Cervical Cancer Metastasis and Recurrence Risk Prediction Based on Deep Convolutional Neural Network

2021 ◽  
Vol 16 ◽  
Author(s):  
Zixuan Ye ◽  
Yunxiang Zhang ◽  
Yuebin Liang ◽  
Jidong Lang ◽  
Xiaoli Zhang ◽  
...  

Background: Evaluating the risk of metastasis and recurrence of a cervical cancer patient is critical for appropriate adjuvant therapy. However, current risk assessment models usually involve the testing of tens to thousands of genes from patients’ tissue samples, which is expensive and time-consuming. Therefore, computer-aided diagnosis and prognosis prediction based on hematoxylin and eosin (H&E) pathological images have received much attention recently. Objective: The prognosis of whether patients will have metastasis and recurrence can support accurate treatment for patients in advance and help reduce patient loss. It is also important for guiding treatment after surgery to be able to quickly and accurately predict the risk of metastasis and recurrence of a cervical cancer patient. Method: To address this problem, we propose a hybrid method. Transfer learning is used to extract features, and it is combined with traditional machine learning in order to analyze and determine whether or not patients have the risks of metastasis and recurrence. First, the proposed model retrieved relevant patches using a color-based method from Hamp;E pathological images, which were then subjected to image preprocessing steps such as image normalization and color homogenization. Based on the labeled patched images, the Xception model with good classification performance was selected, and deep features of patched pathological images were automatically extracted with transfer learning. After that, the extracted features were combined to train a random forest model to predict the label of a new patched image. Finally, a majority voting method was developed to predict the metastasis and recurrence risk of a patient based on the predictions of patched images from the whole-slide H&E image. Results and Conclusion: In our experiment, the proposed model yielded an area under the receiver operating characteristic curve of 0.82 for the whole-slide image. The experimental results showed that the high-level features extracted by the deep convolutional neural network from the whole-slide image could be used to predict the risk of recurrence and metastasis after surgical resection and help identify patients who might receive additional benefit from adjuvant therapy.

Author(s):  
Christopher Singh ◽  
Christoforos Christoforou

This paper focuses on the application of computer vision and convolutional neural network techniques in the automotive industry to reduce the amount of time required to locate a vacant parking spot and to reduce driving time. The main motivation for a vacant parking spot detector is such that today’s drivers are facing major difficulties in finding available spots in largely populated cities. This often time leads to increased congestion and frustration for the driver because they are forced to continue their search for a parking spot. Our approach is able to solve this issue and provide the driver with useful information through the use of transfer learning methodologies. The main contribution of this paper is to examine and improve on previously implemented transfer learning methods in order to better increase the detection accuracy. This paper differs from previous attempts such that it considers all environmental factors such as weather and time of day. Other models are not able to handle these conditions with a high accuracy and subsequently falter. When compared to previous attempts, our implementation focuses solely on the reliance of transfer learning. The results indicate that our model is capable of identifying vacant parking spaces under all conditions with competitive accuracies. The proposed model is able to surpass the accuracy of the latest attempt at solving this issue.


2018 ◽  
Vol 11 (2) ◽  
pp. 59 ◽  
Author(s):  
Yohanes Gultom ◽  
Aniati Murni Arymurthy ◽  
Rian Josua Masikome

Batik fabric is one of the most profound cultural heritage in Indonesia. Hence, continuous research on understanding it is necessary to preserve it. Despite of being one of the most common research task, Batik’s pattern automatic classification still requires some improvement especially in regards to invariance dilemma. Convolutional neural network (ConvNet) is one of deep learning architecture which able to learn data representation by combining local receptive inputs, weight sharing and convolutions in order to solve invariance dilemma in image classification. Using dataset of 2,092 Batik patches (5 classes), the experiments show that the proposed model, which used deep ConvNet VGG16 as feature extractor (transfer learning), achieves slightly better average of 89 ± 7% accuracy than SIFT and SURF-based that achieve 88 ± 10% and 88 ± 8% respectively. Despite of that, SIFT reaches around 5% better accuracy in rotated and scaled dataset.


2020 ◽  
Vol 34 (5) ◽  
pp. 617-622
Author(s):  
Sai Sudha Sonali Palakodati ◽  
Venkata RamiReddy Chirra ◽  
Yakobu Dasari ◽  
Suneetha Bulla

