scholarly journals In-Silico Study of Olive’s (Olea europaea L) Bioactive Compounds as Anti-Cancer Agents

2019 ◽  
Vol 11 (2) ◽  
pp. 21-29
Author(s):  
S. Shahida ◽  
Mohammad Kuddusa ◽  
Mohd Kausara ◽  
Basil Alshammari ◽  
Musaabc Althaqafi ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
In Silico ◽  
Olea Europaea ◽  
Olea Europaea L ◽  
Anti Cancer ◽  
In Silico Study ◽  
Olea Europaéa

scholarly journals An In Vitro and In Silico Study of the Enhanced Antiproliferative and Pro-Oxidant Potential of Olea europaea L. cv. Arbosana Leaf Extract via Elastic Nanovesicles (Spanlastics)

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1860
Author(s):  
Taghreed S. Alnusaire ◽  
Ahmed M. Sayed ◽  
Abeer H. Elmaidomy ◽  
Mohammad M. Al-Sanea ◽  
Sarah Albogami ◽  
...  
Keyword(s):  
Cell Lines ◽  
Antiproliferative Activity ◽  
In Silico ◽  
Olea Europaea ◽  
Leaf Extract ◽  
Olea Europaea L ◽  
In Silico Study ◽  
Mcf 7 ◽  
Olea Europaéa

The olive tree is a venerable Mediterranean plant and often used in traditional medicine. The main aim of the present study was to evaluate the effect of Olea europaea L. cv. Arbosana leaf extract (OLE) and its encapsulation within a spanlastic dosage form on the improvement of its pro-oxidant and antiproliferative activity against HepG-2, MCF-7, and Caco-2 human cancer cell lines. The LC-HRESIMS-assisted metabolomic profile of OLE putatively annotated 20 major metabolites and showed considerable in vitro antiproliferative activity against HepG-2, MCF-7, and Caco-2 cell lines with IC50 values of 9.2 ± 0.8, 7.1 ± 0.9, and 6.5 ± 0.7 µg/mL, respectively. The encapsulation of OLE within a (spanlastic) nanocarrier system, using a spraying method and Span 40 and Tween 80 (4:1 molar ratio), was successfully carried out (size 41 ± 2.4 nm, zeta potential 13.6 ± 2.5, and EE 61.43 ± 2.03%). OLE showed enhanced thermal stability, and an improved in vitro antiproliferative effect against HepG-2, MCF-7, and Caco-2 (IC50 3.6 ± 0.2, 2.3 ± 0.1, and 1.8 ± 0.1 µg/mL, respectively) in comparison to the unprocessed extract. Both preparations were found to exhibit pro-oxidant potential inside the cancer cells, through the potential inhibitory activity of OLE against glutathione reductase and superoxide dismutase (IC50 1.18 ± 0.12 and 2.33 ± 0.19 µg/mL, respectively). These inhibitory activities were proposed via a comprehensive in silico study to be linked to the presence of certain compounds in OLE. Consequently, we assume that formulating such a herbal extract within a suitable nanocarrier would be a promising improvement of its therapeutic potential.

Identification of bioactive compounds and potential inhibitors for Breast cancer from Musa sapientum peel – An in vitro and in silico approach

2021 ◽  
Vol 16 (7) ◽  
pp. 180-196
Author(s):  
P. Sangavi ◽  
R. Rajapriya ◽  
Firthous Sannathul ◽  
K. Langeswaran ◽  
S. Gowtham Kumar
Keyword(s):  
Breast Cancer ◽  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Bioactive Compounds ◽  
In Silico ◽  
Microbial Pathogens ◽  
Musa Sapientum ◽  
Anti Cancer ◽  
In Silico Study

In this study, the aqueous and ethanol extracts of Musa sapientum peel and pulp were investigated for phytochemical screening and antioxidant activity. Antimicrobial activity and Minimal Inhibitory Concentration (MIC) were analyzed against three different microbial pathogens. From the reported GCMS analysis, the selected compounds were subjected to anti-cancer activity against breast cancer using in silico study. The highest antioxidant activity, presence of secondary metabolites and microbial activity were observed in a significant range. MIC examination revealed that the three different microbial pathogens were sensitive for the peel extract. . In silico study, out of 7 selected compounds, 4 compounds exhibit the highest docking score, binding free energy and acceptable pharmaceutical properties. Molecular dynamics simulation was performed for the top two compounds and the resulting analysis explained the protein-ligand stability and the results concluded that the lead compounds possess the highest stability. From this study, it was concluded that the selective bioactive compounds from Musa sapientum peel exhibited significant antioxidant and antimicrobial activity through in vitro analysis and also the bioactive compounds possessed anti-cancer property which was revealed by in silico investigation.

Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens

2019 ◽  
Vol 193 ◽  
pp. 162-171 ◽  
Author(s):  
Anne C.P. da Silva ◽  
Juliana P. Paiva ◽  
Raiane R. Diniz ◽  
Vitor M. dos Anjos ◽  
Ana Beatriz S.M. Silva ◽  
...  
Keyword(s):  
In Silico ◽  
Olea Europaea ◽  
Olea Europaea L ◽  
Olea Europaéa

scholarly journals Profil Histokimia dan Analisis In Silico Senyawa Metabolit Sekunder pada Daun Zaitun (Olea europaea L.)

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Lailatul Maghfiroh ◽  
Tintrim Rahayu ◽  
Ari Hayati
Keyword(s):  
Secondary Metabolites ◽  
Secondary Metabolite ◽  
In Silico ◽  
Olea Europaea ◽  
Chemical Structure ◽  
In Silico Analysis ◽  
Olive Leaves ◽  
Histochemical Analysis ◽  
Olea Europaea L ◽  
Olea Europaéa

Olive (Olea europaea L.) is a plant that is native of the Mediterranean region which was also able to grow in Indonesia. The plants contain secondary metabolite that will be useful for a survival of a certain species. One of the tests to know a compound of the secondary metabolite on the leaves of zaitun is the histochemical analysis. The knowledge about secondary metabolite containing on a tissue of cell can be done the continued testing for ensure secondary metabolite profile of the compound in form of 3D molecular structure that is using in silico analysis. The research aimed to know the histochemical profile and structure of 3D molecular secondary metabolite of olive leaves. The method was used descriptive-qualitative and the research was done two stages; histochemical testing and was continued with visualization of the chemical structure by ‘in silico’ method in form of chemical structure 3D image. The result showed that histochemical analysis at five these secondary metabolites contained in olive leaves; the terpenoids, an alkaloid, phenolic, lipophilic, and flavonoid. While the tannin compound undetectable. All these secondary metabolite containing in olive leaves can be seen in form of 3D structure.Keywords: Olive (Olea europaea L.), secondary metabolites, histochemical, In silicoABSTRAKZaitun (Olea europaea L.) merupakan tanaman yang berasal dari daerah Mediterania yang juga dapat tumbuh di Indonesia. Tanaman zaitun mengandung metabolit sekunder yang bermanfaat untuk pertahanan hidup suatu species tertentu. Salah satu pengujian untuk mengetahui senyawa metabolit sekunder pada daun zaitun adalah dengan analisis histokimia. Pengetahuan tentang kandungan metabolit pada suatu jaringan sel dapat dilakukan pengujian lanjut untuk memastikan profil senyawa metabolit sekunder tanaman dalam bentuk struktur 3D molekular, yaitu menggunakan analisis In silico. Penelitian bertujuan untuk mengetahui profil histokimia dan struktur molekuler 3D metabolit sekunder daun zaitun. Metode penelitian yang digunakan adalah deskriptif kualitatif dan penelitian ini dilakukan dengan 2 tahapan; uji histokimia dan dilanjutkan dengan visualisasi struktur kimia metode in silico berupa struktur kimia gambar 3D. Hasil penelitian menunjukkan bahwa analisis histokimia pada lima metabolit sekunder terkandung pada daun zaitun yaitu terpenoid, alkaloid, fenolik, lipofil, dan flavonoid. Sedangkan senyawa tannin tidak terdeteksi. Semua senyawa metabolit sekunder yang terkandung pada daun zaitun dapat dilihat dalam bentuk struktur 3D.Kata kunci: Zaitun (Olea europaea L.), Metabolit sekunder, Histokimia, In silico

scholarly journals Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 578 ◽  
Author(s):  
Chiara Nediani ◽  
Jessica Ruzzolini ◽  
Annalisa Romani ◽  
Lido Calorini
Keyword(s):  
Olea Europaea ◽  
Kidney Diseases ◽  
Critical Role ◽  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
Beneficial Effects ◽  
Olea Europaea L ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Olea Europaéa

Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.

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