Role of Rhizome Powder of Turmeric in the management of Madhumeha w.s.r. to Diabetes Mellitus - A Case Study

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Krup Vasavda ◽  
Hegde Prakash L ◽  
Harini A.
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Protein Metabolism ◽  
Metabolic Disorder ◽  
Metabolic Disorders ◽  
Single Drug ◽  
Chronic Hyperglycemia ◽  
Relative Deficiency

Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemia associated with disturbances of carbohydrates, fat, protein metabolism due to absolute or relative deficiency in insulin secretion, that metabolic disorder is considered as the Madhumeha in Ayurveda based on their symptoms. It is one of the types of Vataja Prameha. It results from various etiological factors. Here objective was to evaluate the efficacy of Ayurveda treatment in management of Madhumeha. A 35years old male came to SDM College of Ayurveda Hospital Kayachikitsa special OPD with complaint of Prabhoothamutra, Karapada Daha, Avila Mutrata and Kshudaathi Pravrthi. Examination, investigations and history leads to diabetes mellitus. So patient was treated with Haridra Choorna, Pathya, Apathya and Yogasananas. Ayurveda treatment has effective results in the management of Madhumeha by single drug administration orally.

The role of metabolites of steviol glycosides and their glucosylated derivatives against diabetes-related metabolic disorders

2021 ◽  
Author(s):  
Yuqi Li ◽  
wanfang zhu ◽  
Jing Cai ◽  
Wenyuan Liu ◽  
Toshihiro Akihisa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Protein Metabolism ◽  
Metabolic Disorder ◽  
Metabolic Disorders ◽  
Target Cells ◽  
Steviol Glycosides

Diabetes mellitus (DM), characterized by abnormal carbohydrate, lipid, and protein metabolism, is a metabolic disorder caused by shortage of insulin secretion or decreased sensitivity of target cells to insulin. In...

A Critical Review on Madhumeha (Diabetes Mellitus) with its Preventive Approach

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Anagha Gosavi ◽  
Ram V. Ramekar
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Protein Metabolism ◽  
Insulin Action ◽  
Preventive Measures ◽  
Sweet Taste ◽  
Whole Body ◽  
Appropriate Use ◽  
Chronic Hyperglycemia ◽  
Therapeutic Measures

Prameha is disease of Mutravaha Srotasa having Kapha dominancy which can be correlated with diabetes mellitus. The term diabetes mellitus describes a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Madhumeha is considered as a subtype under the Vatika type of Prameha and it is characterized by passage of urine with sweet taste like honey along with sweetness of whole body. With appropriate use of Ayurvedic preventive measures such as Dincharya, Ritucharya, Aharvidhi and therapeutic measures Madhumeha (DM) can be prevented.

scholarly journals ROLE OF VIRECHANA IN THE EFFECTIVE MANAGEMENT OF DIABETES MELLITUS W.S.R. TO PRAMEHA - A CASE STUDY

2021 ◽  
Vol 9 (6) ◽  
Author(s):  
Vaishnavi Joshi ◽  
Rajendra Huparikar
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disorders ◽  
Glucose Utilization ◽  
Glucose Production ◽  
Keywords Diabetes Mellitus ◽  
Effective Management ◽  
Keywords Diabetes ◽  
All Diseases

Diabetes Mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemias. Depending upon factors contributing to hyperglycemia include reduced insulin secretion, glucose utilization and increased glucose production. Diabetes mellitus is now become most common among all diseases in the present era. In India, this is increasing rapidly and seems that India is going to be capital of Diabetes Mellitus in next coming years. According to Ayurvedic texts, Acharya Charaka has explained about Prameha which can be com- pared with Diabetes Mellitus. The main symptom of Prameha is ‘Prabhuta Aavila Mutrata. Tridosha dushti in Prameha progressively leads to affect Rasa, Meda, Shukra, Ambu, Lasika, Majja and Oja. All these affected Dosha and Dushya influence Basti and manifest the symptom like ‘Prabhuta Avila Mutrata’. Virechana was giv- en in this case because Acharya Charak has mentioned dushti of Kapha, Pitta and Vata is present in Prameha. Phalashruti of Virechana says that there is elimination of Dosha in the sequence of Vit (mala), Pitta, Kapha, Anil. Hence role of Virechana is important in the Chikitsa of Prameha. Keywords: Diabetes Mellitus, Prameha, Samshodhan, Virechan.

scholarly journals The Role of Ethnomedicinal Plants for Treatment and Management of Diabetes Mellitus: An Updated Review

2021 ◽  
Vol 23 (07) ◽  
pp. 1014-1049
Author(s):  
Rakesh K Sindhu ◽  
◽  
Balraj Saini ◽  
Prabhjot Kaur ◽  
Gaber El-Saber Batiha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Blood Glucose ◽  
Pancreatic Islets ◽  
Bioactive Compounds ◽  
Metabolic Disorders ◽  
Review Article ◽  
Treatment Mode ◽  
Significant Treatment

