OSH BPI: 0.80 [95% CI 0.14–0.479]; p = 0.006)Conclusion. BPIs provided by an internist to the patients with ABD for 12 months after alcohol-induced decompensation leads to a higher rate of achieving total abstinence and decrease in the frequency of failures to achieve abstinence within 24 months after discharge from the hospital.

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IMPORTANT ROLE OF TRACE ELEMENTS (MG AND ZN) IN THE SERUM OF PATIENTS SUFFERING FROM NON-ALCOHOLIC LIVER DISEASE AND COMPARE THEIR LEVEL WITH HEALTHY SUBJECTS OF RAJASTHAN

10.36106/ijsr/6928037 ◽

2021 ◽

pp. 29-31

Author(s):

halini Vyas ◽

RK Vyas ◽

Hemlata Sharma

Keyword(s):

Trace Elements ◽

Liver Disease ◽

Alcoholic Liver Disease ◽

Healthy Subjects ◽

Control Group ◽

P Value ◽

Wide Range ◽

Range Of Functions ◽

Serum Trace Elements

Liver is the largest major organ of our body. liver having a wide range of functions so, it is prone to many diseases which are very commonly seen in India. Any disturbance of liver function that causes illness is called liver disease. It is also known as hepatic disease. It is major leading cause of morbidity and mortality worldwide. Aim of this study was to nd out the role of Trace Elements (Mg & Zn) levels in diagnosis of Non-alcoholic liver disease. Material and methods: 200 subjects were selected out of them 100 were selected as study group (Non-alcoholic (NALD) and 100 were selected as control group and distributed according to their age and sex. Trace elements were estimated by Atomic adsorption spectrophotometer (AAS). Result: the serum trace elements level was decreased in non-alcoholic liver disease patients. P-value was found to be signicant when compared with healthy subjects. (P≤0.001). Conclusion: We came to the conclusion that serum level trace elements (Mg, Zn) activity looks specic and can be used for prognostic evolution of non-alcoholic liver disease.

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Optimization of long-term prognosis of patients with alcoholic liver disease

Medical Council ◽

10.21518/2079-701x-2019-21-176-181 ◽

2020 ◽

pp. 176-181

Author(s):

V. D. Lunkov ◽

M. V. Maevskaya ◽

V. T. Ivashkin

Keyword(s):

Liver Disease ◽

Liver Function ◽

Alcoholic Liver Disease ◽

Psychological Assessment ◽

Decompensated Cirrhosis ◽

Control Group ◽

Term Survival ◽

Long Term Survival

Aim: to prove the effectiveness of combined physical and psychological assessment in improving the long-term outcome of patients with alcoholic liver disease (ALD).Materials and methods: the active outpatient follow-up (AOF) group included 29 patients with ALD consisted of active liver function and motivation assessment, motivational interviewing, liver panel lab tests with the rate once at 3 months. The AOF program consisted of dynamic monitoring of liver function at least 1 time in 3 months and psychological support provided by the hepatologist using brief interventional approach. The control of abstinence was provided by using self-reports and indirect biomarkers of alcohol consumption. The control group included 36 patients with ALD and history of two-years follow-up after first alcoholinduced liver injury who received comprehensive therapy and a simple advice to avoid alcohol.Results: the adherence to abstinence were significantly higher in AOF group compared with control group. The proportion of patients with decompensated cirrhosis was significantly lower in AOF group compared with control group at 12 and 24 months after enrollment. The long-term survival in AOF-group was significantly higher than in control group. The only parameter independently associated with long-term survival was the presence of AOF program.Conclusion: the combined physical and psychological assessment of patients with ALD, provided by internists improves adherence to abstinence, reduces the risk of decompensation of liver function, severity of ALD and improves patients survival in the long term period.

