scholarly journals Age May Be the Only Variable Effecting Microhematuria Prevalance in Pelvic Organ Prolapse

2018 ◽  
Vol 24 (3) ◽  
pp. 143
Author(s):  
Ayse Filiz Gokmen Karasu ◽  
Serdar Aydin ◽  
Ilknur Adanir ◽  
Gulsah Ilhan ◽  
Senad Kalkan ◽  
...  
Keyword(s):  
Early Stage ◽  
Smoking Status ◽  
Systemic Disease ◽  
Pelvic Organ ◽  
Integrated System ◽  
Urinary Symptoms ◽  
Microscopic Hematuria ◽  
International Continence Society ◽  
Record System ◽  
Tract Infections

<p><strong>Objective:</strong> We aimed to estimate the prevalence of microscopic hematuria in women with pelvic organ descent and compare the results in terms of severity and accompanying urinary symptoms. We hypothesized that microhematuria incidence would be higher in advanced prolapse and accompanying urinary symptoms.</p><p><strong>Study Design:</strong> Women who presented to our clinic from January 2013 to July 2016 were analyzed using our electronic medical record system. Those who were classified in the system under the "N81: female genital prolapse" code were included. Records were checked to certify that samples were acquired properly. Urogynecological examinations were performed by specialist gynecologists and documented according to the international continence society classification system. After ruling out urinary tract infections urinalysis was performed by an integrated system composed of an urine strip analyzer and a sediment autoanalyzer.</p><p><strong>Results:</strong> Gravidity, parity, menopause onset, smoking status and presence of systemic disease were similar for both groups. Women in the hematuria group were older (p&lt;0.001). Hematuria prevalance was greater ininternational continence society Stage 3-4 anterior prolapse and total prolapse (p=0.03) compared to early stage prolapse. However after logistic regression analysis; age was the only factor left in association with hematuria.</p><p><strong>Conclusions:</strong> Women who were older and with advanced stage prolapse ( ≥ international continence society stage 3) were more likely to have microscopic hematuria. Urine tests are requested routinely in the work-up of urogynecological patients. As the prevalance is microhematuria is high in this population; we believe that evidence based algorithms should be set as guidelines when hematuria is encountered in patients with organ prolapse.</p>

Gene expression analysis in modeling Parkinson’s disease

2020 ◽  
pp. 103-104
Author(s):  
М.М. Руденок ◽  
А.Х. Алиева ◽  
А.А. Колачева ◽  
М.В. Угрюмов ◽  
П.А. Сломинский ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Stage ◽  
Systemic Disease ◽  
Molecular Genetic ◽  
Presymptomatic Stage ◽  
Whole Transcriptome Analysis ◽  
Whole Transcriptome ◽  
The Brain ◽  
Transcriptome Level

Несмотря на очевидный прогресс, достигнутый в изучении молекулярно-генетических факторов и механизмов патогенеза болезни Паркинсона (БП), в настоящее время стало ясно, что нарушения в структуре ДНК не описывают весь спектр патологических изменений, наблюдаемых при развитии заболевания. В настоящее время показано, что существенное влияние на патогенез БП могут оказывать изменения на уровне транскриптома. В работе были использованы мышиные модели досимптомной стадии БП, поздней досимптомной и ранней симптомной (РСС) стадиями БП. Для полнотранскриптомного анализа пулов РНК тканей черной субстанции и стриатума мозга мышей использовались микрочипы MouseRef-8 v2.0 Expression BeadChip Kit («Illumina», США). Полученные данные указывают на последовательное вовлечение транскриптома в патогенез БП, а также на то, что изменения на транскриптомном уровне процессов транспорта и митохондриального биогенеза могут играть важную роль в нейродегенерации при БП уже на самых ранних этапах. Parkinson’s disease (PD) is a complex systemic disease, mainly associated with the death of dopaminergic neurons. Despite the obvious progress made in the study of molecular genetic factors and mechanisms of PD pathogenesis, it has now become clear that violations in the DNA structure do not describe the entire spectrum of pathological changes observed during the development of the disease. It has now been shown that changes at the transcriptome level can have a significant effect on the pathogenesis of PD. The authors used models of the presymptomatic stage of PD with mice decapitation after 6 hours (6 h-PSS), presymptomatic stage with decapitation after 24 hours (24 h-PSS), advanced presymptomatic (Adv-PSS) and early symptomatic (ESS) stages of PD. For whole transcriptome analysis of RNA pools of the substantia nigra and mouse striatum, the MouseRef-8 v2.0 Expression BeadChip Kit microchips (Illumina, USA) were used. As a result of the analysis of whole transcriptome data, it was shown that, there are a greater number of statistically significant changes in the tissues of the brain and peripheral blood of mice with Adv-PSS and ESS models of PD compared to 6 h-PSS and 24 h-PSS models. In general, the obtained data indicate the sequential involvement of the transcriptome in the pathogenesis of PD, as well as the fact that changes at the transcriptome level of the processes of transport and mitochondrial biogenesis can play an important role in neurodegeneration in PD at an early stage.

