THE COMPARATIVE ANALYSIS OF SOMATIC PHRASEOLOGICAL UNITS WITH КЬИЛ / ГОЛОВА / HEAD IN THE LEZGIN, RUSSIAN AND ENGLISH LANGUAGES

2020 ◽  
Vol 76 (4) ◽  
pp. 24-29
Author(s):  
FATIMA B. VERDIKHANOVA ◽  
◽  
GULNARA SH. PAVLOVA ◽  
Keyword(s):  
Comparative Analysis ◽  
Contrastive Analysis ◽  
Core Component ◽  
The Core ◽  
Semantic Fields

The object of the contrastive analysis in this article is the group of Lezgin, Russian and English phraseological (somatic) units with the component кьил/голова/head. The analysis aims at identifying the universal and specific issues in their contentits characteristic semantic fields, correlation of the general phraseological value with the core component, structural and grammatical features. In the process of the study we have used the method of comparative analysis of Lezgin, Russian and English phraseological units selected by us from foreign and domestic lexicographic sources. As the result of the analysis we have found that there was a similarity in structure, imagery and stylistic coloration of phraseological units. The peculiar characteristics of the studied languages in phraseological units were carried out. This work can serve as a material for further research in the field of phraseology whether the question of education plays an important role in the life of society.

scholarly journals Avolition as the core negative symptom in schizophrenia: relevance to pharmacological treatment development

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Gregory P. Strauss ◽  
Lisa A. Bartolomeo ◽  
Philip D. Harvey
Keyword(s):  
Negative Symptom ◽  
Negative Symptoms ◽  
Clinical Trial Design ◽  
Core Component ◽  
Treatment Target ◽  
Global Improvement ◽  
Treatment Development ◽  
The Core ◽  
Current Review ◽  
Symptom Domains

AbstractNegative symptoms have long been considered a core component of schizophrenia. Modern conceptualizations of the structure of negative symptoms posit that there are at least two broad dimensions (motivation and pleasure and diminished expression) or perhaps five separable domains (avolition, anhedonia, asociality, blunted affect, alogia). The current review synthesizes a body of emerging research indicating that avolition may have a special place among these dimensions, as it is generally associated with poorer outcomes and may have distinct neurobiological mechanisms. Network analytic findings also indicate that avolition is highly central and interconnected with the other negative symptom domains in schizophrenia, and successfully remediating avolition results in global improvement in the entire constellation of negative symptoms. Avolition may therefore reflect the most critical treatment target within the negative symptom construct. Implications for targeted treatment development and clinical trial design are discussed.

scholarly journals Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Anastasiia Samsonova ◽  
Krystel El Hage ◽  
Bénédicte Desforges ◽  
Vandana Joshi ◽  
Marie-Jeanne Clément ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Cold Shock ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Rna Binding Protein ◽  
Large Set ◽  
Core Component ◽  
The Core ◽  
Cold Shock Domain ◽  
Global Translation

AbstractThe RNA-binding protein Lin28 (Lin28a) is an important pluripotency factor that reprograms translation and promotes cancer progression. Although Lin28 blocks let-7 microRNA maturation, Lin28 also binds to a large set of cytoplasmic mRNAs directly. However, how Lin28 regulates the processing of many mRNAs to reprogram global translation remains unknown. We show here, using a structural and cellular approach, a mixing of Lin28 with YB-1 (YBX1) in the presence of mRNA owing to their cold-shock domain, a conserved β-barrel structure that binds to ssRNA cooperatively. In contrast, the other RNA binding-proteins without cold-shock domains tested, HuR, G3BP-1, FUS and LARP-6, did not mix with YB-1. Given that YB-1 is the core component of dormant mRNPs, a model in which Lin28 gains access to mRNPs through its co-association with YB-1 to mRNA may provide a means for Lin28 to reprogram translation. We anticipate that the translational plasticity provided by mRNPs may contribute to Lin28 functions in development and adaptation of cancer cells to an adverse environment.

