Review on the Role of the Metal Catalysts in the Synthesis of Pharmacologically Important Quinoline Substrate

2019 ◽  
Vol 16 (7) ◽  
pp. 631-652 ◽  
Author(s):  
Akhil Mahajan ◽  
Tejpal Singh Chundawat
Keyword(s):  
Driving Force ◽  
Antimalarial Activity ◽  
Coal Tar ◽  
Biologically Active ◽  
Metal Catalyst ◽  
Quinoline Derivatives ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Therapeutic Activities

Quinoline stands out amongst the most essential N-based heterocyclic biologically active compounds. Friedlieb Ferdinand Runge was first to isolate quinoline from coal tar in 1834. Chemical component, quinine found in the bark of cinchona tree was used for treatment of malaria in the year of 1820. Quinoline derivatives have been found to exhibit different therapeutic activities such as antimalarial, antibacterial, antifungal, antiplatelet, anticancer, antitubercular, etc. There are a couple of promising compounds with the Quinoline skeleton like Pamaquine, Chloroquine, Tafenoquine, Bulaquine, Quinine and Mefloquine which show Antimalarial activity. All the methodologies in last decade had been covered to provide a comprehensive review on the development of Quinoline analogs using metal catalyst. Since quinoline and its auxiliaries have extensive pharmacological activities and are moreover utilized as ligands in various metal complexes, various procedures have been now and again reported for their synthesis. We have tried here undertaking to collect a huge part of the procedure that has been represented in the written work by use of metal driving force. This review will be especially profitable to the examiner in quick exploring and developing another ecopleasing, capable and judicious protocol.

Advancement in Pharmacological Activities of Benzothiazole and its Derivatives:An Up to Date Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Sumit ◽  
Arvind Kumar ◽  
Arun Kumar Mishra
Keyword(s):  
Molecular Structures ◽  
Biologically Active ◽  
Future Research ◽  
Thiazole Ring ◽  
Bicyclic Compound ◽  
Pharmacological Activities ◽  
Broad Variety ◽  
Bioactive Heterocycles ◽  
Available Information ◽  
Therapeutic Activities

: Benzothiazole is a heterocyclic aromatic and bicyclic compound in which, benzene ring is attached with thiazole ring. This nucleus is established in marine as well as terrestrial natural compounds. The benzothiazole skeleton is established in a broad variety of bioactive heterocycles and natural products. The benzothiazole nucleus is considered as the principle moiety in several biologically active compounds. Thus, over the decade, chemists are more and more paying attention towards the revision on the biological and therapeutic activities such including antimicrobial, analgesic, antininflammatory, antitubercular, antiviral and antioxidant of benzothiazole containing compounds. Additionally, the molecular structures of a number of potent drugs including Frentizole, Pramipexole, Thioflavin T and Riluzole etc are based on benzothiazole skeleton. The present work is the compilation and presentation of all available information in a systematic manner with an aim to present the findings in a way, which may be beneficial for future research.

Aryltetralin-type lignan of Podophyllum: a comprehensive review

2021 ◽  
Vol 11 ◽  
Author(s):  
Dharmendra Kumar ◽  
Mogana Rajagopal ◽  
Gabriel Akyirem Akowuah ◽  
Yong-Xin Lee ◽  
Chua Wei Chong ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Chemical Synthesis ◽  
Chemical Modification ◽  
Broad Spectrum ◽  
Anticancer Agent ◽  
Review Article ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Podophyllotoxin Derivatives

: Podophyllotoxin is a nonalkaloidtoxin aryltetralin lactone lignan, occurring naturally and extracted from the rhizomes and roots of Podophyllum species. Podophyllotoxin and its derivatives have shown to possess a broad spectrum of pharmacological activities, mainly antineoplastic and antiviral properties. Podophyllotoxin is served as a potential anticancer agent and also the precursor for the chemical synthesis of some clinically important anticancer agents.The chemical modification and pharmacological investigation of podophyllotoxin derivatives have become a concern nowadays. Research interest has been stimulated in the innovation of podophyllotoxin derivatives as the semi-synthetic anticancer agent, especially etoposide and teniposide. Podophyllotoxin and its derivatives are available in several formulations and also found to be effective in combination therapy. This review article aims to provide an overview of the role of podophyllotoxin, its mechanism of action, pharmacological activities, pharmacokinetics, available formulations, and its effects in combination therapy. This article also reviewed the biosynthesis, structure and modifications of podophyllotoxin and its derivatives as an anticancer agent.

Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism

2021 ◽  
Vol 21 ◽  
Author(s):  
Serena Fiorito ◽  
Francesco Epifano ◽  
Lorenzo Marchetti ◽  
Lucia Palumbo ◽  
Ilkay Erdogan Orhan ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Metabolic Disorders ◽  
Sugar Metabolism ◽  
Review Article ◽  
Food Plants ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Beneficial Effects ◽  
Related Compounds

: O-Prenylcoumarins (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural compounds. The most part of these secondary metabolites have been obtained from plant species belonging to the Rutaceae, Apiaceae, andFabaceae families, and from fungi, and bacteria. In the last two decades prenyloxycoumarinshave been found to possess a great potential in terms of pharmacological activities. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about these valuable phytochemicals and structurally related compounds about their modulatory properties of lipid and sugar metabolism. Literature data have been acquired from the main Internet database. Several oxyprenylated secondary metabolites have been surveyed. Among these prenyloxycoumarins represented the main group exerting displayed valuable effects as modulators of lipid and sugar metabolism. The title phytochemicals have been found in common edible and fruits vegetables already known to have beneficial effects to this concern, thus enforcing the nutraceutical role of these food plants. All compounds outlined in the present review article have a great potential for the next future for the prevention and management of acute and chronic metabolic disorders

Propitious Profile of Peppery Piperine

2020 ◽  
Vol 13 ◽  
Author(s):  
Harman Bakshi ◽  
Manju Nagpal ◽  
Manjinder Singh ◽  
Gitika Arora Dhingra ◽  
Geeta Aggarwal
Keyword(s):  
Pharmacological Activities ◽  
Drug Molecules ◽  
Anti Cancer ◽  
The Common ◽  
Toxic Potential ◽  
Receptor Targets ◽  
Therapeutic Activities ◽  
Potential Area ◽  
Therapeutic Profile

Background: Piperine is a key bioactive alkaloid found in plants of piperaceae family. The compound possesses various medicinal and pharmacological activities (cholesterol lowering, anti cancer, alzheimer’s disease etc). Owing to its various target receptors (TRPV1, P-gp, CYP3A4 etc.) and several mechanisms, piperine has been studied as bio-enhancer for other drugs and its role has been evidenced in literature. When administered with other drugs, it increases absorption of other drugs thereby reducing the dose and dose related toxic potential. There are various mechanisms of piperine as a bio-enhancer and the common ones are i) prevention of efflux of drug molecules out of the cells; ii) decreased metabolism of drugs thereby prolonging half-life of drugs resulting in reduced urinary excretion. The detailed mechanism indicating bio-enhancing role of piperine along with various target receptors have not been comprehensively summarised till date. Methods: Literature related to the molecular, enzymatic and receptor targets of piperine were studied and database was collected using various search engines such as j-gate, google scholar, scihub, pubmed, sciencedirect etc. The literature related to therapeutic activities of piperine and its bio-enhancer role for other drugs has been thoroughly studied and compiled in brief. Results: A detailed summary of piperine targets along with related mechanisms has been stated. A brief therapeutic profile of piperine alone has been produced with supporting literature. Piperine role as a potential bio-enhancer for other drugs has been summarized. Conclusion: Piperine is fascinating molecule of natural origin with several modes of its action, not only possess its own therapeutic activity but also enhances the therapeutic efficacy of other synthetic and natural drug molecules. Combination dosage forms of various API incorporating piperine as a bio-enhancer can be potential area of thrust for upcoming drug design and development.

scholarly journals RECENT STRATEGIES FOR EFFICIENT SYNTHESIS AND BIOLOGICAL ACTIVITIES OF COUMARIN-CHALCONE DERIVATIVES

2020 ◽  
pp. 28-37
Author(s):  
SATHISH KUMAR KONIDALA ◽  
VIJAY KOTRA
Keyword(s):  
Antimalarial Activity ◽  
Biological Activities ◽  
Clinical Applications ◽  
Biologically Active ◽  
Efficient Synthesis ◽  
Huge Number ◽  
Pharmacological Activities ◽  
Chalcone Derivatives ◽  
Naturally Occurring ◽  
Anti Inflammatory

Coumarins and chalcones are potential pharmacological and biologically active molecules obtained from natural source. Coumarins have predominant pharmacological activities such as antidiabetic, antitumor, and anti-inflammatory activity. Chalcones are also one of the naturally occurring pharmacologically vital molecules with different activities such as anti-inflammatory, antitumor, antimicrobial, and antimalarial activity. Literature reveals that a huge number of coumarinyl chalcone derivatives have various pharmacological activities. Coumarinyl chalcone derivatives gained more prominence due to their significant biological activities. This work explains the current information about synthesis techniques, pharmacological importance, and clinical applications of coumarinyl chalcone derivatives.