scholarly journals Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Justyna Mika ◽  
Joanna Tobiasz ◽  
Joanna Zyla ◽  
Anna Papiez ◽  
Małgorzata Bach ◽  
...  
Keyword(s):  
Pilot Study ◽  
Body Temperature ◽  
Respiratory Tract ◽  
Older Patients ◽  
Respiratory Tract Infections ◽  
Early Stage ◽  
Patient Groups ◽  
Project Data ◽  
Tract Infections ◽  
Infection Stage

AbstractIn the DECODE project, data were collected from 3,114 surveys filled by symptomatic patients RT-qPCR tested for SARS-CoV-2 in a single university centre in March-September 2020. The population demonstrated balanced sex and age with 759 SARS-CoV-2( +) patients. The most discriminative symptoms in SARS-CoV-2( +) patients at early infection stage were loss of taste/smell (OR = 3.33, p < 0.0001), body temperature above 38℃ (OR = 1.67, p < 0.0001), muscle aches (OR = 1.30, p = 0.0242), headache (OR = 1.27, p = 0.0405), cough (OR = 1.26, p = 0.0477). Dyspnea was more often reported among SARS-CoV-2(-) (OR = 0.55, p < 0.0001). Cough and dyspnea were 3.5 times more frequent among SARS-CoV-2(-) (OR = 0.28, p < 0.0001). Co-occurrence of cough, muscle aches, headache, loss of taste/smell (OR = 4.72, p = 0.0015) appeared significant, although co-occurrence of two symptoms only, cough and loss of smell or taste, means OR = 2.49 (p < 0.0001). Temperature > 38℃ with cough was most frequent in men (20%), while loss of taste/smell with cough in women (17%). For younger people, taste/smell impairment is sufficient to characterise infection, whereas in older patients co-occurrence of fever and cough is necessary. The presented study objectifies the single symptoms and interactions significance in COVID-19 diagnoses and demonstrates diverse symptomatology in patient groups.

Verification of Alarm Displays for the Nuclear Power Plant With Two Modular High-Temperature Gas-Cooled Reactors

2018 ◽  
Author(s):  
Jia Qianqian ◽  
Guo Chao ◽  
Li Jianghai ◽  
Qu Ronghong
Keyword(s):  
High Temperature ◽  
Power Plant ◽  
Nuclear Power Plant ◽  
Nuclear Power ◽  
Modular Design ◽  
Early Stage ◽  
Integrated System ◽  
Alarm System ◽  
Control Room ◽  
High Temperature Gas

