Propitious Profile of Peppery Piperine

2020 ◽  
Vol 13 ◽  
Author(s):  
Harman Bakshi ◽  
Manju Nagpal ◽  
Manjinder Singh ◽  
Gitika Arora Dhingra ◽  
Geeta Aggarwal
Keyword(s):  
Pharmacological Activities ◽  
Drug Molecules ◽  
Anti Cancer ◽  
The Common ◽  
Toxic Potential ◽  
Receptor Targets ◽  
Therapeutic Activities ◽  
Potential Area ◽  
Therapeutic Profile

Background: Piperine is a key bioactive alkaloid found in plants of piperaceae family. The compound possesses various medicinal and pharmacological activities (cholesterol lowering, anti cancer, alzheimer’s disease etc). Owing to its various target receptors (TRPV1, P-gp, CYP3A4 etc.) and several mechanisms, piperine has been studied as bio-enhancer for other drugs and its role has been evidenced in literature. When administered with other drugs, it increases absorption of other drugs thereby reducing the dose and dose related toxic potential. There are various mechanisms of piperine as a bio-enhancer and the common ones are i) prevention of efflux of drug molecules out of the cells; ii) decreased metabolism of drugs thereby prolonging half-life of drugs resulting in reduced urinary excretion. The detailed mechanism indicating bio-enhancing role of piperine along with various target receptors have not been comprehensively summarised till date. Methods: Literature related to the molecular, enzymatic and receptor targets of piperine were studied and database was collected using various search engines such as j-gate, google scholar, scihub, pubmed, sciencedirect etc. The literature related to therapeutic activities of piperine and its bio-enhancer role for other drugs has been thoroughly studied and compiled in brief. Results: A detailed summary of piperine targets along with related mechanisms has been stated. A brief therapeutic profile of piperine alone has been produced with supporting literature. Piperine role as a potential bio-enhancer for other drugs has been summarized. Conclusion: Piperine is fascinating molecule of natural origin with several modes of its action, not only possess its own therapeutic activity but also enhances the therapeutic efficacy of other synthetic and natural drug molecules. Combination dosage forms of various API incorporating piperine as a bio-enhancer can be potential area of thrust for upcoming drug design and development.

scholarly journals The role of the common gamma-chain family cytokines in γδ T cell-based anti-cancer immunotherapy

2018 ◽  
Vol 41 ◽  
pp. 54-64 ◽  
Author(s):  
Heleen H. Van Acker ◽  
Diana Campillo-Davo ◽  
Gils Roex ◽  
Maarten Versteven ◽  
Evelien L. Smits ◽  
...  
Keyword(s):  
T Cell ◽  
Cancer Immunotherapy ◽  
Γδ T Cell ◽  
Gamma Chain ◽  
Common Gamma Chain ◽  
Anti Cancer ◽  
The Common

scholarly journals Pharmacological Role of Ostericum koreanum: A Short Viewpoint

2021 ◽  
Vol 16 (10) ◽  
pp. 1934578X2110507
Author(s):  
Narges Hosseini Nasab ◽  
Fahad Hassan Shah ◽  
Song Ja Kim
Keyword(s):  
Pharmacological Activity ◽  
Asian Countries ◽  
Pharmacological Activities ◽  
Respiratory Problems ◽  
Chinese Herbal ◽  
Anti Cancer ◽  
Ostericum Koreanum ◽  
Phytochemical Constituents ◽  
Rich Content

Ostericum koreanum Maxim., a perennial medicinal plant native to Asian countries, is traditionally exploited in Korean Oriental and Chinese Herbal Medicine. It has been used in the treatment of neuralgia, respiratory problems, and joint pain due to its rich content of phytochemicals. Therefore, the significant role of compounds present in O. koreanum should not be overlooked to explore and develop drugs against diseases. The purpose of this review is to provide a reference for researchers and to describe the phytochemical constituents and pharmacological activity of O. koreanum. In this mini review, we have collected the data from 1980 to 2020 regarding the phytochemicals present and pharmacological activities of this plant. Our findings indicated that this plant possesses a rich source of phytochemicals that have significant pharmacological activities, such as anti-microbial, anti-inflammatory, anti-pyretic, anti-influenza, anti-cancer, and neuroprotective. These phytochemicals have promising pharmacological activity which should be further explored for the treatment of various diseases.