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The Role of Nitric Oxide and Ferritin in the Pathogenesis of Alcoholic Liver Disease: a Controlled Clinical Study

Bosnian Journal of Basic Medical Sciences ◽

10.17305/bjbms.2009.2807 ◽

2009 ◽

Vol 9 (3) ◽

pp. 204-209 ◽

Cited By ~ 2

Author(s):

Azra Husić-Selimović ◽

Jasminko Huskić ◽

Zora Vukobrat-Bijedić ◽

Rusmir Mesihović ◽

Mehmed Gribajčević

Keyword(s):

Liver Disease ◽

Alcoholic Liver Disease ◽

Binding Capacity ◽

Liver Parenchyma ◽

Total Iron ◽

Control Group ◽

Total Iron Binding Capacity ◽

Male Patients ◽

Iron Binding Capacity

The role of ferritin in fibrogenesis of liver parenchyma in patients with alcoholic liver disease has been investigated in previous studies. Ferritin was shown to be an indirect marker of ferum deposition in liver parenchyma in alcohol liver disease. The aim of the present study was to examine the role of nitric oxide (NO) in the pathogenesis of alcoholic liver disease as well as the influence of NO on iron (ferritin) me-tabolism in patients with alcoholic liver disease.Serum concentrations of NO and iron markers (iron, total iron binding capacity, ferritin) were measured in 30 male patients (aged 20-60 years) with alcoholic liver disease, as well as from a control group (30 male patients (aged 20-60 years) without liver disease). NO concentration was detected by measuring production of nitrates and nitrites using classical colorimetric Griess reactions.There was a statistically significant increase in serum NO concentration in patients with alcoholic liver disease compared to the control group (mean ± SEM; 41,2 ± 25,3 vs. 28,9 ± 12,3 mmol/dm3, respectively; p<0,03). Similarly, serum iron levels (18,7 ± 8,2 vs. 13,2 ± 10,2 g/100 cm3, respectively; p<0,03) and serum total iron binding capacity (51,3 ± 13,9 vs. 41,4 ± 11,4 μmol/dm3, respectively; p<0,005) were also signifi-cantly higher in patients with alcoholic liver disease compared to control patients. The serum concentration of ferritin was 27% higher in patients with alcoholic liver disease than in the control group; however this was not statistically significant (283,2 ± 291,0 vs. 222,9 ± 252,0 g, respectively; p<0,4). There was no correlation between NO and ferritin in the investigated groups.These results suggest a possible role of NO and iron in the pathogenesis of alcoholic liver disease. NO and iron may be used as non-invasive predictors of liver damage. Also the role of iron in sera, and its deposition in liver parenchyma, could be used in clinical practice, especially in regards to assessing the fibrogenesis of liver parenchyma induced by ferritin.

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Hepatic iron overload in alcoholic liver disease: The role of sinusoidal endothelial cells in iron sensing

10.1055/s-0039-3402118 ◽

2020 ◽

Author(s):

S Wang ◽

T Peccerella ◽

V Rausch ◽

S Mueller

Keyword(s):

Endothelial Cells ◽

Liver Disease ◽

Iron Overload ◽

Alcoholic Liver Disease ◽

Hepatic Iron ◽

Sinusoidal Endothelial Cells ◽

Hepatic Iron Overload

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Factors associated with the development of paediatric chronic otitis media by age nine: a prospective longitudinal cohort study of 6560 children

The Journal of Laryngology & Otology ◽

10.1017/s0022215120002182 ◽

2020 ◽

pp. 1-12

Author(s):

P J Clamp ◽

K De-Loyde ◽

A R Maw ◽

S Gregory ◽

J Golding ◽

...