The nuclear power plant with two modular high-temperature gas-cooled reactors (HTR-PM) is under construction now. The control room of HTR-PM is designed. This paper introduces the alarm displays in the control room, and describes some verification and validation (V&V) activities of the alarm system, especially verification for some new human factor issues of the alarm system in the two modular design. In HTR-PM, besides the regular V&V similar to other NPPs, the interference effect of the alarm rings of the two reactor modules at the same time, and the potential discomfort of the two reactor operators after shift between them are focused. Verifications at early stage of the two issues are carried on the verification platform of the control room before the integrated system validation (ISV), and all the human machine interfaces (HMIs) in the control room, including the alarm system are validated in ISV. The test results on the verification platform show that the alarm displays and rings can support the operators understand the alarm information without confusion of the two reactors, and the shift between the two reactor operators have no adverse impact on operation. The results in ISV also show that the alarm system can support the operators well.

scholarly journals Leptin/adiponectin ratio in overweight patients – gender differences

2018 ◽  
Vol 15 (3) ◽  
pp. 260-262 ◽  
Author(s):  
Selthofer-Relatić K ◽  
Radić R ◽  
Stupin A ◽  
Šišljagić V ◽  
Bošnjak I ◽  
...  
Keyword(s):  
Early Stage ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Visceral Obesity ◽  
Blood Analysis ◽  
Total Serum ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diabetic Patients ◽  
Adult Males ◽  
Anthropometric Parameters

Objective: Obesity-related atherosclerosis is a systemic disease with a background connected to multiple metabolic-neurohumoral pathways. The leptin/adiponectin ratio has been suggested as an atherosclerotic marker in obese patients. The aim of this study was to assess (1) the significance of the L/A ratio in overweight subjects, (2) the relation with anthropometric/metabolic parameters and (3) gender difference. Method: The study included 80 adult males and females, overweight, non-diabetic patients. Biochemical blood analysis and anthropometric and cardiovascular measurements were performed. Serum leptin levels were measured with a radioimmunoassay test and total adiponectin levels with enzyme-linked immunosorbent assay. Leptin/adiponectin ratios were calculated as ratios between total serum concentrations of leptin and adiponectin. Results: Differences between leptin, adiponectin serum levels and leptin/adiponectin ratios are presented in overweight persons, where females have a significantly higher leptin/adiponectin ratio than men ( p < 0.001). In men, the leptin/adiponectin ratio showed a positive correlation with total cholesterol levels ( p = 0.011), low-density lipoprotein ( p = 0.013) and triglycerides ( p = 0.032). In females, the leptin/adiponectin ratio correlated with anthropometric parameters of visceral obesity: waist circumference ( p = 0.001) and waist-to-hip ratio ( p = 0.025). Conclusion: The leptin/adiponectin ratio could represent an atherosclerotic risk marker of the early stage of obesity. Gender plays a significant role in pathophysiological changes, with different clinical manifestations, where sex hormones have a crucial effect on neurohumoral adipose tissue activity.

scholarly journals Evaluation of a Balloon-Type Vaginal Endoscope Based on Three-Dimensional Printing Technology for Self-Assessment of Pelvic Organ Prolapse

2020 ◽  
Vol 10 (15) ◽  
pp. 5108
Author(s):  
Myoungjae Jun ◽  
Hieyong Jeong ◽  
Masayuki Endo ◽  
Michiko Kodama ◽  
Yuko Ohno
Keyword(s):  
Pelvic Organ Prolapse ◽  
Early Stage ◽  
Low Cost ◽  
Three Dimensional ◽  
Evaluation Study ◽  
Pelvic Organ ◽  
Self Assessment ◽  
Overweight Women ◽  
Depth Sensors ◽  
Feasibility Evaluation

Pelvic organ prolapse (POP) can occur if the support tissues or the pelvic floor muscles are weakened and damaged. There is increased probability for POP occurrence after childbirth, menopause, or in overweight women. Because the natural history and progression of POP is still unknown, the approaches used to prevent it have not been clear. POP is an uncomfortable condition that affects one every three women. However, most people feel uncomfortable to discuss it. Herein, we conducted a feasibility evaluation study for self-assessment approaches with a vaginal endoscope based on three-dimensional (3D) printing. The proposed endoscope has two parts: (a) rubber material used to cover it for its intended insertion, to avoid direct contact with the walls of the vagina, and (b) two types of sensors at the tip for measurements. The condition inside the vagina was observed with a camera and depth sensors based on the regulation of the amount of air. Arbitrary temporary prolapses from the testbed’s generator enabled us to perceive the location of the problem and symptoms that were regarded as the early stage. As discussed, the low-cost design of the 3D-printed-based vaginal endoscope provides a self-check capability and allows continuous observations that help prevent POP.

