Spindle Cell Metaplastic Breast Carcinoma

2021 ◽  
Vol 17 ◽  
Author(s):  
Vithya Sanmugasiva ◽  
Marlina Tanty Ramli Hamid ◽  
Farhana Fadzli ◽  
Nazimah Ab Mumin ◽  
Kartini Rahmat
Keyword(s):  
Breast Carcinoma ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Final Diagnosis ◽  
Spindle Cell Carcinoma ◽  
Left Breast ◽  
Metaplastic Carcinoma ◽  
Breast Cancers ◽  
Breast Lump ◽  
Metaplastic Breast Carcinoma

Introduction: Metaplastic breast carcinoma is an uncommon malignancy that constitutes < 5% of all breast cancers. There are 5 subtypes which are spindle cell, squamous cell, carcinosarcoma, matrix-producing and metaplastic with osteoclastic giant cells. Spindle cell carcinoma represents approximately <0.3% of invasive breast carcinomas. It is typically a triple-negative cancer with distinct pathological characteristics, but relatively a non-conclusive imaging findings. Case report: An elderly lady presented with an enlarging painful left breast lump for 1 year. Palpable left breast lump noted on clinical examination. Mammography demonstrated a high density, oval lesion with a partially indistinct margin. Corresponding ultrasound showed a large irregular heterogeneous lesion with solid-cystic areas. Histopathology showed atypical spindle-shaped cells which stained positive for cytokeratins and negative for hormone and human epidermal growth factor receptors, which favours spindle cell metaplastic carcinoma. Left mastectomy and axillary dissection were performed, and the final diagnosis was consistent with metaplastic spindle cell carcinoma. Conclusion: Spindle cell carcinoma of the breast is a rare aggressive histological type of carcinoma which may present with benign features on imaging. Tissue diagnosis is essential for prompt diagnosis with multidisciplinary team discussion to guide management and improve patient’s outcome.

scholarly journals Spindle cell carcinoma of the breast managed with neoadjuvant AIM: A case report

Rare Tumors ◽  
2020 ◽  
Vol 12 ◽  
pp. 203636132097702 ◽  
Author(s):  
April Choi ◽  
Philip M Carpenter ◽  
Shefali Chopra ◽  
Kristi M Lara ◽  
William W Tseng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Cell Carcinoma ◽  
Randomized Trials ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Metaplastic Carcinoma ◽  
Cell Type ◽  
Carcinoma Of The Breast ◽  
Spindle Cell Type

Spindle cell carcinoma (SpC), also known as metaplastic carcinoma—spindle cell type, is a subtype of metaplastic carcinoma. Metaplastic carcinomas of the breast are rare but are thought to be more aggressive than invasive ductal carcinomas. Due to their rarity, there are few randomized trials that can inform any standardized approaches to treatment. Treatment is instead extrapolated from other types of breast cancer or metaplastic carcinomas of different locations. Here we present the first known case report of a patient with spindle cell carcinoma of the breast successfully treated with a standard sarcoma neoadjuvant regimen of doxorubicin, ifosfamide, and mesna (AIM) that resulted in >99% necrosis of the tumor and negative margins at the time of resection.

scholarly journals HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Katsumi Kito ◽  
Toshiharu Maeda ◽  
Keiko Ninomiya ◽  
Atsuro Sugita ◽  
Teiri Sagawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Metaplastic Carcinoma ◽  
Apocrine Carcinoma ◽  
Her2 Positive ◽  
First Case ◽  
Spindle Cell Lesion ◽  
Apocrine Differentiation ◽  
The Right

Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coincident in the right breast. Both apocrine carcinomas were immunohistochemically negative for estrogen receptor (ER) and progesterone receptor (PgR), but diffusely positive for androgen receptor (AR), GCDFP-15, and HER2. The presence of intraductal components in bilateral carcinomas and the absence of lymph node metastasis suggested that they were more likely to be individual primary lesions rather than metastatic disease. The spindle cell lesion showed a relatively well-circumscribed nodule contiguous with the apocrine carcinoma. HER2 oncoprotein overexpression was observed not only in the apocrine carcinoma, but also in the spindle cell lesion. Since the spindle cell component was intimately admixed with apocrine carcinoma and had focal cytokeratin expression, we diagnosed it as metaplastic spindle cell carcinoma, which was originated from the apocrine carcinoma. To our knowledge, this is the first case report of a patient with synchronous bilateral apocrine carcinomas coinciding with metaplastic carcinoma.

