Inhalation therapy for bronchial asthma in the conditions of paediatric section

Medical Council ◽

10.21518/2079-701x-2020-10-108-114 ◽

2020 ◽

pp. 108-114

Author(s):

W. V. Delyagin

Keyword(s):

Bronchial Asthma ◽

Inhalation Therapy ◽

Bronchial Inflammation ◽

Difficulty Breathing ◽

Choice Of Treatment ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Inhalation Techniques ◽

Acute And Chronic Inflammation ◽

Degree Of Severity

The prevalence of bronchial asthma among children in different regions of Russia ranges from 10.9–9.6‰ to 50–55‰. The frequency of bronchial asthma among lyceum students is 33.1‰, while in the most overcrowded school it is 45.8‰. Bronchial asthma occurs more frequently in the mild, less frequently in the medium form. Therefore, the main burden on the management of such patients falls on the ambulatory segment. Diagnosed on the basis of respiratory symptoms such as wheezing, difficulty breathing, strain and bloating of the chest, coughing. Asthmatic attack with bronchial asthma of any degree of severity can be as severe or even asthmatic status, which, along with the prevalence of bronchial asthma, determines the primary importance of ambulatory control of the disease. It is fundamental to suppress local bronchial inflammation and remove bronchospasm. Adequacy and systematic treatment is essential for the outcome of bronchial asthma in children. Timely anti-inflammatory treatment can lead to remission. Inhalation techniques of anti-inflammatory drugs and bronchodilators are the most optimal. The possibility of application of beclometasone (inhalation glucocorticosteroid), a combination of fluticasone and salmeterol, ipratropium bromide of Russian manufacture, which efficiency is proved in practical work and economically justified, is considered. IGCS, acting locally, have a pronounced anti-inflammatory activity, suppressing both acute and chronic inflammation. Clinical examples of children with atopic dermatitis and the revealed diagnosis of bronchial asthma, with an optimum choice of treatment are given. It is proved that application of modern inhalation drugs in complex treatment leads to bronchial asthma remission.

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Alternative Anti-Inflammatory Drugs in the Treatment of Bronchial Asthma

Clinical Pulmonary Medicine ◽

10.1097/00045413-199401020-00001 ◽

1994 ◽

Vol 1 (2) ◽

pp. 69-77 ◽

Cited By ~ 4

Author(s):

Gregory C. Kane ◽

Stephen P. Peters ◽

James E. Fish

Keyword(s):

Bronchial Asthma ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Quinoline as TRPV1 Antagonists: A New Approach against Inflammation

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i4-s.3414 ◽

2019 ◽

Vol 9 (4-s) ◽

pp. 782-788

Author(s):

Megha P. Ambatkar ◽

Pramod B. Khedekar

Keyword(s):

Transient Receptor Potential ◽

Receptor Potential ◽

Transient Receptor Potential Vanilloid ◽

The Novel ◽

Quinoline Ring ◽

First Response ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Transient Receptor ◽

Acute And Chronic Inflammation

Inflammation is the first response of the immune system to harmful stimuli such as infection or irritation, consists of a cascade of biochemical events that propagates and matures the inflammatory response. Number of anti-inflammatory drugs are available for treatment of acute and chronic inflammation. Many anti-inflammatory drugs cause adverse side effects. The quinoline class of compounds are important for searching the safe and effective anti-inflammatory drugs. These drugs are classified based on the number of substituents present on the quinoline ring or compounds containing a quinoline ring fused to other heterocyclic compounds. Quinolines have the ability to target several causes of inflammation includes transient receptor potential vanilloid 1 receptor. The TRPV1 receptor, first cloned and characterized in 1997, is a non-selective cation channel expressed in primary sensory neurons, and is a key pain sensor and integrator. This review provides the discovery of various quinoline derivatives as transient receptor potential vanilloid 1 (TRPV1) antagonists. Overall, the quinoline moiety will be used as a new template for designing and identifying the novel anti-inflammatory drugs in future. Keywords: Quinoline, Inflammation, Transient receptor Potential Vanilloid 1, Antagonists.

