Decarboxylative Propargylation/Hydroamination/Aromatization Enabled by Copper/ Amine Cooperative Catalysis: Construction of Cyclopenta[b]indole Derivatives
Keyword(s):
An efficient decarboxylative cycloaddition of 2,3-dioxopyrrolidines and ethynyl benzoxazinanones has been established by cooperative copper/amine catalysis. A copper– allenylidene complex and enolate intermediate, each catalytically generated from distinct substrates, underwent a cascade propargylation/hydroamination/aromatization process to construct a big library of cyclopenta[b]indole derivatives with good to excellent yields and excellent diastereoselectivity.
Keyword(s):
2016 ◽
Vol 20
(20)
◽
pp. 2038-2054
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Keyword(s):
2018 ◽
Vol 15
(10)
◽
pp. 1079-1086
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2021 ◽
Vol 36
(1)
◽
pp. 1665-1678