scholarly journals Chemical constituents of the Rhizomes of Curcuma zedoaria

2021 ◽  
Vol 5 (2) ◽  
pp. first
Author(s):  
Truong Nhat Van Do ◽  
Hai Xuan Le ◽  
Tho Huu Le ◽  
Mai Thanh Thi Nguyen
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Preparative Thin Layer Chromatography ◽  
Chemical Constituent ◽  
Scientific Data ◽  
Curcuma Zedoaria ◽  
Etoac Extract ◽  
Chemical Structures ◽  
Pure Compounds

Curcuma zedoaria (Berg.), belongs to the Zingiberaceae family, is one of the medicinal plants that is found in Southeast Asia. This plant is known as “Nghe tim” in Vietnam; and a decoction of its rhizomes has been used traditionally for the cure flatulence, fatigue, and hepatitis. Previously, some studies on the chemical constituent of the rhizomes of C. zedoaria have reported plenty of curcuminoids and sesquiterpenoids together with their derivatives, which have shown a lot of various bioactivities such as antiproliferative characteristic, anti-ulcer, antioxidant and antibacterial potential. By chromatography column method along with preparative thin layer chromatography on a normal phase silica gel on the EtOAc extract of the rhizomes of Curcuma zedoaria, we have isolated five pure compounds. Their chemical structures have been elucidated by NMR techniques and comparison with publishing data that have determined to be gajustulactone A (1), isozedoarondiol (2), neolitacumone (3), β-sitosterol (4), and β-stigmasterol (5). The results of this study have contributed to the scientific data system on the chemical composition of Vietnamese medicinal plants, especially the rhizomes of Curcuma zedoaria grown in Tinh Bien, An Giang. Therefore, there is more evidence to continue screening studies to detect interesting biological activities from this species.

Potential Antiulcer Agents From Plants: A Comprehensive Review

2019 ◽  
Vol 5 (3) ◽  
pp. 170-231
Author(s):  
Minky Mukhija ◽  
Bhuwan Chandra Joshi
Keyword(s):  
Medicinal Plants ◽  
Developed Countries ◽  
Scientific Data ◽  
Antiulcer Activity ◽  
Peptic Ulcers ◽  
Comprehensive Review ◽  
Chemical Structures ◽  
Mucosal Thickness

Background: Peptic ulcer is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Nowadays, several plants and compounds derived from it have been screened for their antiulcer activity. In the last few years, there has been an exponential growth in the field of herbal medicine. This field has gained popularity in both developing and developed countries because of their natural origin and less side effects. Objective: This review aims to provide a comprehensive summary of currently available knowledge of medicinal plants and phytoconstituents reported for their anti-ulcer properties. Methods: The worldwide accepted database like SCOPUS, PUBMED, SCIELO, NISCAIR, ScienceDirect, Springerlink, Web of Science, Wiley, SciFinder and Google Scholar were used to retrieve available published literature. Results: A comprehensive review of the present paper is an attempt to list the plants with antiulcer activity. The review narrates the dire need to explore potential chemical moieties that exert an antiulcer effect, from unexploited traditional plants. Furthermore, the present study reveals the intense requirement to exploit the exact mechanism through which either the plant extracts or their active constituents exhibit their antiulcer properties. Conclusion: This article is the compilation of the plants and its constituents reported for the treatment of peptic ulcers. The Comprehensive data will surely attract the number of investigators to initiate further research that might lead to the drugs for the treatment of ulcers. As sufficient scientific data is not available on plants, most of the herbals cannot be recommended for the treatment of diseases. This can be achieved by research on pure chemical structures derived from plants or to prepare new lead compounds with proven beneficial preclinical in vitro and in vivo effects. However, a lot remains to be done in further investigations for the better status of medicinal plants.

scholarly journals A Further Comprehensive Review on the Phytoconstituents from the Genus Erythrina

2020 ◽  
Vol 23 (1) ◽  
pp. 65-77 ◽  
Author(s):  
Mohammad Musarraf Hussain
Keyword(s):  
Chemical Structure ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Pharmaceutical Journal ◽  
Significant Source ◽  
Comprehensive Review ◽  
Chemical Structures ◽  
Previous Review

