scholarly journals Clinical observation of the use of portable pulmonary function test trainer in patients with stable COPD

2019 ◽  
Vol 02 (04) ◽  
pp. 185-191
Author(s):  
Yuhua Wu ◽  
Jian Zhou ◽  
Mengyu Ma ◽  
Jing Xie ◽  
Ahong Wang ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Daily Living ◽  
Comparison Group ◽  
Psychological Symptoms ◽  
Social Activity ◽  
Intervention Group ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Clinical Effects ◽  
Obstructive Pulmonary Disease

Objective: To investigate the clinical effects of the use of portable pulmonary function tester in patients with stable Chronic Obstructive Pulmonary Disease (COPD). Methods: A total of 80 patients with stable COPD were enrolled in our hospital from March 2018 to March 2019. They were divided into two groups according to different treatment methods. The comparison group was used for routine pulmonary function training, and the intervention group was trained for Portable Pulmonary Function Training and Test Device (PPFTTD). Comparison was made of forced expiratory volume in one second/forced vital capacity (FEV1/FVC), measured/predicted value of the first second forced expiratory volume (FEV1 measured/predicted value), measured/predicted value of maximal voluntary ventilation per minute between the two groups. Quality of life (QOL) scores such as daily living ability, social activity, depressive psychological symptoms, and anxiety psychological symptoms were measured. Results: The FEV1/FVC value, measured/predicted value of FEV1 and MVV of intervention group were higher than those in the comparison group ([Formula: see text]). QOL scores, such as daily living ability, social activity, depression psychological symptoms, and anxiety psychological symptoms in the intervention group, were lower than those in the comparison group ([Formula: see text]). Conclusion: In the treatment of stable COPD, the use of portable pulmonary function tester is significant, and it should be widely promoted and applied in clinical practice.

Distinctive patterns of pulmonary function change according to baseline lung volume and diffusing capacity

2020 ◽  
Vol 24 (6) ◽  
pp. 597-605
Author(s):  
J. Kang ◽  
Y-M. Oh ◽  
J-H. Lee ◽  
E. K. Kim ◽  
S. Y. Lim ◽  
...  
Keyword(s):  
South Korea ◽  
Pulmonary Function ◽  
Lung Volume ◽  
Forced Expiratory Volume ◽  
Random Coefficients ◽  
Chronic Obstructive ◽  
Diffusing Capacity ◽  
Obstructive Pulmonary Disease ◽  
Function Change ◽  
Physiological Markers

SETTING: Multicentre retrospective study in South Korea.OBJECTIVE: To longitudinally evaluate changes in lung volume and diffusing capacity for carbon monoxide (DLCO) with forced expiratory volume in 1 sec (FEV1).DESIGN: A total of 155 patients with chronic obstructive pulmonary disease (COPD), whose pulmonary function parameters were measured annually for 5 years, were selected from a prospective cohort in South Korea. A random coefficients model was used to estimate mean annual FEV1, lung volume parameter and DLCO change rates.RESULTS: Patients were classified into four groups based on baseline DLCO and residual volume/total lung capacity (RV/TLC) measurements. The annual FEV1 decline rate was greater in patients with low DLCO than in those with normal DLCO, with the greatest decline occurring in patients with low DLCO and normal RV/TLC. RV and RV/TLC declined in patients with high RV/TLC, whereas these increased in patients with normal RV/TLC. DLCO decreased longitudinally in all four groups, with the greatest decline occurring in patients with normal DLCO and normal RV/TLC.CONCLUSIONS: Different subgroups of patients with COPD exhibited distinctive pulmonary function change patterns. Baseline DLCO and RV/TLC may be used as physiological markers to predict long-term changes in pulmonary function.

scholarly journals Sex-related differences in bronchial parameters and pulmonary function test results in patients with chronic obstructive pulmonary disease based on three-dimensional quantitative computed tomography