scholarly journals Enhancing Postgraduate Learning and Teaching: Postgraduate Summer School in Dairy Science

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Pietro Celi ◽  
Gianfranco Gabai ◽  
Massimo Morgante ◽  
Luigi Gallo
Keyword(s):  
Summer School ◽  
Research Collaboration ◽  
Learning Experience ◽  
Scientific Investigation ◽  
Core Component ◽  
Learning And Teaching ◽  
Transferable Skills ◽  
The Core ◽  
Dairy Science ◽  
The University

Dairy science is a multidisciplinary area of scientific investigation and Ph.D. students aiming to do research in the field of animal and/or veterinary sciences must be aware of this. Ph.D. students often have vast spectra of research interests, and it is quite challenging to satisfy the expectation of all of them. The aim of this study was to establish an international Ph.D. training program based on research collaboration between the University of Sydney and the University of Padova. The core component of this program was a two-week Postgraduate Summer School in Dairy Science, which was held at the University of Padova, for Ph.D. students of both universities. Therefore, we designed a program that encompassed seminars, workshops, laboratory practical sessions, and farm visits. Participants were surveyed using a written questionnaire. Overall, participants have uniformly praised the Summer School calling it a rewarding and valuable learning experience. The Ph.D. Summer School in Dairy Science provided its participants a positive learning experience, provided them the opportunity to establish an international network, and facilitated the development of transferable skills.

Architectural Design of Trusted Platform for IaaS Cloud Computing

2018 ◽  
Vol 8 (2) ◽  
pp. 47-65 ◽  
Author(s):  
Ubaidullah Alias Kashif ◽  
Zulfiqar Ali Memon ◽  
Shafaq Siddiqui ◽  
Abdul Rasheed Balouch ◽  
Rakhi Batra
Keyword(s):  
Cloud Computing ◽  
Service Provider ◽  
Architectural Design ◽  
Cloud Services ◽  
Core Component ◽  
Malicious Activity ◽  
The Core ◽  
Potential Benefits ◽  
Trusted Platform ◽  
Access Right

This article describes how the enormous potential benefits provided by the cloud services, made enterprises to show huge interest in adopting cloud computing. As the service provider has control over the entire data of an organization stored onto the cloud, a malicious activity, whether internal or external can tamper with the data and computation. This causes enterprises to lack trust in adopting services due to privacy, security and trust issues. Despite of having such issues, the consumer has no root level access right to secure and check the integrity of procured resources. To establish a trust between the consumer and the provider, it is desirable to let the consumer to check the procured platform hosted at provider side for safety and security. This article proposes an architectural design of a trusted platform for the IaaS cloud computing by the means of which the consumer can check the integrity of a guest platform. TCG's TPM is deployed and used on the consumer side as the core component of the proposed architecture and it is distributed between the service provider and the consumer.

scholarly journals Mitochondria-driven assembly of a cortical anchor for mitochondria and dynein

2017 ◽  
Vol 216 (10) ◽  
pp. 3061-3071 ◽  
Author(s):  
Lauren M. Kraft ◽  
Laura L. Lackner
Keyword(s):  
Plasma Membrane ◽  
Mitotic Spindle ◽  
Cell Cortex ◽  
Dual Function ◽  
Mitochondrial Inheritance ◽  
Cellular Functions ◽  
Core Component ◽  
Spindle Positioning ◽  
The Core ◽  
Contact Sites

Interorganelle contacts facilitate communication between organelles and impact fundamental cellular functions. In this study, we examine the assembly of the MECA (mitochondria–endoplasmic reticulum [ER]–cortex anchor), which tethers mitochondria to the ER and plasma membrane. We find that the assembly of Num1, the core component of MECA, requires mitochondria. Once assembled, Num1 clusters persistently anchor mitochondria to the cell cortex. Num1 clusters also function to anchor dynein to the plasma membrane, where dynein captures and walks along astral microtubules to help orient the mitotic spindle. We find that dynein is anchored by Num1 clusters that have been assembled by mitochondria. When mitochondrial inheritance is inhibited, Num1 clusters are not assembled in the bud, and defects in dynein-mediated spindle positioning are observed. The mitochondria-dependent assembly of a dual-function cortical anchor provides a mechanism to integrate the positioning and inheritance of the two essential organelles and expands the function of organelle contact sites.

