scholarly journals Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119

2021 ◽  
Vol 14 ◽  
Author(s):  
Parmissa Randhawa ◽  
Aeli P. Olson ◽  
Shaohuang Chen ◽  
Kaley Lexi Gower-Fry ◽  
Cornelia Hoehr ◽  
...  
Keyword(s):  
Radionuclide Therapy ◽  
Auger Electron ◽  
State Of The Art ◽  
Delivery Systems ◽  
Cellular Level ◽  
The State ◽  
Targeted Radionuclide Therapy ◽  
University Of Wisconsin ◽  
Electron Emitters ◽  
The University

Abstract:: Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art in production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony-119 (119Sb) and mercury-197 (197Hg). Both radionuclides have great potential to become efficient tools for TRT. We also highlight our current progress on the production of both radionuclides at TRIUMF and the University of Wisconsin.

scholarly journals Targeted Radionuclide Therapy Using Auger Electron Emitters: The Quest for the Right Vector and the Right Radionuclide

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 980
Author(s):  
Malick Bio Idrissou ◽  
Alexandre Pichard ◽  
Bryan Tee ◽  
Tibor Kibedi ◽  
Sophie Poty ◽  
...  
Keyword(s):  
Radionuclide Therapy ◽  
Auger Electron ◽  
Nuclear Dna ◽  
Clonogenic Survival ◽  
Targeted Radionuclide Therapy ◽  
Nuclear Uptake ◽  
Tat Peptides ◽  
Electron Emitters ◽  
The Right

Auger electron emitters (AEEs) are attractive tools in targeted radionuclide therapy to specifically irradiate tumour cells while sparing healthy tissues. However, because of their short range, AEEs need to be brought close to sensitive targets, particularly nuclear DNA, and to a lower extent, cell membrane. Therefore, radioimmunoconjugates (RIC) have been developed for specific tumour cell targeting and transportation to the nucleus. Herein, we assessed, in A-431CEA-luc and SK-OV-31B9 cancer cells that express low and high levels of HER2 receptors, two 111In-RIC consisting of the anti-HER2 antibody trastuzumab conjugated to NLS or TAT peptides for nuclear delivery. We found that NLS and TAT peptides improved the nuclear uptake of 111In-trastuzumab conjugates, but this effect was limited and non-specific. Moreover, it did not result in a drastic decrease of clonogenic survival. Indium-111 also contributed to non-specific cytotoxicity in vitro due to conversion electrons (30% of the cell killing). Comparison with [125I]I-UdR showed that the energy released in the cell nucleus by increasing the RIC’s nuclear uptake or by choosing an AEE that releases more energy per decay should be 5 to 10 times higher to observe a significant therapeutic effect. Therefore, new Auger-based radiopharmaceuticals need to be developed.

Planning of Material Handling : Literature Review

2019 ◽  
Vol 13 (2) ◽  
pp. 29-44
Author(s):  
Péter Telek ◽  
Ákos Cservenák
Keyword(s):  
Literature Review ◽  
Material Handling ◽  
State Of The Art ◽  
The State ◽  
Integrated Planning ◽  
Complex Process ◽  
Individual Planning ◽  
The Individual ◽  
The University

Nowadays, there are many well proved, effective processes to solve planning tasks in the field of material handling used advanced calculations forms and software. Unfortunately, most of them are used for individual tasks, so the applicability of their results is limited. The Institute of Logistics of the University of Miskolc has been working on integrated planning of handling machines for decades, where the individual planning tasks have to be solved together in a complex process. The main aim of this paper to give an overview about the state of the art of the planning of material handling, based on a literature review of the Science Direct publication database. As a result of this research we can determine some new direction for the planning of material handling.

scholarly journals The Seventh Answer Set Programming Competition: Design and Results

2019 ◽  
Vol 20 (2) ◽  
pp. 176-204 ◽  
Author(s):  
MARTIN GEBSER ◽  
MARCO MARATEA ◽  
FRANCESCO RICCA
Keyword(s):  
Knowledge Representation ◽  
Logic Programming ◽  
State Of The Art ◽  
Answer Set Programming ◽  
The State ◽  
International Conference ◽  
Knowledge Representation Language ◽  
Representation Language ◽  
The University ◽  
Answer Set

AbstractAnswer Set Programming (ASP) is a prominent knowledge representation language with roots in logic programming and non-monotonic reasoning. Biennial ASP competitions are organized in order to furnish challenging benchmark collections and assess the advancement of the state of the art in ASP solving. In this paper, we report on the design and results of the Seventh ASP Competition, jointly organized by the University of Calabria (Italy), the University of Genova (Italy), and the University of Potsdam (Germany), in affiliation with the 14th International Conference on Logic Programming and Non-Monotonic Reasoning (LPNMR 2017).

