Pattern of Malignant Tumors among Cancer Patients during the Year 2014 in Minia Governorate, Egypt

2020 ◽  
Vol 38 (2) ◽  
pp. 1-6
Keyword(s):  
Cancer Patients ◽  
Malignant Tumors

EFFECTS OF SMOKING ON THE DISEASE PROGNOSIS IN CANCER PATIENTS

2019 ◽  
Vol 65 (3) ◽  
pp. 321-329
Author(s):  
David Zaridze ◽  
Anush Mukeriya
Keyword(s):  
Smoking Cessation ◽  
Cancer Patients ◽  
Malignant Tumors ◽  
Scientific Data ◽  
Second Primary ◽  
Primary Tumors ◽  
Smoking Intensity ◽  
Risk Of Death ◽  
Disease Prognosis ◽  
Increased Risk

Smoking not only increases the risk of the development of malignant tumors (MT), but affects the disease prognosis, mortality and survivability of cancer patients. The link between the smoking of cancer patients and increased risk of death by all diseases and oncological causes has been established. Mortality increases with the growth of the smoking intensity, i.e. the number of cigarettes, smoked per day. Smoking is associated with the worst general and oncological survivability. The statistically trend-line between the smoking intensity and survivability was observed: each additional unit of cigarette consumption (pack/year) leads to the Overall Survival Reduction by 1% (p = 0.002). The link between smoking and the risk of developing second primary tumors has been confirmed. Smoking increases the likelihood of side effects of the antitumor therapy both drug therapy and radiation therapy and reduces the treatment efficacy. The smoking cessation leads to a significant improvement in the prognosis of a cancer patient. Scientific data on the negative effect of smoking on the prognosis of cancer patients have a major clinical importance. The treatment program for cancer patients should include science-based methods for the smoking cessation. The latter is fundamentally important, taking into account that the smoking frequency among cancer patients is much higher than in the population.

scholarly journals Radiation therapy for oligometastatic cancer

2021 ◽  
Vol 10 (3) ◽  
pp. 5-14
Author(s):  
N.  V. Dengina ◽  
T. V. Mitin ◽  
I.  V. Tsimafeyeu ◽  
S.  V. Usychkin
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Malignant Tumors ◽  
Local Treatment ◽  
Supportive Therapy ◽  
Local Method ◽  
The Past ◽  
Oligometastatic Cancer

Current approaches to the treatment of patients with metastatic malignant tumors have changed significantly over the past decade. Instead of a purely palliative systemic or just supportive therapy, a large proportion of patients receive an aggressive local treatment directed not only to the primary tumor, but also to metastatic foci, and a number of studies demonstrate the advantage of such approach. This review provides information on the role of radiation therapy as a local method of treatment of cancer patients with oligometastases.

scholarly journals THE EFFICACY OF MICROWAVE THERAPY VIA BRONCHOFIBERSCOPE IN THE TREATMENT OF SEVERE TRACHEA STENOSIS

2013 ◽  
Vol 06 (01) ◽  
pp. 1350006 ◽  
Author(s):  
WEIMIN LIU ◽  
LI DAI ◽  
YUHUI LIN
Keyword(s):  
Cancer Patients ◽  
Malignant Tumors ◽  
Life Quality ◽  
Effective Rate ◽  
Benign Diseases ◽  
Microwave Therapy

To evaluate the efficacy of microwave therapy via bronchofiberscope for treatment of severe trachea stenosis. Microwave tissue coagulation (MTC) and diathermy (MD) therapy via bronchofiberscope were performed on 37 patients with severe trachea stenosis diseases at least two times. The effective rate immediately after treatment was 100% in all cases. After one month, the rate remained 100% in the patients with benign diseases, but it dropped to 67% in the patients with malignant tumors. We have demonstrated that the microwave thermotherapy via bronchofiberscope is an effective method to treat patients with benign trachea stenosis noninvasively. For cancer patients with trachea soakage and blockage, it can be performed to improve their life quality by alleviating their agonies.

Cysteine Proteinases and Their Inhibitors in Extracellular Fluids: Markers for Diagnosis and Prognosis in Cancer

2000 ◽  
Vol 15 (1) ◽  
pp. 84-89 ◽  
Author(s):  
J. Kos ◽  
B. Werle ◽  
T. Lah ◽  
N. Brunner
Keyword(s):  
Cancer Patients ◽  
Cystatin C ◽  
Malignant Tumors ◽  
Clinical Information ◽  
Serum Levels ◽  
High Serum ◽  
Diagnosis And Prognosis ◽  
Cysteine Cathepsins ◽  
C Complex ◽  
Colorectal Cancer Patients

Cathepsins B, H and L have been shown to participate in processes of tumor growth, vascularization, invasion and metastasis. Their levels in tumor tissue extracts can provide useful clinical information to predict disease-free and overall survival in breast, lung, colorectal, brain and head and neck cancer patients. Recently we have found that both cysteine cathepsins and their endogenous protein inhibitors stefins and cystatin C can also predict prognosis when measured extracellularly. In melanoma and colorectal cancer patients high serum levels of cathepsins B and H correlated with shorter survival. Similarly, increased extracellular levels of stefins A and B and cystatin C correlated significantly with high risk of adverse outcome in cancer patients. However, the cathepsin B/cystatin C complex was found to be less abundant in sera of patients with malignant tumors than in those with benign diseases or in healthy controls, suggesting an imbalance between the enzyme and its inhibitor in cancer patients.

