A Novel 4H-Chromen-4-One Derivative from Marine Streptomyces ovatisporus S4702T as Potential Antibacterial and Anti-Cancer Agent

2021 ◽  
Vol 21 ◽  
Author(s):  
Aslıhan Kurt-Kızıldoğan ◽  
Neslihan Akarsu ◽  
Çiğdem Otur ◽  
Arif Kivrak ◽  
Nevroz Aslan-Ertas ◽  
...  
Keyword(s):  
Micrococcus Luteus ◽  
Chemical Characterization ◽  
Bioactive Compound ◽  
Human Colon ◽  
Cytotoxic Activities ◽  
Human Embryonic Kidney Cells ◽  
Anti Cancer ◽  
Cancer Agent ◽  
Bioactive Potential

Background: Marine actinomycetes are among indispensable sources of natural bioactive compounds with unique antimicrobial and anti-cancer activities. Objective: Herein, it was aimed to elucidate bioactive potential of a marine-derived Streptomyces ovatisporus S4702T, isolated previously. Methods: Streptomyces ovatisporus S4702T was cultured in N-Z Amine broth and extraction was carried out using different organic solvents. Bioassay guided purification was followed by chemical characterization using NMR and LC-MS/MS. The compound was then evaluated for its antibacterial, antioxidant and cytotoxic activities. Results: Etyl acetate extracts gave the highest antibacterial activity and chemical characterization of this extract indicated the formula as C15H29O5N3 and the corresponding possible molecular structure as 4H-chromen-4-one derivative. It was found highly potent against Bacillus subtilis ATCC 6633 (MIC: 0.25 µg ml-1) and Micrococcus luteus ATCC 9341 (MBC: 0.5 µg ml-1). It has no remarkable antioxidant activity, but higher EC50 value and less cytotoxicity against normal cells. The EC50 values of this chromen derivative were found as 9.68 µg ml-1 for human colon carcinoma, 9.93 µg ml-1 for human prostate adenocarcinoma and 25.5 µg ml-1 for human embryonic kidney cells. Conclusion: Overall, the presented 4H-chromen-4-one derivative is a remarkable bioactive compound with potent antibacterial and cytotoxic activity. With its high bioactive potential, it is proposed as a good candidate in medicine.

scholarly journals ISOLATION AND CHEMICAL CHARACTERIZATION OF VOLATILE OILS OF CENTRATHERUM ANTHELMINTICUM AND CITRUS AURANTIFOLIA

2019 ◽  
Vol 1 (1) ◽  
pp. 06-09
Author(s):  
Shweta Srivastava
Keyword(s):  
Essential Oils ◽  
Antioxidant Properties ◽  
Chemical Characterization ◽  
Volatile Oil ◽  
Daily Consumption ◽  
Citrus Aurantifolia ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Centratherum Anthelminticum

Introduction: Centratherum anthelminticum is an ethnomedicinal plant in India and a common ingredient in Ayurvedic formulations. The pharmacological effects of C. anthelminticum ranges from anti-oxidant, anti-diabetic, anti-microbial to recently found anti-cancer activity. Citrus aurantifolia (Rutaceae) is mainly used in daily consumption, in many cultural cuisines, and in juice production. It is widely used because of its antibacterial, anticancer, antidiabetic, antifungal, anti-hypertensive, anti-inflammation, anti-lipidemia, and antioxidant properties. Objective: To isolate and identify the compounds in the essential oils from the seeds of C. anthelminticum Kuntz and peels of C. aurantifolia (Christm.) swingle collected from the Delhi NCR region. Materials and Methods: The essential oils from seeds of C. anthelminticum Kuntz and peels of C. aurantifolia were extracted by steam distillation and analyzed by gas chromatograph and gas chromatography–mass spectrometer. Results: Chemical characterization of the volatile oil and seeds of C. anthelminticum Kuntz showed that the oil is greenish and semi viscous. The major component of the oil was found to be beta-caryophyllene (64.43%), beta-pinene (9.81%), alpha-humulene (4.64%), caryophyllene oxide (2.24%), gamma-elemene (1.73%), limonene (1.48%) and myrecene (0.11%). Whereas the major constituents of volatile oil from peels of C. aurantifolia comprises of twenty nine components viz.  sesquiterpne alcohols (20.68%) including  Globulol, Hurmularel, 6 - dien - 3 - ol. (-) -Spathulenol, ledol,alpha-bisabolol, - (-) Spathulenol and Sesquíterpene esters (20.68%), caryophyllene, alpha- Farnesene, alpha-Caryophylline, gamma -elemene, gamma-.neoclovene, monoterpene alcohol (13.79%). Conclusion: The present study revealed the chemical composition of essential oils of both the drugs under study which can be used as references in the food, pharmaceutical and cosmetic industries.

