Effect of Statin Supplementation on Pulmonary Function and Inflammatory Markers in Patients of Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 15 (1) ◽  
pp. 45-50
Author(s):  
Mradul K. Daga ◽  
Ankit Chhoda ◽  
Shashank Singh ◽  
Govind Mawari ◽  
Naresh Kumar ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Exercise Capacity ◽  
Negative Correlation ◽  
Inflammatory Markers ◽  
Intervention Group ◽  
Significant Negative Correlation ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Wide Range ◽  
Systemic Inflammatory Disease

Background: COPD being a systemic inflammatory disease is accompanied by alteration of various inflammatory cytokines which affect the metabolic equilibrium of body. Some therapeutic options, mainly statins via their wide range of pharmacologic actions alter the level of proinflammatory cytokines hence, helpful in attenuating various extra-pulmonary consequences of COPD. We did a randomised case-control study to study the effect of statin supplementation on pulmonary function and inflammatory markers in patients of COPD. Methods: We included 40 stable COPD subjects & randomized them in two groups, Intervention & Non-intervention. Intervention group received 40 mg atorvastatin once daily for 3 months in addition to the conventional treatment of COPD similar to the prior one. We studied levels of IL-6 & CRP and correlated them with disease severity before and after the aforementioned intervention. Results: We observed that CRP levels decreased in both the groups after a follow up of 3 months, but neither of them was statistically significant (p=0.57 & 0.63 respectively) nor the mean of their difference (p=0.969). IL-6 levels showed a persistent decline in intervention group but, was not significant (p=0.91). In this study, we noticed statistically significant improvement in FEV1 (p=0.008) in the intervention group which was in contrast to non-intervention group. Similarly, the exercise capacity also statistically increased in the intervention group (p=0.002). There was also evident negative correlation between exercise capacity and IL-6 as well CRP levels. FEV1 also showed statistically significant negative correlation with IL-6 levels (p=0.023). Conclusion: We can improve the disease outcome and alter its natural progression by altering the levels of inflammatory markers with the aid of some additional pharmacological interventions i.e., in this study was atorvastatin.

scholarly journals The risks and benefits of yoga for patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

2019 ◽  
Vol 33 (12) ◽  
pp. 1847-1862 ◽  
Author(s):  
Holger Cramer ◽  
Heidemarie Haller ◽  
Petra Klose ◽  
Lesley Ward ◽  
Vincent CH Chung ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pulmonary Function ◽  
Exercise Capacity ◽  
Meta Analysis ◽  
Chronic Obstructive ◽  
Controlled Trials ◽  
Obstructive Pulmonary Disease ◽  
Randomized Controlled ◽  
Mean Differences

Objectives: To determine the effectiveness and safety of yoga interventions on disease symptoms, quality of life and function in patients diagnosed with chronic obstructive pulmonary disease (COPD). Data sources: Medline/PubMed, Scopus, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched through 6 June 2019. Review methods: Randomized controlled trials assessing the effects of yoga on quality of life, dyspnea, exercise capacity, and pulmonary function (FEV1) in patients with COPD were included. Safety was defined as secondary outcome. Mean differences (MD) and standardized mean differences (SMD) with 95% confidence intervals (CIs) were computed. Risk of bias was assessed using the Cochrane tool. Results: Eleven randomized controlled trials with a total of 586 patients were included. Meta-analysis revealed evidence for effects of yoga compared to no treatment on quality of life on the COPD Assessment Test (MD = 3.81; 95% CI = 0.97 to 6.65; P = 0.009, I2 = 70%), exercise capacity assessed by the 6-minute walk test (MD = 25.53 m; 95% CI = 12.16 m to 38.90 m; P = 0.001, I2 = 0%), and pulmonary function assessed by FEV1 predicted (MD  = 3.95%; 95% CI = 2.74% to 5.17%; P < 0.001, I2 = 0%). Only the effects on exercise capacity and pulmonary function were robust against methodological bias. Effects were only present in breathing-focused yoga interventions but not in interventions including yoga postures. Adverse events were reported infrequently. Conclusion: This meta-analysis found robust effects of yoga on exercise capacity and pulmonary function in patients with COPD. Yoga, specifically yoga breathing techniques, can be an effective adjunct intervention for patients with COPD. Yoga’s safety needs to be assessed in more depth in future studies.

scholarly journals Clinical observation of the use of portable pulmonary function test trainer in patients with stable COPD

2019 ◽  
Vol 02 (04) ◽  
pp. 185-191
Author(s):  
Yuhua Wu ◽  
Jian Zhou ◽  
Mengyu Ma ◽  
Jing Xie ◽  
Ahong Wang ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Daily Living ◽  
Comparison Group ◽  
Psychological Symptoms ◽  
Social Activity ◽  
Intervention Group ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Clinical Effects ◽  
Obstructive Pulmonary Disease

