Chemical Composition and Biological Activities from Croton delpyi Croton decalvatus and Croton caudatus

2020 ◽  
Vol 10 ◽  
Author(s):  
Sakchai Chaibun ◽  
Wilart Pompimon ◽  
Chanika Tidchai ◽  
Noraset Chalaemwongwan ◽  
Jutarut Wongping ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Antibacterial Activities ◽  
Cytotoxic Activities ◽  
Separation And Purification ◽  
Pure Compounds ◽  
Cytotoxicity Activities ◽  
Anti Hiv ◽  
Hiv 1

Background: C. delpyi, C. decalvatus and C. caudatus are in the Euphorbiaceae family. The aerial parts; twigs, leaves and barks of these plants were used as traditional medicine such as anti-inflammatory, cytotoxicity, and antifungal properties. Objectives: The aims of this work were 1) to study the chemical composition of C. delpyi, C. decalvatus, and C. caudatus 2) to test their antibacterial, anti-HIV-1 RT, and cytotoxicity activities of crude extracts and pure compounds from these plants. Methods: Extraction, separation and purification of three plants were performed under chromatographic method. The biological activities including antibacterial, anti-HIV-1 RT and cytotoxicity assay of three plants were evaluated by the standard methods. Results: Phytochemical investigation of C. delpyi was founded a new clerodanes diterpenoids; crotondelpyitin A (1). The five known compounds, such as acetyl aleuritolic acid (2), 5-hydroxy-7,4- dimethoxyflavone (3), and pilloin (4) were founded in C. decalvatus and 3α-benzoyloxy-D:A-friedo-oleanan-27,16αlactone (5), and bergenin (6) were founded in C. caudatus. The compound 3 show the most effective antibacterial activities with MIC in range <0.16 -1.25 mg/mL, and MBC in range 0.6 - >5.0 mg/mL. The six compounds were inactive with antiHIV-1 RT. In addition, compound 4 was active for cytotoxic activities on FaDu and KKU-M213 at <4 µg/mL. Conclusion: The present study reveals that the Croton species are sources of diterpenoid-type compounds and significant guide for further research of the chemical constituents from these plants as potential medicines.

In Vitro Screening for Cytotoxic, Anti-bacterial, Anti-HIV1-RT Activities and Chemical Constituents of Croton fluviatilis, Croton acutifolius, and Croton thorelii

2021 ◽  
Vol 11 ◽  
Author(s):  
Charina Worarat ◽  
Wilart Pompimon ◽  
Phansuang Udomputtimekakul ◽  
Sukee Sukdee ◽  
Punchavee Sombutsiri ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Bacterial Activity ◽  
Cytotoxic Activities ◽  
Separation And Purification ◽  
Crude Extracts ◽  
Cytotoxicity Activities

Background: Although the chemical constituents and biological activities of a large number of plants in the Croton genus have been studied, there are still recently discovered plants to be investigated. Objective: 1. To investigate the anti-bacterial, anti-HIV1-RT, and cytotoxicity activities of crude extracts from these plants. 2. To investigate the chemical constituents of Croton fluviatilis, Croton acutifolius, and Croton thorelii. Method: The anti-bacterial, anti-HIV1-RT, and cytotoxicity of the three plants were evaluated by standard techniques. Extraction, separation, and purification of extracts from the three plants were undertaken. Results: The ethyl acetate extract of C. fluviatilis showed low anti-bacterial activity against E. aerogenes, E. coli 0157: H7, and P. mirabilis, together with the ethyl acetate extract of C. acutifolius displayed low anti-bacterial activity against E. aerogenes, while all the crude extracts of C. thorelii were inactive. The ethyl acetate extracts of C. thorelii, and C. fluviatilis showed strong inhibited HIV1-RT, whereas the ethyl acetate extract of C. acutifolius, and the hexane extract of C. fluviatilis displayed moderate inhibited HIV1-RT. Cytotoxic properties of three Croton plants were specific to KKU-M213, MDA-MB-231, A-549, and MMNK-1. Especially, the ethyl acetate extract of C. acutifolius exhibited strong cytotoxic activities against MDA-MB-231, A-549, and MMNK-1. Furthermore, the ethyl acetate extract of C. thorelii showed high cytotoxic activities against KKU-M213, and MDA-MB-231. Compounds 1, and 4 were found in C. fluviatilis. Compounds 2 and 4 were also found in C. acutifolius. Moreover, compound 3 was only found in C. thorelii. Conclusion: The present study revealed that the three Croton species are good sources of flavonoid compounds and further investigation of the chemical constituents from these plants may prove to be fruitful to discover more active compounds to be tested as potential medicines.

scholarly journals Chemical Composition, Enantiomeric Distribution, and Biological Activities of Rhododendron anthopogon Leaf Essential Oil from Nepal

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Noura S. Dosoky ◽  
Prabodh Satyal ◽  
Suraj Pokharel ◽  
William N. Setzer
Keyword(s):  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Biological Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Components ◽  
Cytotoxic Activities ◽  
Blood Disorders ◽  
Leaf Essential Oil ◽  
Microbroth Dilution

