scholarly journals Evaluation of Awareness, Knowledge and Attitudes regarding Common Rheumatic Diseases (Rheumatoid Arthritis and Systemic Lupus Erythematous) in Sohag Governorate

2020 ◽  
Vol 38 (2) ◽  
pp. 25-36
2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 819.1-819
Author(s):  
L. Long ◽  
G. Tang ◽  
Y. Han ◽  
Q. Peng ◽  
J. Liu ◽  
...  

Background:Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and syndrome(SS) are common rheumatic diseases with high incidence. Patients with those rheumatic diseases are at high risk of tuberculosis (TB) infection. However, manifestations can be atypical and easily confused with those of rheumatic disease itself. For those patients, diagnosis is usually much more difficult and further make treatment delayed. Sometimes it may lead to mistreatment. Therefore, it is important to recognize the clinical characteristics of those patients.Objectives:To explore the clinical characteristics and high risk factors of common systemic rheumatism complicated with tuberculosis infection.Methods:A total of 3,906 cases of RA, SLE, and SS common systemic rheumatism diagnosed in the People’s Hospital of Sichuan Province from January 2007 to January 2017 were collected with carefully exclusion with other infectious diseases and neoplastic disease. One hundred and five patients with TB were included as infection group, including 42 cases of RA, 41 cases of SLE, and 22 cases of SS. In the control group, 84 patients with RA, 82 patients with SLE, and 44 patients with SS were randomly selected from the corresponding rheumatoid non-infected patients hospitalized during the same period.Results:Fever was the most common symptom among 42 cases of RA, 41 cases of SLE, and 22 cases of SS with TB, accounting for 83.3%, 92.7%, and 68.2%, respectively. Cough, weight loss or fatigue was less common. For 41 cases of SLE and 22 cases of SS with TB, the proportion of pulmonary was 46.3%, 59.01%, respectively.In TB infection group, 27 cases of RA, 21 cases of SLE, and 13 cases of SS with TB had two or more chest CT findings, accounting for 59%, 57%, 62%, respectively. Lesions located in the posterior or posterior segment which TB usually affected were 9 cases(33.3%),9cases(42.9%),6cases(27.2%),respectively.The daily average dose of hormones within 1 year in TB infection group was higher than that in the control group (P<0.05). For SLE patients, lower counts of CD4+TL were found in TB infection group (P<0.05), while no such differences were found in RA and SS group.Conclusion:Patients with RA who have TB infection are mainly pulmonary TB. For SLE and SS patients, the chance of pulmonary tuberculosis and extra-pulmonary tuberculosis is similar.Symptoms of RA, SLE, SS with TB, such as fever, cough, weight loss, fatigue, are similar with the primary disease or other infection. Chest imaging is diversity. It is difficult to diagnose.Daily average dose of hormone within one year may be a common risk factor for RA, SLE and SS patients with TB. Decreased CD4+TL may also be a risk factor for SLE patients with TB.References:[1]Cantini F, Nannini C, Niccoli L, et al. Risk of Tuberculosis Reactivation in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Receiving Non-Anti-TNF-Targeted Biologics[J]. Mediators of Inflammation, 2017, 2017(6):1-15.[2]Ruangnapa K, Dissaneewate P, Vachvanichsanong P. Tuberculosis in SLE patients: rare diagnosis, risky treatment.[J]. Clinical & Experimental Medicine, 2015, 15(3):429-432.[3]Manuela D F, Bruno L, Martina S, et al. Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections[J]. International Journal of Molecular Sciences, 2017, 18(2):293-315.[4]Disseminated tuberculosis masquerading as a presentation of systemic lupus erythematosus.Li JC, Fong W, Wijaya L, Leung YY.Int J Rheum Dis. 2017 Oct 2. doi: 10.1111/1756-185X.13195.[5]Handa R, Upadhyaya S, Kapoor S, et al. Tuberculosis and biologics in rheumatology: India – A special situation[J]. International Journal of Rheumatic Diseases, 2017, 51(2):115.Disclosure of Interests:None declared


2020 ◽  
Vol 12 (6) ◽  
pp. 127-128
Author(s):  
Susana Rodrigues ◽  
Catrine Ferreira ◽  
Tiago Coelho ◽  
Diogo Gaspar ◽  
Jean Fallah ◽  
...  