The Legislature Speaks

2019 ◽  
pp. 56-60
Author(s):  
Michael V. Metz
Keyword(s):  
The State ◽  
University Of Wisconsin ◽  
The University ◽  
State Senate

The state senate pressured the board to rescind the decision on the DuBois Club under threat of budgetary implications for the university; the governor supported the board. Letters poured into the president’s office, and Henry asked Millet to delay implementation of the decision. A bill to repeal the Clabaugh Act was introduced in the legislature and easily defeated. A campus Committee to End the War was formed. At the University of Wisconsin a Dow Chemical campus recruiter drew protests. The chapter also examines a little-known Illinois connection with Dow’s napalm product.

Introductory remarks

2003 ◽  
Vol 31 (5) ◽  
pp. 971-972 ◽  
Author(s):  
S.E. Harding ◽  
P. O'Shea
Keyword(s):  
Aqueous Solution ◽  
Molecular Interactions ◽  
State Of The Art ◽  
Wide Spectrum ◽  
The State ◽  
Wide Range ◽  
Biophysical Society ◽  
Introductory Paper ◽  
The University

An overview is given of a stimulating Meeting held at the University of Nottingham in June 2003 focusing on molecular interactions occurring in membranes or ‘2D’ and those occurring in aqueous solution or ‘3D’. It was held jointly between the Biochemical Society and the British Biophysical Society. The 80 or so delegates who attended benefitted from an exciting exchange of ideas between researchers from a wide spectrum of backgrounds. It is hoped the collection of papers which follow this Introductory paper will provide a useful summary of the state of the art and help stimulate collaboration across the wide range of disciplines represented.

scholarly journals Raccomandazioni per lo sviluppo dell'Editoria Elettronica negli Atenei Italiani

2006 ◽  
Keyword(s):  
Working Group ◽  
Electronic Publishing ◽  
State Of The Art ◽  
The State ◽  
Academic World ◽  
The Future ◽  
Definition Of ◽  
University Of Florence ◽  
The University

In May 2004, the delegates of the Library Commission of the CRuI had already identified the issue of electronic publishing as one of the strategic aspects to be addressed and explored with the utmost attention. The setting up of the working group on Electronic Publishing, co-ordinated by the University of Florence, formalised this interest, stimulating the analysis of the state of the art in this field in Italy, the opportunities which it offered to the academic world and the definition of possible lines of development. The "Recommendations" comprised in this publication are addressed to the delegates of the Chancellors of the Italian universities and their collaborators, and intended to provide information and suggestions for the development of electronic publishing initiatives. They are consequently designed not only as a tool for help and guidance for those who are already moving in the direction of a University publishing initiative, but also as an invitation to reflect on the importance that electronic publishing is acquiring for the teaching and scientific activities of the future.

scholarly journals "Art Is Energy": Barbara Hammer Speaks with Sarah Keller about the State of Experimental Cinema after Maya Deren

2017 ◽  
Vol 3 ◽  
Author(s):  
Barbara Hammer
Keyword(s):  
The State ◽  
Kind Permission ◽  
University Of Wisconsin ◽  
Experimental Cinema ◽  
The University

No abstract availableThis article was originally published by Parallel Press, an imprint of the University of Wisconsin-Madison Libraries, as part of The International Journal of Screendance, Volume 3 (2013), Parallel Press, http://journals.library.wisc.edu/index.php/screendance/issue/view/55. It is made available here with the kind permission of Parallel Press.

scholarly journals Historische formelhafte Wendungen als Konstruktionen: Möglichkeiten und Grenzen der diachronen Konstruktionsgrammatik

2018 ◽  
Vol 90 (3) ◽  
Author(s):  
Natalia Filatkina
Keyword(s):  
Case Studies ◽  
Research Group ◽  
State Of The Art ◽  
Construction Grammar ◽  
The State ◽  
Formulaic Language ◽  
Empirical Basis ◽  
The University ◽  
Theoretical Considerations

Construction Grammar and research on phraseology have both commenced as purely synchronically oriented subfields of linguistics and are nowadays only starting to gain a historical dimension. Both disciplines put such units of language in the center of their research that I address in the present paper as formulaic patterns. The paper aims to discuss the possibilities and limits of multifold interactions between the two subfields of linguistics with regard to historical formulaic language. An overview of the state of the art in the field of diachronic Construction Grammar (Section 2) is followed by reflections on historical phraseology that can already partially offer some answers to the questions posed by the Construction grammar only now (cf. Section 3). The case studies (Section 4) provide an empirical basis for the preceding theoretical considerations and are based on the data of the Research Group HiFoS at the University of Trier. The data consist of about 32.000 fully annotated formulaic patterns from historical German texts since the beginning of the written tradition in the 8th century to 1650.

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