Association between cardiometabolic index and stroke: A population-based cross-sectional study

2021 ◽  
Vol 18 ◽  
Author(s):  
Feng-E Li ◽  
Yi Yang ◽  
Zhen-Ni Guo ◽  
Yun Luo ◽  
Fu-Liang Zhang ◽  
...  
Keyword(s):  
Stroke Risk ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cluster Sampling ◽  
Sectional Study ◽  
Cross Sectional ◽  
Discrimination Ability ◽  
Cardiometabolic Index

Background: Cardiometabolic index (CMI) is associated with several risk factors for stroke; however, few studies have assessed the role of CMI in stroke risk. Objective: This study aimed to assess the association between CMI and stroke in a population-based cross-sectional study. Methods: This study included 4445 general residents aged ≥40 years selected by multistage stratified random cluster sampling. CMI was calculated as the product of the ratio of waist circumference to height (WHtR) and the ratio of triglyceride levels to high-density lipoprotein cholesterol levels (TG/HDL-C). Participants were categorized according to CMI quartiles: quartile 1 (Q1), quartile 2 (Q2), quartile 3 (Q3), and quartile 4 (Q4). Multivariate logistic regression analysis and receiver operating characteristic (ROC) curves were used to assess the association between CMI and stroke. Results: A total of 4052 participants were included in the study, with an overall stroke prevalence of 7.2%. The prevalence of stroke increased with CMI quartiles, ranging from 4.4% to 9.2% (p for trend <0.001). Compared with Q1, stroke risk for Q2, Q3, and Q4 were 1.550-, 1.693-, and 1.704- fold, respectively. The area under the ROC curve (AUC) [95% CI] was (0.574 [0.558−0.589]) for CMI, 0.627 [0.612−0.642]) (p=0.0024) for WHtR, 0.556 [0.540−0.571]) (p<0.0001) for TG/HDL-C. CMI was inferior to WHtR, but CMI had marginal advantage over TG/HDL-C in terms of its stroke discrimination ability. Conclusion: Although there was a strong and independent association between CMI and stroke in the general population, CMI had limited discriminating ability for stroke. Thus, new parameters should be developed.

scholarly journals Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: A cross-sectional study in China

2020 ◽  
Author(s):  
Yan Liu ◽  
Zhenwen Zhang ◽  
Binlan Xia ◽  
Liping Wang ◽  
Hengzhong Zhang ◽  
...  
Keyword(s):  
High Risk ◽  
Stroke Risk ◽  
Heart Diseases ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Carotid Plaques ◽  
Lack Of Exercise ◽  
The Relationship

Abstract Background: Evidence on the association between the non-high-density lipoprotein cholesterol (non-HDLc)-to-high-density lipoprotein cholesterol (HDLc) ratio (non-HDLc/HDLc) and carotid plaques is still limited. This study aims to assess the relationship between the non-HDLc/HDLc and carotid plaques in a population with a high risk of stroke.Methods: A cross-sectional study based on the community was conducted in Yangzhou, China. Residents (no younger than 40 years old) underwent questionnaire interviews, physical examinations, and laboratory testing during 2013-2014. The subjects with a high risk of stroke were further selected (at least three of eight risk factors including hypertension, atrial fibrillation, type 2 diabetes mellitus, dyslipidaemia, smoking, lack of exercise, overweight, and family history of stroke) or a transient ischaemic attack (TIA) or stroke history. Carotid ultrasonography was then performed on the high stroke risk participants. Carotid plaque was defined as a focal carotid intima-media thickness (cIMT) ≥1.5 cm or a discrete structure protruding into the arterial lumen at least 50% of the surrounding cIMT. Logistic regression was employed to evaluate the relationship between the non-HDLc/HDLc and carotid plaques.Results: Overall, 839 subjects with a high risk of stroke were ultimately included in the analysis, and carotid plaques were identified in 341 (40.6%) of them. Participants in the highest non-HDLc/HDLc tertile group presented a higher proportion of carotid plaques than did those in the other two groups. After adjustment for other confounders, each unit increase in the non-HDLc/HDLc was significantly associated with carotid plaques (OR 1.55, 95%CI 1.28-1.88). In the subgroup analysis, the non-HDLc/HDLc was positively and significantly associated with the presence of carotid plaques in most subgroups. Additionally, the non-HDLc/HDLc interacted significantly with three stratification variables, including sex (OR 1.31 for males vs. OR 2.37 for females, P interaction = 0.016), exercise (OR 1.18 for subjects without lack of exercise vs. OR 1.99 for subjects with lack of exercise, P interaction = 0.004) and heart diseases (OR 1.40 for subjects without heart diseases vs. OR 3.12 for subjects with heart diseases, P interaction = 0.033). Conclusion: The non-HDLc/HDLc was positively associated with the presence of carotid plaques in a Chinese high stroke risk population. A prospective study or randomized clinical trial of lipid-lowering therapy in the Chinese population is needed to evaluate their causal relationship.

