Serum and Bronchoalveolar Lavage Fluid 25(OH)Vitamin D3 Levels in HIV-1 and Tuberculosis: A Cross-Sectional Study from a Tertiary Care Center in North India

2018 ◽  
Vol 16 (2) ◽  
pp. 167-173
Author(s):  
Sanjeev Sinha ◽  
Kartik Gupta ◽  
Dibyakanti Mandal ◽  
B.K. Das ◽  
R.M. Pandey
Keyword(s):  
Vitamin D ◽  
Lavage Fluid ◽  
Cross Sectional Study ◽  
P Value ◽  
Vitamin D Metabolites ◽  
Cross Sectional ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: Vitamin D is an immunomodulator, and its deficiency is associated with Tuberculosis (TB) infection. Bronchoalveolar lavage fluid (BALF) is a rich milieu of macrophages that form the first line of defense against invading TB bacilli. As there is an increased prevalence of vitamin D deficiency in TB and human immunodeficiency virus-1 (HIV-1) subjects, we intend exploring the possibility of a localized deficiency of vitamin D metabolites in BALF of these patients. Objective: The primary objective was to assess the level of 25D3 in serum and BALF of subjects and look for a significant difference among patients and controls. The secondary objective was to find a correlation between serum and BALF 25D3 levels. Methods: We performed a cross-sectional study with subjects divided into four groups: Controls (group 1), HIV positive without active TB (group 2), active TB without HIV (group 3), and HIV-TB coinfection (group 4). BALF and serum 25D3 levels were compared between the groups. Results: Among the 149 (an immunomodulator) successive subjects enrolled, there were 40 subjects in group 1 (HIV-TB-), 48 in group 2 (HIV+TB-), 37 in group 3 (HIV-TB+), and 24 in group 4 (HIV+TB+). Females constituted 31.6% of the study subjects. In groups 3 and 4, there were significantly lower serum 25D3 levels compared to group 1 (p-value group 3: 0.002; group 4: 0.012). In groups 2, 3, and 4, there were significantly lower BALF 25D3 levels compared to group 1 (p-value group 2: 0.000; group 3: 0.000; group 4: 0.001). There was a significant correlation between serum and BALF 25D3 levels (Spearman’s rank correlation coefficient 0.318, p-value = 0.0001). Conclusion: Lower levels of serum and BALF 25D3 were observed in HIV, TB, and HIV-TB coinfected patients. Localized deficiency of vitamin D metabolites might be associated with increased vulnerability to TB infection.

scholarly journals Prevalence of prediabetes in patients with metabolic risk

2011 ◽  
Vol 129 (5) ◽  
pp. 300-308 ◽  
Author(s):  
Lívia Nascimento de Matos ◽  
Guilherme de Vieira Giorelli ◽  
Amir Saado ◽  
Cristiane Bitencourt Dias
Keyword(s):  
Clinical Laboratory ◽  
Tolerance Test ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Group 4 ◽  
Laboratory Variables ◽  
Group 3 ◽  
Group 2 ◽  
Anthropometric Profile ◽  
Group 1

CONTEXT AND OBJECTIVE: Early diagnosis of prediabetes should be done to avoid complications relating to diabetes mellitus (DM). The aim here was to assess the prevalence of prediabetes among individuals at high risk of developing DM, and to seek variables relating to glucose intolerance (GI) among individuals with normal fasting plasma glucose (FPG). DESIGN AND SETTING: Cross-sectional study at Hospital do Servidor Público Estadual, São Paulo. METHODS: The FPG and glucose tolerance test (GTT) were analyzed, from which the subjects were divided as follows: group 1 (FPG and GTT both normal), group 2 (normal FPG but abnormal GTT), group 3 (abnormal FPG but normal GTT), and group 4 (FPG and GTT both abnormal). The subjects' clinical, laboratory and anthropometric profile was determined. RESULTS: 138 subjects were studied: 44 in group 1, 11 in group 2, 33 in group 3 and 50 in group 4. The prevalence of prediabetes was 68.0%. Group 4 individuals were older than group 1 individuals [69.0 (55.5-74.0) versus 58.9 ± 11.8 years; P < 0.05], with greater prevalence of risk conditions for DM [5.0 (4.0-5.0) versus 4.0 (3.0-5.0); P < 0.05]. Among individuals with normal FPG, GI prevalence was 20.0%. No variables analyzed correlated with GTT. CONCLUSION: The prevalence of prediabetes was 68.0%, and 20.0% of subjects with normal FPG had GI. Although some anthropometric, clinical and laboratory variables have been correlated with DM and prediabetes, none, except for GTT, was able to screen for GI among subjects with normal FPG in the present study

scholarly journals Effect of the Cut-Off Level for Thyroid-Stimulating Hormone on the Prevalence of Subclinical Hypothyroidism among Infertile Mexican Women