Rhododendron anthopogon D. Don., a small compact Himalayan shrub growing in Nepal, is a known medicinal plant used to treat sore throat, colds, blood disorders, bone disease, potato allergies, and vomiting, and to relieve liver disorders, headaches and back pain. The present study investigated the chemical composition and bioactivities of the leaf essential oil from R. anthopogon from Dhankuta, Nepal. The essential oil from leaves was obtained by hydrodistillation and a detailed chemical analysis was conducted by gas chromatography – mass spectrometry (GC-MS). The enantiomeric distribution of monoterpenoid components was determined using chiral gas chromatography and represents the first chiral examination of R. anthopogon essential oil. The essential oil was screened for antimicrobial activity using the microbroth dilution test, and for cytotoxic activity against MCF-7, MDA-MB-231, and 5637 using the MTT assay. A total of 70 volatile components were identified from the essential oil. The major components were α-pinene (21.5%), δ-cadinene (13.8%), β-pinene (9.5%), limonene (5.9%), δ-amorphene (4.6%), α-muurolene (4.5%), and ( E)-caryophyllene (3.2%) with other minor constituents (< 3%). The essential oil showed marginal antibacterial and cytotoxic activities, but no antifungal effects.

scholarly journals Biological Activity and Chemical Constituents of Essential Oil and Extracts of Murraya microphylla

2015 ◽  
Vol 10 (9) ◽  
pp. 1934578X1501000
Author(s):  
Hai-Ning Lv ◽  
Ke-Wu Zeng ◽  
Bing-Yu Liu ◽  
Yun Zhang ◽  
Peng-Fei Tu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Human Cancer ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Cytotoxic Activities ◽  
Active Components ◽  
Human Cancer Cell Lines ◽  
Total Oil ◽  
Promising Development ◽  
Carbazole Alkaloids

Murraya microphylla is the most closely related species to M. koenigii (Curry tree). Inspired by the traditional effects of M. koenigii, the antioxidant, anti-inflammatory, and cytotoxic activities of the essential oil and extracts of M. microphylla were evaluated for the first time. The light petroleum and chloroform extracts were found to be able to scavenge DPPH free radicals, inhibit linoleic acid peroxidation, and nitric oxide production, as well as to present cytotoxicity to the human cancer cell lines HepG2, Bel7402, Bel7403, and Hela, but the essential oil only showed moderate activities. Chemical analysis of the active extracts by LC-DAD-MSn indicated that carbazole alkaloids were the main constituents. GC-MS analysis of the essential oil resulted in identification of 91 constituents, representing 96.9% of the total oil, with ( E)-caryophyllene (18.4%) and terpinen-4-ol (12.6%) as the major constituents. These results demonstrate that M. microphylla has similar biological activities, as well as chemical constituents to M. koenigii, and the carbazole alkaloids were disclosed to be the main potential active components. A promising development as a flavor and potential therapeutic agent could thus be predicated for this plant.

scholarly journals Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Carla de Moura Martins ◽  
Sérgio A. L. de Morais ◽  
Mário M. Martins ◽  
Luís C. S. Cunha ◽  
Cláudio V. da Silva ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Gallic Acid ◽  
Total Phenolics ◽  
Biological Activities ◽  
Ethanolic Extract ◽  
Ethyl Acetate Fraction ◽  
Vero Cells ◽  
Quercetin Glycosides ◽  
Cytotoxicity Activities ◽  
First Time

The species Inga laurina is native to the Brazilian Cerrado. There are no studies about the chemical composition and biological activities of extracts of this endangered species. The ethanolic extract and its successive fractions are rich in phenolic compounds and presented good antifungal activities. HPLC/MS-MS/MS and H1/C13 analysis led to the identification of seventeen compounds, most of which are gallic acid derivatives, myricetin and quercetin glycosides. The ethyl acetate fraction (EAF) contained high levels of total phenolics, expressed in milligrams of gallic acid equivalents per gram of extract (475.3 ± 1.9 mg GAE gextract-1) and flavonoids expressed in milligrams of quercetin equivalents per gram of extract (359.3 ± 10.6 mg QE gextract-1). This fraction was active against fungi of the Candida genus. The EAF showed MIC value 11.7 μg mL−1 against C. glabrata and a selectivity index of 1.6 against Vero cells. The flavonol glycoside myricetin-3-O-rhamnoside was isolated for the first time from the Inga laurina. These results make I. laurina a promising plant as a source of pharmaceutical and biological active antifungal compounds.

scholarly journals Chemical Composition, and Cytotoxic, Antioxidant and Antibacterial Activities of the Essential Oil from Ginseng Leaves

2014 ◽  
Vol 9 (6) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Rui Jiang ◽  
Liwei Sun ◽  
Yanbing Wang ◽  
Jianzeng Liu ◽  
Xiaodan Liu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Complex Mixture ◽  
Annexin V ◽  
Antibacterial Activities ◽  
Cytotoxic Activities ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Gram Positive Bacteria

