Nucleosides and Nucleoside Analogues as Emerging Antiviral Drugs

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohamed Ibrahim Elzagheid
Keyword(s):  
Significant Role ◽  
Mode Of Action ◽  
Crucial Role ◽  
Viral Infections ◽  
Antiviral Drugs ◽  
Review Article ◽  
Nucleoside Analogues ◽  
The Past ◽  
Nucleoside Drugs

: Nucleosides and their analogues have been in use for many years and have become essential for treating patients with viral infections. Many additional nucleoside drugs have been approved over the past decades. This strongly demonstrates how important these compounds are and the crucial role they play. Given that a significant amount of research and literature has been documented regarding nucleoside analogues, this review article mainly focuses the discussion on nucleosides and nucleoside analogous that have proven to play significant role or be emerging in the treatment of known viral infections. This covers the names, structures, applications, toxicity, and mode of action of relevant nucleoside analogues.

scholarly journals Oude waarheden - Over de terugkeer van de klassieke oudheid in de verlichtingshistoriografie

2014 ◽  
Vol 127 (2) ◽  
pp. 229-246
Author(s):  
Wyger R.E. Velema
Keyword(s):  
Eighteenth Century ◽  
Political Thought ◽  
Crucial Role ◽  
Review Article ◽  
Ancient World ◽  
The Past ◽  
The Enlightenment ◽  
Recent Scholarship ◽  
The Many

Since the publication of Peter Gay’s The Enlightenment: An Interpretation, scholarly interest in the classical presence in Enlightenment culture has waned. Over the past decade, however, this topic has returned to center stage. This review article discusses the ways in which recent research has contributed to the rediscovery of the classical past in the Enlightenment. It starts with an evaluation of the current reinterpretation of the Querelle des anciens et des modernes, continues with an overview of recent scholarship on the various intellectual and institutional environments in which knowledge of the classical past was acquired and transmitted, and ends with a discussion of the crucial role of the ancient world in eighteenth-century historiography and political thought. In its conclusion the article draws attention to the many ways in which recent scholarship on the eighteenth-century reception of the classics has broken new ground. It also argues that the ‘classical turn in Enlightenment studies’ is still unjustifiably neglected in general interpretations of the Enlightenment.

scholarly journals Repurposing antiviral drugs on recently emerged viral infections: A review article

2021 ◽  
Author(s):  
K. Swathi ◽  
B .Nikitha ◽  
B. Chandrakala ◽  
K. Lakshmanadevi ◽  
M. Malleswari
Keyword(s):  
Viral Infections ◽  
Antiviral Drugs ◽  
Review Article

scholarly journals A perspective review of deadly viral diseases: An era of viruses

2021 ◽  
Vol 10 (8) ◽  
pp. 1038
Author(s):  
Abhishek Sharma ◽  
Sarita J. Bhyan ◽  
Abdul Malik
Keyword(s):  
Mortality Rate ◽  
West Africa ◽  
Health Risk ◽  
Viral Infections ◽  
Antiviral Drugs ◽  
Review Article ◽  
Viral Diseases ◽  
The Novel ◽  
Novel Coronavirus ◽  
Scarcity Of Resources

This review article overviewed briefly about the era of deadly viruses. Humans have been combating viruses since before our species had even evolved into its recent form. In some cases of viral infections, vaccines and antiviral drugs have allowed us to treat infections from spreading broadly, and have facilitated to patient recover. But it is far from over to fight the viruses. In recent decades, a number of viruses have sprung from animals to humans and have caused massive outbreaks, claiming thousands of lives such as the virus that led to the 2014-2016 Ebola outbreak in West Africa kills up to 90% of the population, making it the deadliest member of the Ebola family. But there are some viruses that are equally deadly, and some are even more deadly. Some viruses, including the novel coronavirus currently undergoing global outbreaks, have a low mortality rate but still pose a serious health risk as we have no means of access to the health facilities and scarcity of resources and infrastructure. Here we are reporting such type of ten deadly viruses. those have infected humans within last 50 years.