Erythrina is a significant source of phytoconstituents. The aim of this review is to solicitude of classification, synthesis, and phytochemicals with biological activities of Erythrina. In our previous review on this genus (Hussain et. al., 2016a) fifteen species (Erythrina addisoniae, E. caribeae, E. indica, E. lattisima, E. melanacantha, E. mildbraedii, E. poeppigiama, E. stricta, E. subumbrans, E. veriagata, E. vespertilio, E. velutina, E. zeberi, E. zeyheri and E. americana) have been studied and 155 molecules with chemical structures were reported. A further comprehensive review was done upon continuation on the same genus and thirteen species (E. abyssinica, E. arborescens, E. berteroana, E. burttii, E. caffra, E. coralloids, E. crista-galli, E. fusca, E. herbaceae, E. lysistemon, E. mulungu, E. speciosa and E. tahitensis) of Erythrina have been studied and 127 compounds are reported as phytoconstituents with their chemical structure in this review. Erythrina crista-galli and E. lysistemon consist of highest number of chemical constituents. Bangladesh Pharmaceutical Journal 23(1): 65-77, 2020

scholarly journals Chemical constituents and their alpha-glucosidase inhibitory activity of Solanum procumbens

2021 ◽  
Vol 5 (3) ◽  
pp. 1326-1333
Author(s):  
Nhan Trung Nguyen ◽  
Truong Nhat Van Do ◽  
Tho Huu Le ◽  
Phu Hoang Dang ◽  
Hai Xuan Nguyen ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Positive Control ◽  
Scientific Data ◽  
Chemical Compositions ◽  
Chromatography Method ◽  
Perennial Shrub ◽  
Ic50 Values ◽  
Folk Remedies

Solanum procumbens called ``Cà gai leo'' in Vietnam, belonged to the family of Solanaceae, which is a prickly diffuse, bright green perennial shrub, woody at the base. This plant has been sought for plenty of Vietnamese folk remedies for diseases such as rheumatism, back pain, detoxification, cough, pain relief, hemostasis, hepatitis, and cirrhosis. Chemical reports revealed the presence of lots of secondary metabolites such as steroids, triterpenoids, alkaloids, and phenolic compounds that have good biological activities such as antibacterial, antidiabetic, antioxidant, and antimicrobial... By column chromatography method together with thin layer normal-phase chromatography on the ethyl acetate extract of its entire plant, we isolated four compounds including dioscin (1), b -sitosterol (2), daucosterol (3) and 6'-O-acetyl-b -daucosterol (4). The result of theira-glucosidase inhibitory activity showed that compounds 2 and 4 had strong inhibition with IC50 values of 35.2 and 209.5 mM, comparing to the positive control, acarbose with an IC50 value of 214.5 mM. The results of this study have contributed to the scientific data of chemical compositions of Vietnamese medicinal plants, among them S. procumbens would potentially be developed as a plant-based drug to decrease the blood glucose level.

scholarly journals Chemical constituents and bioactivity of Gynura procumbens (Lour.) Merr.

2020 ◽  
Vol 22 (4) ◽  
pp. 391-399
Author(s):  
Quyen Thi My Le ◽  
Quynh Thi Diem Nguyen ◽  
Phu Hoang Dang ◽  
Nhi Thi Y Nguyen ◽  
Quan Le Tran
Keyword(s):  
Traditional Medicine ◽  
Chemical Constituents ◽  
Syringic Acid ◽  
Chromatographic Technique ◽  
Test Results ◽  
Chemical Structures ◽  
Pure Compounds ◽  
Ic50 Values ◽  
Medicinal Properties ◽  
First Time

Introduction: Gynura procumbens (Lour.) Merr. (Family: Asteraceae) is mainly popular in South-East Asian countries for its traditional medicinal properties. It is usually used as a traditional medicine for the treatment of eruptive fevers, rash, kidney disease, migraines, constipation, hypertension, diabetes mellitus, and cancer. It is commonly used as a traditional medicine in Vietnam for the treatment of many diseases. Methods: The leaves and trunks of G. procumbens were collected, macerated with methanol. The extracts from MeOH-soluble extract were processed by the column chromatographic technique to give pure compounds and the nuclear magnetic resonance methods were applied to determine their chemical structures. The inhibitory activities of these extracts against α-glucosidase were conducted and compared with acarbose. Results: Seven organic compounds were isolated and determined the structures, including syringic acid (1), quercetin (2), N,N-dimethylanthranilic acid (3), dehydrovomifoliol (4), β-sitosterol 3-O-β-D-glucopyranoside (5), schottenol (6), montanic acid (7). The inhibition of α-glucosidase test results the IC50 values of the four extracts which were lower than those of acarbose. Conclusion: Seven pure compounds were identified from the leaves and trunks of G. procumbens, including two compounds being isolated from G. procumbens for the first time. The test results showed that the the parts of G. procumbens were active as α-glucosidase inhibitor, which would be useful to support the treatment for diabetes.  