Keyword(s):

Cohort Study ◽

Otitis Media ◽

Maternal Education ◽

Univariate Analysis ◽

Chronic Otitis Media ◽

Birth Cohort Study ◽

Control Group ◽

Factors Associated ◽

Prospective Longitudinal

Abstract Objective This study aimed to analyse social, health and environmental factors associated with the development of chronic otitis media by age nine. Method This was a prospective, longitudinal, birth cohort study of 6560 children, reviewed at age nine. Chronic otitis media defined as previous surgical history or video-otoscopic changes of tympanic membrane retraction, perforation or cholesteatoma. Non-affected children were used as the control group. Results Univariate analysis demonstrated an association between chronic otitis media and otorrhoea, snoring, grommet insertion, adenoidectomy, tonsillectomy, hearing loss, abnormal tympanograms and preterm birth. Multivariate analysis suggests many of these factors may be interrelated. Conclusion The association between chronic otitis media and otorrhoea, abnormal tympanograms and grommets supports the role of the Eustachian tube and otitis media (with effusion or acute) in the pathogenesis of chronic otitis media. The role of snoring, adenoidectomy and tonsillectomy is unclear. Associations suggested by previous studies (sex, socioeconomic group, parental smoking, maternal education, childcare, crowding and siblings) were not found to be significant predictors in this analysis.

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Metabolism of vitamin D in patients with primary biliary cirrhosis and alcoholic liver disease

Clinical Science ◽

10.1042/cs0690561 ◽

1985 ◽

Vol 69 (5) ◽

pp. 561-570 ◽

Cited By ~ 42

Author(s):

E. Barbara Mawer ◽

H. J. Klass ◽

T. W. Warnes ◽

Jacqueline L. Berry

Keyword(s):

Vitamin D ◽

Liver Disease ◽

Primary Biliary Cirrhosis ◽

Alcoholic Liver Disease ◽

Vitamin D3 ◽

Control Group ◽

Biliary Cirrhosis ◽

Vitamin D2 ◽

Dihydroxyvitamin D3 ◽

Poor Renal Function

1. The metabolism of isotopically labelled vitamin D2 and D3 has been investigated in eight patients with primary biliary cirrhosis and in five controls. The concentration of labelled vitamin D2 was lower than that of vitamin D3 in serum of patients with primary biliary cirrhosis on days 1 and 2 after intravenous injection (P < 0.005 and P < 0.05, respectively) but no difference was seen in controls. 2. Similar amounts of labelled 25-hydroxyvitamin D2 and D3 were seen in serum of the control group; the same pattern was observed in the primary biliary cirrhosis group, and no significant differences were observed between the two groups. 3. In both control and primary biliary cirrhosis groups, the serum concentration of labelled 24,25-dihydroxyvitamin D2 exceeded that of 24,25-dihydroxyvitamin D3 (significant for controls on day 2, P < 0.02) but concentrations in the two groups were not different. 4. Concentrations of labelled 25,26-dihydroxyvitamin D3 were significantly higher than those of 25,26-dihydroxyvitamin D2 in the primary biliary cirrhosis group at all times and in the control group on days 2 and 3. Both 25,26-dihydroxyvitamin D2 and D3 were higher in the serum of patients with primary biliary cirrhosis than in controls (significant on day 1, P < 0.05). 5. Urinary excretion over days 0–3 of radioactivity from both vitamins D2 and D3 was significantly higher in the primary biliary cirrhosis group than in controls: 12.03 vs 1.80% for vitamin D2 and 8.98 vs 1.76% for vitamin D3(P < 0.005). Vitamin D2-derived urinary radioactivity in primary biliary cirrhosis correlated strongly with serum bilirubin (P = 0.005). 6. The metabolism of labelled vitamin D3 was studied in seven patients with alcoholic liver disease, three of whom showed low serum concentrations of labelled 25-hydroxyvitamin D3 suggesting impaired hepatic synthesis. The 25-hydroxylation response was quantified as the relative index of 25-hydroxylation and was significantly related to two other indices of liver function. It is concluded that impaired 25-hydroxylation of vitamin D may occur in alcoholic liver disease and results from hepatocellular dysfunction. 7. Less than the predicted amounts of 1,25-dihydroxyvitamin D3 were produced in four of the seven patients with alcoholic liver disease; this defect may be attributable in part to decreased precursor 25-hydroxyvitamin D and to poor renal function.

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