2017 ◽  
Vol 46 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Yan Li ◽  
Yong-liang Dai ◽  
Nan Yu ◽  
You-min Guo
Keyword(s):  
Computed Tomography ◽  
Chronic Obstructive Pulmonary Disease ◽  
Smoking Cessation ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Quantitative Computed Tomography ◽  
Three Dimensional ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Objective This study was performed to evaluate the effect of sex on bronchial parameters and the predicted forced expiratory volume in 1 s expressed as a percentage of the forced vital capacity (FEV1% pred) on pulmonary function testing. Methods The data of 359 patients with chronic obstructive pulmonary disease (COPD) with available FEV1% pred and computed tomography (CT) images were retrospectively reviewed. FACT-Digital lung TM software (DeXin, Xi’an, China) was used to perform fully automated three-dimensional CT quantitative measurements of the bronchi. Generation 5 to 7 bronchi were measured, and the parameters analyzed were the lumen diameter (LD), wall thickness (WT), lumen area (LA), and WA% [WA / (WA + LA) × 100%]. Results In the smoking, smoking cessation, and nonsmoking groups, women had a significantly larger WA% and smaller LD, WT, and LA than men. The FEV1% pred was significantly lower in women than men in the smoking and smoking cessation groups. The FEV1% pred was significantly higher in women than men in the nonsmoking group. Conclusion Sex-related differences may partially explain why smoking women experience more severe pulmonary function impairment than men among patients with COPD.

scholarly journals Obesity Impact on Respiratory Function

2021 ◽  
Vol 18 (1) ◽  
pp. 41-58
Author(s):  
Anca Hâncu ◽  
Florin Mihălţan
Keyword(s):  
Pulmonary Function ◽  
Respiratory Function ◽  
Healthy Lifestyle ◽  
Respiratory Health ◽  
Forced Expiratory Volume ◽  
Overweight And Obesity ◽  
Chronic Obstructive ◽  
Dietary Recommendations ◽  
Obstructive Pulmonary Disease ◽  
The Impact

Abstract Not so much emphasize in literature and studies, obesity consequences on respiratory function may influence chronic obstructive pulmonary disease COPD and asthma, triggering important healthcare issues. Pulmonary function is a mortality predictor. The largest populational study European Community Respiratory Health Survey shows the impact of overweight and obesity on pulmonary function by decreasing forced expiratory volume in first second FEV1 and forced vital capacity FVC. By the contrary, weight loss is decreasing both. Inflammatory and mechanical mechanisms should be considered in lung function impairment, as a consequence of obesity. Important aspect, lifestyle, will consider tobacco, physical activity, diet. Adopting a healthy lifestyle with a Mediterranean Diet MD will preserve a good pulmonary function on long term. We detailed below specific dietary recommendations, favorable nutrients or foods to be avoided. In conclusion comprehensive lifestyle interventions should become populational based interventions for a better prevention for pulmonary diseases and NCD’s and finally for a better health status.

Effect of Statin Supplementation on Pulmonary Function and Inflammatory Markers in Patients of Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 15 (1) ◽  
pp. 45-50
Author(s):  
Mradul K. Daga ◽  
Ankit Chhoda ◽  
Shashank Singh ◽  
Govind Mawari ◽  
Naresh Kumar ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Exercise Capacity ◽  
Negative Correlation ◽  
Inflammatory Markers ◽  
Intervention Group ◽  
Significant Negative Correlation ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Wide Range ◽  
Systemic Inflammatory Disease