scholarly journals Curcuma zedoaria Rosc (Zingiberaceae): a review on its chemical, pharmacological and biological activities

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Shankar Gharge ◽  
Sushmita I. Hiremath ◽  
Pooja Kagawad ◽  
Kadambari Jivaje ◽  
Mahesh S. Palled ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Biological Effects ◽  
Present Review ◽  
Main Body ◽  
Curcuma Zedoaria ◽  
Care Needs ◽  
Wide Range ◽  
Crude Drugs ◽  
Online Sources

Abstract Background Around 80% of human population in the world relies on herbal or phytomedicines for their primary health care needs. The treatment of many diseases and disorders with phytomedicines is considered and observed as very safe with no or minimal side effects. Many medicinal plants and their preparations are practised at home as remedies for treating and preventing various diseases and disorders. For example, medicinal plants and their crude parts such as tulsi, neem, turmeric and ginger are used to cure or treat several common ailments, out of which Curcuma zedoaria Rosc commonly known as white turmeric is one of the important crude drugs belonging to Zingiberaceae family and genus Curcuma. Traditionally, it has been reported to possess many biological activities been used for many therapeutic actions due to the presence of wide range of phytoconstituents in it. The main objectives of the present work are to carry out extensive review on its chemical, pharmacological and biological activities of plant. Main body In the present review article, extensive data on its chemical, pharmacological and biological activities have been collected from various online sources including indexing sites such as Web of Science, Scopus, PubMed and Research Gate and presented. Various articles published in indexed journals and other databases have been collected and reviewed systematically. Conclusion The present review investigation is very much helpful for researchers and readers to collectively have valuable information on chemistry, pharmacology and biological effects of Curcuma zedoaria Rosc. The present investigation concludes that the white turmeric is found to possess complex range of phytoconstituents such as curcumin, ethyl p-methoxycinnamate, β-turmerone, β-eudesmol, zingiberene, dihydrocurcumin, furanodiene, α-phellandrene, 1–8 cineole, β-elemense and germacrone. Due to the presence of wide range of phytoconstituents, plants have been reported for its diverse biological activities.

scholarly journals Studies on the Chemical Constituents and Biological Activities of Four Medicinal Plants from Ilex Genus

Planta Medica ◽  
2009 ◽  
Vol 75 (04) ◽  
Author(s):  
PF Tu ◽  
SX Zhou ◽  
GB Xie ◽  
J Zheng ◽  
L Tang ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Biological Activities ◽  
Chemical Constituents

A Sesquiterpene Aldehyde Isolated From Ethyl Acetate Extract of Lansium Domesticum Fruit Peel

2021 ◽  
pp. 394-398
Author(s):  
Khusnul Fadhilah ◽  
Subagus Wahyuono ◽  
Puji Astuti
Keyword(s):  
Ethyl Acetate ◽  
Cell Lines ◽  
Mobile Phase ◽  
Spectroscopic Data ◽  
Biological Activities ◽  
Preparative Thin Layer Chromatography ◽  
Insoluble Fraction ◽  
Fruit Peel ◽  
Etoac Extract ◽  
Lansium Domesticum

Lansium domesticum (fam. Meliaceae) contains various compounds with various biological activities. Based on the previous research, extracts from several parts of the plant have biological activity. This study aimed to isolate a compound from the fruitpeel of L. domesticum and evaluate cytotoxic activity against T47D, WiDr and HepG2 cell lines. Powdered peels were macerated with ethyl acetate and the filtrate was evaporated to give EtOAc extract. Dried extract was triturated with n-hexane to give n-hexane soluble fraction (A) and insoluble fraction (B). The fraction B was separated using vacuum column chromatography (VLC) with mobile phase n-hexane: ethyl acetate and given 5 fractions. Fractions B3-B5 were combined and separated using VLC with n-hexane and ethyl acetate as mobile phase. This VLC separation gave 18 subractions, subfractions 6-9 with the similar TLC profile were combined. This subfraction was separated further using preparative thin layer chromatography to give compound 1. The Isolated compound (1) appeared as liquid. The chemical structure of 1 was identified acoording to spectroscopic data and comparison with literature. Cytotoxic bioassay was performed on T-47D, WiDr and Hep G2 cell lines in a series of concentrations at 50, 40, 30, 20, 10 and 5µg/mL, with Doxorubicine used as positive control. According to spectroscopic data, compound 1 was identified as 2-ethyl,3-(1’-hydroxy-2’-menthene) propenal, and demonstrate the strongest cytotoxicity against T-47D cell lines (IC50=39.18+1.54 µg/mL).