scholarly journals Relationship between sleep duration and hypertension in northeast China: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e023916 ◽  
Author(s):  
Meng Li ◽  
Shoumeng Yan ◽  
Shan Jiang ◽  
Xiaoyu Ma ◽  
Tianyu Gao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sleep Duration ◽  
Northeast China ◽  
Total Sample ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cluster Sampling ◽  
Sectional Study ◽  
Short Sleep Duration ◽  
Cross Sectional

ObjectivesPrevious studies have reported that sleep duration might increase the risk of hypertension. However, the results have been conflicting. We investigated whether sleep duration is independently associated with hypertension. We aimed to assess the relationship between sleep duration and hypertension in a population-based cross-sectional study.MethodsIn this study we used multistage stratified cluster sampling. A total of 19 407 adults aged 18–79 years were enrolled in the study. The participants were divided into three groups (<7 hours/day, 7–8 hours/day and >8 hours/day) according to self-reported sleep duration. Hypertension was defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg or the use of anti-hypertensive medications. Univariate and multivariate logistic regressions were performed to determine the association between hypertension and sleep duration adjusted for sociodemographic, body mass index, and lifestyle covariates.ResultsThe overall prevalence of hypertension was 32.6%. Among participants aged 18–44 years, individuals sleeping less than 7 hours per day had a higher risk of hypertension (OR=1.24, 95% CI: 1.05 to 1.46), compared with those who slept 7–8 hours per day. There were no significant associations between sleep duration and hypertension in the total sample, among middle-aged adults (45–59 years) or older adults (60–79 years).ConclusionsOur study demonstrates that short sleep duration was significantly associated with hypertension among people aged 18–44 years in northeast China.

scholarly journals Prevalence of dyslipidemia and associated risk factors among adults aged ≥ 35 years in northern China: a cross-sectional study

2020 ◽  
Author(s):  
Yunfeng Xi ◽  
Liwei Niu ◽  
Ning Cao ◽  
Han Bao ◽  
Xiaoqian Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Postmenopausal Women ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Northern China ◽  
Cross Sectional Study ◽  
Lipoprotein Cholesterol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Han Ethnicity

Abstract Background: Cardiovascular disease (CVD) prevalence has increased continuously over the last 30 years in China. Dyslipidemia is an important modifiable risk factor in CVD. We aimed to collect current data on the prevalence of dyslipidemia in northern China and explore potential influencing factors. Methods: In this cross-sectional study, we selected a representative sample of 65,128 participants aged ≥35 years in Inner Mongolia during 2015–2017. All participants completed a questionnaire and were examined for risk factors. Dyslipidemia was defined according to 2016 Chinese guidelines for adults. The associated factors for dyslipidemia were estimated by multivariate logistic regression analysis. Results: The age-standardized prevalence of dyslipidemia was 31.2% overall, with 4.3%, 2.4%, 14.7%, and 17.4% for high total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and low high-density lipoprotein cholesterol (HDL-C), respectively. The dyslipidemia prevalence was significantly higher in men than women (37.9% vs. 27.5%, P <0.001), but postmenopausal women had a higher prevalence of dyslipidemia components (except low HDL-C). Compared with Han participants, Mongol participants had a lower prevalence of dyslipidemia (29.1% vs. 31.4%, P <0.001). Male sex, living in urban areas, Han ethnicity, smoking, obesity, central obesity, hypertension, and diabetes were all positively correlated with dyslipidemia; alcohol consumption was linked to lower risk of dyslipidemia. Conclusions: Our study revealed that dyslipidemia is a health problem in northern China. Greater efforts to prevent and manage dyslipidemia, especially in men under age 55 years, postmenopausal women, and people with unhealthy lifestyles or chronic diseases.