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Effects of aqueous and ethanolic extracts of Aegle marmelos (BAEL) leaves on chronic inflammation in rats

Ibrahim Medical College Journal ◽

10.3329/imcj.v9i2.28854 ◽

2016 ◽

Vol 9 (2) ◽

pp. 52-54

Author(s):

Sharmin Rahman ◽

Eliza Omar Eva ◽

Rezaul Quader ◽

Muqbula Tasrin ◽

Md Ismail Khan

Keyword(s):

Chronic Inflammation ◽

Granuloma Formation ◽

Aegle Marmelos ◽

Inflammatory Conditions ◽

Flower Stem ◽

Ethanolic Extracts ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Acute And Chronic Inflammation ◽

Inflammatory Effect

Aegle Marmelos Linn (Rutaceae) is used as ethno medicine against various human ailments. Several curde extracts from various parts (Leaves, flower, stem, root etc) of the plant A. marmelos Linn have shown variable anti-inflammatory effects in acute and chronic inflammation in animal models. The anti-inflammatory effects of A marmelos linn may be of special advantage compared to conventional anti-inflammatory drugs. The present study has therefore been undertaken with the objective to evaluate the anti inflammatory effect of aqueous and ethanolic extracts of A. marmelos leaves, compared to a standard anti-inflammatory drug (indomethacin) in chronic inflammatory conditions. The anti-inflammatory effect was studied in rats using cotton pellet implantation, where granuloma formation was used as an index of chronic inflammation. Aqueous and ethanolic extracts of A. marmelos leaves were given orally for 7 days daily at doses of 100 mg/kg body weight. The percent inhibition of granuloma formation following treatment with aqueous and ethanolic extracts of A. marmelos leaves, and indomethacin compared to control were 16.5%, 25.72%, and 39.37% respectively. The differences were statistically significant (p<0.05 in case of aqueous and ethanolic extracts and p<0.001 in case of indomethacin). The results suggest that in case of chronic inflammation, both aqueous and ethanolic extracts of A. marmelos have significant anti- inflammatory effect. The ethanolic extracts compared to aqueous extract produced greater anti- inflammatory effects.Ibrahim Med. Coll. J. 2015; 9(2): 52-54

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Is there a role for cherries in the management of gout?

Therapeutic Advances in Musculoskeletal Disease ◽

10.1177/1759720x19847018 ◽

2019 ◽

Vol 11 ◽

pp. 1759720X1984701 ◽

Cited By ~ 5

Author(s):

Marcum W. Collins ◽

Kenneth G. Saag ◽

Jasvinder A. Singh

Keyword(s):

Adverse Events ◽

Novel Treatment ◽

Lowering Therapy ◽

Tnf Α ◽

Potential Benefits ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Acute And Chronic Inflammation ◽

Destructive Arthropathy ◽

Gout Flares

Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs for the treatment of gout, there is considerable interest in novel treatment approaches. Patients with gout often have a multitude of comorbidities, leading to concern over drug–drug interactions and medication adverse events. The cherry is a small nutrient-rich fruit that has garnered a great deal of attention in recent years as a nonpharmacologic option for the treatment of a multitude of disease manifestations. Perhaps a quarter of patients with gout try cherries or cherry products to treat their gout, which have antioxidant and anti-inflammatory (IL-6, TNF-α, IL-1β, IL-8, COX-I and -II) properties, hypouricemic effects, and the ability to downregulate NFkB-mediated osteoclastogenesis. Based on these properties, cherries may reduce both the acute and chronic inflammation associated with recurrent gout flares and its chronic destructive arthropathy. In this review, we explore the potential benefits of cherries and cherry products as a nonpharmacologic option for the treatment of gout.