Detecting the rotten fruits become significant in the agricultural industry. Usually, the classification of fresh and rotten fruits is carried by humans is not effectual for the fruit farmers. Human beings will become tired after doing the same task multiple times, but machines do not. Thus, the project proposes an approach to reduce human efforts, reduce the cost and time for production by identifying the defects in the fruits in the agricultural industry. If we do not detect those defects, those defected fruits may contaminate good fruits. Hence, we proposed a model to avoid the spread of rottenness. The proposed model classifies the fresh fruits and rotten fruits from the input fruit images. In this work, we have used three types of fruits, such as apple, banana, and oranges. A Convolutional Neural Network (CNN) is used for extracting the features from input fruit images, and Softmax is used to classify the images into fresh and rotten fruits. The performance of the proposed model is evaluated on a dataset that is downloaded from Kaggle and produces an accuracy of 97.82%. The results showed that the proposed CNN model can effectively classify the fresh fruits and rotten fruits. In the proposed work, we inspected the transfer learning methods in the classification of fresh and rotten fruits. The performance of the proposed CNN model outperforms the transfer learning models and the state of art methods.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Young-Gon Kim ◽  
Sungchul Kim ◽  
Cristina Eunbee Cho ◽  
In Hye Song ◽  
Hee Jin Lee ◽  
...  

AbstractFast and accurate confirmation of metastasis on the frozen tissue section of intraoperative sentinel lymph node biopsy is an essential tool for critical surgical decisions. However, accurate diagnosis by pathologists is difficult within the time limitations. Training a robust and accurate deep learning model is also difficult owing to the limited number of frozen datasets with high quality labels. To overcome these issues, we validated the effectiveness of transfer learning from CAMELYON16 to improve performance of the convolutional neural network (CNN)-based classification model on our frozen dataset (N = 297) from Asan Medical Center (AMC). Among the 297 whole slide images (WSIs), 157 and 40 WSIs were used to train deep learning models with different dataset ratios at 2, 4, 8, 20, 40, and 100%. The remaining, i.e., 100 WSIs, were used to validate model performance in terms of patch- and slide-level classification. An additional 228 WSIs from Seoul National University Bundang Hospital (SNUBH) were used as an external validation. Three initial weights, i.e., scratch-based (random initialization), ImageNet-based, and CAMELYON16-based models were used to validate their effectiveness in external validation. In the patch-level classification results on the AMC dataset, CAMELYON16-based models trained with a small dataset (up to 40%, i.e., 62 WSIs) showed a significantly higher area under the curve (AUC) of 0.929 than those of the scratch- and ImageNet-based models at 0.897 and 0.919, respectively, while CAMELYON16-based and ImageNet-based models trained with 100% of the training dataset showed comparable AUCs at 0.944 and 0.943, respectively. For the external validation, CAMELYON16-based models showed higher AUCs than those of the scratch- and ImageNet-based models. Model performance for slide feasibility of the transfer learning to enhance model performance was validated in the case of frozen section datasets with limited numbers.


2021 ◽  
Vol 11 (6) ◽  
pp. 2838
Author(s):  
Nikitha Johnsirani Venkatesan ◽  
Dong Ryeol Shin ◽  
Choon Sung Nam

In the pharmaceutical field, early detection of lung nodules is indispensable for increasing patient survival. We can enhance the quality of the medical images by intensifying the radiation dose. High radiation dose provokes cancer, which forces experts to use limited radiation. Using abrupt radiation generates noise in CT scans. We propose an optimal Convolutional Neural Network model in which Gaussian noise is removed for better classification and increased training accuracy. Experimental demonstration on the LUNA16 dataset of size 160 GB shows that our proposed method exhibit superior results. Classification accuracy, specificity, sensitivity, Precision, Recall, F1 measurement, and area under the ROC curve (AUC) of the model performance are taken as evaluation metrics. We conducted a performance comparison of our proposed model on numerous platforms, like Apache Spark, GPU, and CPU, to depreciate the training time without compromising the accuracy percentage. Our results show that Apache Spark, integrated with a deep learning framework, is suitable for parallel training computation with high accuracy.


Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2648
Author(s):  
Muhammad Aamir ◽  
Tariq Ali ◽  
Muhammad Irfan ◽  
Ahmad Shaf ◽  
Muhammad Zeeshan Azam ◽  
...  

Natural disasters not only disturb the human ecological system but also destroy the properties and critical infrastructures of human societies and even lead to permanent change in the ecosystem. Disaster can be caused by naturally occurring events such as earthquakes, cyclones, floods, and wildfires. Many deep learning techniques have been applied by various researchers to detect and classify natural disasters to overcome losses in ecosystems, but detection of natural disasters still faces issues due to the complex and imbalanced structures of images. To tackle this problem, we propose a multilayered deep convolutional neural network. The proposed model works in two blocks: Block-I convolutional neural network (B-I CNN), for detection and occurrence of disasters, and Block-II convolutional neural network (B-II CNN), for classification of natural disaster intensity types with different filters and parameters. The model is tested on 4428 natural images and performance is calculated and expressed as different statistical values: sensitivity (SE), 97.54%; specificity (SP), 98.22%; accuracy rate (AR), 99.92%; precision (PRE), 97.79%; and F1-score (F1), 97.97%. The overall accuracy for the whole model is 99.92%, which is competitive and comparable with state-of-the-art algorithms.


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