Chemical Composition and Biological Activities from Croton delpyi Croton decalvatus and Croton caudatus

2020 ◽  
Vol 10 ◽  
Author(s):  
Sakchai Chaibun ◽  
Wilart Pompimon ◽  
Chanika Tidchai ◽  
Noraset Chalaemwongwan ◽  
Jutarut Wongping ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Antibacterial Activities ◽  
Cytotoxic Activities ◽  
Separation And Purification ◽  
Pure Compounds ◽  
Cytotoxicity Activities ◽  
Anti Hiv ◽  
Hiv 1

Background: C. delpyi, C. decalvatus and C. caudatus are in the Euphorbiaceae family. The aerial parts; twigs, leaves and barks of these plants were used as traditional medicine such as anti-inflammatory, cytotoxicity, and antifungal properties. Objectives: The aims of this work were 1) to study the chemical composition of C. delpyi, C. decalvatus, and C. caudatus 2) to test their antibacterial, anti-HIV-1 RT, and cytotoxicity activities of crude extracts and pure compounds from these plants. Methods: Extraction, separation and purification of three plants were performed under chromatographic method. The biological activities including antibacterial, anti-HIV-1 RT and cytotoxicity assay of three plants were evaluated by the standard methods. Results: Phytochemical investigation of C. delpyi was founded a new clerodanes diterpenoids; crotondelpyitin A (1). The five known compounds, such as acetyl aleuritolic acid (2), 5-hydroxy-7,4- dimethoxyflavone (3), and pilloin (4) were founded in C. decalvatus and 3α-benzoyloxy-D:A-friedo-oleanan-27,16αlactone (5), and bergenin (6) were founded in C. caudatus. The compound 3 show the most effective antibacterial activities with MIC in range <0.16 -1.25 mg/mL, and MBC in range 0.6 - >5.0 mg/mL. The six compounds were inactive with antiHIV-1 RT. In addition, compound 4 was active for cytotoxic activities on FaDu and KKU-M213 at <4 µg/mL. Conclusion: The present study reveals that the Croton species are sources of diterpenoid-type compounds and significant guide for further research of the chemical constituents from these plants as potential medicines.

scholarly journals The Distribution of Asterosaponins, Polyhydroxysteroids and Related Glycosides in Different Body Components of the Far Eastern Starfish Lethasterias fusca

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 523 ◽  
Author(s):  
Roman S. Popov ◽  
Natalia V. Ivanchina ◽  
Alla A. Kicha ◽  
Timofey V. Malyarenko ◽  
Boris B. Grebnev ◽  
...  
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Protective Role ◽  
Individual Variability ◽  
Coelomic Fluid ◽  
Pyloric Caeca ◽  
Chemical Structures ◽  
Body Components ◽  
Distribution In The Organism ◽  
Far Eastern

Glycoconjugated and other polar steroids of starfish have unique chemical structures and show a broad spectrum of biological activities. However, their biological functions remain not well established. Possible biological roles of these metabolites might be indicated by the studies on their distribution in the organism–producer. In order to investigate the localization of polar steroids in body components of the Far Eastern starfish Lethasterias fusca, chemical constituents of body walls, gonads, stomach, pyloric caeca, and coelomic fluid were studied by nanoflow liquid chromatography/mass spectrometry with captive spray ionization (nLC/CSI–QTOF–MS). It has been shown that the levels of polar steroids in the studied body components are qualitatively and quantitatively different. Generally, the obtained data confirmed earlier made assumptions about the digestive function of polyhydroxysteroids and protective role of asterosaponins. The highest level of polar steroids was found in the stomach. Asterosaponins were found in all body components, the main portion of free polyhydroxysteroids and related glycosides were located in the pyloric caeca. In addition, a great inter-individual variability was found in the content of most polar steroids, which may be associated with the peculiarities in their individual physiologic status.

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