scholarly journals LDL-C:HDL-C ratio and common carotid plaque in Xinjiang Uygur obese adults: a cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e022757 ◽  
Author(s):  
Qiang Zhao ◽  
Fen Liu ◽  
Ying-Hong Wang ◽  
Hong-Mei Lai ◽  
Qian Zhao ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Independent Predictor ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Multivariate Logistic Regression ◽  
Obese Adults ◽  
Cross Sectional

ObjectiveThe aim of this study was to explore the relationship between low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C) ratio and common carotid atherosclerotic plaque (CCAP) among obese adults of Uygur community in Xinjiang, China.DesignA hospital-based cross-sectional study.SettingFirst Affiliated Hospital of Xinjiang Medical University.ParticipantsA total of 1449 obese adults of Uygur population who were free of coronary artery disease were included in our study from 1 January 2014 to 31 December 2016.MethodologyLipid profiles, other routine laboratory parameters and intima-media thickness of the common carotid artery were measured in all participants. Multivariate logistic regression analysis was used to examine the association between LDL-C:HDL-C ratio and CCAP.ResultsFour hundred and fifteen (28.64%) participants had CCAP. Participants with CCAP had significantly higher LDL-C:HDL-C ratio compared with those without CCAP (3.21 [2.50, 3.88] vs 2.33 [1.95, 2.97], p<0.001). Multivariate logistic regression analysis showed high LDL-C:HDL-C ratio as independent predictor of CCAP after adjusting for conventional cardiovascular risk factors. The top LDL-C:HDL-C ratio quartile (≥3.25) had an OR of 9.355 (95% CI 6.181 to 14.157) compared with the bottom quartile (<2.07) of LDL-C:HDL-C ratio (p<0.001) after adjustment for age, body mass index, smoking, diabetes mellitus and serum level of total cholesterol.ConclusionCCAP is highly prevalent in Uygur obese adults. A high LDL-C:HDL-C ratio is an independent predictor of CCAP. It may help identify obese individuals who are at high risk of CCAP and who may benefit from intensive LDL-lowering therapy.

scholarly journals Undernutrition and associated factors among children aged 5–10 years in West Bengal, India: a community-based cross-sectional study

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Amitava Pal ◽  
Sourav Manna ◽  
Rishna Dalui ◽  
Rupanjan Mukhopadhyay ◽  
Prakash C. Dhara
Keyword(s):  
Risk Factors ◽  
Drinking Water ◽  
West Bengal ◽  
Multivariate Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Child Malnutrition ◽  
Cluster Sampling ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional

Abstract Background In the previous few decades, India has made significant progress in reducing child mortality and fertility rates; yet, undernutrition remains one of the country’s primary public health issues. The goal of this study was to determine the extent of child malnutrition in West Bengal, India, as well as the risk factors linked with it. In diverse districts of West Bengal, a community-based cross-sectional study was undertaken utilizing multi-stage stratified cluster sampling followed by systematic random sampling. Anthropometric, individual, and household characteristics were collected from 2070 children in this study. Height-for-age, weight-for-age, and BMI-for-age z-scores were calculated. The levels and factors related with child undernutrition were studied using univariate and multivariate logistic regression analysis. Results Stunting, underweight, and thinness were shown to be prevalent in 25.48%, 33%, and 26.88% of children, respectively. With age, the likelihood of a child becoming malnourished increased. In comparison with girls, boys had a greater chance of being malnourished. Separately, parental educational and occupational statuses were linked to child malnutrition. Undernourished children were more likely to have a mother who was uneducated or undereducated (stunting: OR = 1.46; underweight: OR = 1.49; thinness: OR = 1.49). Children from economically disadvantaged families were more likely to be malnourished. Children from households with untreated drinking water and poor sanitation were more likely to be malnourished. Conclusions The current study showed that there are several risk variables linked to child malnutrition. Undernutrition was caused by illiteracy, filthy drinking water, and poor sanitation, all of which were independent risk factors.

scholarly journals Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: A cross-sectional study in China

2020 ◽  
Author(s):  
Yan Liu ◽  
Zhenwen Zhang ◽  
Binlan Xia ◽  
Liping Wang ◽  
Hengzhong Zhang ◽  
...  
Keyword(s):  
High Risk ◽  
Stroke Risk ◽  
Heart Diseases ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Carotid Plaques ◽  
Lack Of Exercise ◽  
The Relationship

