scholarly journals Myokine Regulation as Marker of Sarcopenia in Elderly

2018 ◽  
Vol 2 (2) ◽  
pp. 38
Author(s):  
I Gusti Putu Suka Aryana ◽  
Anak Agung Ayu Ratih Hapsari ◽  
Raden Ayu Tuty Kuswardhani
Keyword(s):  
Muscle Strength ◽  
Muscle Mass ◽  
Aging Process ◽  
Striated Muscle ◽  
The Elderly ◽  
Liver Fat ◽  
Fibroblast Growth Factor 21 ◽  
Striated Muscles ◽  
Fat Tissue ◽  
Comprehensive Management

The elderly population will increase as well as increasing life expectancy. Health problems in elderly will be more complex and need a comprehensive management. One of the problems that arise from the aging process is sarcopenia. Sarcopenia is a decreasing in muscle mass and muscle strength or muscle function caused by multifactorial not only due to aging process, but also nutrition, immobilization, genetics and others risk factors. Muscle is an endogen organ that produces various proteins that can affect the health system. This protein is referred to as myokine. Myokine is anti-inflammation cytokine and peptide produced by striated muscles. Physical activity results in myokine secretion that can reduce inflammation due to a sedentary lifestyle. Inflammation can lead to worsening sarcopenia and fat accumulation in striated muscles, thus reducing muscle mass, muscle strength and causing physical inactivity. The most of this type myokine have antiinflammation effect have work as autocrine, paracrine and endocrine. Chronic inflammation is a contributor that plays a role in the pathophysiology of various diseases including sarcopenia, it will protected by myokine. Myokine can affect the metabolism of glucose, fatty acids, angiogenesis, myogenesis, neurogenesis, and can explain the relationship between muscle, liver, fat, tissue and brain. Some knewn myokines include interleukin (IL)-6, IL-8, IL-5, brain-derived neurotrophic factor (BDNF), fibroblast growth factor 21 (FGF-21), leukemia Inhibitory factor (LIF), irisin and secreted protein acidic and rich in cysteine (SPARC). Physical exercise can induce myokine secretion from striated muscle to circulation. Through these mechanisms, myokine is expected to improve metabolism of glucose, fat and protein muscle, liver, fat, tissue, brain and reduce the incidence some comorbidity especially sarcopenia. Finally, it's will be decreasing of disability, morbidity and mortality rate in elderly.Keywords: myokine, sarcopenia, elderly

Association between Muscle Mass and Muscle Strength with Physical Performance in Elderly in Surabaya

2020 ◽  
Vol 2 (1) ◽  
pp. 24
Author(s):  
Titin Kristiana ◽  
Novira Widajanti ◽  
Rwahita Satyawati
Keyword(s):  
Muscle Strength ◽  
Muscle Mass ◽  
Physical Performance ◽  
Handgrip Strength ◽  
Positive Association ◽  
The Elderly ◽  
Bivariate Analysis ◽  
Weak Correlation ◽  
Elderly Age ◽  
Cross Sectional

ABSTRACTBackground: Sarcopenia is a decrease in muscle mass and strength that mostly happens in the elderly. Sarcopenia is a problem that is often found in the elderly who are at risk of disability, hospitalization and death. This data on muscle mass and strength with physical performance is expected to support the theory of sarcopenia and as a reference in promoting and preventing sarcopenia in elderly.Aims: To analyze the association between muscle mass and strength (handgrip strength) with physical performance assessed using Short Physical Performance Battery (SPPB) in an elderly community.Methods: This study was a cross-sectional observational analytic study involving 203 sample of elderly (age >60 years old). The subjects were categorized as the strong and weak muscle mass and muscle strength, also the high, moderate and low physical performance. We used Bioimpedance Analysis (BIA) and hand dynamometer to measure muscle mass and muscle strength (handgrip strength). SPPB was used to assess physical performance.The association between muscle mass and strength with physical performance was displayed in bivariate analysis with chi square.Result: Of all 203 subjects, 57 were males and 146 were females. Chi square test showed association between muscle strength (handgrip strength) with physical performance (SPPB) (p=0.001), with a weak correlation (r=0.26) and no association between muscle mass and physical performance (SPPB) (p=0.517).Conclusion: There is a positive association between muscle strength with physical performance, with a weak correlation and no association between muscle mass and physical performance in the elderly community in Surabaya.