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 417
Author(s):  
Lidia Arce-Sánchez ◽  
Salvatore Giovanni Vitale ◽  
Claudia Montserrat Flores-Robles ◽  
Myrna Souraye Godines-Enriquez ◽  
Marco Noventa ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Subclinical Hypothyroidism ◽  
Thyroid Autoimmunity ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Mexican Women ◽  
Cross Sectional ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

The primary aim of this study was to compare the prevalence of subclinical hypothyroidism (SCH) using two different cut-off levels for TSH values (≥2.5 mIU/L versus ≥4.1 mIU/L). The secondary objective was to analyze the clinical-biochemical characteristics in women with and without SCH. This was a retrospective cross-sectional study. In total, 1496 Mexican women with infertility were included: Group 1, women with TSH levels ranging between 0.3 and 2.49 mIU/L, n = 886; Group 2, women with TSH between 2.5 and 4.09 mIU/L, n = 390; and Group 3, women with TSH ≥4.1 mIU/L n = 220. SCH prevalence was 40.7% (CI 95%: 38.3–43.3%) with TSH cut-off ≥ 2.5 mIU/L, and 14.7% (CI 95%: 12.7–16.5%) with TSH cut-off ≥ 4.1 mIU/L, (p = 0.0001). The prevalence of overweight was higher in Group 2 than in Groups 1 and 3. Thyroid autoimmunity, obesity and insulin resistance were higher in Group 3 than in Group 1 (p < 0.05). No other differences were observed between groups. Conclusions: The prevalence of SCH in our selected patients increased almost three times using a TSH cut-off ≥ 2.5 mIU/L compared with a TSH cut-off ≥ 4.1 mIU/L. Women with TSH ≥4.1 mIU/L compared with TSH cut-off ≤ 2.5 mIU/L more often presented with obesity, thyroid autoimmunity and insulin resistance.

scholarly journals Sensitivity and Specificity of Belin Ambrosio Enhanced Ectasia Display in Early Diagnosis of Keratoconus

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Shahram Bamdad ◽  
Mohammad Reza Sedaghat ◽  
Masoud Yasemi ◽  
Aliraza Vahedi
Keyword(s):  
Early Diagnosis ◽  
Sensitivity And Specificity ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Normal Thickness

Purpose. Early diagnosis of keratoconus disease (KCN) is the first priority in the preoperative evaluations of refractive surgery (RS).The aim of this study was to investigate the correlation between findings of Belin Ambrosio enhanced ectasia display (BAD) software and conventional corneal imaging (Orbscan and topography) in the early diagnosis of KCN. Methods. For conducting this cross-sectional study, a total of 1000 eyes were selected from 500 patients that underwent the myopic photorefractive keratectomy surgery and were compared in four study groups during the years 2017–2018. In group 1, all topography, Orbscan, and BAD criteria were normal (65.8%).In contrast, in Group 2, at least one of the topography or Orbscan criteria as well as at least one BAD criterion (12.6%) were abnormal. In Group 3, the eyes had normal Orbscan and topography criteria with at least one abnormal BAD criterion (18.5%). Also, in Group 4, the patients had at least one abnormal Orbscan or topography criterion, but all BAD criteria (3.1%) were normal. Thickness of the thinnest point (TP) of cornea was compared in Pentacam and topography. Data analysis was done by SPSS software (version 21). Results. BAD criteria were normal in 78.5% of all eyes with normal topography and Orbscan criteria (specificity). BAD criteria were also abnormal in 80.2% of eyes (sensitivity). There was also no significant difference between TP in Orbscan and Pentacam. Conclusions. BAD criteria had a relatively acceptable sensitivity and specificity, compared with conventional Orbscan and topography criteria. Thus, BAD criteria can be more effective in the early diagnosis of KCN.

scholarly journals The effect of coronary angiography and femoral access on femoral artery distensibility and elasticity