A review of eugenol-based nanomedicine: Recent Advancements

2020 ◽  
Vol 16 ◽  
Author(s):  
Mohammed Asadullah Jahangir ◽  
Mohamad Taleuzzaman ◽  
Sarwar Beg ◽  
Surajpal Verma ◽  
Sadaf Jamal Gilani ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Chemical Properties ◽  
Aqueous Solubility ◽  
Bioactive Compound ◽  
Anti Cancer ◽  
Herbal Plants ◽  
Cancer Agent ◽  
Therapeutic Activities ◽  
Different Sources ◽  
Holy Basil

: Eugenol is a bioactive compound frequently available in many herbal plants. The different sources reported for eugenol are clove, cinnamon, holy basil, and pepper. There are several therapeutic activities reported for eugenol as antioxidant, antimicrobial, anesthetic, antiinflammatory, anti-carcinogenic, neuroprotective agent, anti-diabetic and anti-cancer agent. However, due to limited aqueous solubility they have poor bioavailability. Their therapeutic potential has been enhanced with the eugenol nano-formulations developed as liposome, nanoparticles, microemulsions and micelles. This article extensively reviews the chemical properties, pharmacological properties, andeugenol nano-formulations with their biological activity.

scholarly journals CHEMICAL CHARACTERIZATION AND EVALUATION OF ANTIBACTERIAL, ANTIFUNGAL, ANTIMYCOBACTERIAL, AND CYTOTOXIC ACTIVITIES OF Talinum paniculatum

2015 ◽  
Vol 57 (5) ◽  
pp. 397-405 ◽  
Author(s):  
Luis F.C. DOS REIS ◽  
Cláudio D. CERDEIRA ◽  
Bruno F. DE PAULA ◽  
Jeferson J. da SILVA ◽  
Luiz F.L. COELHO ◽  
...  
Keyword(s):  
Micrococcus Luteus ◽  
Folk Medicine ◽  
Chemical Characterization ◽  
Antimycobacterial Activity ◽  
Cytotoxic Activities ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Low Toxicity ◽  
Diffusion Assay

SUMMARY In this study, the bioactivity of Talinum paniculatum was evaluated, a plant widely used in folk medicine. The extract from the T. paniculatum leaves (LE) was obtained by percolation with ethanol-water and then subjecting it to liquid-liquid partitions, yielding hexane (HX), ethyl acetate (EtOAc), butanol (BuOH), and aqueous (Aq) fractions. Screening for antimicrobial activity of the LE and its fractions was evaluated in vitro through broth microdilution method, against thirteen pathogenic and non-pathogenic microorganisms, and the antimycobacterial activity was performed through agar diffusion assay. The cytotoxic concentrations (CC90) for LE, HX, and EtOAc were obtained on BHK-21 cells by using MTT reduction assay. The LE showed activity against Serratia marcescens and Staphylococcus aureus, with Minimum Inhibitory Concentration (MIC) values of 250 and 500 µg/mL, respectively. Furthermore, HX demonstrated outstanding activity against Micrococcus luteus and Candida albicans with a MIC of 31.2 µg/mL in both cases. The MIC for EtOAc also was 31.2 µg/mL against Escherichia coli. Conversely, BuOH and Aq were inactive against all tested microorganisms and LE proved inactive against Mycobacterium tuberculosisand Mycobacterium bovisas well. Campesterol, stigmasterol, and sitosterol were the proposed structures as main compounds present in the EF and HX/EtOAc fractions, evidenced by mass spectrometry. Therefore, LE, HX, and EtOAc from T. paniculatumshowed potential as possible sources of antimicrobial compounds, mainly HX, for presenting low toxicity on BHK-21 cells with excellent Selectivity Index (SI = CC90/MIC) of 17.72 against C. albicans.

New perspectives into the chemical characterization of Sida acuta Burm. f. extracts with respect to its anti-cancer, antioxidant and enzyme inhibitory effects

2021 ◽  
Author(s):  
Sengul Uysal ◽  
Reneta Gevrenova ◽  
Kouadio Ibrahime Sinan ◽  
Aslı Ugurlu Bayarslan ◽  
Yasemin Celik Altunoglu ◽  
...  
Keyword(s):  
Chemical Characterization ◽  
Inhibitory Effects ◽  
Sida Acuta ◽  
Anti Cancer

scholarly journals ETHNO-MEDICINAL POTENTIALS AND PHYTOCHEMICAL PROPERTIES OF Aloe vera: A REVIEW

2019 ◽  
Vol 5 (1) ◽  
pp. 57-73
Author(s):  
John Adewole Alara ◽  
Oluwaseun Ruth Alara
Keyword(s):  
Analytical Chemistry ◽  
Side Effect ◽  
Aloe Vera ◽  
Chemical Characterization ◽  
Adverse Side Effect ◽  
Laboratory Equipment ◽  
Food Industries ◽  
Positive Effects ◽  
Bioactive Potential

Aloe vera is a perennial ethno-medicinal potential plant with a xerophytic characteristic, but not a cactus. It has a famous history owing to its phytopharmaceutical properties and this had made it useful in the pharmaceutical, cosmetic and food industries. Studies had shown the positive effects of its extract against bacteria, organisms. The phytochemical properties of A. vera have fungi, virus and parasitic been exploited for various economic and commercial purposes. This review contributes literature on the bioactive potential composition, processing and the pharmaceutical potential uses, an adverse side-effect that might spring up in case of over dosage and important safety precautions are summarized. More scientific innovations and developments in the aspect of analytical chemistry are on the way to provide more acceptable, purified chemical characterization of A. vera using sophisticated laboratory equipment and machines.

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