scholarly journals Approved Antiviral Drugs over the Past 50 Years

2016 ◽  
Vol 29 (3) ◽  
pp. 695-747 ◽  
Author(s):  
Erik De Clercq ◽  
Guangdi Li
Keyword(s):  
Protease Inhibitors ◽  
Antiviral Drugs ◽  
Nucleoside Analogues ◽  
Virus Infections ◽  
Reverse Transcriptase Inhibitors ◽  
Entry Inhibitors ◽  
The Past ◽  
Polymerase Inhibitors ◽  
Acyclic Nucleoside ◽  
Acyclic Nucleoside Phosphonate

SUMMARYSince the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs categorized into 13 functional groups have been formally approved for the treatment of the following 9 human infectious diseases: (i) HIV infections (protease inhibitors, integrase inhibitors, entry inhibitors, nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and acyclic nucleoside phosphonate analogues), (ii) hepatitis B virus (HBV) infections (lamivudine, interferons, nucleoside analogues, and acyclic nucleoside phosphonate analogues), (iii) hepatitis C virus (HCV) infections (ribavirin, interferons, NS3/4A protease inhibitors, NS5A inhibitors, and NS5B polymerase inhibitors), (iv) herpesvirus infections (5-substituted 2′-deoxyuridine analogues, entry inhibitors, nucleoside analogues, pyrophosphate analogues, and acyclic guanosine analogues), (v) influenza virus infections (ribavirin, matrix 2 protein inhibitors, RNA polymerase inhibitors, and neuraminidase inhibitors), (vi) human cytomegalovirus infections (acyclic guanosine analogues, acyclic nucleoside phosphonate analogues, pyrophosphate analogues, and oligonucleotides), (vii) varicella-zoster virus infections (acyclic guanosine analogues, nucleoside analogues, 5-substituted 2′-deoxyuridine analogues, and antibodies), (viii) respiratory syncytial virus infections (ribavirin and antibodies), and (ix) external anogenital warts caused by human papillomavirus infections (imiquimod, sinecatechins, and podofilox). Here, we present for the first time a comprehensive overview of antiviral drugs approved over the past 50 years, shedding light on the development of effective antiviral treatments against current and emerging infectious diseases worldwide.

The Diagnosis of Viral Disease by Electron Microscopy

1982 ◽  
Vol 40 ◽  
pp. 270-273
Author(s):  
William B. McCombs ◽  
Cameron E. McCoy
Keyword(s):  
Electron Microscopy ◽  
Hospital Stay ◽  
Viral Infections ◽  
Medical Profession ◽  
Bacterial Pathogens ◽  
Viral Disease ◽  
Viral Pathogens ◽  
Academic Interest ◽  
The Past

Recent years have brought a reversal in the attitude of the medical profession toward the diagnosis of viral infections. Identification of bacterial pathogens was formerly thought to be faster than identification of viral pathogens. Viral identification was dismissed as being of academic interest or for confirming the presence of an epidemic, because the patient would recover or die before this could be accomplished. In the past 10 years, the goal of virologists has been to present the clinician with a viral identification in a matter of hours. This fast diagnosis has the potential for shortening the patient's hospital stay and preventing the administering of toxic and/or expensive antibiotics of no benefit to the patient.

Literacy and Education: Fifth Release From the 1961 Census of Pakistan (Review Article)

1963 ◽  
Vol 3 (3) ◽  
pp. 424-442
Author(s):  
Jamila Akhtar
Keyword(s):  
Population Growth ◽  
Urban Areas ◽  
Review Article ◽  
Interim Report ◽  
Educational Levels ◽  
Rural And Urban Areas ◽  
The Past ◽  
Review Articles ◽  
Rural And Urban ◽  
Age And Sex

This review of the Literacy and Education Bklletin1 of the 1961 Census is fourth in the series of review articles published in this journal2. The Bulletin under review forms a part of the interim report on the characteristics of the population of Pakistan. It gives information on the number of illiterate and literate persons by age and sex for rural and urban areas on division and district basis; illiterate and literate.population in selected cities and towns; and the educational levels attained by the literate population by age and sex for divisions and districts. Relevant statistical notes and statements precede the tables in the Bulletin. The objective of this review is to describe the meaningfulness and significance of literacy statistics. To this end, a distinction is made between formal and functional levels of literacy. Comparisons of the 1951 and 1961 census figures are undertaken to indicate the progress of literacy and education during the past decade with reference to the effect of intercensal rate of population growth on such progress. Certain questions regarding the reliability of data are raised, which emphasize the need for caution in the interpretation of literacy statistics.

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