Design, Synthesis and Acetylcholinesterase and Butylcholinesterase Inhibi-tion Activity of Novel 1-(Alkyl)-3-(2-oxo-2H-chromenyloxy acetamido) methylpyridinium Salts

2020 ◽  
Vol 17 ◽  
Author(s):  
Mehri Abdollahi fard ◽  
Mohammadreza Manafi ◽  
Manijeh Motevalian ◽  
Seyed Saied Homami
Keyword(s):  
Kinetic Study ◽  
1H Nmr ◽  
Mechanism Of Action ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Docking Studies ◽  
Inhibition Activity ◽  
Design Synthesis ◽  
Ft Ir ◽  
Insight Into

Abstract: In this paper, a novel series of 1-(alkyl)-3-(2-oxo-2H-chromenyloxy acetamido) methylpyridinium salts were syn-thesized in a simple and efficient way. The method showed to be facile and the compounds were obtained in high isolated yields. All the synthesized compounds were characterized by 1H NMR, 13C NMR, FT-IR, Mass and elemental analysis. AChE and BuChE inhibition activity of the synthesized compounds were evaluated and the results showed that, all the com-pounds were active in the inhibition of the mentioned enzymes. All the compounds were active in the inhibition of the two studied enzymes. Among all the compounds, the compound 6a (1.85 μM) and 6i (0.106 μM) showed the highest inhibition activity against AChE and BuChE, respectively. The kinetic study was performed to get more insight into the mechanism of action of the synthesized compounds. Docking studies were also performed to obtain the interactions between the synthe-sized compounds and the enzymes.

scholarly journals Synthesis, characterization and theoretical studies of novel pyrimidine derivatives as potential corrosion inhibitors

2020 ◽  
Vol 85 (4) ◽  
pp. 481-492
Author(s):  
Esvet Akbas ◽  
Ela Yildiz ◽  
Ahmet Erdogan
Keyword(s):  
Benzoic Acid ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Corrosion Inhibitors ◽  
Dft Method ◽  
Theoretical Studies ◽  
Inhibition Activity ◽  
Pyrimidine Derivatives ◽  
Characterization Methods ◽  
Ft Ir

In this study, five new pyrimidine derivatives were synthesized and characterized by characterization methods such as 1H-NMR, 13C-NMR, FT- -IR and elemental analysis. The corrosion inhibition activity of the synthesized compounds was examined by theoretical calculation using DFT method at the level of B3LYP/6-31G (d,p). According to the calculations, 4-(6-benzoyl-2- -benzylidene-3-oxo-7-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-yl)- benzoic acid (6) appears to be a good inhibitor for corrosion.

scholarly journals Synthesis, Spectral Analysis and Biological Potency of Hydrazoneoxime Ligands Incorporating Pyrazolone Moiety and Their Metal Complexes

2020 ◽  
Vol 36 (6) ◽  
pp. 1194-1204
Author(s):  
Nursabah Sarıkavaklı ◽  
Emrah Koç ◽  
Meshari M.H. Aljohani ◽  
Syed Khalid Mustafa
Keyword(s):  
Magnetic Susceptibility ◽  
Spectral Analysis ◽  
Metal Complexes ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Biological Activities ◽  
Biological Potency ◽  
Ft Ir ◽  
Group 1

A modest attempt has been made for the synthesis of hydrazoneoxime ligands bearing pyrazolone group (1-4) and their successive metal complexes such as: 1(a-c), 2(a-c), 3(a-c) and 4(a-c). The precursor (1Z,2E)-2-(hydroxyimino) ethanehydroximohydrazide (GH2) was obtained through coupling of (1Z,2E)-N-hydroxy-2-(hydroxyimino) ethanimidoyl chloride and hydrazinium hydroxideto generate hydrazonoxime compounds bearing the pyrazolone group. The ligands (1-4) were reacted with MX2.nH2O, where M = Co(II), Ni(II) and Cu(II) to obtain the successive metal coordinated compounds into good yields. The ligands and their metal complexes were investigated by using 1H NMR, 13C NMR, FT-IR, elemental analysis and magnetic susceptibility measurements.Tautomerism in the ligands is investigated spectroscopically and biological activities are evaluated as well. Finally, the findings of present study were found within good egreement with other workers.

Synthesis and Biological Evaluation of Various New Substituted 1,3,4-oxadiazole-2-thiols

2008 ◽  
Vol 59 (4) ◽  
Author(s):  
Gabriela Laura Almajan ◽  
Stefania Felicia Barbuceanu ◽  
Ioana Saramet ◽  
Mihaela Dinu ◽  
Cristian Vasile Doicin ◽  
...  
Keyword(s):  
Biological Activity ◽  
Plant Growth ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Biological Evaluation ◽  
Ethyl Chloroacetate ◽  
Low Concentrations ◽  
Synthesis And Biological Evaluation

5-[4-(4X-phenylsulfonyl)phenyl]-1,3,4-oxadiazole-2-thiols, X=H, Cl, Br, reacted with ethyl chloroacetate to give S-alkylated compounds. Aminomethylation of the thione form of oxadiazoles yielded N(3)-derivatives. All the products have been characterized by elemental analysis, IR, 1H-NMR and 13C-NMR. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak stimulatory activities at low concentrations.