Abstract Background: Evidence on the association between the non-high-density lipoprotein cholesterol (non-HDLc)-to-high-density lipoprotein cholesterol (HDLc) ratio (non-HDLc/HDLc) and carotid plaques is still limited. This study aims to assess the relationship between the non-HDLc/HDLc and carotid plaques in a population with a high risk of stroke.Methods: A cross-sectional study based on the community was conducted in Yangzhou, China. Residents (no younger than 40 years old) underwent questionnaire interviews, physical examinations, and laboratory testing during 2013-2014. The subjects with a high risk of stroke were further selected (at least three of eight risk factors including hypertension, atrial fibrillation, type 2 diabetes mellitus, dyslipidaemia, smoking, lack of exercise, overweight, and family history of stroke) or a transient ischaemic attack (TIA) or stroke history. Carotid ultrasonography was then performed on the high stroke risk participants. Carotid plaque was defined as a focal carotid intima-media thickness (cIMT) ≥1.5 cm or a discrete structure protruding into the arterial lumen at least 50% of the surrounding cIMT. Logistic regression was employed to evaluate the relationship between the non-HDLc/HDLc and carotid plaques.Results: Overall, 839 subjects with a high risk of stroke were ultimately included in the analysis, and carotid plaques were identified in 341 (40.6%) of them. Participants in the highest non-HDLc/HDLc tertile group presented a higher proportion of carotid plaques than did those in the other two groups. After adjustment for other confounders, each unit increase in the non-HDLc/HDLc was significantly associated with carotid plaques (OR 1.55, 95%CI 1.28-1.88). In the subgroup analysis, the non-HDLc/HDLc was positively and significantly associated with the presence of carotid plaques in most subgroups. Additionally, the non-HDLc/HDLc interacted significantly with three stratification variables, including sex (OR 1.31 for males versus OR 2.37 for females, P interaction = 0.016), exercise (OR 1.18 for subjects without lack of exercise versus OR 1.99 for subjects with lack of exercise, P interaction = 0.004) and heart diseases (OR 1.40 for subjects without heart diseases versus OR 3.12 for subjects with heart diseases, P interaction = 0.033). Conclusion: The non-HDLc/HDLc was positively associated with the presence of carotid plaques in a Chinese high stroke risk population. A prospective study or randomized clinical trial of lipid-lowering therapy in the Chinese population is needed to evaluate their causal relationship.

scholarly journals The Comparation of Anthropometric and Metabolic Indices in the Regulation and Prediction of Fatty Liver: a population-based cross-sectional study in China

2020 ◽  
Author(s):  
Fangfei Xie ◽  
Yuyu Pei ◽  
Yun Wang ◽  
Jiongyan Li ◽  
Xuehua Xu ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Strong Association ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Field Methods ◽  
Cross Sectional ◽  
Discrimination Ability ◽  
Metabolic Indices

Abstract Background: The association between anthropometric and metabolic indices and fatty liver (FL) remain not fully elucidated. We aimed to determine the role of these anthropometric and metabolic indices on FL prediction and regulation via cross-sectional study, thus providing clues for further research in FL field. Methods: A total of 658 participants aged over 18 years were included in this study. Anthropometric and metabolic indices (including WC, WHR, BMI, BFM, VFA, TG/HDL, AST/ALT, SBP, DBP and FBG) were measured. Difference analyses, logistic and predictive analyses were used to evaluate the association and discrimination ability between these indices and FL. Results: Compared with non-FL, anthropometric and metabolic indices in FL and mild FL people showed a significant increase after adjustment. In the multivariate ranked logistic regression analysis, WC, TG/HDL, AST/ALT and FBG have a strong association with FL (β = 0.03, 0.19, 0.41, -1.89 and 0.28, P<0.05). And AST/ALT showed the lowest predicted power with an AUC of 0.22 among all indices. WC showed to be the best predictors with an AUC of 0.86 in participants.Conclusions: This is a comprehensive profile for FL related indices. These can enhance our understanding of the mechanisms for hepatic on inflammation and fat and is also important for the prevention and treatment of FL.

