Aryl Hydrocarbon Receptor: Its Regulation and Roles in Transformation and Tumorigenesis
2019 ◽
Vol 20
(6)
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pp. 625-634
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Keyword(s):
AhR is an environmental response gene that mediates cellular responses to a variety of xenobiotic compounds that frequently function as AhR ligands. Many AhR ligands are classified as carcinogens or pro-carcinogens. Thus, AhR itself acts as a major mediator of the carcinogenic effect of many xenobiotics in vivo. In this concise review, mechanisms by which AhR trans-activates downstream target gene expression, modulates immune responses, and mediates malignant transformation and tumor development are discussed. Moreover, activation of AhR by post-translational modifications and crosstalk with other transcription factors or signaling pathways are also summarized.
Keyword(s):
2020 ◽
Vol 18
◽
pp. 205873922093456
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2014 ◽
Vol 289
(35)
◽
pp. 24452-24462
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Keyword(s):
2015 ◽
Vol 112
(51)
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pp. 15654-15659
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2007 ◽
Vol 7
(3)
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pp. 227-232
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