Calcinosis cutis is a rare disorder characterized by of deposition of insoluble calcium salts in the skin and subcutaneous tissue. Five subtypes of calcinosis cutis are described: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis.1 Of these subtypes, dystrophic calcinosis (DC) is the most common, and it is the most frequently seen in association with underlying autoimmune connective tissue diseases.2 Dermatomyositis, systemic sclerosis and less commonly systemic lupus erythematous were described to be complicated by DC. However, DC associated with rheumatoid arthritis (RA) is extremely rare.2 The condition causes substantial morbidity and is associated with pain and limitation of movement when the process involves areas close to joints or when ulceration occurs.2 We report a middle age Sudanese woman with good controlled RA who developed dystrophic calcinosis cutis.


Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 303
Author(s):  
Sandra Rodríguez ◽  
Andrés Muñoz ◽  
Rosa-Helena Bustos ◽  
Diego Jaimes

Since we have gained an understanding of the immunological pathophysiology of rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus, treatment based on biological drugs has become a fundamental axis. These therapies are oriented towards the regulation of cytokines such as tumour necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1, and the modulation of cell-mediated immunity (B cells and T cells) by anti CD20 or anti CTAL-4 agents, and can increase the risk of associated infections or adverse events (AE). In this context, the entry of biotherapeutics represented a challenge for pharmacovigilance, risk management and approval by the main global regulatory agencies regarding biosimilars, where efficacy and safety are based on comparability exercises without being an exact copy in terms of molecular structure. The objective of this review is divided into three fundamental aspects: (i) to illustrate the evolution and focus of pharmacovigilance at the biopharmaceutical level, (ii) to describe the different approved recommendations of biopharmaceuticals (biological and biosimilars) and their use in rheumatic diseases (RDs) such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE) and other less frequent RD like cryopyrin-associated autoinflammatory syndromes (CAPS), and (iii) to identify the main AE reported in the post-marketing phase of RD biopharmaceuticals.


2018 ◽  
Vol 7 (1) ◽  
pp. 374-387
Author(s):  
Matheus Santos Gomes Jorge ◽  
Willian Guerra De Lima ◽  
Patrícia Rodigheri Vieira ◽  
Letícia Antoniolli Siiss ◽  
Caroline Zanin ◽  
...  