Salidroside - Can it be a Multifunctional Drug?

2020 ◽  
Vol 21 (7) ◽  
pp. 512-524
Author(s):  
Sri Krishna Jayadev Magani ◽  
Sri Durgambica Mupparthi ◽  
Bhanu Prakash Gollapalli ◽  
Dhananjay Shukla ◽  
AK Tiwari ◽  
...  
Keyword(s):  
Biological Activities ◽  
Neuroprotective Activity ◽  
Pharmacological Activities ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Target Molecules ◽  
Medicinal Properties ◽  
Therapeutic Activities ◽  
Near Future ◽  
Phase I And Ii

Background: Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. It exhibits diverse biological and pharmacological properties. In the last decade, enormous research is conducted to explore the medicinal properties of salidroside; this research reported many activities like anti-cancer, anti-oxidant, anti-aging, anti-diabetic, anti-depressant, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, etc. Objective: Despite its multiple pharmacological effects, a comprehensive review detailing its metabolism and therapeutic activities is still missing. This review aims to provide an overview of the metabolism of salidroside, its role in alleviating different metabolic disorders, diseases and its molecular interaction with the target molecules in different conditions. This review mostly concentrates on the metabolism, biological activities and molecular pathways related to various pharmacological activities of salidroside. Conclusion: Salidroside is produced by a three-step pathway in the plants with tyrosol as an intermediate molecule. The molecule is biotransformed into many metabolites through phase I and II pathways. These metabolites, together with a certain amount of salidroside may be responsible for various pharmacological functions. The salidroside based inhibition of PI3k/AKT, JAK/ STAT, and MEK/ERK pathways and activation of apoptosis and autophagy are the major reasons for its anti-cancer activity. AMPK pathway modulation plays a significant role in its anti-diabetic activity. The neuroprotective activity was linked with decreased oxidative stress and increased antioxidant enzymes, Nrf2/HO-1 pathways, decreased inflammation through suppression of NF-κB pathway and PI3K/AKT pathways. These scientific findings will pave the way to clinically translate the use of salidroside as a multi-functional drug for various diseases and disorders in the near future.

scholarly journals Anti-Cancer Activity of Andrographolide: A Review

2021 ◽  
pp. 1-9
Author(s):  
Vishwanadham Yerragunta ◽  
Kavita Waghray ◽  
. Shivraj ◽  
N. J. P. Subhashini
Keyword(s):  
Biological Activities ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Cytotoxic Effects ◽  
Research Activities ◽  
Anti Cancer ◽  
Research Findings ◽  
Anti Oxidant ◽  
Anti Inflammation

Andrographolide, is a chemical compound obtained from the Andrographis paniculata (Family- Acanthaceae), maybe a diterpene lactone ring is responsible for various biological activities like anti-inflammation, anti-microbial anti-cancer, anti-obesity, anti-diabetes, anti-oxidant immunomodulatory, antiseptic, hypolipidemic, cardioprotective, hepatoprotective, neuroprotective effects and other biological activities. In Current research activities worldwide to exhibit the beneficial role of Andrographolide are continuously enriching the therapeutic arsenal of this important Phyto molecule. For this purpose, several databases were accustomed explore for the anticancer/cytotoxic effects of the andrographolide in pre-clinical and clinical studies. During this report, an attempt has been given to spotlight the research findings, related to therapeutic potentials and up-to-date development within the pharmacological activities of andrographolide. Andrographolide is often one of the potential agents within the treatment of cancer.

scholarly journals Therapeutic Role of Ginger (Zingiber officinale) - A Review

2021 ◽  
pp. 9-16
Author(s):  
Tahreem Kausar ◽  
Sadaf Anwar ◽  
Entesar Hanan ◽  
Mifftha Yaseen ◽  
Shimaa M. H. Aboelnaga ◽  
...  
Keyword(s):  
Antioxidant Properties ◽  
Zingiber Officinale ◽  
Lipid Lowering ◽  
Pharmacological Properties ◽  
Home Remedy ◽  
Anti Cancer ◽  
The Family ◽  
Therapeutic Properties ◽  
The Common