Panax ginseng C.A.Meyer is one of the most valuable traditional Chinese medicines. In this study, the essential oil of ginseng leaves (EOGL), collected using hydrodistillation and analyzed by GC/MS, contained a complex mixture of aliphatic (69.0%), terpenoid (21.5%) and aromatic compounds (2.4%). Among 54 components identified, the major ones were palmitic acid (36.1%), β-farnesene (15.4%), linoleic acid (9.8%) and phytol (5.6%). In the cytotoxicity study, EOGL exhibited obvious cytotoxic activities against different cancer cell lines, including Hela, A549, ZR-75-1, HT-29, SGC7901 and B16 cells. Furthermore, Annexin V-FITC/PI staining assay indicated that EOGL can induce late apoptosis of ZR-75-1 cells, and the percentage of apoptotic cells increased in a concentration-dependent manner (0.9% to 5.6% and 67.4%). In addition to this, we also found that EOGL exhibited weak DPPH radical scavenging (12.0 ± 0.4 mg/mL) and ABTS radical scavenging activities (1.6 ± 0.1 mg/mL), and showed antibacterial activity against the Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, and the Gram-negative bacterium, Escherichia coli. The data suggest that EOGL, which possesses important biological activities, especially significant anticancer activity, could be a potential medicinal resource.

ChemInform Abstract: Synthesis of Zidovudine Derivatives with anti-HIV-1 and Antibacterial Activities.

ChemInform ◽  
2009 ◽  
Vol 40 (30) ◽  
Author(s):  
Palaniappan Senthilkumar ◽  
Jing Long ◽  
Raparla Swetha ◽  
Vaidyanathan Shruthi ◽  
Rui-Rui Wang ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Anti Hiv ◽  
Hiv 1

Highly Potent and Orally Active CCR5 Antagonists as Anti-HIV-1 Agents:  Synthesis and Biological Activities of 1-Benzazocine Derivatives Containing a Sulfoxide Moiety

2006 ◽  
Vol 49 (6) ◽  
pp. 2037-2048 ◽  
Author(s):  
Masaki Seto ◽  
Katsuji Aikawa ◽  
Naoki Miyamoto ◽  
Yoshio Aramaki ◽  
Naoyuki Kanzaki ◽  
...  
Keyword(s):  
Biological Activities ◽  
Ccr5 Antagonists ◽  
Orally Active ◽  
Anti Hiv ◽  
Hiv 1

Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety

2005 ◽  
Vol 13 (2) ◽  
pp. 363-386 ◽  
Author(s):  
Masaki Seto ◽  
Naoki Miyamoto ◽  
Katsuji Aikawa ◽  
Yoshio Aramaki ◽  
Naoyuki Kanzaki ◽  
...  
Keyword(s):  
Biological Activities ◽  
Ccr5 Antagonists ◽  
Orally Active ◽  
Anti Hiv ◽  
Hiv 1

Synthesis, anti-HIV-1 integrase, and cytotoxic activities of 4-chloro-N-(4-oxopyrimidin-2-yl)-2-mercaptobenzenesulfonamide derivatives

2008 ◽  
Vol 43 (6) ◽  
pp. 1188-1198 ◽  
Author(s):  
Zdzisław Brzozowski ◽  
Jarosław Sławiński ◽  
Franciszek Sączewski ◽  
Tino Sanchez ◽  
Nouri Neamati
Keyword(s):  
Cytotoxic Activities ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals Chemical constituents of the Rhizomes of Curcuma zedoaria

2021 ◽  
Vol 5 (2) ◽  
pp. first
Author(s):  
Truong Nhat Van Do ◽  
Hai Xuan Le ◽  
Tho Huu Le ◽  
Mai Thanh Thi Nguyen
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Preparative Thin Layer Chromatography ◽  
Chemical Constituent ◽  
Scientific Data ◽  
Curcuma Zedoaria ◽  
Etoac Extract ◽  
Chemical Structures ◽  
Pure Compounds

Curcuma zedoaria (Berg.), belongs to the Zingiberaceae family, is one of the medicinal plants that is found in Southeast Asia. This plant is known as “Nghe tim” in Vietnam; and a decoction of its rhizomes has been used traditionally for the cure flatulence, fatigue, and hepatitis. Previously, some studies on the chemical constituent of the rhizomes of C. zedoaria have reported plenty of curcuminoids and sesquiterpenoids together with their derivatives, which have shown a lot of various bioactivities such as antiproliferative characteristic, anti-ulcer, antioxidant and antibacterial potential. By chromatography column method along with preparative thin layer chromatography on a normal phase silica gel on the EtOAc extract of the rhizomes of Curcuma zedoaria, we have isolated five pure compounds. Their chemical structures have been elucidated by NMR techniques and comparison with publishing data that have determined to be gajustulactone A (1), isozedoarondiol (2), neolitacumone (3), β-sitosterol (4), and β-stigmasterol (5). The results of this study have contributed to the scientific data system on the chemical composition of Vietnamese medicinal plants, especially the rhizomes of Curcuma zedoaria grown in Tinh Bien, An Giang. Therefore, there is more evidence to continue screening studies to detect interesting biological activities from this species.

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