A review of eugenol-based nanomedicine: Recent Advancements

: Eugenol is a bioactive compound frequently available in many herbal plants. The different sources reported for eugenol are clove, cinnamon, holy basil, and pepper. There are several therapeutic activities reported for eugenol as antioxidant, antimicrobial, anesthetic, antiinflammatory, anti-carcinogenic, neuroprotective agent, anti-diabetic and anti-cancer agent. However, due to limited aqueous solubility they have poor bioavailability. Their therapeutic potential has been enhanced with the eugenol nano-formulations developed as liposome, nanoparticles, microemulsions and micelles. This article extensively reviews the chemical properties, pharmacological properties, andeugenol nano-formulations with their biological activity.

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Development of Small-Molecule STING Activators for Cancer Immunotherapy

Biomedicines ◽

10.3390/biomedicines10010033 ◽

2021 ◽

Vol 10 (1) ◽

pp. 33

Author(s):

Hee Ra Jung ◽

Seongman Jo ◽

Min Jae Jeon ◽

Hyelim Lee ◽

Yeonjeong Chu ◽

...

Keyword(s):

Cancer Immunotherapy ◽

Cyclic Gmp ◽

Therapeutic Potential ◽

Interferon Response ◽

Type I ◽

Anti Cancer ◽

Cancer Agent ◽

Sting Pathway

In cancer immunotherapy, the cyclic GMP–AMP synthase–stimulator of interferon genes (STING) pathway is an attractive target for switching the tumor immunophenotype from ‘cold’ to ‘hot’ through the activation of the type I interferon response. To develop a new chemical entity for STING activator to improve cyclic GMP-AMP (cGAMP)-induced innate immune response, we identified KAS-08 via the structural modification of DW2282, which was previously reported as an anti-cancer agent with an unknown mechanism. Further investigation revealed that direct STING binding or the enhanced phosphorylation of STING and downstream effectors were responsible for DW2282-or KAS-08-mediated STING activity. Furthermore, KAS-08 was validated as an effective STING pathway activator in vitro and in vivo. The synergistic effect of cGAMP-mediated immunity and efficient anti-cancer effects successfully demonstrated the therapeutic potential of KAS-08 for combination therapy in cancer treatment.

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A Novel 4H-Chromen-4-One Derivative from Marine Streptomyces ovatisporus S4702T as Potential Antibacterial and Anti-Cancer Agent

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520621666210311085748 ◽

2021 ◽

Vol 21 ◽

Author(s):

Aslıhan Kurt-Kızıldoğan ◽

Neslihan Akarsu ◽

Çiğdem Otur ◽

Arif Kivrak ◽

Nevroz Aslan-Ertas ◽

...

Keyword(s):

Micrococcus Luteus ◽

Chemical Characterization ◽

Bioactive Compound ◽

Human Colon ◽

Cytotoxic Activities ◽

Human Embryonic Kidney Cells ◽

Anti Cancer ◽

Cancer Agent ◽

Bioactive Potential

Background: Marine actinomycetes are among indispensable sources of natural bioactive compounds with unique antimicrobial and anti-cancer activities. Objective: Herein, it was aimed to elucidate bioactive potential of a marine-derived Streptomyces ovatisporus S4702T, isolated previously. Methods: Streptomyces ovatisporus S4702T was cultured in N-Z Amine broth and extraction was carried out using different organic solvents. Bioassay guided purification was followed by chemical characterization using NMR and LC-MS/MS. The compound was then evaluated for its antibacterial, antioxidant and cytotoxic activities. Results: Etyl acetate extracts gave the highest antibacterial activity and chemical characterization of this extract indicated the formula as C15H29O5N3 and the corresponding possible molecular structure as 4H-chromen-4-one derivative. It was found highly potent against Bacillus subtilis ATCC 6633 (MIC: 0.25 µg ml-1) and Micrococcus luteus ATCC 9341 (MBC: 0.5 µg ml-1). It has no remarkable antioxidant activity, but higher EC50 value and less cytotoxicity against normal cells. The EC50 values of this chromen derivative were found as 9.68 µg ml-1 for human colon carcinoma, 9.93 µg ml-1 for human prostate adenocarcinoma and 25.5 µg ml-1 for human embryonic kidney cells. Conclusion: Overall, the presented 4H-chromen-4-one derivative is a remarkable bioactive compound with potent antibacterial and cytotoxic activity. With its high bioactive potential, it is proposed as a good candidate in medicine.