Synthesis and Spectral Characterization of New S-Alkylated 1,2,4-Triazoles as Potential Biological Agents

2017 ◽  
Vol 68 (10) ◽  
pp. 2436-2439
Author(s):  
Stefania Felicia Barbuceanu ◽  
Laura Ileana Socea ◽  
Constantin Draghici ◽  
Elena Mihaela Pahontu ◽  
Theodora Venera Apostol ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Ethyl Bromide ◽  
Spectral Characterization ◽  
Basic Medium ◽  
Phenacyl Bromide

In the work we presented the behavior of 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(n-propyl)-2H-1,2,4-triazole-3(4H)-thiones (X= Cl or Br) with some alkylation agents. Thus, new S-alkylated 1,2,4-triazole derivatives were synthesized by reaction of the corresponding 1,2,4-triazole-3-thione derivatives with different �-halogenated compounds (ethyl bromide, ethyl chloroacetate or phenacyl bromide), in basic medium. The structures of synthesized compounds were elucidated by spectral data (1H-NMR, 13C-NMR, mass spectrometry) and elemental analysis.

Design, Synthesis and Docking Studies of Some Novel Fluoroquinolone Compounds with Antibacterial Activity

2018 ◽  
Vol 69 (4) ◽  
pp. 815-822 ◽  
Author(s):  
Lucia Pintilie ◽  
Amalia Stefaniu ◽  
Alina Ioana Nicu ◽  
Maria Maganu ◽  
Miron Teodor Caproiu
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Molecular Docking ◽  
Drug Discovery ◽  
Elemental Analysis ◽  
Docking Studies ◽  
Receptor Protein ◽  
Chemical Methods ◽  
Design Synthesis ◽  
Gram Negative

A new series of fluoroquinolone compounds have been obtained by Gould-Jacobs method. The compounds have been characterized by physic-chemical methods (elemental analysis, FTIR, NMR, UV-Vis) and by antimicrobial activity against Gram-positive and Gram-negative microorganisms. For the synthesized compounds have been performed calculations of characteristics and molecular properties, using Spartan�14 Software from Wavefunction, Inc. Irvine, CA. and molecular docking studies using CLC Drug Discovery Workbench 2.4 software, to identify and visualize the most likely interaction ligand (fluoroquinolone) with the receptor protein.

Synthesis and Anticonvulsant Activity of 3-(alkylamino, alkoxy)-1,3,4,5- Tetrahydro-2H-benzo [b] azepine-2-one Derivatives

2018 ◽  
Vol 17 (6) ◽  
pp. 448-457 ◽  
Author(s):  
Xia Huang ◽  
Tie Chen ◽  
Rong-Bi Han ◽  
Feng-Yu Piao
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Anticonvulsant Activity ◽  
Mass Spectra ◽  
Maximal Electroshock ◽  
Test Compound ◽  
Maximal Electroshock Test ◽  
Mes Test ◽  
Structure Activity

Background & Objective: A series of novel 3-Substituted-1,3,4,5-Tetrahydro-2H-benzo [b] azepine-2-one Derivatives (4, 5, 7, 10, 12, 5a-j, 8a-e) were synthesized from 1,2,3,4-Tetrahydro-1- naphthalenone. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR, MASS spectra and elemental analysis. Their anticonvulsant activity was evaluated by the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scPTZ) test, and their neurotoxicity was evaluated by the rotarod neurotoxicity test. Compound 4 showed the maximum anticonvulsant activity against the maximal electroshock test (ED50=26.4, PI =3.2) and against the subcutaneous pentylenetetrazol test (ED50=40.2, PI =2.1). Conclusion: Possible structure-activity relationship was discussed.

scholarly journals N-Benzo[c][1,2,5]thiazol-4-yl-3-trifluoromethylbenzamide

Molbank ◽  
10.3390/m1075 ◽  
2019 ◽  
Vol 2019 (3) ◽  
pp. M1075 ◽  
Author(s):  
Hamad H. Al Mamari ◽  
Nasser Al Awaimri ◽  
Yousuf Al Lawati
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Title Compound ◽  
Structural Motif ◽  
Spectroscopic Methods ◽  
Bond Functionalization ◽  
Directing Group ◽  
Metal Catalyzed

The title compound, N-benzo[c][1,2,5]thiazol-4-yl-3-trifluoromethylbenzamide (1) was synthesized by reacting 3-trifluoromethylbenzoyl chloride (4) and 4-aminobenzo[c][1,2,5]thiadiazole (5). The compound was characterized by various spectroscopic methods (1H NMR, 13C NMR, IR, GC-MS) and its composition confirmed by elemental analysis. The importance of this compound lies in its possession of an N,N-bidentate directing group. Such a structural motif is potentially suitable for metal-catalyzed C-H bond functionalization reactions.