The Relationship between Muscle Mass and Muscle Strength in the Elderly

1991 ◽  
Vol 39 (6) ◽  
pp. 555-561 ◽  
Author(s):  
Richard L. Reed ◽  
Lori Pearlmutter ◽  
Kathleen Yochum ◽  
Keith E. Meredith ◽  
Arshag D. Mooradian
Keyword(s):  
Muscle Strength ◽  
Muscle Mass ◽  
The Elderly ◽  
The Relationship

scholarly journals PIH2 Relationship Between Muscle Mass and Muscle Strength in the Elderly Population in the United States

2012 ◽  
Vol 15 (4) ◽  
pp. A191
Author(s):  
L. Chen ◽  
D.R. Nelson ◽  
Y. Zhao ◽  
Z. Cui ◽  
J.A. Johnston
Keyword(s):  
United States ◽  
Muscle Strength ◽  
Muscle Mass ◽  
Elderly Population ◽  
The Elderly ◽  
The United States

scholarly journals Potential of Omega-3 Supplementation on Muscle Mass, Muscle Strength, and Physical Performance in Elderly Community

2021 ◽  
Vol 9 (B) ◽  
pp. 55-59
Author(s):  
Nur Riviati ◽  
Taufik Indrajaya ◽  
Erial Bahar ◽  
Dobi Saputra Burni
Keyword(s):  
Muscle Strength ◽  
Muscle Mass ◽  
Physical Performance ◽  
Functional Ability ◽  
Functional Performance ◽  
Handgrip Strength ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
The Elderly ◽  
Omega 3

BACKGROUND: Geriatric problem characterized by reduced functional ability and impaired adaptation function caused by the decline in various body systems, as well as increased vulnerability to various kinds of stressors, which reduce a person’s functional performance. AIM: This study was aimed to explore the effect of omega-3 supplementation on muscle mass, muscle strength, and physical performance in the elderly community in Palembang, Indonesia. METHODS: This study is an open clinical trial, to assess the potential of omega-3 supplementation on muscle mass, handgrip strength, and physical activity of elderly community. Omega-3 is given as much as 1.2 g once a day for 12 weeks orally. Muscle strength was assessed using Bioelectrical Impedance Analysis. Meanwhile, the muscle strength was assessed with a muscle dynamometer. RESULTS: Omega-3 supplementation has only shown potent efficacy in improving muscle strength in geriatrics patients (before omega-3 supplementation 25.1 + 5.11; after omega-3 supplementation 26.2 + 5.16; p < 0.05). Omega 3 supplementation did not show significant improvement in muscle mass and gait ability in elderly patients. CONCLUSIONS: Omega-3 supplementation improves handgrip strength but does not increase muscle mass and physical performance for geriatrics.

scholarly journals A Review on Aging, Sarcopenia, Falls, and Resistance Training in Community-Dwelling Older Adults

2022 ◽  
Vol 19 (2) ◽  
pp. 874
Author(s):  
Filipe Rodrigues ◽  
Christophe Domingos ◽  
Diogo Monteiro ◽  
Pedro Morouço
Keyword(s):  
Resistance Training ◽  
Muscle Strength ◽  
Physical Exercise ◽  
Muscle Mass ◽  
Well Being ◽  
The Elderly ◽  
Community Dwelling ◽  
Narrative Review ◽  
Current Evidence ◽  
Resistance Training Program

As aging continues to grow in our society, sarcopenia and associated fall risk is considered a public health problem since falling is the third cause of chronic disability. Falls are negatively related to functionality and independence and positively associated with morbidity and mortality. The cost of treatment of secondary injuries related to falls is high. For example, one in ten fall incidents leads to bone fractures and several other comorbidities. As demonstrated by several experimental studies, adopting a more active lifestyle is critical for reducing the number of fall episodes and their consequences. Therefore, it is essential to debate the proven physical exercise methods to reduce falls and fall-related effects. Since muscle mass, muscle strength, bone density, and cartilage function may play significant roles in daily activities, resistance training may positively and significantly affect the elderly. This narrative review aimed to examine current evidence on existing resistance training using resistance machines and bodyweight or low-cost equipment for the elderly and how they are related to falls and fall-related consequences. We provide theoretical links between aging, sarcopenia, and falls linking to resistance training and offer practical suggestions to exercise professionals seeking to promote regular physical exercise to promote quality of life in this population. Exercise programs focusing on strength may significantly influence muscle mass and muscle strength, minimizing functional decline and risk of falling. Resistance training programs should be customized to each elderly according to age, sex, and other fundamental and individual aspects. This narrative review provides evidence to support recommendations for practical resistance training in the elderly related to intensity and volume. A properly designed resistance training program with adequate instructions and technique is safe for the elderly. It should include an individualized approach based on existing equipment (i.e., body weight, resistance machines). Existing literature shows that exercise performance towards 2–3 sets of 1–2 exercises per major muscle group, performing 5–8 repetitions or achieving intensities of 50–80% of 1RM, 2–3 times per week should be recommended, followed by training principles such as periodization and progression. Bearing this in mind, health and exercise professionals should combine efforts focusing on efficient strategies to reduce falls among the elderly and promote higher experiences of well-being at advanced stages in life.