Background: COPD being a systemic inflammatory disease is accompanied by alteration of various inflammatory cytokines which affect the metabolic equilibrium of body. Some therapeutic options, mainly statins via their wide range of pharmacologic actions alter the level of proinflammatory cytokines hence, helpful in attenuating various extra-pulmonary consequences of COPD. We did a randomised case-control study to study the effect of statin supplementation on pulmonary function and inflammatory markers in patients of COPD. Methods: We included 40 stable COPD subjects & randomized them in two groups, Intervention & Non-intervention. Intervention group received 40 mg atorvastatin once daily for 3 months in addition to the conventional treatment of COPD similar to the prior one. We studied levels of IL-6 & CRP and correlated them with disease severity before and after the aforementioned intervention. Results: We observed that CRP levels decreased in both the groups after a follow up of 3 months, but neither of them was statistically significant (p=0.57 & 0.63 respectively) nor the mean of their difference (p=0.969). IL-6 levels showed a persistent decline in intervention group but, was not significant (p=0.91). In this study, we noticed statistically significant improvement in FEV1 (p=0.008) in the intervention group which was in contrast to non-intervention group. Similarly, the exercise capacity also statistically increased in the intervention group (p=0.002). There was also evident negative correlation between exercise capacity and IL-6 as well CRP levels. FEV1 also showed statistically significant negative correlation with IL-6 levels (p=0.023). Conclusion: We can improve the disease outcome and alter its natural progression by altering the levels of inflammatory markers with the aid of some additional pharmacological interventions i.e., in this study was atorvastatin.

scholarly journals Pulmonary function testing in COPD: looking beyond the curtain of FEV1

2021 ◽  
Vol 31 (1) ◽  
Author(s):  
Sotirios Kakavas ◽  
Ourania S. Kotsiou ◽  
Fotis Perlikos ◽  
Maria Mermiri ◽  
Georgios Mavrovounis ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Clinical Symptoms ◽  
Pulmonary Function Tests ◽  
Cardiopulmonary Exercise Testing ◽  
Forced Expiratory Volume ◽  
Airflow Limitation ◽  
Chronic Obstructive ◽  
Forced Oscillation Technique ◽  
Comprehensive Overview ◽  
Obstructive Pulmonary Disease

AbstractChronic obstructive pulmonary disease (COPD) management remains challenging due to the high heterogeneity of clinical symptoms and the complex pathophysiological basis of the disease. Airflow limitation, diagnosed by spirometry, remains the cornerstone of the diagnosis. However, the calculation of the forced expiratory volume in the first second (FEV1) alone, has limitations in uncovering the underlying complexity of the disease. Incorporating additional pulmonary function tests (PFTs) in the everyday clinical evaluation of COPD patients, like resting volume, capacity and airway resistance measurements, diffusion capacity measurements, forced oscillation technique, field and cardiopulmonary exercise testing and muscle strength evaluation, may prove essential in tailoring medical management to meet the needs of such a heterogeneous patient population. We aimed to provide a comprehensive overview of the available PFTs, which can be incorporated into the primary care physician’s practice to enhance the efficiency of COPD management.

scholarly journals Chronic obstructive pulmonary disease patients and steroids: benefit or harm

2019 ◽  
Vol 8 (10) ◽  
pp. 2247
Author(s):  
Abdul Hamid Khan ◽  
Mehwish Majeed
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Control Group ◽  
Chronic Obstructive ◽  
Case Group ◽  
Obstructive Pulmonary Disease ◽  
Function Tests

Background: Corticosteroids are being widely used in conditions related to allergy and inflammation. There are great species differences in the responses to glucocorticoids that mean a “steroid resistant” species. Steroids have profound effect on inflammatory response by way of vasoconstriction, decreased chemotaxis and interference with macrophages. There still are enormous gaps in our knowledge of the action of glucocorticosteroids in patients of chronic obstructive lung disease (COPD).Methods: This study was done in the department of general medicine at SKIMS, Srinagar from December 2017 to December 2018 on patients of chronic obstructive pulmonary disease. A total number of 100 patients were enrolled for the study but 20 patients, 10 from each group lost their follow up. To see the effect of steroids on pulmonary function tests, patients were divided into case and control group. Patients in case group were given prednisolone 30 mg orally for two week (tapering dose). Patients in control group were given placebo for the same duration of two weeks. Steroid response was defined as 15% improvement in baseline forced expiratory volume (FEV).Results: Steroid response was defined as 15% increase in forced expiratory volume in one second/forced vital capacity (FEV1/FVC) after receiving tapering dose of prednisone 30 mg for 2 weeks, no patients in case group showed increase in FEV1/FVC of 15%. The change in pulmonary function tests was comparable in each group (p>0.5).Conclusions: The change in pulmonary function tests were comparable in each group (p>0.5). So, steroids in stable patients of COPD are best to be avoided.

