Extracts of Bacopa monnieri (L) Pennell Down-Regulate the Expression of Leukotriene C4 Synthase mRNA in HL-60 Cells and Suppress OVAInduced Inflammation in BALB/c Mice

2014 ◽  
Vol 10 (1) ◽  
pp. 21-30
Author(s):  
Kapil K. Soni ◽  
P.N. Shrivastava ◽  
Tristesse Jones ◽  
Laura J. Mahady ◽  
Udeshi Patel ◽  
...  
Keyword(s):  
Bacopa Monnieri

Preclinical Profile of Bacopasides From Bacopa monnieri (BM) As An Emerging Class of Therapeutics for Management of Chronic Pains

2013 ◽  
Vol 20 (8) ◽  
pp. 1028-1037 ◽  
Author(s):  
K. Rauf ◽  
F. Subhan ◽  
A.M. Al-Othman ◽  
I. Khan ◽  
A. Zarrelli ◽  
...  
Keyword(s):  
Bacopa Monnieri

Neuroprotection with Bacopa monnieri–A review of experimental evidence

2021 ◽  
Author(s):  
Vijayanna Tirumalapura Shalini ◽  
Sajjanar Jambappa Neelakanta ◽  
Jaideep Sitaram Sriranjini
Keyword(s):  
Experimental Evidence ◽  
Bacopa Monnieri

Bacopa monnieri alleviates aluminium chloride-induced anxiety by regulating plasma corticosterone level in Wistar rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Senthil Murugan Murugaiyan ◽  
Rajesh Bhargavan
Keyword(s):  
Oral Administration ◽  
Corticosterone Level ◽  
Tween 80 ◽  
Treated Group ◽  
Plasma Corticosterone ◽  
Bacopa Monnieri ◽  
Aluminium Chloride ◽  
Control Group ◽  
Plasma Corticosterone Level ◽  
Protective Groups

AbstractObjectivesAluminium is present in food preparations, antacids and many medications. It causes neurodegeneration thereby resulting in a spectrum of neurological disorders such as dementia, Alzheimer’s disease and anxiety. Bacopa monnieri (BM) is widely used in ayurvedic medicine to improve memory functions. Its anxiolytic property was investigated in this study by using elevated plus maze (EPM) and plasma corticosterone level.MethodsThirty rats were assigned into five groups. Control group received distilled water, and 0.5% tween 80, AlCl3 group received Aluminium Chloride (AlCl3), Protective groups (BM100 + AlCl3 group and BM200 + AlCl3 group) received AlCl3 and BM at two different doses, and the BM200 group received BM. The EPM experiment was performed at the end of the 4th week of oral administration of BM and AlCl3 followed by the measurement of plasma corticosterone.ResultsOral administration of AlCl3 to rats increases the levels of anxiety as seen in a decrease in the percentage of entries into the open arms of EPM, an increase in grooming frequency and defecation index. However, the rats in the protective groups shown an increase in the percentage of open arm entries and rearing frequency, and decreased grooming frequency and defecation index. AlCl3 alone treated group showed a significant increase in the plasma corticosterone levels compared to the control group. Whereas the protective groups have shown a significant decrease in the plasma corticosterone levels than the AlCl3 alone treated group.ConclusionsHence the BM has potential role in reverting the anxiogenic effect of AlCl3 in the amygdala as it is evident from the plasma corticosterone levels and the EPM parameters of different groups under study.

Study of Contro-vercial Aspect of Cleome viscosa, Linn. and Gynandropsis gynandra, Linn. – A literary Review

2019 ◽  
Vol 7 (05) ◽  
Author(s):  
Sharavati Goroba Kamble
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Bacopa Monnieri ◽  
Single Plant ◽  
Classical Text ◽  
Clitoria Ternatea ◽  
Gynandropsis Gynandra ◽  
Second Category ◽  
Cleome Viscosa