scholarly journals Correlation of Serum IL-6 Levels with Muscle Mass, Muscle Strength, and Physical Performance in Elderly Gymnastics Community in Mohammad Hoesin General Hospital Palembang

2021 ◽  
Vol 5 (9) ◽  
pp. 862-870
Author(s):  
Muhammad Erfin ◽  
Nur Riviati ◽  
Nova Kurniati ◽  
Erial Bahar ◽  
Erwin Sukandi ◽  
...  
Keyword(s):  
Muscle Strength ◽  
General Hospital ◽  
Muscle Mass ◽  
Physical Performance ◽  
Negative Correlation ◽  
Elevated Serum ◽  
The Elderly ◽  
Significant Negative Correlation ◽  
Geriatric Syndrome ◽  
Correlation Strength

Introduction. Old age is related to geriatric syndrome where there are several health problems that often occur related to a decrease in body function and an increase in the inflammatory process. Decrease in muscle mass, muscle strength and physical performance will cause a condition of sarcopenia and frailty syndrome in the elderly. The importance of prevention so that sarcopenia does not occur in the elderly by evaluating the factors that can cause it, one of which is controlling interleukin 6 (IL-6) as proinflammatory. The purpose of this study was to determine the correlation between serum IL-6 levels with muscle mass, muscle strength and physical performance in the elderly gymnastics-community in Mohammad Hoesin General Hospital, Palembang. Methods. This research is an observational analytic study with a cross-sectional approach which was conducted at the Integrated Geriatric Clinic Internal Medicine RSMH Palembang from November 2019 to November 2020. A sample of 31 people aged > 60 years was examined for muscle mass, muscle strength, physical performance and IL-levels. 6 serum. All data processing and analysis in this study used the SPSS version 25 for Windows program. Results. of the 31 subjects, 27 were female (87.1%) and 4 male (12.9%). The mean value of muscle mass is37.9 kg/m2, muscle strength 23 kg, and physical performance 6.1 m/sec.There were 28 (90.3%) samples with elevated serum IL-6 levels, while 3 (9.7%) samples had normal levels. There was a significant negative correlation (p = 0.000) with a strong correlation strength (r = -0.722) between serum IL-6 levels and muscle mass and a significant negative correlation (p = 0.050) with a weak correlation strength (r = -0.354) between IL levels -6 serums with physical performance. Conclusions. There was a significant negative correlation between serum IL-6 levels and muscle mass and physical performance. So, it is very important to prevent an increase in serum IL-6 levels so that the elderly do not fall into a state of sarcopenia.

scholarly journals The Role of Serum Omega 3 Levels on Muscle Mass, Muscle Strength, and Physical Performance in the Elderly Community

2021 ◽  
Vol 5 (3) ◽  
pp. 329-339
Author(s):  
Welly Salutondok ◽  
Nur Riviati ◽  
Yulianto kusnadi ◽  
Erial Bahar ◽  
Nova Kuniati ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Muscle Mass ◽  
Physical Performance ◽  
Significant Relationship ◽  
The Elderly ◽  
Mean Value ◽  
Geriatric Syndrome ◽  
Omega 3 ◽  
Cross Sectional ◽  
Geriatric Clinic