scholarly journals A Comparison of Spirometric Parameters and Serum Malondialdehyde Level in Actively Smoking Chronic Obstructive Pulmonary Disease Patients and Non- Smoking Apparently Normals- A Crosssectional Comparative Study

2021 ◽  
pp. 103-110
Author(s):  
. Ranjana ◽  
Mishra Indira Sushil ◽  
Rajiv Ranjan Prasad
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Flow Rate ◽  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Introduction: The antioxidants requirement depend on one’s exposure to endogenous and exogenous reactive oxygen species.Cigarette smoking leads to increased exposure to reactive oxygen species,hence they require more antioxidant nutrients In this study, we aimed to study the serum levels of malondialdehyde (MDA) as a marker of oxidative stress and pulmonary function tests (PFT) and to study if there is any correlation between PFTand MDA levels in, smokers,chronic obstructive pulmonary disease (COPD) patients. Aim: To compare the pulmonary function tests (PFT) and serum malondialdehyde (MDA) level in smokers, chronic obstructive pulmonary disease (COPD) patients with non-smoker controls. Methods and Materials: N=30, 35-50 years age group smokers, COPD patients were enrolled as cases.N=30 age and sex matched were enrolled as control group. Serum MDA and PFT parameters like forced vital capacity (FVC), forced expiratory volume in first second (FEV1), FEV1/FVC ratio, Peak expiratory flow rate (PEFR) were measured. Result: PFT parameters like forced vital capacity (FVC), forced expiratory volume in first second (FEV1), FEV1/FVC ratio, peak expiratory flow rate(PEFR) were decreased and found statistically significant in smokers, COPD group.MDA level were increase and found statistically highly significant in smokers, COPD group. Conclusion: MDA is negatively correlated with FEV1% predicted, FEV1/FVC % predicted ratio and FVC in smokers, COPD patients

scholarly journals Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population

Metabolites ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 61 ◽  
Author(s):  
Bing Yu ◽  
Claudia Flexeder ◽  
Robert McGarrah ◽  
Annah Wyss ◽  
Alanna Morrison ◽  
...  
Keyword(s):  
General Population ◽  
Pulmonary Function ◽  
Meta Analysis ◽  
Forced Expiratory Volume ◽  
European Ancestry ◽  
Chronic Obstructive ◽  
Early Disease ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Atherosclerosis Risk In Communities

Determination of metabolomic signatures of pulmonary function and chronic obstructive pulmonary disease (COPD) in the general population could aid in identification and understanding of early disease processes. Metabolome measurements were performed on serum from 4742 individuals (2354 African-Americans and 1529 European-Americans from the Atherosclerosis Risk in Communities study and 859 Europeans from the Cooperative Health Research in the Region of Augsburg study). We examined 368 metabolites in relation to cross-sectional measures of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), their ratio (FEV1/FVC) and COPD using multivariable regression followed by meta-analysis. At a false discovery rate of 0.05, 95 metabolites were associated with FEV1 and 100 with FVC (73 overlapping), including inverse associations with branched-chain amino acids and positive associations with glutamine. Ten metabolites were associated with FEV1/FVC and seventeen with COPD (393 cases). Enriched pathways of amino acid metabolism were identified. Associations with FEV1 and FVC were not driven by individuals with COPD. We identified novel metabolic signatures of pulmonary function and COPD in African and European ancestry populations. These may allow development of biomarkers in the general population of early disease pathogenesis, before pulmonary function has decreased to levels diagnostic for COPD.