Objective: To investigate the clinical effects of the use of portable pulmonary function tester in patients with stable Chronic Obstructive Pulmonary Disease (COPD). Methods: A total of 80 patients with stable COPD were enrolled in our hospital from March 2018 to March 2019. They were divided into two groups according to different treatment methods. The comparison group was used for routine pulmonary function training, and the intervention group was trained for Portable Pulmonary Function Training and Test Device (PPFTTD). Comparison was made of forced expiratory volume in one second/forced vital capacity (FEV1/FVC), measured/predicted value of the first second forced expiratory volume (FEV1 measured/predicted value), measured/predicted value of maximal voluntary ventilation per minute between the two groups. Quality of life (QOL) scores such as daily living ability, social activity, depressive psychological symptoms, and anxiety psychological symptoms were measured. Results: The FEV1/FVC value, measured/predicted value of FEV1 and MVV of intervention group were higher than those in the comparison group ([Formula: see text]). QOL scores, such as daily living ability, social activity, depression psychological symptoms, and anxiety psychological symptoms in the intervention group, were lower than those in the comparison group ([Formula: see text]). Conclusion: In the treatment of stable COPD, the use of portable pulmonary function tester is significant, and it should be widely promoted and applied in clinical practice.

scholarly journals Six-Minute Walk Test and its Correlation with Spirometry in Stable COPD Patients

2021 ◽  
Author(s):  
B. Sai Krishna ◽  
Amrut Kumar Mohapatra ◽  
Debasis Behera ◽  
Suman Kumar Jagaty ◽  
Saswat Subhankar ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Negative Correlation ◽  
Significant Negative Correlation ◽  
Chronic Obstructive ◽  
P Value ◽  
Walk Test ◽  
Predisposing Factor ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Minute Walk

Abstract Objectives An impaired exercise tolerance, the main feature in chronic obstructive pulmonary disease (COPD), occurs due to multiple factors. The 6-minute walk test (6MWT) is easy to perform, well-tolerated, and more reflective of activities of daily living. The facility of spirometry is unavailable in many areas of India, where 6MWT can be done easily. This study aims to compare the six-minute walk distance (6MWD) with various demographic, clinical, and spirometry parameters. Materials and Methods A total of 118 consecutive stable COPD patients fitting the criteria were included in the study. Spirometry was performed in these patients before and after giving a short-acting bronchodilator. 6MWT was performed according to the ATS guidelines. All patients underwent the 6MWT after 10 minutes of spirometry. Statistical analysis was done using GraphPad calculator and SPSS 24.0. Statistical Analysis All data were clubbed together in a single Excel chart. Statistical analysis was done using SPSS 24.0. Descriptive data are presented as mean ± standard deviation (SD). Qualitative data are presented as a percentage. Analysis of variance (ANOVA) was used to compare between means. The linear regression model was used to compare between variables. A p-value less than 0.05 was considered significant. Results The majority of the patients were > 60 years of age (mean age = 62.99 ± 6.68 years) and comprised males and females in the ratio 5.9:1. Smoking was determined to be the most important predisposing factor for the development of COPD. There was a significant negative correlation between 6MWD, age, and smoking index (p = 0.0075 and 0.0295 respectively). The 6MWD showed a significant positive correlation with FEV1 (in liters), FEV1 (%), FVC (in liters), and FVC (%). The 6MWD (meters) and % predicted 6MWD showed a significant negative correlation with a drop in SpO2 after the 6MWT (r = –0.36; p = 0.000769, r = –0.3; p = 0.004, respectively). Conclusion 6MWT can be used in cases of COPD where spirometry is unavailable as it correlates significantly with various parameters of the latter.

scholarly journals Relationship between Periodontal Variables and Disease Severity in Patients with Chronic Obstructive Pulmonary Disease (COPD)

2018 ◽  
Vol 10 (1) ◽  
pp. 1-7
Author(s):  
Amir Moeintaghavi ◽  
Shahrzad Mohammadzadeh Lari ◽  
Farid Shiezadeh ◽  
Zakieh Mohammadian ◽  
Shamim Tajik ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Periodontal Diseases ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Copd Assessment Test ◽  
The Relationship

Background. The present study investigated the relationship between certain periodontal variables and severity of disease in COPD patients. Methods. The present cross-sectional study included 50 patients suffering from COPD. Lung function examination, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC, SpO2, and Modified Medical Research Council (MMRC) Dyspnea Scale were performed. Periodontal clinical examination index included probing depth (PD), attachment loss (AL), gingival index (GI) and plaque index (PI). A quality of life validated index, the COPD assessment test (CAT index), was also calculated. Results. The FEV1 and FVC indices showed a significant negative correlation with PI and AL variables only. The COPD assessment test (CAT) index showed a significant but positive correlation with PI and AL variables only. The SpO2 index presented a significant negative correlation with GI and AL variables. The FEV1/FVC ratio was found to have a negative correlation with PD and AL variables. It is worth noting that MMRC exhibited no significant relationship with any of the periodontal variables. The only variable that was significantly different (P=0.022) among the three smoking groups was the FVC index. The FVC value was significantly higher in the group of subjects who smoked more than 10 cigarettes per day versus the non-smoking group (P=0.017). Conclusion. Based on the findings of this study, in view of the relationship between periodontal variables and respiratory indices in the course of COPD, early treatment of periodontal diseases, might considerably reduce the severity of COPD.

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