Bimetallic Group 6 Tricarbonyls Triply-Bridged by Bis(phenylthio)alkane Bidentate Ligands

2010 ◽  
Vol 93-94 ◽  
pp. 13-16
Author(s):  
Khalil J. Asali
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Thermodynamic Stability ◽  
Chlorinated Hydrocarbons ◽  
Metal Center ◽  
Molar Ratio ◽  
Bidentate Ligands ◽  
Group 6 ◽  
Ft Ir

Reactions of the labile complex (Me3tach)M(CO)3 (Me3tach = 1,3,5-trimethyl-1,3,5-triazacyclohexane; M = W, Mo) with bis(phenylthio)alkanes ( = PhS(CH2)nSPh), (2:3 molar ratio) in CH2Cl2 as solvent (at 35 oC M = W, 0 oC M = Mo) afforded in good yields bimetallic tricarbonyl complexes triply- bridged by bis(phenylthio)alkanes of the type [M(CO)3]2(μ-PhS-(CH2)n-SPh)3 [n = 3 (a), 4 (b), 5 (c), 6 (d); M = W (1), Mo (2)]. These new triply-bridged complexes were characterized by 1H NMR, FT-IR and elemental analysis. Additionally, it has been observed that the thermodynamic stability of some of these new complexes in chlorinated hydrocarbons depends mainly on the nature of the metal center and varies in the order W >> Mo.

تحضير وتشخيص بعض مركبات 5،2-ثنائي المعوض-4،3،1- اوكسادايازول الجديدة المشتقة من حامض الدايكلوفيناك وتقييم فعاليتها البايولوجية

2021 ◽  
Vol 2 (3) ◽  
pp. 31-48
Author(s):  
محمد حسن احمد ◽  
فاضل داود خالد
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
1H Nmr ◽  
13C Nmr ◽  
Ft Ir

تم في هذا البحث تحضير وتشخيص بعض مركبات 5،2-ثنائي المعوض-4،3،1-اوكسادايازول المشتقة من حامض الدايكلوفيناك (H1). حيث تضمن العمل تحضير الاستر المثيلي لحامض الدايكلوفيناك (H2) من مفاعلته مع الميثانول بطريقة فشر ثم تحويل الاستر المذكور الى هيدرازايد الحامض المقابل (H3) ثم مفاعلة هذا الهيدرازايد مع بعض الحوامض الكاربوكسيلية بوجود اوكسي كلوريد الفسفور للحصول على مشتقات 5,2-ثنائي المعوض-43،1- اوكسادايازول (H4-H7). ثم مفاعلة المركب (H7) مع بعض الامينات الأولية للحصول على مركبات 5,2-ثنائي المعوض-4،3،1-اوكسادايازول امين (H8-H12). وقد شخصت هذه المركبات باستخدام تقنيات FT-IR و 1H-NMR و 13C-NMR علاوة على قياس درجات الانصهار لها. أظهرت نتائج التقييم الاولية لفعاليتها البيولوجية ضد نوعين من البكتريا، الاولى (Pseudomonas aeruginosa)، والثانية (Staphylococcus aureus) بأن للمركبات المحضرة ( H4 ، H6، H11، H12) فعالية تثبيطية متوسطة غالباً ضد هذين النوعين، بينما لوحظ بأن للمركبات (H7 ، H8، H9، H10) فعالية تثبيطية جيدة ضدهما على الاغلب، وكلاهما مقارنة بالمثبط القياسي المستعمل. وقد أظهرت نتائج التقييم الاولية للفعالية البيولوجية ضد نوعين من البكتريا، الاولى (Pseudomonas aeruginosa)، والثانية (Staphylococcus aureus) بأن للمركبات المحضرة ( H4 ، H6، H11، H12) فعالية تثبيطية متوسطة غالباً ضد هذين النوعين، بينما لوحظ بأن للمركبات (H7 ، H8، H9، H10) فعالية تثبيطية جيدة ضدهما على الاغلب، وكلاهما مقارنة بالمثبط القياسي المستعمل.

scholarly journals 6-[1-Acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-yl]-2(3H)-benzoxazolone

Molbank ◽  
10.3390/m1021 ◽  
2018 ◽  
Vol 2018 (4) ◽  
pp. M1021
Author(s):  
Yordanka Ivanova ◽  
Antonya Todorova ◽  
Christo Chanev ◽  
Ognyan Petrov
Keyword(s):  
Acetic Acid ◽  
Hydrazine Hydrate ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Title Compound ◽  
Target Compound

The title compound, 6-[1-acetyl-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]-2(3H)-benzoxazolone, was synthesized by condensation of 6-[3-(4-methoxyphenyl)-2-propenoyl]-2(3H)-benzoxazolone (1) and hydrazine hydrate in acetic acid in 84% yield. The structure of the target compound was confirmed using 1H-NMR, 13C-NMR, IR, MS, and elemental analysis.

Sign in / Sign up

Export Citation Format

Share Document