A B S T R A C TIntroduction. Old age is related to geriatric syndrome where there are several healthproblems that often occur related to a decrease in body function and an increase inthe inflammatory process. Decrease in muscle mass, muscle strength and physicalperformance will lead to a condition of sarcopenia and frailty syndrome in the elderly.The importance of prevention so that sarcopenia does not occur in the elderly byevaluating the factors that can cause it, one of which is controlling nutritional factors(macro and micro nutrients), such as in research, namely omega-3 macronutrients.The purpose of this study was to determine the correlation between serum omega-3levels with muscle mass, muscle strength, and physical performance in the elderlycommunity at Moehammad Hoesin Hospital Palembang. Methods. This research isan observational analytic study with a cross-sectional approach which wasconducted at the Integrated Geriatric Clinic Internal Medicine RSMH Palembangfrom November 2019 to November 2020. A sample of 21 people aged> 60 years wasexamined for muscle mass, muscle strength, physical performance and omega-levels. 3 serums. All data processing and analysis in this study used SPSS version25 for Windows. Results. Of the 21 subjects, it was found that women were 19people (90.5%) and 2 men (9.5%). The mean value of muscle mass was 37.65 ± 5.7,hand grip strength was 24.04 ± 5 kg, and walking speed was 6.72 ± 1.8 seconds per6 meters. There were 11 subjects with low serum omega-3 levels of 485.25 ± 110.19mg. There was a significant relationship between serum omega-3 levels and musclemass (p = 0.041) with moderate correlation strength (r = 0.448). Conclusion: Musclemass has a significant relationship with serum omega-3 levels in the elderly withmoderate strength. Meanwhile, muscle strength and physical performance did nothave a significant relationship.

scholarly journals Androgen Signaling in Myocytes Contributes to the Maintenance of Muscle Mass and Fiber Type Regulation But Not to Muscle Strength or Fatigue

Endocrinology ◽  
2009 ◽  
Vol 150 (8) ◽  
pp. 3558-3566 ◽  
Author(s):  
Jill Ophoff ◽  
Karen Van Proeyen ◽  
Filip Callewaert ◽  
Karel De Gendt ◽  
Katrien De Bock ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Mouse Model ◽  
Muscle Mass ◽  
Fiber Type ◽  
Levator Ani ◽  
Chronically Ill ◽  
The Elderly ◽  
Specific Marker ◽  
Male Body ◽  
Skeletal Homeostasis

Muscle frailty is considered a major cause of disability in the elderly and chronically ill. However, the exact role of androgen receptor (AR) signaling in muscle remains unclear. Therefore, a postmitotic myocyte-specific AR knockout (mARKO) mouse model was created and investigated together with a mouse model with ubiquitous AR deletion. Muscles from mARKO mice displayed a marked reduction in AR protein (60–88%). Interestingly, body weights and lean body mass were lower in mARKO vs. control mice (−8%). The weight of the highly androgen-sensitive musculus levator ani was significantly reduced (−46%), whereas the weights of other peripheral skeletal muscles were not or only slightly reduced. mARKO mice had lower intra-abdominal fat but did not demonstrate a cortical or trabecular bone phenotype, indicating that selective ablation of the AR in myocytes affected male body composition but not skeletal homeostasis. Furthermore, muscle contractile performance in mARKO mice did not differ from their controls. Myocyte-specific AR ablation resulted in a conversion of fast toward slow fibers, without affecting muscle strength or fatigue. Similar results were obtained in ubiquitous AR deletion, showing lower body weight, whereas some but not all muscle weights were reduced. The percent slow fibers was increased, but no changes in muscle strength or fatigue could be detected. Together, our findings show that myocyte AR signaling contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. The levator ani weight remains the most sensitive and specific marker of AR-mediated anabolic action on muscle.

scholarly journals Elastic Band Training Effect to Parameters of Sarcopenia in Elderly Community-Dwelling

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Vitriana Biben ◽  
Irma Ruslina Defi ◽  
Derry Suselo
Keyword(s):  
Muscle Strength ◽  
Muscle Mass ◽  
Physical Performance ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
The Elderly ◽  
Community Dwelling ◽  
Walking Distance ◽  
Elastic Band ◽  
Strengthening Exercise

