Advancing Drug Therapy for Brain Tumours: A Current Review of the Pro-inflammatory Peptide Substance P and its Antagonists as Anti-cancer Agents

2014 ◽  
Vol 9 (2) ◽  
pp. 110-121 ◽  
Author(s):  
Kimberley Mander ◽  
Elizabeth Harford-Wright ◽  
Kate Lewis ◽  
Robert Vink
Keyword(s):  
Drug Therapy ◽  
Substance P ◽  
Brain Tumours ◽  
Current Review ◽  
Anti Cancer ◽  
A Current

scholarly journals A Current Review on Analytical Tools for Determination of New Oral Antidiabetic Drugs, Empagliflozin, Linagliptin and Biguanides in Bulk Materials, Pharmaceuticals & Biological Samples

2020 ◽  
pp. 67-83
Author(s):  
S. Baokar ◽  
K. Mane ◽  
A. Bhujbal ◽  
S. Pharande ◽  
G. Patil ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase 4 ◽  
Current Review ◽  
Anti Cancer ◽  
Cardio Vascular ◽  
Bioanalytical Assays ◽  
Analytical Tools ◽  
A Current ◽  
Metformin Hcl

Worldwide the R & D divisions of Pharma industry are actively involved in the development of new therapeutic agents. These agents may be either new entities or partial structural modification of the existing one. The recent FDA statistics represent that the average number of drug filings are increasing every year in the thrust areas like anti-cancer agents, anti-diabetic, antibiotics, cardio-vascular drugs, respiratory drugs etc. Sodium glucose co-transporter-2(SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and biguanides are effective oral anti-diabetic agents used in treatment of type 2 Diabetes Mellitus. Therefore, the necessity to explore and compare the existing analytical and bioanalytical assays used for determination of such drugs either single or in combination is crucial. Many methods were reported in the literature for the bio-analysis and analysis of four novel gliptins combinations, empagliflozin-linagliptin, empagliflozin-metformin HCl, linagliptin-metformin HCl, empagliflozin-linagliptin-metformin HCl combination with application on Glyxambi®, Synjardy®, Jentadueto®, Trijardy® XR tablets respectively. Furthermore, this review offered an overview of different methods used for determination of every drug alone as empagliflozin from SGLT-2 inhibitors, linagliptin from DPP-4 inhibitors and metformin from biguanides in a tabulated comparative way. Moreover, the current review emphasizes the most common stability indicating assays to be of interest to the analysts in the area of drug control. This review helps in understanding the further need for the development of analytical methods for the estimation of such drugs.

scholarly journals Lignans from Bursera fagaroides: Chemistry, Pharmacological Effects and Molecular Mechanism. A Current Review

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 685
Author(s):  
Mayra Antúnez-Mojica ◽  
Antonio Romero-Estrada ◽  
Israel Hurtado-Díaz ◽  
Alfonso Miranda-Molina ◽  
Laura Alvarez
Keyword(s):  
Molecular Mechanisms ◽  
Medicinal Tree ◽  
Chemical Structures ◽  
In Vivo Assays ◽  
Current Review ◽  
Anti Cancer ◽  
Future Direction ◽  
A Current

Bursera fagaroides is a medicinal tree endemic to México, it belongs to the Burseraceae family and has proven antitumor activity. Modern research, performed principally with the bark extracts, have indicated that lignans are the main active constituents of B. fagaroides, with a high content of aryltetralin, aryldihydronaphtalene, dibenzylbutirolactone, and dibenzylbutane-type lignans as the constituents of the active extracts. In general, lignans from B. fagaroides exhibited potent anti-cancer activity, although antitumor, anti-bacterial, anti-protozoal, anti-inflammatory, and anti-viral properties have also been described. This review covers literature-reported lignans from B. fagaroides, chemical structures, nomenclature, chromatographic techniques of isolation, characterization strategies, and highlights the anti-cancer molecular mechanisms of lignans. Evaluation of the anticancer function of lignans has been extensively investigated since the cytotoxic in vitro results and in vivo assays in mice and zebrafish models to the tubulin molecular recognition by NMR. Also, we discuss the future direction for studying this important plant species and its lignan metabolites.

The Potential for Substance P Antagonists as Anti-Cancer Agents in Brain Tumours

2013 ◽  
Vol 8 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Elizabeth Harford-Wright ◽  
Kate Lewis ◽  
Robert Vink
Keyword(s):  
Substance P ◽  
Brain Tumours ◽  
Anti Cancer ◽  
Substance P Antagonists

Physiological Proteins in Therapeutics: A Current Review on Interferons

2016 ◽  
Vol 16 (12) ◽  
pp. 947-952 ◽  
Author(s):  
Debosree Ghosh ◽  
Debjani Ghosh ◽  
Pratap Parida
Keyword(s):  
Current Review ◽  
A Current

scholarly journals Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marjan Talebi ◽  
Mohsen Talebi ◽  
Tahereh Farkhondeh ◽  
Jesus Simal-Gandara ◽  
Dalia M. Kopustinskiene ◽  
...  
Keyword(s):  
Blood Cells ◽  
Molecular Mechanisms ◽  
Web Of Science ◽  
Experimental Studies ◽  
Protective Effects ◽  
Pharmacological Activities ◽  
Current Review ◽  
Mesh Terms ◽  
Online Databases ◽  
Anti Cancer

AbstractChrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies. Graphic abstract

Innovatory role of nanomaterials as bio-tools for treatment of cancer

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Khuram Shahzad Ahmad ◽  
Muntaha Talat ◽  
Shaan Bibi Jaffri ◽  
Neelofer Shaheen
Keyword(s):  
Cancer Treatment ◽  
Cancer Therapeutics ◽  
Physicochemical Characteristics ◽  
Global Scale ◽  
Current Review ◽  
Anti Cancer ◽  
Different Types ◽  
Cancerous Cells

AbstractConventional treatment modes like chemotherapy, thermal and radiations aimed at cancerous cells eradication are marked by destruction pointing the employment of nanomaterials as sustainable and auspicious materials for saving human lives. Cancer has been deemed as the second leading cause of death on a global scale. Nanomaterials employment in cancer treatment is based on the utilization of their inherent physicochemical characteristics in addition to their modification for using as nano-carriers and nano-vehicles eluted with anti-cancer drugs. Current work has reviewed the significant role of different types of nanomaterials in cancer therapeutics and diagnostics in a systematic way. Compilation of review has been done by analyzing voluminous investigations employing ERIC, MEDLINE, NHS Evidence and Web of Science databases. Search engines used were Google scholar, Jstore and PubMed. Current review is suggestive of the remarkable performance of nanomaterials making them candidates for cancer treatment for substitution of destructive treatment modes through investigation of their physicochemical characteristics, utilization outputs and long term impacts in patients.

Saccular cysts: A current review of characteristics and management

2010 ◽  
Vol 120 (S3) ◽  
pp. S63-S63
Author(s):  
VyVy Young ◽  
Libby Smith
Keyword(s):  
Current Review ◽  
A Current

scholarly journals Outcomes of total hip arthroplasty in patients with osteonecrosis of the femoral head—a current review

2015 ◽  
Vol 8 (3) ◽  
pp. 246-251 ◽  
Author(s):  
Todd P. Pierce ◽  
Randa K. Elmallah ◽  
Julio J. Jauregui ◽  
Daniel F. Verna ◽  
Michael A. Mont
Keyword(s):  
Femoral Head ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Total Hip ◽  
Current Review ◽  
A Current
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