THE ROLE OF LEPIDIUM SATIVUM SEED AND BOSWELLIA CARTERII POLAR EXTRACTS ‎IN AMELIORATING BLOOD GLUCOSE, LIPID PROFILE, IRON STATUS, IMMUNE ‎SYSTEM AND CARDIAC AND HEPATIC PATHOLOGY IN RAT MODEL OF DIABESITY

In this study, the role of the immune system in nevirapine- (NVP-) induced subclinical liver injury was investigated by observing for changes of some immune parameters during the initial stages of NVP-induced hepatotoxicity in a rat model. In the acute phase, two test-groups of 10 Sprague-Dawley rats each were administered with bacterial lipopolysaccharide (LPS) or saline (S) intraperitoneally, followed by oral NVP, after which 5 rats from each group were sacrificed at 6 and 24 hours. For the chronic phase, two groups of 15 rats each received daily NVP, and on days 7, 14, and 21, five rats from each group were administered with either LPS or S, followed by that day’s NVP dose, and were sacrificed 24 hours later. NVP caused liver injury up to seven days and progressively increased IL-2 and IFN-γ levels and lymphocyte count over the 21 days. NVP-induced liver injury was characterized by apoptosis and degeneration changes, while, for LPS, it was cell swelling, leukostasis, and portal inflammation. Coadministration of NVP and LPS attenuated NVP-induced liver injury. In conclusion, the immune system is involved in NVP toxicity, and the LPS effects may lay the clue to development of therapeutic strategies against NVP-induced hepatotoxicity.

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Effect of Pearl Millet on Glycaemic Control and Lipid Profile in Streptozocin Induced Diabetic Wistar Rat Model

Asian Journal of Medicine and Health ◽

10.9734/ajmah/2020/v18i330193 ◽

2020 ◽

pp. 40-51

Author(s):

Khalid Abbas Owish Sukar ◽

Rihab Ibrahim Abdalla ◽

Humeda Suekit Humeda ◽

Ahmed Omer Alameen ◽

Eltayeb Ibrahim Mubarak

Keyword(s):

Blood Glucose ◽

Glycaemic Control ◽

Lipid Profile ◽

Pearl Millet ◽

Rat Model ◽

Wistar Rat ◽

Diabetic Rats ◽

Male Rats ◽

Diabetic Rat ◽

High Blood Glucose

Aims: This study was designed to investigate the effect of Pear millet on glycaemic control and lipid profile in streptozocin diabetic rat model. Methodology: Forty healthy mature male rats were used in this study. The rats divided into 4 groups, ten rats in each and group (A) and (B) normal control rats while group (C) and (D) considered as diabetic rats. Diabetes induced by intraperitoneal injection of 40 mg/kg streptozocin and confirmed by high blood glucose level which considered day 0. The experiment 1, included two groups (A and C), equal rats and the parameters investigated were measured in days 0, 14 and 28. The experiment 2 included two groups (B and D) were received 20% pearl millet and the blood samples were measured in days 0, 14 and 28. Results: The obtained results revealed significant (P<0.05) reduction in insulin and adiponectin (P<0.001) and elevation of blood glucose (P<0.001) in diabetic rats in group C, while significant (P<0.05) reductions in blood glucose, LDL levels and significant (P<0.05) elevation in adiponectin and HDL levels were detected in rats in group B and D. Conclusions: The studies provide evidence that pearl millet induces hypoglycemic effect and improved lipidemic control in diabetic rats.

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Role of Macronutrient in Better Survival of Critically Sick Neonates Admitted in Neonatal Intensive Care Unit (NICU)

Dhaka Shishu (Children) Hospital Journal ◽

10.3329/dshj.v35i2.49689 ◽

2020 ◽

Vol 35 (2) ◽

pp. 105-110

Author(s):

Mir Mohammad Yusuf ◽

MAK Azad Chowdhury ◽

Md Jahangir Alam

Keyword(s):

Energy Source ◽

Blood Glucose ◽

Critical Illness ◽

Serum Albumin ◽

Serum Calcium ◽

Complete Blood Count ◽

Perinatal Asphyxia ◽

Iron Status ◽

Increased Risk

Background: Neonates are considered more susceptible to macronutrient deficits. During critical illness, sick children cannot normally be fed by mouth, and as a result a pronounced macronutrient deficit often develops after a few days. This macronutrient deficit has been associated with weakness, infections and increased risk of mortality. Therefore, macronutrient as energy source is an important key concern to care and for overall to achieve better survival. Objective: The present study is intended to evaluate the role of macronutrient such as blood glucose, serum calcium, hemoglobin as iron status, serum albumin, in critically sick neonates admitted in NICU and their outcome. Methods: This observational prospective study was carried out at NICU of Dhaka Shishu (Children) Hospital from January 2014 to July 2014. Total 121 neonates were enrolled and analyzed their essential macronutrient profile e.g, blood glucose, serum calcium, hemoglobin, serum albumin and other relevant investigation as complete blood count with film, CRP, blood culture and chest X ray as a part of management as well as to predict their survival. Results: Macronutrient of critically sick neonates play important role to predict their better survival. Perinatal asphyxia and sepsis were major diagnosed pathological conditions of these neonates. In sepsis lower value of serum albumin were statistically significant. Lower value of glucose, calcium, hemoglobin and albumin were also statistically significant in Non-survivors than Survivors. Conclusion: During critical illness in neonates, emphasis should be paid on of adequate macronutrient as energy source. This is necessary for better optimization survival of critically sick neonates. DS (Child) H J 2019; 35(2) : 105-110

