The Effect of Stenotic Geometry and Non-newtonian Property of Blood Flow through Arterial Stenosis

Author(s):  
Somchai Sriyab

Background: A mathematical model of blood flow is a way to study the blood flow behavior. In this research work, a mathematical model of non-Newtonian blood flow through different stenosis, namely bell shape and cosine shape, is considered. The physiologically important flow quantities of blood flow behavior to describe the blood flow phenomena are obtained such as resistance to flow, skin friction and blood flow rate. Methods: Mathematical methods are used to analyze a mathematical model of blood flow through stenosed artery. The resistance to flow, skin friction and blood flow rate were obtained to describe the blood flow in stenosis. The resistance to flow is a relation between pressure and blood flow rate while the skin friction is the friction at the artery membrane. Results: The blood flow in cosine geometry exhibits higher resistance to flow and flow rate than in the bell geometry, while the blood flow in bell geometry gives a higher skin friction than in cosine geometry. Not only the effect of stenotic geometry was studied but also the effect of stenosis depth and stenosis height on the flow quantities Moreover, the power law index was adjusted to explore the non-Newtonian behavior. When blood exhibits Newtonian behavior, the resistance to flow and skin friction decrease but the blood flow rate increases. Conclusion: The stenosed artery geometry, the stenosis length, stenosis depth and the power law index (non-Newtonian behavior) are important factors affecting the blood flow through the stenosed artery. This work provides some potential aspects to further study the causes and development of cardiovascular diseases.

2019 ◽  
Vol 24 (3) ◽  
pp. 645-659 ◽  
Author(s):  
J. Nandal ◽  
S. Kumari ◽  
R. Rathee

Abstract In this analysis, we present a theoretical study to examine the combined effect of both slip velocity and periodic body acceleration on an unsteady generalized non-Newtonian blood flow through a stenosed artery with permeable wall. A constant transverse magnetic field is applied on the peristaltic flow of blood, treating it as an elastico-viscous, electrically conducting and incompressible fluid. Appropriate transformation methods are adopted to solve the unsteady non-Newtonian axially symmetric momentum equation in the cylindrical polar coordinate system with suitably prescribed conditions. To validate the applicability of the proposed analysis, analytical expressions for the axial velocity, fluid acceleration, wall shear stress and volumetric flow rate are computed and for having an adequate insight to blood flow behavior through a stenosed artery, graphs have been plotted with varying values of flow variables, to analyse the influence of the axial velocity, wall shear stress and volumetric flow rate of streaming blood.


2007 ◽  
Vol 07 (03) ◽  
pp. 337-353 ◽  
Author(s):  
J. C. MISRA ◽  
G. C. SHIT

A mathematical model is developed in this paper for studying blood flow through a stenosed arterial segment by taking into account the slip velocity at the wall of the artery. Consideration of the non-Newtonian character of blood is made, where a constitutive relation of blood is described by the Herschel–Bulkley equation. The effect of slip at the arterial wall in the presence of mild, moderate, and severe stenosis growth at the lumen of an artery is investigated. Analytical expressions for skin friction, flow resistance, and the flow rate are derived by using the model. The derived expressions are computed numerically by considering an illustrative example. The study provides an insight into the effects of slip velocity on the volumetric flow rate of blood, flow resistance, and skin friction.


2018 ◽  
Vol 9 (7) ◽  
pp. 871-879
Author(s):  
Rajesh Shrivastava ◽  
R. S. Chandel ◽  
Ajay Kumar ◽  
Keerty Shrivastava and Sanjeet Kumar

1972 ◽  
Vol 50 (8) ◽  
pp. 774-783 ◽  
Author(s):  
Serge Carrière ◽  
Michel Desrosiers ◽  
Jacques Friborg ◽  
Michèle Gagnan Brunette

Furosemide (40 μg/min) was perfused directly into the renal artery of dogs in whom the femoral blood pressure was reduced (80 mm Hg) by aortic clamping above the renal arteries. This maneuver, which does not influence the intrarenal blood flow distribution, produced significant decreases of the urine volume, natriuresis, Ccreat, and CPAH, and prevented the marked diuresis normally produced by furosemide. Therefore the chances that systemic physiological changes occurred, secondary to large fluid movements, were minimized. In those conditions, however, furosemide produced a significant increase of the urine output and sodium excretion in the experimental kidney whereas Ccreat and CPAH were not affected. The outer cortical blood flow rate (ml/100 g-min) was modified neither by aortic constriction (562 ± 68 versus 569 ± 83) nor by the subsequent administration of furosemide (424 ± 70). The blood flow rate of the outer medulla in these three conditions remained unchanged (147 ± 52 versus 171 ± 44 versus 159 ± 54). The initial distribution of the radioactivity in each compartment remained comparable in the three conditions. In parallel with the results from the krypton-85 disappearance curves, the autoradiograms, silicone rubber casts, and EPAH did not suggest any change in the renal blood flow distribution secondary to furosemide administration.


1983 ◽  
Vol 6 (3) ◽  
pp. 127-130 ◽  
Author(s):  
C. Woffindin ◽  
N.A. Hoenich ◽  
D.N.S. Kerr

Data collected during the evaluation of a series of hemodialysers were analysed to see the effect of hematocrit on the clearance of urea and creatinine. All evaluations were performed on patients with a range of hematocrits with a mean close to 20%. The urea clearance of those in the upper half of the distribution curve (mean hematocrit 29.4%) was not significantly different from that of patients in the lower half of the distribution curve (mean hematocrit 16.9%) whether the clearance was studied at high or low blood flow rates and with hollow fibre or flat plate disposable hemodialysers. Likewise, there was no correlation between hematocrit and urea clearance by regression analysis. In contrast, the clearance of creatinine was affected by hematocrit being greater at lower hematocrit values. This difference was independent of blood flow rate and dialyser type and was confirmed by regression analysis.


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