Babchi (Psoralea corylifolia): From a Variety of Traditional Medicinal Application to its Novel Roles in Various Diseases: A Review

2021 ◽  
pp. 238-244
Author(s):  
Habeeba S. Shaikh ◽  
Siddiqua S. Shaikh
Keyword(s):  
Cardiovascular Diseases ◽  
Skin Diseases ◽  
Biologically Active ◽  
Psoralea Corylifolia ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Traditional System ◽  
Pharmacological Aspect ◽  
Biologically Active Compound ◽  
Medicinal Properties

Psoralea corylifolia (Leguminosae) commonly known as babchi or babachi has been used in different traditional system of various aliments since, ancient time. Psoralea corylifolia grow throughout Asia and India or many other countries. This article aims to provide a comprehensive review on the phytochemical and pharmacological aspect of Psoralea corylifolia. In traditional medicine, it has been used in treatment of various diseases such as leucoderma skin diseases, cardiovascular diseases, nephritis, osteoporosis, and cancer vitiligo, poisoning, for conception, caries, deafness, filarial. The stem, seeds, leaves, of this plant containe a variety of biologically active compound such as flavonoids, coumarins, phenols, benzofurans, benzopyrans, quinines, sesquiterpenoids, triterpenoids, steroids, and some other components. Those have varuous medicinal properties. The different part of the plant showed the antimicrobial, antipregnancy, estrogenic, antitumor, antioxidant, and many other pharmacological activities. The article focus on traditional as well as modern use and various activities of the plant.

Economic Growth: New Problems and New Risks

2006 ◽  
pp. 20-37 ◽  
Author(s):  
M. Ershov
Keyword(s):  
Economic Growth ◽  
Foreign Exchange ◽  
Driving Force ◽  
Structural Changes ◽  
Rate Of Growth

The economic growth, which is underway in Russia, raises new questions to be addressed. How to improve the quality of growth, increasing the role of new competitive sectors and transforming them into the driving force of growth? How can progressive structural changes be implemented without hampering the rate of growth in general? What are the main external and internal risks, which may undermine positive trends of development? The author looks upon financial, monetary and foreign exchange aspects of the problem and comes up with some suggestions on how to make growth more competitive and sustainable.

Vitamin D in trichology: a comprehensive review of the role of vitamin D and its receptor in hair and scalp disorders

2020 ◽  
Vol 155 (2) ◽  
Author(s):  
Giovanni Damiani ◽  
Rosalynn Conic ◽  
Gloria Orlando ◽  
Anna Zampetti ◽  
Elena Marinello ◽  
...  
Keyword(s):  
Vitamin D ◽  
Comprehensive Review

A REVIEW ON RECENT ADVANCES IN CHEMISTRY, SYNTHESIS AND BIOLOGICAL APPLICATIONS OF ISATIN DERIVATIVES

2018 ◽  
pp. 16-22
Author(s):  
Shukla PK ◽  
Singh MP ◽  
Patel R
Keyword(s):  
Heterocyclic Compounds ◽  
Biologically Active ◽  
Biological Applications ◽  
Plant Origin ◽  
Recent Past ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Recent Advances ◽  
Biological Aspects ◽  
Isatin Derivatives

Indole and its derivatives have engaged a unique place in the chemistry of nitrogen heterocyclic compounds. The recognition of the plant growthhormone, heteroauxin, the significant amino acids, tryptamine & tryptophan and anti-inflammatory drug, indomethacine are the imperativederivatives of indole which have added stimulus to this review work. Isatin (1H-indole-2,3-dione), an indole derivative of plant origin. Althoughit is a naturally occurring compound, but was synthesized by Erdmann and Laurent in 1840 before it was found in nature. Isatin is a versatileprecursor for many biologically active molecules and its diversified nature makes it a versatile substrate for further modifications. It is concernedin many pharmacological activities like anti-malarial, antiviral, anti-allergic, antimicrobial etc; isatin and its derivatives have been also found todemonstrate promising outcomes against various cancer cell lines. This review provides a brief overview on the recent advances and futureperspectives on chemistry and biological aspects of isatin and its derivatives reported in the recent past.

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