Physiologically aging causes the decreased of muscle mass, strength, and or limited activity known as sarcopenia in the elderly. The decrease in muscle capacity occurs in all elderly, active, or sedentary. Exercise for the elderly is considered not enough to prevent the decrease of function that will occur. Therefore, it is necessary to add strength training to the elderly, such as elastic band exercise. The effect of strength training in 12 weeks with elastic band strengthening exercise on muscle mass, muscle strength, and physical performance as sarcopenia parameters measured in this study. The interventional study design was conducted in elderly community-dwelling in Bandung city, West Java, from May to July 2016. Thirty elderly (60–81 years old) muscle mass measured using bioelectrical impedance analysis (BIA), handgrip strength using hand dynamometer and walking distance as the parameter of physical performance, using 6-minute walking test. Significant differences found in hand muscle strength (p=0.007), walking distance (p=0.000) after elastic band strengthening exercise, but there were no significant changes in muscle mass (p=0.236) even though the muscle mass increased after 12 weeks of strengthening exercise. In conclusion, additional elastic band strength exercise for regular elderly exercise can increase muscle strength and physical performance. PENGARUH LATIHAN DENGAN PITA ELASTIK TERHADAP PARAMETER SARKOPENIA PADA USILA DI KOMUNITASPenuaan secara fisiologis menyebabkan penurunan massa, kekuatan otot dan/atau keterbatasan aktivitas pada usia lanjut (usila). Penurunan kemampuan otot ini terjadi pada semua usila, baik yang aktif maupun nonaktif sehingga senam usila yang ada dianggap tidak mencukupi untuk mencegah penurunan fungsi yang akan terjadi. Oleh karena itu, diperlukan penambahan latihan kekuatan pada usila seperti latihan kekuatan menggunakan pita elastik. Penelitian ini bertujuan mengetahui pengaruh latihan kekuatan dengan pita elastik selama 12 minggu terhadap massa otot, kekuatan otot, dan performa fisik yang merupakan parameter sarkopenia pada usila. Desain penelitian intervensi dilakukan pada usila di komunitas Kota Bandung, Jawa Barat periode bulan Mei sampai Juli 2016. Sebanyak 30 partisipan (usia 60–81 tahun) diukur massa otot menggunakan bioelectrical impedance analysis (BIA) dan kekuatan otot menggunakan dinamometer tangan, serta uji jalan 6 menit untuk mengukur performa fisik. Perbedaan bermakna ditemukan pada kekuatan otot tangan (p=0,007) dan jarak tempuh jalan (p=0,000) setelah dilakukan latihan kekuatan dengan pita elastik, tetapi tidak didapatkan perbedaan bermakna pada massa otot tangan dan kaki (p=0,236) walaupun terjadi peningkatan massa otot setelah dilakukan latihan selama 12 minggu. Simpulan, penambahan latihan kekuatan dengan pita elastik pada program senam usila meningkatkan secara bermakna kekuatan otot dan performa fisik usila.

scholarly journals Association between Muscle Mass and Muscle Strength with Physical Performance in Elderly in Surabaya

2020 ◽  
Vol 2 (1) ◽  
pp. 24
Author(s):  
Titin Kristiana ◽  
Novira Widajanti ◽  
Rwahita Satyawati
Keyword(s):  
Muscle Strength ◽  
Muscle Mass ◽  
Physical Performance ◽  
Handgrip Strength ◽  
Positive Association ◽  
The Elderly ◽  
Bivariate Analysis ◽  
Weak Correlation ◽  
Elderly Age ◽  
Cross Sectional

ABSTRACTBackground: Sarcopenia is a decrease in muscle mass and strength that mostly happens in the elderly. Sarcopenia is a problem that is often found in the elderly who are at risk of disability, hospitalization and death. This data on muscle mass and strength with physical performance is expected to support the theory of sarcopenia and as a reference in promoting and preventing sarcopenia in elderly.Aims: To analyze the association between muscle mass and strength (handgrip strength) with physical performance assessed using Short Physical Performance Battery (SPPB) in an elderly community.Methods: This study was a cross-sectional observational analytic study involving 203 sample of elderly (age >60 years old). The subjects were categorized as the strong and weak muscle mass and muscle strength, also the high, moderate and low physical performance. We used Bioimpedance Analysis (BIA) and hand dynamometer to measure muscle mass and muscle strength (handgrip strength). SPPB was used to assess physical performance.The association between muscle mass and strength with physical performance was displayed in bivariate analysis with chi square.Result: Of all 203 subjects, 57 were males and 146 were females. Chi square test showed association between muscle strength (handgrip strength) with physical performance (SPPB) (p=0.001), with a weak correlation (r=0.26) and no association between muscle mass and physical performance (SPPB) (p=0.517).Conclusion: There is a positive association between muscle strength with physical performance, with a weak correlation and no association between muscle mass and physical performance in the elderly community in Surabaya.

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