2021 ◽  
Vol 21 (84) ◽  
pp. e48-e52
Author(s):  
Aylin Güneşli ◽  
◽  
Aynur Acıbuca ◽  
Keyword(s):  
Coronary Angiography ◽  
Femoral Artery ◽  
Long Term Effects ◽  
Cross Sectional ◽  
Femoral Access ◽  
Group 4 ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim of the study: The aim of this study was to evaluate the long-term effects of access to the femoral artery for the purposes of coronary angiography through the measurement of femoral artery distensibility and elasticity on the accessed and non-accessed sides. Material and methods: This cross-sectional study included patients who underwent femoral angiography at least 1 year previously. Those whose femoral artery was accessed once formed Group 1 (n = 59), those who were accessed twice formed Group 2 (n = 57), those accessed 3 times formed Group 3 (n = 55), and those with more than 3 accesses, Group 4 (n = 60). The groups were compared in respect of femoral artery elasticity and distensibility in the accessed and non-accessed sides. Results: No statistically significant difference was determined in respect of femoral distensibility and elasticity in Group 1 (9.40 ± 0.84 vs 9.48 ± 0.75, p = 0.107 and 0.23 ± 0.03 vs 0.23 ± 0.03, p = 0.433, respectively). However, a significant difference was observed between the two sides in terms of distensibility and elasticity in Group 2 (9.02 ± 0.81 vs 9.23 ± 0.75, and 0.21 ± 0.02 vs 0.22 ± 0.02), in Group 3 (8.49 ± 0.77 vs 9.18 ± 0.9 and 0.19 ± 0.02 vs 0.21 ± 0.02), and in Group 4 (8.14 ± 0.74 vs 9.03 ± 0.81 and 0.16 ± 0.01 vs 0.2 ± 0.02, p <0.001, for all comparisons). Conclusion: While a single access in the femoral artery for coronary angiography does not affect femoral artery elasticity and distensibility, multiple accesses may have adverse effects.

scholarly journals DIFFERENCES AMONG THE PERCEPTIONS OF ORTHODONTISTS, PROSTHODONTISTS AND CONSERVATIVE DENTISTRY SPECIALISTS REGARDING BUCCAL CORRIDOR WIDTHS

2021 ◽  
Vol 12 (1) ◽  
pp. 44-50
Author(s):  
Muhammad Azeem ◽  
Ali Raza ◽  
Rashid Mahmood ◽  
Erum Behroz
Keyword(s):  
Cross Sectional Study ◽  
Cross Sectional ◽  
Present Cross Sectional Study ◽  
Conservative Dentistry ◽  
Group 3 ◽  
The Subject ◽  
Group 2 ◽  
Post Hoc ◽  
Buccal Corridor ◽  
Group 1

ABSTRACT BACKGROUND & OBJECTIVE: To find out the optimal ranges of smile attractiveness on basis of different amounts of buccal corridor widths, as judged by Pakistani orthodontists, prosthodontists and conservative dentistry specialists (CDS). METHODOLOGY: Present cross-sectional study was conducted from June 2016 to June 2017. The anterior smiling image of a female model was edited to be converted to 10 images displaying different amounts of buccal corridor width. After informed consent from the subject, different buccal corridors widths images were created at following widths: 0%, 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, and 18%. This was followed by measurement of smile attractiveness of these 10 images on a visual analogue scale by 30 evaluators in three groups. Group 1 consisted of 10 CDS, group 2 consisted of 10 prosthodontists and group 3 consisted of 10 orthodontists. The data was collected and scores of smile attractiveness were presented in form of mean and standard deviation for each group. The differences in the three groups regarding perception of smile attractiveness were found out using ANOVA test and Turkey’s post-hoc test was used for multiple comparisons. RESULTS: For group 1, the highest scoring was obtained by image showing 10% buccal corridor width. In group 2, the highest score was by image showing 14% buccal corridor width, whereas in group 3, the highest scoring was showing 12% buccal corridor width. The differences found were statistically insignificant. CONCLUSION: Dental specialty does not affect perception of smile attractiveness. Buccal corridor width greater than 14% should be avoided.

scholarly journals Is striae gravidarum related to cesarean scar and peritoneal adhesions?