scholarly journals Clinicopathological Examination of Metaplastic Spindle Cell Carcinoma of the Breast: Case Series

2021 ◽  
Vol 15 ◽  
pp. 117822342110394
Author(s):  
Yumiko Ishizuka ◽  
Yoshiya Horimoto ◽  
Naotake Yanagisawa ◽  
Atsushi Arakawa ◽  
Katsuya Nakai ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Triple Negative ◽  
Spindle Cell ◽  
Case Series ◽  
Spindle Cell Carcinoma ◽  
Metaplastic Carcinoma ◽  
Programmed Death ◽  
Significant Difference ◽  
Cell Components ◽  
The Mean

Background: Spindle cell carcinoma (SpCC) of the breast is a rare histological type, a subtype of metaplastic carcinoma characterized by atypical spindle cell and epithelial carcinoma. The proportions of the spindle cell and epithelial components vary among tumours. Due to its rarity, biological characteristics of this disease have been poorly studied. Methods: In total, 10 patients with SpCC were surgically treated at our institution from January 2007 to December 2018. We retrospectively investigated these SpCC cases, focusing on the differences between spindle cell and epithelial components. Microsatellite status was also examined. Results: Nine cases were triple-negative breast cancer (TNBC). The rates of high tumour grade were 70% in spindle cell components and 56% in epithelial components ( P = .65), while the mean Ki67 labelling index were 63% and 58%, respectively ( P = .71). Mean programmed death ligand 1 (PD-L1) expression in these components was 11% and 1%, respectively ( P = .20). All 10 tumours were microsatellite stable. Patient outcomes of triple-negative SpCC did not differ from those of propensity-matched patients with conventional TNBC. Conclusions: Spindle cell components showed higher values in factors examined, although there was no statistically significant difference. Our data reveal that these 2 components of SpCC may be of different biological nature.

scholarly journals Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney with Sarcomatoid Change

2016 ◽  
Vol 3 (2) ◽  
pp. 8-13
Author(s):  
Kafil Akhtar ◽  
Pragati Agnihotri ◽  
Kiran Alam ◽  
Kashif Raza
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Left Kidney ◽  
Final Diagnosis ◽  
Large Mass ◽  
Spindle Cell Carcinoma ◽  
World Health ◽  
Low Grade ◽  
High Power Field ◽  
Health Organization

Mucinous tubular and spindle cell carcinoma (MTSCC) is a recent entity introduced in the World Health Organization 2004 Classification. It is a tumour of low malignant potential. MTSCC is a subtype of renal cell carcinoma (RCC), which is characterized by a polymorphous histology, wherein the spindled epithelial cell is an inherent carcinomatous component. We report the case of a 57-year-old man presenting with loin pain and dragging sensation. Imaging revealed a large mass arising from the left kidney. Radical nephrectomy was performed, and histopathology revealed spindle cell elements of MTSCC with low-grade cytology, which occasionally blended with tubular structures in variable mucinous stroma admixed with spindle sarcomatoid cells with marked nuclear pleomorphism, associated with significant necrosis and mitoses of up to 5/10 high-power field. A final diagnosis of MTSCC along with high-grade areas consistent with sarcomatoid dedifferentiation was made. Sarcomatoid dedifferentiation has been well documented in various subtypes of RCC, and its presence signifies a worse prognosis in RCC.

scholarly journals Fibromatosis-like spindle-cell metaplastic carcinoma of the breast – a case report