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STUDY OF LIPID PROFILE, SERUM MAGNESIUM AND BLOOD GLUCOSE IN HYPERTENSION

10.36106/ijsr/0723858 ◽

2020 ◽

pp. 24-26

Author(s):

Divya Sinha ◽

S. R. Padmeodev ◽

Debarshi Jana

Keyword(s):

Blood Pressure ◽

Blood Glucose ◽

Systolic Blood Pressure ◽

Lipid Profile ◽

Serum Magnesium ◽

Fasting Blood Glucose ◽

Age Groups ◽

Normal Individuals ◽

Blood Pressures

An attempt was made to study the role of lipid profile serum Mg+2, and blood glucose in hypertension individuals. Moreover, all the parameters are analyzed biochemically. In about 80 samples (50cases and 30 controls) and it is observed that dyslipidemia is seen in Hypertensive individuals with no change in HDL concentration. There is no correlation of serum magnesium in hypertensive cases with controls. It has been observed that serum magnesium of hypertensive cases is slightly higher than that of normal individuals. Fasting blood glucose of hypertensive cases (101.62mg/dl ±33.78) is higher than that of Controls (82.46 mg/dl±10.8). This increase is statistically significant (p<0.001). But this increase may be due to the presence 12% diabetic cases present in the cases. Even then, there is a tendency of developing impaired glucose tolerance in hypertensive subjects. The blood pressure is noted separately as systolic blood pressure and diastolic blood pressures. The systolic blood pressure was more significant than the diastolic blood pressure with increasing age groups.

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Role of Lipid Profile and Fasting Blood Glucose in Metabolic Syndrome

International Journal of Medical Science and Diagnosis Research ◽

10.32553/ijmsdr.v5i10.865 ◽

2021 ◽

Vol 5 (10) ◽

Author(s):

Pavan Gautam ◽

Shreya Nigoskar ◽

Bibek Bhurer Yadav

Keyword(s):

Metabolic Syndrome ◽

Blood Glucose ◽

Lipid Profile ◽

Fasting Blood Glucose ◽

Critical Factor ◽

High Blood Glucose ◽

Glucose Levels ◽

The Metabolic Syndrome ◽

Obesity Hypertension

Background: The metabolic syndrome is defined by the clustering of risk factors that predisposes people to diabetes and cardiovascular disease (CVD. MetS had a high (58%) prevalence of dyslipidemia, and increasing age, greater BMI, central obesity, hypertension, and high blood glucose levels have been found as independent predictors of dyslipidemia. Aim of the Work: This study aimed to role of lipid profile and fasting blood glucose in metabolic syndrome. Subjects and Methods: The research was carried out at the Index Medical College and Research Center in Indore, in the Department of Biochemistry. A total of 120 people with metabolic syndrome and 120 healthy controls were included in the study. A blood sample was taken from the anticubital vein and centrifuged to obtain serum, which was then evaluated for lipid profile and FBS levels quantitatively. Result and Conclusion: Present study suggested that the FBG is the most critical factor in MS, and all aspects of the lipid profile have significant relationships with MS. Keywords: Metabolic syndrome, fasting blood glucose

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Cytoprotective Effects of Lepidium sativum Seed Extract on Liver and Pancreas of HFD/STZ Induced Type 2 Diabetic Mice

International Journal of Pharmacognosy and Phytochemical Research ◽

10.25258/phyto.v9i4.8121 ◽

2017 ◽

Vol 9 (4) ◽

Cited By ~ 1

Author(s):

Desai S. S. ◽

Walvekar M. V. ◽

Shaikh N. H.

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Seed Extract ◽

Lepidium Sativum ◽

Type Ii ◽

Diabetic Mice ◽

Liver And Pancreas

Type II diabetes mellitus (TIIDM) is the world’s largest endocrine disorder. Obesity is one of the leading causes for type II diabetes. In the present study antihyperglycemic and cytoprotective role of Lepidium sativum seed extract (LSE) for obesity associated diabetes in normal and high fat diet (HFD)-streptozotocin induced mice was investigated. Blood glucose, histology of liver and pancreas and body weight in obese diabetic mice was evaluated. Administration of LSE for 28 days significantly lowered blood glucose while increased body weight and recovered degenerative changes in liver and pancreas. These findings suggest that LSE possess antihyperglycemic and cytoprotective action and might be a good candidate for obesity associated diabetes.

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