scholarly journals Clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease

2017 ◽  
Vol 15 (3) ◽  
pp. 306-314 ◽  
Author(s):  
Esra Ertan Yazar ◽  
Senay Aydin ◽  
Gulsah Gunluoglu ◽  
Sadettin Kamat ◽  
Adil Can Gungen ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cognitive Impairment ◽  
Cognitive Functions ◽  
Daily Living ◽  
Chronic Obstructive ◽  
Clinical Effects ◽  
Obstructive Pulmonary Disease ◽  
Arterial Partial Pressure ◽  
Group 2 ◽  
Group 1

The aim of this study was to evaluate the clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease (COPD). A total of 91 patients with stable moderate to very severe COPD were included in this study. Cognitive functions of the patients were evaluated using the mini-mental state examination (MMSE) tool and clock-drawing test. The Brody’s Instrumental Activities of Daily Living (IADL) Questionnaire; COPD assessment test (CAT); body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE); and Charlson comorbidity index were assessed. The patients were divided into two groups as those who were diagnosed with cognitive impairment (group 1, n = 16) and those with normal cognitive functions (group 2, n = 75). Group 1 had a lower arterial partial pressure of oxygen , shorter 6-min walking distance, and higher arterial partial pressure of carbon dioxide (PaCO2) than group 2 ( p = 0.01, p = 0.024, p = 0.018, respectively). In group 1, the IADL score was lower, and CAT and BODE scores were higher than group 2 ( p = 0.002, p = 0.037, p = 0.012, respectively). When we considered all the patients, there was an independent correlation between the IADL score and MMSE score ( p = 0.03). This study revealed that COPD patients with cognitive impairment may have more hypoxemia and limited activities of daily living.

scholarly journals Molecular Diagnosis of Intermediate and Severe α1-Antitrypsin Deficiency: MZ Individuals with Chronic Obstructive Pulmonary Disease May Have Lower Lung Function Than MM Individuals

2001 ◽  
Vol 47 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Morten Dahl ◽  
Børge G Nordestgaard ◽  
Peter Lange ◽  
Jørgen Vestbo ◽  
Anne Tybjærg-Hansen
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Antitrypsin Deficiency ◽  
Lower Lung ◽  
Compound Heterozygotes

Abstract Background: We tested whether intermediate (MZ, SZ) and severe (ZZ) α1-antitrypsin deficiency affects lung function in the population at large. Methods: We performed spirometry [forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)] and genotyping of 9187 individuals from the adult general population of Copenhagen, Denmark. Results: As expected, the frequencies of individuals with MM, MS, SS, MZ, SZ, and ZZ genotypes were 0.891, 0.054, 0.001, 0.052, 0.001, and 0.001, respectively. Genotype interacted with clinically established chronic obstructive pulmonary disease (COPD) on the percentage of the predicted FEV1 (P = 0.004): the percentage of the predicted FEV1 was reduced in MZ compared with MM individuals among those with clinically established COPD, but not among those without COPD. Furthermore, SZ compound heterozygotes had lower FEV1/FVC ratios than MM individuals (P <0.05), and ZZ homozygotes had lower percentages of the predicted FEV1 and FEV1/FVC ratios than MM, MS, SS, and MZ individuals (all Ps <0.01). Reduced lung function in SZ and ZZ vs MM individuals could be demonstrated in current and ex-smokers, but not in nonsmokers. Compared with MM individuals in the same groups, FEV1 was reduced 655 mL in MZ individuals with clinically established COPD, 364 mL in SZ current smokers, and 791 mL in ZZ current smokers. Conclusions: In the population at large, MZ was associated with reduced pulmonary function in individuals with clinically established COPD, whereas SZ and ZZ were associated with reduced pulmonary function in smokers. The presence of the α1-antitrypsin MZ genotype may in certain circumstances produce marked aggravation of airway obstruction in individuals prone to develop COPD.

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