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Eugenol as a potential drug candidate: A review

Current Topics in Medicinal Chemistry ◽

10.2174/1568026621666210701141433 ◽

2021 ◽

Vol 21 ◽

Author(s):

Mohamad Taleuzzaman ◽

Pooja Jain ◽

Rishabh Verma ◽

Zeenat Iqbal ◽

Mohd. Aamir Mirza

Keyword(s):

Chemical Properties ◽

Bioactive Compound ◽

Alcoholic Beverages ◽

Personal Hygiene ◽

Drug Candidate ◽

Drug Products ◽

Physico Chemical ◽

Chewing Gums ◽

Anti Cancer ◽

Baked Foods

: Eugenol is a bioactive compound widely available in many herbs like clove, cinnamon, tulsi, pepper etc. The compound is known for its antioxidant, antimicrobial, anaesthetic, anti-inflammatory, neuroprotective, anti-diabetic, and anti-cancer activities. In pharmaceutical analysis, eugenol is used as a marker for single drugs and drug products. Dental care, household, and personal hygiene products are other areas where it has established its potential. In the food industry, eugenol is used as a flavouring agent in non-alcoholic beverages, baked foods, and chewing gums. Considering the huge potential of eugenol, this review is an attempt to collate the regulatory information, physico-chemical properties, toxicity profile, marketed conventional and novel formulations, analytical methods, extraction procedures, recent patents and clinical trials of the moiety. Based on the literature survey, a schematic diagram of the mechanism of action has also been made.

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Abstract C218: Novel therapeutic potential in targeting micro tubules by naturally occurring anti cancer agent withaferin A in human cancers.

10.1158/1535-7163.targ-11-c218 ◽

2011 ◽

Author(s):

Kamalini Ghosh ◽

Sumita Sengupta

Keyword(s):

Therapeutic Potential ◽

Withaferin A ◽

Human Cancers ◽

Naturally Occurring ◽

Anti Cancer ◽

Cancer Agent ◽

Novel Therapeutic

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The Therapeutic Potential of Common Herbal and Nano-Based Herbal Formulations against Ovarian Cancer: New Insight into the Current Evidence

Pharmaceuticals ◽

10.3390/ph14121315 ◽

2021 ◽

Vol 14 (12) ◽

pp. 1315

Author(s):

Fatemeh Rezaei-Tazangi ◽

Hossein Roghani-Shahraki ◽

Mahdi Khorsand Ghaffari ◽

Firoozeh Abolhasani Zadeh ◽

Aynaz Boostan ◽

...

Keyword(s):

Ovarian Cancer ◽

Water Solubility ◽

Therapeutic Potential ◽

Disease Recurrence ◽

Current Evidence ◽

Herbal Products ◽

Anti Cancer ◽

Cancer Agent ◽

Gynecological Disorder ◽

Herbal Formulations

Ovarian cancer (OCa) is characterized as one of the common reasons for cancer-associated death in women globally. This gynecological disorder is chiefly named the “silent killer” due to lacking an association between disease manifestations in the early stages and OCa. Because of the disease recurrence and resistance to common therapies, discovering an effective therapeutic way against the disease is a challenge. According to documents, some popular herbal formulations, such as curcumin, quercetin, and resveratrol, can serve as an anti-cancer agent through different mechanisms. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the contrary, using nano-based material, e.g., nanoparticles (NPs), micelles, liposomes, can significantly solve these limitations. Therefore, in the present study, we will summarize the anti-cancer aspects of these herbal and-nano-based herbal formulations with a focus on their mechanisms against OCa.

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Potential of Zerumbone as an Anti-Cancer Agent

Molecules ◽

10.3390/molecules24040734 ◽

2019 ◽

Vol 24 (4) ◽

pp. 734 ◽

Cited By ~ 30

Author(s):

Sosmitha Girisa ◽

Bano Shabnam ◽

Javadi Monisha ◽

Lu Fan ◽

Clarissa Halim ◽

...

Keyword(s):

Therapeutic Potential ◽

Janus Kinase ◽

Treatment Modalities ◽

Downstream Target ◽

Current Review ◽

Molecular Modulation ◽

Anti Cancer ◽

Medicinal Properties ◽

Cancer Agent ◽

Transcription 3

Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effects, non-specific toxicities, and tumour recurrence. Therefore, there is an immediate need for essential alternative therapeutics, which can prove to be beneficial and safe against cancer. Various phytochemicals from natural sources have been found to exhibit beneficial medicinal properties against various human diseases. Zerumbone is one such compound isolated from Zingiber zerumbet Smith that possesses diverse pharmacological properties including those of antioxidant, antibacterial, antipyretic, anti-inflammatory, immunomodulatory, as well as anti-neoplastic. Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-κB, Akt, and IL-6/JAK2/STAT3 (interleukin-6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins. The current review briefly summarizes the modes of action and therapeutic potential of zerumbone against various cancers.

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