Introdução: as doenças reumáticas apresentam manifestações musculoesqueléticas e sistêmicas que podem acometer quaisquer regiões do corpo. No caso das mãos, uma das manifestações é a diminuição da força de preensão palmar destes indivíduos. Objetivo: verificar os efeitos da cinesioterapia sobre a força de preensão palmar em indivíduos com doenças reumáticas. Material e métodos: estudo longitudinal e intervencionista com 24 indivíduos portadores de doenças reumáticas (osteoartrite, artrite reumatoide, fibromialgia, lúpus eritematoso sistêmico, esclerose sistêmica e dermatopolimiosite), com idade média de 50,23 anos. Os indivíduos realizaram 10 sessões de fisioterapia, baseadas em cinesioterapia, com exercícios globais e funcionais, 02 vezes por semana, com duração média de 50 minutos, de março de 2014 a novembro de 2015, na Clínica de Fisioterapia da Universidade de Passo Fundo, Passo Fundo/RS. As avaliações inicial e final envolveram a coleta de dados e a mensuração da força de preensão palmar, por meio da dinamometria manual. Resultados: observou-se que os indivíduos apresentaram melhora da força de preensão palmar, porém os resultados foram estatisticamente significativos apenas para a mão direita dos indivíduos com osteoartrite, para ambas as mãos dos indivíduos com artrite reumatoide e lúpus eritematoso sistêmico e para a força de preensão palmar geral dos indivíduos. Conclusão: o protocolo fisioterapêutico proposto produziu aumento da força de preensão palmar de indivíduos com doenças reumáticas.Palavras-chave: Força da mão. Doenças reumáticas. Fisioterapia. Reabilitação. Exercício. ABSTRACT: Introduction: rheumatic diseases present musculoskeletal and systemic manifestations that can affect any region of the body. In the case of the hands, one of the manifestations is the decrease of the handgrip strength of these individuals. Aim: to verify the effects of kinesiotherapy on handgrip strength in individuals with rheumatic diseases. Material and methods: longitudinal and interventional study with 24 individuals with rheumatic diseases (osteoarthritis, rheumatoid arthritis, fibromyalgia, systemic lupus erythematosus, systemic sclerosis and dermatopolymyositis), mean age 50.23 years. The individuals performed 10 sessions of physiotherapy, based on kinesiotherapy, with global and functional exercises, 02 times a week, with an mean duration of 50 minutes, from March 2014 to November 2015, at the Physiotherapy Clinic of Passo Fundo University, Passo Fundo/RS. The initial and final evaluations involved data collection and measurement of handgrip strength using manual dynamometry. Results: it was observed that the individuals presented improvement of the handgrip strength, but the results were statistically significant only for the right hand of individuals with osteoarthritis, for both hands of individuals with rheumatoid arthritis and systemic lupus erythematosus and for the handgrip strength of individuals. Conclusion: the proposed physiotherapeutic protocol produced an increase in the handgrip strength of individuals with rheumatic diseases.Keywords: Hand strength. Rheumatic diseases. Physical therapy specialty. Rehabilitation. Exercise.


2012 ◽  
Vol 93 (1) ◽  
pp. 12-17
Author(s):  
D V Ivanov ◽  
L A Sokolova ◽  
E Yu Gusev ◽  
L N Kamkina ◽  
N O Plekhanova

Aim. To compare the course of chronic systemic inflammation during various rheumatic diseases. Methods. Examined were three groups of patients: with ankylosing spondylitis - 25 people (20 males and 5 females), with rheumatoid arthritis - 26 people (11 males and 15 females) and with systemic lupus erythematosus - 49 people (3 males and 46 females). The control group included 50 practically healthy individuals (26 males and 24 females). Analyzed were the following parameters: the content of interleukin-6, -8, -10, C-reactive protein. The integral index of the reactivity coefficient was calculated. Results. The level of the studied cytokines was significantly higher in systemic lupus erythematosus, than in ankylosing spondylitis and rheumatoid arthritis, while the content of C-reactive protein was significantly higher in ankylosing spondylitis and rheumatoid arthritis. The values of the reactivity coefficient were also significantly higher in systemic lupus erythematosus. Conclusion. The presence of systemic inflammation was determined in most patients with systemic lupus erythematosus, while ankylosing spondylitis and rheumatoid arthritis were characterized only by mild manifestations of systemic inflammatory response.


2005 ◽  
Vol 133 (Suppl. 1) ◽  
pp. 55-60 ◽  
Author(s):  
Djunajdar Kerimovic-Morina

Musculosceletal manifestations were found in patients with hyperthyroidism as well as hypothyroidism. This article will review the available evidence that autoimmune thyroid disease is associated with: Sj?gren?s sydrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis, rheumatoid arthritis (RA) and spondyloarthropathies. Possible pathogenesis of these manifestations has not been completely established. Sj?gren?s syndrome occurs in about 1/10 of patients with autoimmune thyroid disease; patients with SLE and antithyroid antibodies were significantly older than those pattiens without antibodies. Patients with systemic sclerosis and thyroid disease were significantly younger than those without antibodies. Thyroid disfunction was found three times more often in women with RA than in women with noninflammatory rheumatic diseases, and those with thyroid disease tended to have a shorter duration of arthritis.


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