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Low radiation dose to treat pneumonia and other inflammations

British Journal of Radiology ◽

10.1259/bjr.20201265 ◽

2021 ◽

pp. 20201265

Author(s):

Ming Tsuey Chew ◽

Eman Daar ◽

Mayeen Uddin Khandaker ◽

Bleddyn Jones ◽

Andrew Nisbet ◽

...

Keyword(s):

Low Dose ◽

External Beam ◽

Pathogenic Microorganisms ◽

Malignant Diseases ◽

Malignant Tumours ◽

Low Radiation Dose ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Radiation Treatments ◽

Acute And Chronic Inflammation

Infection, the invasion of pathogenic microorganisms and viruses, causes reactive inflammation mediated by endogenous signals, with influx of leucocytes with distinct properties and capable of mounting a cellular or antibody response. Different forms of inflammation may also occur in response to tumours, in allergy and autoimmune disorders. Pneumonia, respiratory tract infection and septic shock for instance can arise as serious complications of the Covid-19 virus. While radiotherapy has been most widely used to control malignant tumours, it has also been used for treatment of non-malignant diseases, including acute and chronic inflammation in situations where anti-inflammatory drugs may be ineffective or contraindicated. The present review examines the history and prospects for low-dose anti-inflammatory radiation treatments, the present interest largely being motivated by the increased incidence of pulmonary disease associated Covid-19 infections. Evidence in support of the suggested efficacy are covered, together with an appraisal of one of the number of potential convenient sources that could complement external beam arrangements.

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NEW FEATURES OF THE PHARMACOLOGICAL CONTROL OF ASTHMA

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja813 ◽

2011 ◽

Vol 8 (3) ◽

pp. 73-78

Author(s):

E V Nazarova ◽

Nataliya Ivanovna Il'ina ◽

E V Nazarova ◽

N I Ilina

Keyword(s):

Respiratory Tract ◽

Asthma Control ◽

Bronchial Asthma ◽

Lung Tissue ◽

Lower Respiratory Tract ◽

Airflow Obstruction ◽

Convincing Evidence ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Pharmacological Control

traditionally, bronchial asthma (Ba) was considered as a disease of large and medium bronchi, but recently obtained convincing evidence that inflammation in asthma captures the distal parts of the lower respiratory tract. several studies have proved that the peripheral respiratory ways, including the lung tissue itself, are the principal place of airflow obstruction in patients with asthma. there are currently actively being developed devices for improving the delivery of anti-inflammatory drugs on the periphery of the lung, to improve asthma control.

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Evaluation of anti - inflammatory activity of aqueous extract of leaves of hibiscus sabdariffa in albino rats

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20171669 ◽

2017 ◽

Vol 6 (5) ◽

pp. 1155

Author(s):

Soumya B. Patil ◽

Swetha Munoli

Keyword(s):

Aqueous Extract ◽

Inflammatory Activity ◽

Albino Rats ◽

Paw Edema ◽

Standard Drug ◽

Inflammatory Agent ◽

Chronic Model ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Acute And Chronic Inflammation

Background: Inflammation continues to be an area of great interest for research, probably due to the non-availability of a safer and more effective analgesic and anti-inflammatory agent. This has led to increase in demand for natural products with anti-inflammatory activity having fewer side effects. Non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin are used in the treatment of inflammation, fever and pain. However, NSAIDs cause gastric damage as a major adverse reaction. In this study, the anti-inflammatory activity of aqueous extract H. sabdariffa Linn was studied using carrageenan and formalin for acute and chronic inflammation respectively in albino rats.Methods: In this study, anti-inflammatory activity of H. sabdariffa was studied and compared with standard drug, indomethacin. Aqueous extract of leaves of H. sabdariffa (200mg/kg or 400mg/kg) and indomethacin (25mg/kg) were used to separate groups of rats and paw edema was measured by plethysmometer and compared with control group.Results: H. sabdariffa did not show any significant reduction of paw edema (P >0.05) in both the models of inflammation i.e. carrageenan induced acute model and formalin induced chronic model of inflammation.Conclusions: H. sabdariffa didn’t show any significant anti-inflammatory activity.

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