scholarly journals In vitro Apoptotic effects of the medicinal plants Achillea santolina and Raphanus sativus extracts on different cancer cell lines

2019 ◽  
Vol 1 (2) ◽  
pp. 1-10
Author(s):  
Reham Mohasseb ◽  
Mohamed Salem ◽  
Reda Gaafar ◽  
Mohamed Abd-Elbaseer
Keyword(s):  
Medicinal Plants ◽  
Cell Lines ◽  
Cancer Cell ◽  
Raphanus Sativus ◽  
Cancer Cell Lines ◽  
Apoptotic Effects

In vitro antiproliferative activity of selected medicinal plants from the North-West of Morocco on several cancer cell lines

2018 ◽  
Vol 18 ◽  
pp. 23-29 ◽  
Author(s):  
Abdelhakim Bouyahya ◽  
Youssef Bakri ◽  
Abdeslam Et-Touys ◽  
Inès Christelle Chadon Assemian ◽  
Jamal Abrini ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Cancer Cell Lines ◽  
North West ◽  
The North

scholarly journals Antiproliferative and Apoptotic Effects of the Medicinal Plants on Breast Cancer Cell Lines

Proceedings ◽  
2017 ◽  
Vol 1 (10) ◽  
pp. 1021 ◽  
Author(s):  
Pınar Kılıçaslan Sönmez ◽  
Gülşah Albayrak ◽  
Mahmud Özkut ◽  
Büşra Şen ◽  
Pelin Toros ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Medicinal Plants ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Apoptotic Effects

scholarly journals MALAYSIAN MEDICINAL PLANTS’ POTENTIAL FOR BREAST CANCER THERAPY

2018 ◽  
Vol 11 (6) ◽  
pp. 101
Author(s):  
Muhammad Murtala Mainasara ◽  
Mohd Fadzelly Abu Bakar ◽  
Alona C Linatoc
Keyword(s):  
Breast Cancer ◽  
Medicinal Plants ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Active Components ◽  
Ic50 Values

Objective: This review focused on Malaysian medicinal plants that have been evaluated and pose potentials to treat breast cancer.Methods: Google Scholar, Web of Science, PubMed, Scopus, Biomed, ResearchGate, academia.edu, IEEE Xplore, ScienceDirect, and Ingenta databases were searched for this review and studies reported between January 1st, 2010 and June 30th, 2016.Results: A total of 105 plants species representing 54 different families and 79 genera were reviewed. 97% of the plants were tested using MCF-7 and MDA-231 breast cancer cell lines and exhibited most significant in vitro anticancer activity, and 3% were tested using another type of breast cancer cell lines. Most of the bioactive compounds of the medicinal plants that exhibited good activity (IC50 values <120 μg/mL) are a group of phenols, alkaloids, flavonoids, terpenoids, and saponins. Induction of apoptosis was found to be the significant cell death pathway.Conclusion: This article reviews the available literature concerning research on anti-breast cancer plants. Furthermore, identification and characterization of active components and toxicology evaluation also need to be studied in details and also point out their clinical trials.

ANTITUMOR EFFECT OF SUNITINIB AND BORTEZOMIB ON BREAST CANCER CELL LINE IN VITRO

2017 ◽  
Vol 63 (1) ◽  
pp. 141-145
Author(s):  
Yuliya Khochenkova ◽  
Eliso Solomko ◽  
Oksana Ryabaya ◽  
Yevgeniya Stepanova ◽  
Dmitriy Khochenkov
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Antitumor Effect ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Actual Problem

The discovery for effective combinations of anticancer drugs for treatment for breast cancer is the actual problem in the experimental chemotherapy. In this paper we conducted a study of antitumor effect of the combination of sunitinib and bortezomib against MDA-MB-231 and SKBR-3 breast cancer cell lines in vitro. We found that bortezomib in non-toxic concentrations can potentiate the antitumor activity of sunitinib. MDA-MB-231 cell line has showed great sensitivity to the combination of bortezomib and sunitinib in vitro. Bortezomib and sunitinib caused reduced expression of receptor tyrosine kinases VEGFR1, VEGFR2, PDGFRa, PDGFRß and c-Kit on HER2- and HER2+ breast cancer cell lines

Small Molecular Leads Differentially Active Against HER2 Positive and Triple Negative Breast Cancer Cell Lines

2019 ◽  
Vol 15 (7) ◽  
pp. 738-742 ◽  
Author(s):  
Adnan Badran ◽  
Atia-tul-Wahab ◽  
Sharmeen Fayyaz ◽  
Elias Baydoun ◽  
Muhammad Iqbal Choudhary
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cancer Type

Background:Breast cancer is the most prevalent cancer type in women globally. It is characterized by distinct subtypes depending on different gene expression patterns. Oncogene HER2 is expressed on the surface of cell and is responsible for cell growth regulation. Increase in HER2 receptor protein due to gene amplification, results in aggressive growth, and high metastasis in cancer cells.Methods:The current study evaluates and compares the anti-breast cancer effect of commercially available compounds against HER2 overexpressing BT-474, and triple negative MDA-MB-231 breast cancer cell lines.Results:Preliminary in vitro cell viability assays on these cell lines identified 6 lead molecules active against breast cancer. Convallatoxin (4), a steroidal lactone glycoside, showed the most potent activity with IC50 values of 0.63 ± 0.56, and 0.69 ± 0.59 µM against BT-474 and MDA-MB-231, respectively, whereas 4-[4-(Trifluoromethyl)-phenoxy] phenol (3) a phenol derivative, and Reserpine (5) an indole alkaloid selectively inhibited the growth of BT-474, and MDA-MB-231 breast cancer cells, respectively.Conclusion:These results exhibited the potential of small molecules in the treatment of HER2 amplified and triple negative breast cancers in vitro.

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