2020 ◽  
Vol 27 (08) ◽  
pp. 1550-1554
Author(s):  
Sarwat Faridi ◽  
Humaira Imran ◽  
Bushra Mukhtar
Keyword(s):  
P Value ◽  
Cross Sectional ◽  
Peritoneal Adhesions ◽  
Cesarean Scar ◽  
Intraperitoneal Adhesions ◽  
Gynecology And Obstetrics ◽  
Group 3 ◽  
Group 2 ◽  
Striae Gravidarum ◽  
Group 1

Objectives: Determination of the relationship among the peritoneal adhesions, cesarean scar and striae gravidarum. Study Design: Cross sectional Study. Settings: Gynecology and Obstetrics Department of Bahawal Victoria Hospital, Bahawalpur. Period: June 2018 to May 2018. Material & Methods: A total of 150 cases of cesarean section which presented at gynecology and obstetrics department of Bahawal Victoria Hospital, Bahawalpur were involved in this study. Davey scoring system was applied in order to determine the severity of striae gravidarum. Intraperitoneal adhesions were classified into five subcategories on the basis of Modified Blauer classification. Grouping was done on the random basis. Three groups were made. Group 1 consisted of the women with no striae gravidarum, group 2 had women with number of striae gravidarum from mild to moderate and group 3 had women of severe number of striae gravidarum. Comparison between different groups was done using the Mann-Whitney and student T test. Mean and standard deviation were calculated for quantitative variables while qualitative variables were assessed by their frequency and percentage. Statistically significant P value was 0.05 or less. Results: Intraperitoneal adhesions of grade 2-4, pigmentations and keliods were frequent in group 2 and 3 but the difference between these groups was not statistically significant (p-value 0.517, 0.427 and 0.372, respectively). There was no difference present among the group regarding the appearance of scar as well (p=0.541). As far as the length and width of the scar was concerned, the length was relatively more in patients of group 3 while width was relatively more in patients of group 1 but there were no statistically significant differences (Table-II) (p=0.289 and p=0.248 respectively). Conclusion: It can be concluded that there is no association between intraperitoneal adhesions and striae gravidarum but correlation between scar characteristics and striae gravidarum are evident.

scholarly journals Seroprevalence of Rubella IgG in Pregnant Females

2019 ◽  
Vol 7 (4) ◽  
pp. 295-298
Author(s):  
Huda Rana ◽  
Rijja Chaudhary ◽  
Saeed Alam ◽  
Wajiha Mahjabeen
Keyword(s):  
Cross Sectional Study ◽  
Natural Immunity ◽  
Cross Sectional ◽  
Positive Group ◽  
Group 4 ◽  
Child Bearing ◽  
High Prevalence ◽  
Group 3 ◽  
Group 2 ◽  
Age Range

Objective: To find out the seropositivity of IgG rubella in pregnant women in Pakistan, to assess the prevalence of infection and to estimate the requirement of vaccination.Patients and Methods: In this retrospective cross sectional study total 730 females who visited Salma Kafeel Fertility Clinic (Rawalpindi) for antenatal checkup were inducted. Their age range was 18-45 years. The study was carried out from 2011-2016. ELISA serological testing was used to check the seroprevalence of Rubella IgG.Results: In total the 730 subjects were included in the study and divided in four groups according to their ages. The results were as follows: group 1(18-20yrs) 100% positive, group 2 (21-30yrs) 90.5% positive, group 3 (31-40yrs) 93.5% positive and lastly group 4 (>40yrs) 95%positive. Overall 92.32 % seropositivity was seen while 7.70% were found at risk of developing infection.Conclusion: There is a high prevalence of Rubella in females of child bearing age in Pakistan. This is alarming as it can result in high risk of CRS in newborns and fetal death. Therefore, women planning to become pregnant, who do not have natural immunity to rubella should be vaccinated at least 4 weeks prior to conception.

Ultrastructural Evaluation of the Effects of Vitamin D and Parathyroid Hormone On Bone of Thyroparathyroidectomized Rats

1973 ◽  
Vol 31 ◽  
pp. 350-351
Author(s):  
S. E. Weisbrode ◽  
C. C. Capen
Keyword(s):  
Vitamin D ◽  
Placebo Group ◽  
Parathyroid Hormone ◽  
Experimental Period ◽  
Group 4 ◽  
Low Calcium Diet ◽  
Group 3 ◽  
Group 2 ◽  
Hydroxyproline Excretion ◽  
Group 1

To evaluate the effects of vitamin D (VD) and parathyroid hormone (PTH) individually and in combination on bone, adult male thyroparathyroidectomized (TXPTX) ruts fed a low calcium diet (0.05% CA) were administered 7,500 I.U. VD/day (group 1), 50 USP units PTH/day (group 2), 7,500 I.U. VD and 50 USP units PTH/day (group 3), or placebo (group 4). All animals were supplemented daily with 10 g sodium levothyroxine for the 7 day experimental period. Undemineral ized tibial bone was evaluated electron microscopically and these findings were correlated with changes in terminal serum calcium (CA), serum phosphorus (P) and urinary total hydroxyproline excretion, expressed as a ratio to creatinine (HOP/CR).