Pain Control with Morphine for Vertebral Metastases and Sciatica in Advanced Cancer Patients

1994 ◽  
Vol 10 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Hideo Yoshioka ◽  
Satoru Tsuneto ◽  
Tetsuo Kashiwagi
Keyword(s):  
Bone Metastases ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Bone Pain ◽  
Malignant Tumors ◽  
Spinal Metastases ◽  
Pelvic Bone ◽  
Advanced Cancer Patients ◽  
Direct Invasion ◽  
High Doses

Morphine was administered to 56 advanced cancer patients; of that number spinal metastases had induced bone pain in 28 and malignant tumors had induced sciatica in 28. The sciatica was caused in 16 patients by direct invasion of the sacral plexus, in four by lumbar bone metastases, and in eight by pelvic bone metastases. Spinal bone pain was controlled adequately with morphine. However, sciatica required larger dosages of morphine than did bone pain. Among the group with sciatica, rectal cancer patients needed larger dosages of morphine than the other cancer patients. Even with high doses of morphine, it was occasionally difficult to control neuropathic pain of the sciatic nerve caused by intrapelvic cancer.

scholarly journals Application and Effect of the Gymnastic Exercise Mode during Chemotherapy for Breast Cancer Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Feifei Xie
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Incidence Rate ◽  
Evaluation System ◽  
Malignant Tumors ◽  
Treatment Plan ◽  
Breast Cancer Surgery ◽  
Breast Cancer Patients ◽  
Rehabilitation Training ◽  
Cancer Related Fatigue

Breast cancer is one of the most common malignant tumors in women, which seriously threatens the health of women. With the improvement of living standards, the incidence rate of breast cancer is also rising. In the past ten years, the incidence rate of breast cancer in China’s major cities has increased by 37%, far higher than that in Europe and America. At present, chemotherapy and radiotherapy are the main treatment methods for breast cancer, but many patients will have cancer-related fatigue after surgery. Some studies believe that appropriate sports can improve cancer-related fatigue, but there is no specific research in this area. In view of this problem, this paper puts forward a rehabilitation training method based on gymnastics for breast cancer surgery. This paper is divided into three parts. The first part is the basic theory and core concept of breast cancer and cancer-related fatigue. Through the in-depth study of the theory, this paper believes that breast cancer patients paying attention to rehabilitation training can effectively improve cancer-related fatigue and affect the final therapeutic effect. The second part is the rehabilitation training program based on the way of gymnastics. The corresponding experimental model is established by using real cases as samples. In order to ensure the quality of the experiment, this paper gives the treatment plan in detail and establishes a unified evaluation system. In the third part of this paper, the relevant experiments and results analysis are given, and through data analysis, this paper believes that gymnastics can effectively help breast cancer patients with postoperative rehabilitation and continuous recovery of the upper limb function and improve cancer-related fatigue and other issues.

scholarly journals Association betweenIL17Polymorphisms and Risk of Cervical Cancer in Chinese Women

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Yi Quan ◽  
Bin Zhou ◽  
Yanyun Wang ◽  
Ruiqi Duan ◽  
Kana Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Malignant Tumors ◽  
Chinese Women ◽  
Clinical Stage ◽  
Interleukin 17 ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Human Malignant Tumors ◽  
Genotype And Allele Frequencies

Interleukin-17 (IL-17) is a proinflammatory cytokine that is associated with inflammation, autoimmune disorders, and even tumors. Previous studies revealed that a large group of human malignant tumors have abnormally high IL-17 expression. In the present study, we analyzed two single-nucleotide polymorphisms (SNPs) in theIL17A(rs2275913) andIL17F(rs763780) in 311 cervical cancer patients and 463 controls using TaqMan assays. Our results indicated that the frequencies of AA genotype and A allele of rs2275913 were significantly different between the cervical cancer patients and controls (P=0.008, OR = 1.32, 95% CI, 1.07–1.62). Stratified analyses revealed that the polymorphism of rs2275913 was also associated with positive peritumor intravascular cancer emboli and high clinical stage. The genotype and allele frequencies of rs763780 did not show any difference between patients and controls or relate to patient clinical characteristics. Collectively, these findings suggested thatIL17gene polymorphism rs2275913 was associated with the susceptibility as well as positive peritumor intravascular cancer emboli and high clinical stage of cervical cancer in Chinese women.

scholarly journals GENOME-WIDE ASSOCIATION STUDY OF LOSS OF HETEROZYGOSITY AND METASTASIS-FREE SURVIVAL IN BREAST CANCER PATIENTS