scholarly journals Knowledge, attitudes, and behaviors (KAB) related to brushing teeth with powered toothbrush among doctors: a cross-sectional study

2020 ◽  
Author(s):  
Yanhao Wang ◽  
Lin Jiang
Keyword(s):  
Population Based ◽  
Cross Sectional Study ◽  
Cluster Sampling ◽  
Sectional Study ◽  
Cross Sectional ◽  
Attitudes And Behaviors ◽  
And Behaviors ◽  
Regional Product ◽  
Powered Toothbrush ◽  
Self Administered Questionnaire

Abstract Background This study was to explore the knowledge, attitudes, and behaviors (KAB) regarding brushing teeth with powered toothbrush among doctors. Methods This population-based, cross-sectional study was conducted by using a self-administered questionnaire regarding powered toothbrush based on the KAB model. Multistage cluster sampling was used to enrol doctors. Results A total of 403 doctors were included in the study. The proportion of “need to be strengthen” on knowledge, attitude and behaviors was 68.0 percent, 71.0 percent and 80.4 percent, respectively. The usage rate of powered toothbrush was low in doctors (12.2 percent). Doctors from dental department had higher knowledge (p<0.001) and attitude (p<0.01) scores than the doctors from non-dental department. Doctors from the district with a higher gross regional product had higher knowledge (p<0.01) and behaviors score (p<0.001), and doctors from higher-level hospitals had higher knowledge (p<0.001). Using powered toothpaste was positively associated with the knowledge (p<0.001), attitude (p<0.05) and behaviors (p<0.001) scores. Conclusions The majority of doctors’ knowledge, attitude and behaviors regarding powered toothbrush were needed to be strengthened. Specific health education is needed to improve the knowledge, attitude and behaviors regarding powered toothbrush.

scholarly journals Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: a cross-sectional study in China

2020 ◽  
Author(s):  
Yan Liu ◽  
Zhenwen Zhang ◽  
Binlan Xia ◽  
Liping Wang ◽  
Hengzhong Zhang ◽  
...  
Keyword(s):  
High Risk ◽  
Stroke Risk ◽  
Heart Diseases ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Carotid Plaques ◽  
Lack Of Exercise ◽  
The Relationship

Abstract Background Evidence on the association between the non-high-density lipoprotein cholesterol (non-HDLc)-to-high-density lipoprotein cholesterol (HDLc) ratio (non-HDLc/HDLc) and carotid plaques is still limited. We aimed to assess the relationship between the non-HDLc/HDLc and carotid plaques in a population with a high risk of stroke. Methods A cross-sectional study based on the community was conducted in Yangzhou, China. Residents (no younger than 40 years old) underwent questionnaire interviews, physical examinations, and laboratory testing during 2013–2014. The subjects with a high risk of stroke were further selected (at least three of eight risk factors including hypertension, atrial fibrillation, type 2 diabetes mellitus, dyslipidaemia, smoking, lack of exercise, overweight, and family history of stroke) or a transient ischaemic attack (TIA) or stroke history. Carotid ultrasonography was then performed on the high stroke risk participants. Logistic regression was employed to evaluate the relationship between the non-HDLc/HDLc and carotid plaques. Results Overall, 839 subjects with a high risk of stroke were ultimately included in the analysis, and carotid plaques were identified in 341 (40.6%) of them. Participants in the highest non-HDLc/HDLc tertile group presented a higher proportion of carotid plaques than did those in the other two groups. After adjustment for other confounders, each unit increase in the non-HDLc/HDLc was significantly associated with carotid plaques (OR 1.55, 95%CI 1.28–1.88). In the subgroup analysis, the non-HDLc/HDLc was positively and significantly associated with the presence of carotid plaques in most subgroups. Additionally, the non-HDLc/HDLc interacted significantly with three stratification variables, including sex (OR 1.31 for males versus OR 2.37 for females, P interaction = 0.016), exercise (OR 1.18 for subjects without lack of exercise versus OR 1.99 for subjects with lack of exercise, P interaction = 0.004) and heart diseases (OR 1.40 for subjects without heart diseases versus OR 3.12 for subjects with heart diseases, P interaction = 0.033). Conclusion The non-HDLc/HDLc was positively and consistently associated with the presence of carotid plaques in a Chinese high stroke risk population.

Sign in / Sign up

Export Citation Format

Share Document