Herbal Liposomes: Natural Network for Targeted Drug Delivery System

2021 ◽  
pp. 31-41
Author(s):  
Vijay R. Salunkhe ◽  
Prasanna S. Patil ◽  
Ganesh H. Wadkar ◽  
Somnath D. Bhinge
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Therapeutic Potential ◽  
Herbal Medicines ◽  
Lipid Solubility ◽  
Liposomal Formulations ◽  
Novel Drug ◽  
Herbal Formulations

Herbal medicines have tremendous therapeutic potential that can explored across various effective drug delivery system. Decoctions, herbal teas, tinctures, glyceritum, oxymel, and use much soap, herbal tablets, herbal capsules, and herbal cream, herbal books, and prepared the confection of the most commonly available forms of dosage. The less use of herbal formulations in recent decades due to their lack of standardization. It is possible to use plant extract and isolated constituents to overcome this problem. But these phytoconstituents are suffering from drawbacks, mostly due to problems with stability and low lipid solubility. Novel drug delivery such as liposomes plays an important role in problem solving. Infact, compliance with the patient also improves. The review article discusses the recent status of new herbal liposomal formulations and describes the different ways in which these formulations are prepared.

FA-PEG decorated MOF nanoparticles as a targeted drug delivery system for controlled release of an autophagy inhibitor

2018 ◽  
Vol 6 (10) ◽  
pp. 2582-2590 ◽  
Author(s):  
Zheqi Shi ◽  
Xuerui Chen ◽  
Li Zhang ◽  
Shiping Ding ◽  
Xu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Specific Targeting ◽  
Autophagy Inhibitor ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Targeted Drug Delivery System

A novel drug delivery system with pH-responsive release and specific targeting identification was developed to control the release of an autophagy inhibitor.

Herbal Medicines in Neurodegenerative Disorders: An Evolutionary Approach through Novel Drug Delivery System

2018 ◽  
Vol 37 (3) ◽  
pp. 199-208 ◽  
Author(s):  
Sunil Kumar Dubey ◽  
Gautam Singhvi ◽  
Kowthavarapu Venkata Krishna ◽  
Tejas Agnihotri ◽  
Ranendra Narayan Saha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Neurodegenerative Disorders ◽  
Herbal Medicines ◽  
Evolutionary Approach ◽  
Novel Drug Delivery System ◽  
Novel Drug

Combining vitamin B12 and cisplatin-loaded porous silica nanoparticles via coordination: a facile approach to prepare a targeted drug delivery system

2017 ◽  
Vol 41 (22) ◽  
pp. 13823-13829 ◽  
Author(s):  
Nattanida Thepphankulngarm ◽  
Piyanuch Wonganan ◽  
Chaweewan Sapcharoenkun ◽  
Thawatchai Tuntulani ◽  
Pannee Leeladee
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Noncovalent Interactions ◽  
Porous Silica ◽  
System P ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Targeted Drug Delivery System

In this work, a novel drug delivery system for targeted therapy is developed based on noncovalent interactions.

scholarly journals MAGNETIC MICROSPHERE AN EMERGING DRUG DELIVERY SYSTEM

2017 ◽  
Vol 10 (6) ◽  
pp. 54 ◽  
Author(s):  
Diksha Sharma ◽  
Abhishek Sharma
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
The Body ◽  
Magnetic Microspheres ◽  
Magnetic Microsphere ◽  
Targeted Drug ◽  
Novel Drug

  The drug delivery system has been advanced to release the drug according to the body requirement during the entire period of treatment and also for the delivery at the targeted site. Several novel drug delivery systems have emerged encompassing different route of administration to achieve controlled and targeted drug delivery, magnetic microsphere carrier being one of them. Magnetic microsphere is an alternative to traditional radiation methods. As the traditional radiation methods use highly penetrating radiation that is absorbed throughout the body and cause side effects hence its use is limited. Therefore, a safe and effective alternate is needed like magnetic microsphere. The excessive circulating drug particles are minimized by this delivery system. Moreover, the aim of specific targeting is to enhance the effectiveness of drug delivery and at the same time to lessen the toxicity and side effects. Magnetic carriers receive magnetic responses to a magnetic field from incorporated materials that are used for magnetic microsphere are chitosan, dextran, etc. One of the most utilized magnetic microspheres is serum albumine whether from human or other suitable animals. Drug release from the albumin microsphere can be controlled by various stabilization procedures. Overall, the targeted magnetic microsphere is much valuable novel drug delivery system for what more work have to be done. By knowing the importance of all this, the present paper reviews the mechanism, preparation, and applications of magnetic microspheres. As the targeted drug delivery system implies selective and effective localization of drug into the target at therapeutic concentrations with limited access to non-target sites. Magnetic microspheres hold great promises for reaching the goal of controlled and site-specific drug delivery.

scholarly journals Challenges, Advances and Opportunities of Herbal Medicines in Wound Healing: A Review

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Balap A.R ◽  
Gaikwad A.A
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Herbal Medicines ◽  
Herbal Remedies ◽  
Wound Management ◽  
Wide Range ◽  
Healing Wound ◽  
Herbal Formulations