scholarly journals A plea against over specialisation in forensic psychiatry

1992 ◽  
Vol 16 (7) ◽  
pp. 439-442 ◽  
Author(s):  
Eric F. Mendelson
Keyword(s):  
Forensic Psychiatry ◽  
Psychiatric Care ◽  
Early Stage ◽  
Integrated Approach ◽  
Integrated System ◽  
Forensic Patients ◽  
Secure Care ◽  
Regional Service ◽  
Forensic Psychiatric ◽  
Special Responsibility

The optimal system for delivering forensic psychiatric care has yet to be established. At an early stage, Gunn (1977) drew attention to the differing models of a ‘parallel’ service and an ‘integrated’ approach. Only with the integrated system do forensic patients pass to ordinary NHS facilities when they no longer require security or other specialist expertise. The debate can be extended into whether forensic services should be provided by regional units, by district services, or by a mixture of both. Indeed, the Royal College of Psychiatrists (1988) recognised that in addition to a regional service led by a fully trained forensic psychiatrist, secure care can be provided at a district level by consultants who have sufficient training to hold posts with a special responsibility. Furthermore, managers are understandably keen for as much as possible to be provided by their own district services.

scholarly journals Preventing and Managing Urinary Tract Infections: Enhancing the Role of Community Pharmacists—A Mixed Methods Study

Antibiotics ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 583 ◽  
Author(s):  
Nathan Peiffer-Smadja ◽  
Rosalie Allison ◽  
Leah F. Jones ◽  
Alison Holmes ◽  
Parvesh Patel ◽  
...  
Keyword(s):  
Primary Care ◽  
Mixed Methods ◽  
Urinary Tract ◽  
Community Pharmacists ◽  
Mixed Methods Study ◽  
Urinary Symptoms ◽  
Service Users ◽  
Specific Patient ◽  
Tract Infections

Background: Community pharmacists are involved in antimicrobial stewardship through self-care advice and delivering medications for uncomplicated infections. Objectives: This mixed methods study aimed to identify opportunities to enhance the role of community pharmacists in the management of service users with suspected or confirmed urinary tract infection (UTI). Methods: Data collection was through a service user survey (n = 51) and pharmacist surveys and semi-structured interviews before (16 interviews, 22 questionnaires) and after (15 interviews, 16 questionnaires) trialing UTI leaflets designed to be shared with service users. Data were analysed inductively using thematic analysis and descriptive tabulation of quantitative data. Results: Twenty-five percent (n = 13/51) of service users with urinary symptoms sought help from a pharmacist first and 65% (n = 33/51) were comfortable discussing their urinary symptoms with a pharmacist in a private space. Community pharmacists were confident as the first professional contact for service users with uncomplicated UTI (n = 13/16, 81%), but indicated the lack of a specific patient referral pathway (n = 16/16, 100%), the need for additional funding and staff (n = 10/16, 62%), and the importance of developing prescription options for pharmacists (5/16, 31%). All community pharmacists reported playing a daily role in controlling antimicrobial resistance by educating service users about viral and bacterial infections and promoting a healthy lifestyle. Enhancing their role will need greater integrated working with general practices and more prescribers based in community pharmacy. Conclusion: This study suggests that community pharmacists could play a greater role in the management of uncomplicated UTI. The current reconfiguration of primary care in England with primary care networks and integrated care systems could provide a real opportunity for this collaborative working with potential learning for international initiatives.

Sign in / Sign up

Export Citation Format

Share Document