scholarly journals Pachydrusen in Fellow Eyes Predict Response to Aflibercept Monotherapy in Patients with Polypoidal Choroidal Vasculopathy

2020 ◽  
Vol 9 (8) ◽  
pp. 2459 ◽  
Author(s):  
Yoshiko Fukuda ◽  
Yoichi Sakurada ◽  
Atsushi Sugiyama ◽  
Seigo Yoneyama ◽  
Mio Matsubara ◽  
...  
Keyword(s):  
Polypoidal Choroidal Vasculopathy ◽  
Lower Percentage ◽  
P Value ◽  
First Year ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Choroidal Vasculopathy ◽  
Fellow Eyes ◽  
Group 1

We investigated whether responses to as-needed intravitreal aflibercept injections (IAIs) for polypoidal choroidal vasculopathy (PCV) differed among patients based upon drusen characteristics in fellow eyes. 110 eyes from 110 patients with PCV received 3 monthly IAI and thereafter Pro re nata (PRN) IAI over 12 months. Patients were classified into 4 groups depending on fellow eye findings. Group 1 (n = 16): pachydrusen; Group 2 (n = 45): no drusen; Group 3 (n = 35): soft drusen; Group4 (n = 14) PCV/scarring. Best-corrected visual acuity improved at 12 months in all groups, but not significantly in Group 1 and Group 4; however, visual improvement was similar among the groups after adjusting baseline confounders. Group 1 had a significantly lower percentage of eyes needing retreatment (all p < 0.001; Group 1: 16.7%; Group 2: 50.8%; Group 3: 80%; Group 4: 85.7%). The mean number of retreatments was least in Group 1 among the groups (all p-value < 0.003; Group 1: 0.50 ± 1.32; Group 2: 1.73 ± 2.08; Group 3:2.71 ± 1.99; Group 3: 2.71 ± 2.16). Patients with pachydrusen in fellow eyes were less likely to require additional IAI following the loading dose and may be ideal candidates for aflibercept monotherapy in their first year.

scholarly journals Predictive Factors of Secondary Normocalcemic Hyperparathyroidism after Roux-en-Y Gastric Bypass

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Claudio Casella ◽  
Sarah Molfino ◽  
Francesco Mittempergher ◽  
Carlo Cappelli ◽  
Nazario Portolani
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Gastric Bypass ◽  
Vertical Banded Gastroplasty ◽  
Elapsed Time ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Normocalcemic Hyperparathyroidism ◽  
Group 1

Objective. Aim of this study is to evaluate determinants of secondary normocalcemic hyperparathyroidism (SNHPT) persistence in patients who have undergone Roux-en-Y gastric bypass on vertical-banded gastroplasty.Methods. 226 consecutive patients submitted to bariatric surgery were prospectively enrolled and divided in two groups on the basis of preoperative presence of SNHPT. For each patient, we evaluated anthropometric and laboratory parameters. Calcium metabolism (calcemia, PTH, and 25-hydroxy vitamin D serum levels) was studied before surgery and at 6-month intervals (6, 12, and 18 months) as surgical follow-up.Results. Based on presurgical SNHPT presence or absence, we definedgroup 1—201 patients andgroup 2—25 patients, respectively. Among thegroup 1, 153 (76%) recovered from this endocrinopathy within 6 months after surgery (group 3), while the remaining 48 patients (24%) had persistent SNHPT (group 4). Comparing the anthropometric and laboratory data ofgroup 3withgroup 2, the only statistically significant factor was the elapsed time since a prior effective medically controlled diet that led to a steady and substantial weight loss. We found also a statistically significant difference (p<0.05) betweengroup 3andgroup 4in term of % of weight loss and PTH levels.Conclusions. Patients suitable for bariatric surgery must have history of at least one efficient medically controlled diet, not dating back more than 5 years before surgery. This elapsed time represent the cut-off time within which it is possible to recover from SNHPT in the first semester after Roux-en-Y gastric bypass on vertical-banded gastroplasty. The treatment of vitamin D insufficiency and the evaluation of SNHPT before bariatric surgery should be recommended. The clinical significance of preoperative SNHPT and in particular SNHPT after bariatric surgery remains undefined and further studies are required.

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