A large portion of the world's population relies on herbs for medical purposes today. About 25-30% of modern drugs are chemical intermediates derived from plant constituents. Traditional medicinal plant preparations are frequently utilised for wound healing, encompassing a wide range of skin-related disorders. In wound management, herbal medicine entails cleaning, debridement, and the creation of an environment that promotes natural healing. This review discusses wound, healing of the wound, allopathic treatment in wound healing, types of herbal medicines used in the treatment of wound healing and common excipients used in topical herbal formulations. In this article, we look at 15 plants that have been utilised as wound healers in traditional medicine around the world. This study is an attempt to search the difficulties and challenges of herbal formulations need for novel drug delivery system nanocarriers for herbal remedies with other nanotechnology strategies and techniques as a new drug delivery system and its future prospective. The purpose of this review is to examine the most common excipients used in herbal formulations, as well as various medicinal plants traditionally used in wound healing, wound healing difficulties and challenges, the use of nanotechnology in herbal formulation, the future scope of herbal medicines in wound healing, and a comparison of allopathy and herbal formulations.

scholarly journals Overview and Update on Methods for Cargo Loading into Extracellular Vesicles

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 356
Author(s):  
Yohan Han ◽  
Timothy W. Jones ◽  
Saugata Dutta ◽  
Yin Zhu ◽  
Xiaoyun Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Therapeutic Potential ◽  
Drug Carriers ◽  
Biological Information ◽  
Therapeutic Drugs ◽  
Loading Methods ◽  
Novel Drug

The enormous library of pharmaceutical compounds presents endless research avenues. However, several factors limit the therapeutic potential of these drugs, such as drug resistance, stability, off-target toxicity, and inadequate delivery to the site of action. Extracellular vesicles (EVs) are lipid bilayer-delimited particles and are naturally released from cells. Growing evidence shows that EVs have great potential to serve as effective drug carriers. Since EVs can not only transfer biological information, but also effectively deliver hydrophobic drugs into cells, the application of EVs as a novel drug delivery system has attracted considerable scientific interest. Recently, EVs loaded with siRNA, miRNA, mRNA, CRISPR/Cas9, proteins, or therapeutic drugs show improved delivery efficiency and drug effect. In this review, we summarize the methods used for the cargo loading into EVs, including siRNA, miRNA, mRNA, CRISPR/Cas9, proteins, and therapeutic drugs. Furthermore, we also include the recent advance in engineered EVs for drug delivery. Finally, both advantages and challenges of EVs as a new drug delivery system are discussed. Here, we encourage researchers to further develop convenient and reliable loading methods for the potential clinical applications of EVs as drug carriers in the future.

scholarly journals Formulation development & Evaluation of Phospholipids Complex of Euphorbia neriifolia Linn Extract

2021 ◽  
Vol 10 (6) ◽  
Author(s):  
Pranay Sethiya ◽  
S.C. Mahajan ◽  
Prachi Maheshwari ◽  
Anjali Khantal ◽  
Harshita Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Molecular Size ◽  
Entrapment Efficiency ◽  
Lipid Solubility ◽  
Formulation Development ◽  
Vis Spectroscopy ◽  
Novel Drug Delivery System ◽  
Novel Drug

Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. To overcome this hurdle, Novel Drug Delivery System (NDDS) proves to be a promising method for formulations containing phytoconstituents. In present work, phyto-phospholipids complex (phytosomes) of Euphorbia neriifolia L. has been prepared to improve the absorption and bioavailability of phytoconstituents. Euphorbia neriifolia L. consists of flavonoids, saponins and polyphenols which possess various medicinal properties. These constituents are hydrophilic in nature and have large molecular size, thus causing poor absorption. Phyto-phospholipids complex of Euphorbia neriifoliahas been prepared by taking Phosphatidylcholine (PC), Cholesterol and Euphorbia neriifolia extract in different ratio and the formulation been optimized to achieve maximum entrapment efficiency and smaller molecular size. The prepared phytosomes has been evaluated by Optical Microscopy, Transmission Electron Microscopy, Dynamic Light Scattering and UV/Vis Spectroscopy for physical appearance, entrapment efficiency, particle size, zeta potential and dissolution rate. The result so obtained indicates the improvement in the absorption rate and bioavailability of the phytoconstituents. Thus, Novel Drug Delivery System (NDDS) possess a great potential in overcoming the challenges of plant based formulations. Keywords: Euphorbia neriifolia, Phyto-phospholipids Complex, Novel Drug Delivery System, Phytosomes

scholarly journals Mucoadhesive Microspheres: A Targeted Drug Delivery System

2021 ◽  
Vol 11 (2-S) ◽  
pp. 150-155
Author(s):  
Hans Raj ◽  
Ankita Sharma ◽  
Shagun Sharma ◽  
Kapil Kumar Verma ◽  
Amit Chaudhary
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Drug Targeting ◽  
Local Effects ◽  
Targeted Drug ◽  
Novel Drug ◽  
Targeted Drug Delivery System ◽  
The Ideal

Carrier technology is a novel and groundbreaking drug delivery system. Microspheres transmit the drug by affixing it to carrier particle-like Microspheres, Nanoparticles and Liposomes due to their smaller size and other useful properties. Mucoadhesive Microspheres are an integral component of this multi-particle drug delivery system and play an important function in the delivery of a novel drug. This drug delivery improves the therapeutic effectiveness of the drug. Mucoadhesive microspheres have a longer duration of residence at the absorption site, which leads to the accuracy of the drug targeting at the absorption site and improves the therapeutic efficacy of the drug. Mucoadhesive microspheres are formed by either systemic or local effects in gastrointestinal, oral, vaginal, nasal, rectal, ocular delivery. This is the ideal targeting device which could be done in a variety of ways. Keywords: Microspheres, Bioadhesion, Polymer, Bioavailability

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