PROTECTIVE EFFECTS OF MARJORAM OIL (ORGANIUM MAJORANA L.) ON ANTIOXIDANT ENZYMES IN EXPERIMENTAL DIABETIC RATS

The goal of diabetes treatment is primarily to save life and alleviate symptoms and secondary to prevent long-term diabetic complications resulting from hyperglycemia. Thus, our present investigation was designed to evaluate the hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin (NA/STZ)-induced diabetic rats. Experimental type 2 diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (65 mg/kg b.wt.), after 15 min of i.p. injection of NA (120 mg/kg b.wt.). Gallic acid and p-coumaric acid were orally administered to diabetic rats at a dose of 20, 40 mg/kg b.wt./day, respectively, for 6 weeks. Body weight, serum glucose, protein profile, liver function enzymes and kidney function indicators was assayed. Treatment with either gallic acid or p-coumaric acid significantly ameliorated the elevated levels of glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and uric acid. Both compounds were also found to restore total protein, albumin, and globulin as well as body weight of diabetic rats to near normal values. It can conclude that both gallic acid and p-coumaric acid have potent hypoglycemic and hepato-renal protective effects in diabetic rats. Therefore, our results suggest promising hypoglycemic agents that can attenuate the progression of diabetic hepatopathy and nephropathy.

Download Full-text

Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats

Biotechnic & Histochemistry ◽

10.1080/10520295.2021.1949041 ◽

2021 ◽

pp. 1-10

Author(s):

İbrahim Aktaş ◽

Fatih Mehmet Gür

Keyword(s):

Diabetic Rats ◽

Protective Effects ◽

Aminoisobutyric Acid

Download Full-text

Modulation of hepatic and intestinal Glutathione S-transferases and other antioxidant enzymes by dietary lipids in streptozotocin diabetic rats

Chemosphere ◽

10.1016/s0045-6535(98)00502-5 ◽

1999 ◽

Vol 38 (13) ◽

pp. 3003-3013 ◽

Cited By ~ 12

Author(s):

M.Dolores Girón ◽

Rafael Salto ◽

Yolanda González ◽

Jose A. Girón ◽

Natalia Nieto ◽

...

Keyword(s):

Antioxidant Enzymes ◽

Diabetic Rats ◽

Dietary Lipids ◽

Glutathione S Transferases ◽

Streptozotocin Diabetic Rats

Download Full-text

Attenuation of erythrocyte membrane oxidative stress bySesbania grandiflorain streptozotocin-induced diabetic rats

Biochemistry and Cell Biology ◽

10.1139/bcb-2015-0039 ◽

2015 ◽

Vol 93 (4) ◽

pp. 385-395 ◽

Cited By ~ 7

Author(s):

Chandrabose Sureka ◽

Thiyagarajan Ramesh ◽

Vavamohaideen Hazeena Begum

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Blood Glucose ◽

Erythrocyte Membrane ◽

Osmotic Fragility ◽

Diabetic Rats ◽

Glycosylated Haemoglobin ◽

Albino Rats ◽

Enzymatic Antioxidants ◽

Protective Effects

The aim of the present study was to investigate the protective effects of Sesbania grandiflora flower (SGF) extract on erythrocyte membrane in Streptozotocin (STZ)-induced diabetic rats. Adult male albino rats of Wistar strain, weighing 190–220 g, were made diabetic by an intraperitonial administration of STZ (45 mg/kg). Normal and diabetic rats were treated with SGF, and diabetic rats were also treated with glibenclamide as drug control, for 45 days. In this study plasma insulin and haemoglobin levels were decreased and blood glucose, glycosylated haemoglobin, protein oxidation, lipid peroxidation markers, and osmotic fragility levels were increased in diabetic rats. Moreover, erythrocytes antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxide, glutathione reductase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase activities and non-enzymatic antioxidants such as vitamin C, vitamin E, reduced glutathione (GSH), and oxidized glutathione (GSSG) levels were altered. Similarly, the activities of total ATPases, Na+/K+-ATPase, Ca2+-ATPase, and Mg2+-ATPase were also decreased in the erythrocytes of diabetic rats. Administration of SGF to STZ-induced diabetic rats reduced blood glucose and glycosylated haemoglobin levels with increased levels of insulin and haemoglobin. Moreover, SGF reversed the protein and lipid peroxidation markers, osmotic fragility, membrane-bound ATPases activities, and antioxidant status in STZ-induced diabetic rats. These results suggest that SGF could provide a protective effect on diabetes by decreasing oxidative stress-associated diabetic complications.

Download Full-text

Evaluation of Effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu Polymorphisms in Patients with IBD in the Polish Population

Polish Journal of Surgery ◽

10.1515/pjs-2016-0071 ◽

2016 ◽

Vol 88 (6) ◽

Cited By ~ 4

Author(s):

Jerzy Mrowicki ◽

Małgorzata Mrowicka ◽

Ireneusz Majsterek ◽

Michał Mik ◽

Adam Dziki ◽

...

Keyword(s):

Oxidative Stress ◽

Ulcerative Colitis ◽

Inflammatory Bowel Disease ◽

Antioxidant Enzymes ◽

Bowel Disease ◽

Protective Effects ◽

Polish Population ◽

Nucleotide Polymorphisms ◽

Inflammatory Bowel ◽

Genotype C

AbstractInflammatory bowel disease (IBD) are a heterogeneous group of disorders in the course dominated by chronic, recurrent gastrointestinal inflammation. It is believed that the activation of IBD occurs in patients with a genetic predisposition to their development. Chronic inflammation develops as a result of an excessive reaction of the immune system principally under the influence of environmental risk factors. Among them, it has been shown that the mechanism of oxidative stress is associated with the pathophysiology of inflammatory bowel disease, responsible for the commencement and progress of these diseases.was the relationship between single nucleotide polymorphisms (SNPs) of individual antioxidant enzymes, and the prevalence of inflammatory bowel disease that may be associated with increased levels of oxidative stress.A total of 111 IBD patients, including 65 patients with ulcerative colitis (UC) and 46 with Crohn’s disease (CD) and 125 healthy controls recruited from the Polish population, were genotyped forThe performed analysis of genetic polymorphisms of antioxidant enzymes showed that polymorphic variant of the CAT -262 C / T may have protective effects in patients with ulcerative colitis in the range of genotype C / T; OR = 0.49 (0.25-0.99), p = 0.044. Trend protective, but statistically unrelated, it was also observed for genotype T / T and T allele of the same polymorphism and genotypes and allelesIt has been shown that the polymorphism of antioxidant enzymes

Download Full-text