2021 ◽  
Vol 19 (1) ◽  
pp. 98-101
Author(s):  
Michał Osuchowski ◽  
◽  
Dorota Bartusik-Aebisher ◽  
Ewa Kaznowska ◽  
David Aebisher ◽  
...  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Literature Review ◽  
Female Patient ◽  
Spindle Cell ◽  
Metaplastic Carcinoma ◽  
Diagnostic Challenge ◽  
Carcinoma Of The Breast ◽  
Mesenchymal Tissue ◽  
Metaplastic Breast Carcinoma

Introduction. Metaplastic breast carcinoma is expressing epithelial and/or mesenchymal tissue within the same tumor. Aim. The aim of this study is to evaluate metaplastic breast carcinoma in a case report and literature review. Description of the case. The presented case desribes metaplastic carcinoma of the breast in 65 years old female patient. Conclusion. Fibromatosis-cell metaplastic carcinoma of the breast presents a particularly large diagnostic challenge. Malignant variants of this disease have been described in the literature.

scholarly journals Metaplastic breast carcinoma with chondrosarcomatous differentiation: an unusual disease with a worse prognosis

2020 ◽  
Vol 7 (4) ◽  
pp. 1277
Author(s):  
Samuel Lalhruaizela ◽  
Bhupendra Mehra
Keyword(s):  
Breast Carcinoma ◽  
World Health ◽  
Metaplastic Carcinoma ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Duct Carcinoma ◽  
Increased Risk ◽  
Chondroid Metaplasia ◽  
Worse Prognosis ◽  
Metaplastic Breast Carcinoma

Metaplastic breast carcinoma (MBC) has an incidence of <1% of all breast cancers and MBC with chondrosarcomatous differentiation is even more rare, <0.1% of all cases. The World Health Organization have classified MBC into pure epithelial-type and mixed epithelial and mesenchymal type. The epithelial-type MBC is sub-classified into squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma with spindle cell differentiation; mixed type MBC is sub-classified into carcinosarcoma and carcinoma with osseous and chondroid metaplasia. Metaplastic carcinomas of the breast are characterized by large tumour size and rapid  growth, and they are usually estrogen receptor, progesterone receptor, and HER2/neu negative and tend to have a worse prognosis than other triple negative breast cancers. There is a noteworthy increased risk of tumour recurrence and a worse prognosis with MBC compared with invasive lobular carcinoma and infiltrating duct carcinoma. We report a case of metaplastic carcinoma with extensive chondroid differentiation that is chondrosarcoma and chondroid metaplasia along with classic infiltrating duct carcinoma with involvement of ipsilateral axillary lymph nodes.

scholarly journals Metaplastic Breast Carcinoma with Unusual Presentation: Review of Three Cases

Breast Care ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. 404-407 ◽  
Author(s):  
M. Asunción Fernández Pérez ◽  
Isabel Viqueira Rodriguez ◽  
Alberto Tello Royloa ◽  
Javier Martínez Guisasola
Keyword(s):  
Breast Carcinoma ◽  
Large Mass ◽  
The Other ◽  
Metaplastic Carcinoma ◽  
Breast Lump ◽  
Fast Growing ◽  
Mesenchymal Differentiation ◽  
Myoepithelial Differentiation ◽  
The Mean ◽  
Metaplastic Breast Carcinoma

Background: Metaplastic breast carcinoma is an uncommon type of breast cancer that usually appears as a large, fast growing breast lump. Case Report: We report 3 cases of metaplastic breast carcinoma presented at our clinic in 2014. The mean age at diagnosis was 67.3 years. 1 patient presented with a fast growing, large mass detected by herself. However, in the other 2 patients, the nodule was approximately 1.5 cm in size, not fast growing, and was detected on mammography. All 3 patients were treated surgically (2 lumpectomies and 1 mastectomy), with the final pathology of metaplastic carcinoma with chondroid mesenchymal differentiation in 2 cases and metaplastic carcinoma with myoepithelial differentiation in the 3rd case. The patients are still under adjuvant therapy. Conclusions: Metaplastic breast carcinoma may present unusually as a non-palpable lump. This entity must be considered in any breast lump.

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