2017 ◽  
Vol 39 (2) ◽  
pp. 145-150 ◽  
Author(s):  
I V Deryusheva ◽  
M M Tsygano ◽  
E Y Garbukov ◽  
M K Ibragimova ◽  
Ju G Kzhyshkovska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Loss Of Heterozygosity ◽  
Genome Wide Association Study ◽  
Malignant Tumors ◽  
Chromosome Analysis ◽  
Rank Test ◽  
Breast Cancer Patients ◽  
Free Survival ◽  
Genome Wide

One of the factors providing the diversity and heterogeneity of malignant tumors, particularly breast cancer, are genetic variations, due to gene polymorphism, and, especially, the phenomenon of loss of heterozygosity (LOH). It has been shown that LOH in some genes could be a good prognostic marker. Aim: To perform genome-wide study on LOH in association with metastasisfree survival in breast cancer. Materials and Methods: The study involved 68 patients with breast cancer. LOH status was detected by microarray analysis, using a high density DNA-chip CytoScanTM HD Array (Affymetrix, USA). The Chromosome Analysis Suite 3.1 (Affymetrix, USA) software was used for result processing. Results: 13,815 genes were examined, in order to detect LOH. The frequency of LOH varied from 0% to 63%. The association analysis identified four genes: EDA2R, PGK1, TAF9B and CYSLTR1 that demonstrated the presence of LOH associated with metastasis-free survival (log-rank test, p < 0.03). Conclusions: The presence of LOH in EDA2R, TAF9B, and CYSLTR1 genes is associated with metastasis-free survival in breast cancer patients, indicating their potential value as prognostic markers.

scholarly journals Neurogenic Bladder Dysfunction in Cancer Patients after Operations on the Pelvic Organs

2019 ◽  
Vol 4 (3) ◽  
pp. 89-95
Author(s):  
V. F. Onopko ◽  
E. A. Zagainova ◽  
E. A. Kirilenko
Keyword(s):  
Cancer Patients ◽  
Malignant Tumors ◽  
Endocrine Disorders ◽  
Parasympathetic Ganglia ◽  
Pelvic Organs ◽  
Urological Complications ◽  
Reflex Arc ◽  
Tissue Changes ◽  
Soft Tissue Changes ◽  
Neurogenic Dysfunction

The review is devoted to the generalization and analysis of domestic and foreign works describing the mechanism of development of neurogenic dysfunction of the bladder after surgery on the pelvic organs in cancer patients. All modern authors agree that the cause of these disorders is trauma of the pelvic nerves and interruption of the reflex arc. Unfortunately, when removing malignant tumors of the pelvic organs, urological complications are difficult and often impossible to avoid. This is due to the complex neuroanatomy of the bladder, its proximity to the rectum, the uterus, as well as the volume and radicality of cancer operations. The article shows that if the parasympathetic ganglia are damaged, there is a violation of the evacuation function of the bladder and a weakening or absence of the urge to urinate. If the sympathetic nervous system is damaged in isolation, on the contrary, an increase in the detrusor tone, intravesical pressure and a decrease in the capacity of the bladder is observed, which is in conditions of low bladder sphincter tone causes imperative urges, frequent urination and incontinence. Prior radiation therapy also affects the development of urological complications. Postradiated soft tissue changes, ischemia, fibrosis lead to great technical difficulties during surgery. In addition, factors that are important in the development of pelvic disorders in this category of patients include urinary system diseases and metabolic – endocrine disorders in case history.

scholarly journals Development and Validation of a Novel 13-Genes Prognostic Model for Colon Cancer

2021 ◽  
Author(s):  
Duo Yun ◽  
Zhirong Yang
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Risk Model ◽  
Malignant Tumors ◽  
Expression Profiles ◽  
The Cancer Genome Atlas ◽  
Pathway Enrichment

Abstract Colon cancer is one of the most common malignant tumors in the world. The purpose of this study is to explore the prognostic value of genes in colon cancer. After analyzing gene expression profiles, differential expressed genes between 39 normal tissues and 398 tumor tissues were identified from The Cancer Genome Atlas database. We use Cox and lasso regression to find genes related to prognosis. Through analysis, 13 genes were found to predict the overall survival of colon cancer patients. In addition, the external comparing of gene expression and the single prognostic gene survival analysis were made. Finally, pathway enrichment and mutation status of each gene were also analyzed. After a series of bioinformatics analysis, we select 13 survival-related signature and established a prognostic risk model based on these genes. The prognostic risk model was developed to comprehensively predict the overall survival of colon cancer patients. The prognostic value of the 13-genes (CLDN23,HAND1,IL23A,KLHL35,SIX2,UPK2,HOXC11,KRT6B,SRCIN1,TNNI3,TYRO3,MIR6835,LINC02474) related risk score for each colon cancer patent was calculated to predict the survival. Furthermore, five genes (SIX2 MIR6835 LINC02474 CLDN23 HOXC11) were significantly associated with overall survival (OS). The KEGG pathway enrichment results suggested that most of the pathways are related to the occurrence, metabolism, proliferation and invasion of the tumor cells. It was found that the expression of 13-genes signature can be used as prognostic indicator for colon cancer patients. The 13-genes signature predictive model may help clinicians provide a prognosis and personalized treatment for colon cancer patients.

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