scholarly journals The Study of Personalized Intelligent Cooperative Teaching Service System Based on Grid

2012 ◽  
Vol 4 ◽  
pp. 9-12
Author(s):  
San Jun Liu ◽  
Yan Feng Zhang
Keyword(s):  
Professional Training ◽  
Service System ◽  
Training System ◽  
Grid Technology ◽  
Traditional Teaching ◽  
Grid Services ◽  
Core Component ◽  
Detailed Design ◽  
Cooperative Teaching ◽  
The Core

By studying the theory and method of the Grid Services and analyzing the drawbacks of the traditional teaching system, the article presents a personalized intelligent cooperative teaching service system based on grid. Simultaneously, it makes use of the grid technology to detailed design the teaching service engine. The engine is the core component of the system, it break down and mix of the distributed teaching service sources to provide the advantage of free the usual limitation of space and regions and can work at any time and at any place. The prototype PSPTS software system is developed which can provide useful reference and experiences for institutions or the relevant researches of the enterprise professional training system.

Verfassungsablösung

2021 ◽  
Author(s):  
Friederike Eggert
Keyword(s):  
Comparative Analysis ◽  
Constitutional Theory ◽  
The Core ◽  
The People ◽  
Legal Understanding

In her work, the author examines the question of how democratic constitutional states can give themselves new constitutions. On the basis of a comparative analysis of constitutional practice, the author develops constitutional replacement as a sui generis institute of constitutional theory. The core of the question is in which constitutional cases and under which legal and theoretical conditions the replacement of the current constitution would be permissible. The author justifies constitutional replacement based on a democratic-legal understanding of the pouvoir constituant, the "constitution-replacing power". In this concept, the constituent sovereignty of the people becomes a right of the people to replace its constitution.

Connecticut Copperhead Constitutionalism

2018 ◽  
pp. 53-81
Author(s):  
Matthew Warshauer
Keyword(s):  
Peace Movement ◽  
Home Front ◽  
Political Connections ◽  
Democratic Peace ◽  
Core Component ◽  
Secret Societies ◽  
The Core ◽  
Federal Authority ◽  
National Loyalty ◽  
Litmus Test

Matthew Warshauer examines the Democratic Peace Movement in Connecticut to explain partisan perspectives on national loyalty. Warshauer argues that the state’s anti-war Democrats consistently stressed the importance of the Constitution, rather than the Declaration of Independence, as the litmus test of loyal citizenship. This ideology of Constitutionalism, emphasizing the power of the states and the limits of federal authority, was the core component of their vocal opposition to emancipation, conscription, and other wartime Republican measures. In studying their ideology, Warshauer also speaks to other important themes, including the development of the anti-war movement outside of the Midwest, the debate over alleged Democratic secret societies, Republican rhetoric of Democratic treason, and the vital political connections between the home front and battlefield.

Using Big Data as a Backbone for Thailand 4.0

2018 ◽  
pp. 177-195
Author(s):  
Jirapun Daengdej ◽  
Kitikorn Dowpiset
Keyword(s):  
Big Data ◽  
Conceptual Framework ◽  
Industrial Revolution ◽  
Core Component ◽  
The Core ◽  
Fourth Industrial Revolution ◽  
Government Development

Every country is currently preparing themselves for the fourth industrial revolution, the environment where innovation is the key concept for survival. Most of the countries have developed framework for their e-government development. Unfortunately, most of these frameworks do not contain adequate details on what are the activities required if big data will be used as a backbone of all services. This research focuses on proposing a conceptual framework for development of e-government in Thailand. The proposed framework explicitly contains all important activities to be completed if big data will serve as the core component of all services for their citizens.

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