Ginger (Zingiber officinale) is a common kitchen spice that belongs to the family Zingiberaceae. It is rich in phytochemistry that is promoting health benefits.  It is used as a home remedy to support the common cold, headaches, and pharmacological properties such as anti-inflammatory, antioxidant, antiemetic, antiulcer, and anti-cancer, antiplatelet, anti-diabetic and lipid-lowering activities. Gingerols are key ingredients found in ginger that convert into zingerone, shogaol, and parasols, giving flavor and odor. Zingerone and shogaol are present in limited quantities in fresh ginger and more in dried or extracted goods. Especially 6-gingerol and 6-shogaol  are pharmacological properties that are effective in antipyretic, analgesic, and hypotensive. The present review is about different therapeutic properties of ginger, including antioxidant properties, anti-diabetic properties, anti-cancer properties etc.

Review on the Role of the Metal Catalysts in the Synthesis of Pharmacologically Important Quinoline Substrate

2019 ◽  
Vol 16 (7) ◽  
pp. 631-652 ◽  
Author(s):  
Akhil Mahajan ◽  
Tejpal Singh Chundawat
Keyword(s):  
Driving Force ◽  
Antimalarial Activity ◽  
Coal Tar ◽  
Biologically Active ◽  
Metal Catalyst ◽  
Quinoline Derivatives ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Therapeutic Activities

Quinoline stands out amongst the most essential N-based heterocyclic biologically active compounds. Friedlieb Ferdinand Runge was first to isolate quinoline from coal tar in 1834. Chemical component, quinine found in the bark of cinchona tree was used for treatment of malaria in the year of 1820. Quinoline derivatives have been found to exhibit different therapeutic activities such as antimalarial, antibacterial, antifungal, antiplatelet, anticancer, antitubercular, etc. There are a couple of promising compounds with the Quinoline skeleton like Pamaquine, Chloroquine, Tafenoquine, Bulaquine, Quinine and Mefloquine which show Antimalarial activity. All the methodologies in last decade had been covered to provide a comprehensive review on the development of Quinoline analogs using metal catalyst. Since quinoline and its auxiliaries have extensive pharmacological activities and are moreover utilized as ligands in various metal complexes, various procedures have been now and again reported for their synthesis. We have tried here undertaking to collect a huge part of the procedure that has been represented in the written work by use of metal driving force. This review will be especially profitable to the examiner in quick exploring and developing another ecopleasing, capable and judicious protocol.

On everyday academic research

2017 ◽  
pp. 98-134 ◽  
Author(s):  
J. Tirole
Keyword(s):  
Common Good ◽  
Academic Research ◽  
Research Quality ◽  
Economic Research ◽  
Relevant Research ◽  
The Common ◽  
Verification Of Models ◽  
Science And Research

In the fourth chapter of the book “The economy of the common good”, the nature of economics as a science and research practices in their theoretical and empirical aspects are discussed. The author considers the processes of modeling, empirical verification of models and evaluation of research quality. In addition, the features of economic cognition and the role of mathematics in economic research are analyzed, including the example of relevant research in game theory and information theory.

Contemplative Principles of a Non-dual Praxis: the Unmediated Practices of the Tibetan ‘Heart Essence’ (sNying thig) Tradition

2015 ◽  
Vol 31 (2) ◽  
pp. 215-240
Author(s):  
Eran Laish
Keyword(s):  
Contemplative Practice ◽  
Tibetan Buddhist ◽  
Buddhist Tradition ◽  
The Common

This article focuses on the main contemplative principles of the ‘Heart Essence’ (sNying thig), a Tibetan Buddhist tradition that is characterized by a vision of non-duality and primordial wholeness. Due to this vision, which asserts an original reality that is not divided into perceiving subject and perceived object, the ‘Heart Essence’ advocates a contemplative practice that undermines the usual intuitions of temporality and enclosed selfhood. Hence, unlike the common principles of intentional praxis, such as deliberate concentration and gradual purification, the ‘Heart Essence’ affirms four contemplative principles of non-objectiveness, openness, spontaneity and singleness. As these principles transcend intentionality, temporality, and multiplicity, they are seen to directly disclose the nature of primordial awareness, in which the meanings of knowing and being are radically transformed. Therefore, the article will also consider the role of these non-dual contemplative principles in deeply changing our understanding of being and knowing alike.

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