scholarly journals The possible ameliorative effect of vitamin D3 and/or omega-3 fatty acids in a rat model of type I early diabetic nephropathy: A physiological and histological study

2022 ◽  
Vol 42 (1) ◽  
pp. 101-117
Author(s):  
Nahed El-Sokkary ◽  
Alaaeldin Yusuf ◽  
Rehab Abdel-Moneim ◽  
Hanan Abdulrazeg ◽  
Passainte Hassaan
Keyword(s):  
Fatty Acids ◽  
Diabetic Nephropathy ◽  
Vitamin D3 ◽  
Rat Model ◽  
Histological Study ◽  
Type I ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Ameliorative Effect ◽  
Early Diabetic Nephropathy

Pilot study on omega-3 fatty acids in type I diabetes mellitus

Diabetes ◽  
1990 ◽  
Vol 39 (3) ◽  
pp. 369-375 ◽  
Author(s):  
M. M. Landgraf-Leurs ◽  
C. Drummer ◽  
H. Froschl ◽  
R. Steinhuber ◽  
C. Von Schacky ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acids ◽  
Pilot Study ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment

Biomolecules ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 100 ◽  
Author(s):  
Laiali Alquraan ◽  
Karem H. Alzoubi ◽  
Hana Hammad ◽  
Suzie Y. Rababa’h ◽  
Fadia Mayyas
Keyword(s):  
Fatty Acids ◽  
Rat Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Memory Impairment ◽  
Stress Disorder ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Post Traumatic Stress ◽  
Post Traumatic

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can happen after exposure to a traumatic event. Post-traumatic stress disorder is common among mental health disorders that include mood and anxiety disorders. Omega-3 fatty acids (OMGs) are essential for the maintenance of brain function and prevention of cognition dysfunctions. However, the possible effect of OMG on memory impairment induced by PTSD has not been studied. In here, such an effect was explored using a rat model of PTSD. The PTSD-like behavior was induced in animals using a single-prolonged stress (SPS) rat model of PTSD (2 h restraint, 20 min forced swimming, 15 min rest, 1–2 min diethyl ether exposure). The OMG was administered orally at a dose of 100 mg omega-3 polyunsaturated fatty acid (PUFA)/100 g body weight/day. Spatial learning and memory were assessed using the radial arm water maze (RAWM) method. Changes in oxidative stress biomarkers, thiobarbituric acid reactive substances (TBARS), and brain derived neuroptrophic factor (BDNF) in the hippocampus following treatments were measured. The results revealed that SPS impaired both short- and long-term memory (p < 0.05). Use of OMG prevented memory impairment induced by SPS. Furthermore, OMG normalized SPS induced changes in the hippocampus that reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratios, the activity of catalase, glutathione peroxidase (GPx), and TBARSs levels. In conclusion, the SPS model of PTSD-like behavior generated memory impairment, whereas OMG prevented this impairment, possibly through normalizing antioxidant mechanisms in the hippocampus.

P117 OMEGA-3 FATTY ACIDS INHIBIT OXIDATIVE STRES IN A RAT MODEL OF LIVER REGENERATION

2008 ◽  
Vol 3 ◽  
pp. 78
Author(s):  
O. Makay ◽  
O. Firat ◽  
G. Gokce ◽  
N. Sapaz ◽  
C. Yenisey ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Liver Regeneration ◽  
Rat Model ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Belmiro Parada ◽  
Flávio Reis ◽  
Raquel Cerejo ◽  
Patrícia Garrido ◽  
José Sereno ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bladder Cancer ◽  
Rat Model ◽  
Redox Status ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Markers Of Inflammation ◽  
Male Wistar Rats ◽  
Serum Crp

Omega-3 (ω-3) fatty acids have been tested on prevention and treatment of several cancer types, but the efficacy on “in vivo” bladder cancer has not been analyzed yet. This study aimed at evaluating the chemopreventive efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) mixture in an animal model of bladder cancer. Forty-four male Wistar rats were divided into 4 groups during a 20-week protocol: control; carcinogen—N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN);ω-3 (DHA + EPA); andω-3 + BBN. BBN andω-3 were given during the initial 8 weeks. At week 20 blood and bladder were collected and checked for the presence of urothelium lesions and tumors, markers of inflammation, proliferation, and redox status. Incidence of bladder carcinoma was, control (0%),ω-3 (0%), BBN (65%), andω-3 + BBN (62.5%). Theω-3 + BBN group had no infiltrative tumors or carcinomain situ, and tumor volume was significantly reduced compared to the BBN (0.9 ± 0.1 mm3versus 112.5 ± 6.4 mm3). Also, it showed a reduced MDA/TAS ratio and BBN-induced serum CRP, TGF-β1, and CD31 were prevented. In conclusion, omega-3 fatty acids inhibit the development of premalignant and malignant lesions in a rat model of bladder cancer, which might be due to anti-inflammatory, antioxidant, anti-proliferative, and anti-angiogenic properties.

scholarly journals Evaluation of liver regeneration diet supplemented with omega-3 fatty acids: experimental study in rats

2015 ◽  
Vol 42 (6) ◽  
pp. 393-397 ◽  
Author(s):  
Rosilda Mendes da Silva ◽  
Osvaldo Malafaia ◽  
Orlando Jorge Martins Torres ◽  
Nicolau Gregori Czeczko ◽  
Carlos Hespanha Marinho Junior ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Liver Regeneration ◽  
Wistar Rats ◽  
Statistical Difference ◽  
Histological Study ◽  
Liver Weight ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Serum Aspartate Aminotransferase ◽  
Significant Interference

Objective: to evaluate liver regeneration in rats after partial hepatectomy of 60% with and without action diet supplemented with fatty acids through the study of the regenerated liver weight, laboratory parameters of liver function and histological study. Methods: thirty-six Wistar rats, males, adults were used, weighing between 195 and 330 g assigned to control and groups. The supplementation group received the diet by gavage and were killed after 24h, 72h and seven days. Evaluation of regeneration occurred through analysis of weight gain liver, serum aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltranspeptidase, and mitosis of the liver stained with H&E. Results: the diet supplemented group showed no statistical difference (p>0.05) on the evolution of weights. Administration of fatty acids post-hepatectomy had significant reduction in gamma glutamyltransferase levels and may reflect liver regeneration. Referring to mitotic index, it did not differ between period of times among the groups. Conclusion: supplementation with fatty acids in rats undergoing 60% hepatic resection showed no significant interference related to liver regeneration.

scholarly journals SP352EFFECT OF OMEGA 3 FATTY ACIDS ON STAMP2 EXPRESSION IN 5/6 NEPHRECTOMIZED RAT MODEL

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i207-i207
Author(s):  
Won Suk An ◽  
Hye Won Lee ◽  
Su Mi Lee ◽  
You Jeong Oh ◽  
Hyun Kyung Nam ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Rat Model ◽  
Omega 3 Fatty Acids ◽  
Omega 3
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