Controversy in identification of medicinal plants has been a problem since ages. When we refer the classical text like Caraka Samhita, it becomes important to know the exact medicinal plant mentioned in the formulation or treatment. The controversy regarding a plant is found to be of two types mainly. Single classical plant having multiple botanical identities eg. Parpata, Rasna, Amlavetasa, Bharangi, Pasanabheda Botanically identified single plant with multiple classical identities eg. Bacopa monnieri, Clitoria ternatea The plants of this study fall under second category. The plants C.viscosa, Linn. and G.gynandra, Linn. are having multiple classical identities like Ajagandha, Tilaparni, Suvarcala, Brahmasuvarcala and Adityabhakta. An effort is made to resolve the controversy by comparing the information of these plants from classical Ayurvedic texts and Modern texts in this article.   Method: Compilation of all the data from Literature Comparision of classical data with viscosa and G.gynandra characteristics Conclusion is made on the basis of observations   Observation and Conclusion: Comparisons of all the above discussed classical plants with Cloeme viscosa, Linn. and Gynandropsis gynandra, Linn. shows Ajagandha being similar to Gynandropsis and Tilaparni being similar to Cleome.  

scholarly journals Effect of herb-drug interactions of Bacopa monnieri Linn. (Brahmi) formulation on the pharmacokinetics of amitriptyline in rats

2018 ◽  
Vol 53 (4) ◽  
Author(s):  
Fowad Khurshid ◽  
Jeyabalan Govindasamy ◽  
Habibullah Khalilullah ◽  
Mohammed Shivli Nomani ◽  
Mudassar Shahid ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Bacopa Monnieri

scholarly journals Development and optimization of dispersible tablet of Bacopa monnieri with improved functionality for memory enhancement

2017 ◽  
Vol 9 (3) ◽  
pp. 208 ◽  
Author(s):  
VaishaliTejas Thakkar ◽  
Amol Deshmukh ◽  
Lal Hingorani ◽  
Payal Juneja ◽  
Lalji Baldaniya ◽  
...  
Keyword(s):  
Bacopa Monnieri ◽  
Memory Enhancement ◽  
Dispersible Tablet

scholarly journals Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson’s Disease: An In Silico and In Vivo Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Babita Singh ◽  
Shivani Pandey ◽  
Mohammad Rumman ◽  
Shashank Kumar ◽  
Prem Prakash Kushwaha ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
In Silico ◽  
Dopaminergic Neurons ◽  
Lipid Peroxide ◽  
Bacopa Monnieri ◽  
Dopamine Level ◽  
Mice Model ◽  
Mptp Administration

Ethnopharmacological Relevance: Parkinson’s disease (PD) is characterized by progressive death of dopaminergic neurons. The presently used medicines only tackle the symptoms of PD, but none makes a dent on the processes that underpin the disease’s development. Herbal medicines have attracted considerable attention in recent years. Bacopa monnieri (L.) Wettst (Brahmi) has been used in Indian Ayurvedic medicine to enhance memory and intelligence. Herein, we assessed the neuroprotective role of Bacopa monnieri (L.) Wettst on Parkinson’s disease.Aim of the Study:Bacopa monnieri (L.) Wettst, a medicinal herb, is widely used as a brain tonic. We investigated the neuroprotective and neurorescue properties of Bacopa monnieri (L.) Wettst extract (BME) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of PD.Materials and Methods: The mice model of MPTP-induced PD is used in the study. In the neuroprotective (BME + MPTP) and neurorescue (MPTP + BME) experiments, the animals were administered 40 mg/kg body weight BME orally before and after MPTP administration, respectively. Effect of BME treatment was evaluated by accessing neurobehavioral parameters and levels of dopamine, glutathione, lipid peroxide, and nitrites. An in silico study was performed using AutoDock Tools 1.5.6 (ADT).Results: A significant recovery in behavioral parameters, dopamine level, glutathione level, lipid peroxides, and nitrite level was observed in BME-treated mice. Treatment with BME before or after MPTP administration has a protective effect on dopaminergic neurons, as evidenced by a significant decrease in GFAP immunostaining and expression of inducible nitric oxide synthase (iNOS) in the substantia nigra region; however, the degree of improvement was more prominent in mice receiving BME treatment before MPTP administration. Moreover, the in silico study revealed that the constituents of BM, including bacosides, bacopasides, and bacosaponins, can inactivate the enzyme monoamine oxidase B, thus preventing the breakdown of MPTP to MPP+.Conclusion: Our results showed that BME exerts both neuroprotective and neurorescue effects against MPTP-induced degeneration of the nigrostriatal dopaminergic neurons. Moreover, BME may slow down the disease progression and delay the onset of neurodegeneration in PD.

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