Diabetes mellitus is one of the prominent metabolic disorders nowadays worldwide and it is characterized by an increase in blood glucose, disturbances in metabolism, and alteration in insulin secretion. Nowadays, phytopharmaceuticals have become a significant treatment mode for diabetes, and bioactive compounds have expanded an increasing amount of consideration to this end for they have multiple biological potentials, including the sustained secretion of insulin and revival of pancreatic islets cells. In this review article, we explained the role of bioactive compounds in the treatment and management of diabetes and their mechanisms in prevention.

scholarly journals Association Study of Candidate Gene Uncoupling Protein 2 (UCP2) with Type 2 Diabetes Mellitus in the Different Population Groups of Jammu Region

2019 ◽  
Vol 16 (2) ◽  
pp. 351-357
Author(s):  
Sunil Raina ◽  
Roopali Fotra
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disorders ◽  
Uncoupling Protein ◽  
Molecular Genetic ◽  
Promoter Polymorphism ◽  
Uncoupling Protein 2 ◽  
Population Groups ◽  
Allelic Odds Ratio

Diabetes Mellitus is a group of metabolic disorders characterized by hyperglycaemic resulting from the defects of insulin secretion, insulin action or both. The present study was conducted in order to know the molecular genetic cause of the T2DM patients belonging to the Jammu region of J&K State. Many genes have been known to be linked with the onset and progression of the T2DM therefore the present data represents the role of one of the genes Uncoupling protein 2 (UCP2) known to be strongly associated with T2DM was selected. A total of 250 confirmed cases & controls samples belonging to four population groups (Hindu, Muslim, Sikh & Christians) of Jammu region were also screened for UCP2 -866G/A promoter polymorphism (rs659366). The allelic odds ratio (OR) as observed for UCP2 -866G/A polymorphism in the four population groups showed significant association with Muslim & Sikh population groups. The study undertaken supports the findings of the previous investigations and thus is an addition to the existing literatute in support of UCP2 and T2DM.

scholarly journals THE EFFECT OF CHRONIC HYPERGLYCEMIA ON THE STATE OF MUSCULOSKELETAL SYSTEM (LITERATURE REVIEW)

2021 ◽  
Vol 21 (1) ◽  
pp. 184-187
Author(s):  
A.O. Ponyrko
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Bone Tissue ◽  
Musculoskeletal System ◽  
Metabolic Disorder ◽  
Skeletal System ◽  
Complex Disorders ◽  
Chronic Hyperglycemia ◽  
Wide Range

Diabetes mellitus is a metabolic disorder that today has become a threatening problem for human health. Its prevalence has been constantly increasing throughout the world over the past decades. Diabetes mellitus is regarded as an incurable metabolic disorder characterized by hyperglycemia, which is caused by defects in insulin secretion. This disease annually affects almost 3% of the total population of the planet. Chronic hyperglycemia causes dysfunction of various organs of the body, such as the eyes, kidneys, heart, blood vessels, and nerves. The most common complications of diabetes include lesions of the vessels of the eye, kidneys, lower limbs and nervous system. A high level of glucose in the blood causes the development of a wide range of pathological disorders, which affect bones as well. Recent studies have shown that diseases of the skeletal system are often observed in diabetes mellitus. Speaking about the effect of hyperglycemia on bones, the development of osteopenia and osteoporosis should be noted. In this regard, an important area of research is to study changes in the bone tissue in patients with type 1 diabetes mellitus and the mechanisms that lead to disruption of bone structure and metabolism. The article highlights the pathophysiological mechanisms of hyperglycemia action in type 1 diabetes that explains complex disorders of the organs of the musculoskeletal system. The detrimental effect of hyperglycemia results in marked degenerative changes in bone cells. The pathogenic effect of hyperglycemia on bone tissue is manifested in a decrease in bone mineral density that is due to the lack of insulin and, as a consequence, significant metabolic disorders, a decrease in bone mass, inhibition of bone tissue formation, a significant decrease in the trace element composition of bone. The combination of these factors creates the appropriate pathomorphological basis for the development of diabetic osteopathy. The article highlights the mechanism of action of hyperglycemia on skeletal system in order to stimulate to a more detailed investigation of diabetes mellitus in experimental animals.

Role of Circulating Microparticles in Type 2 Diabetes Mellitus: Implications for Pathological Clotting

2021 ◽  
Author(s):  
Siphosethu Cassandra Maphumulo ◽  
Etheresia Pretorius
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systemic Inflammation ◽  
Blood Cells ◽  
Low Grade ◽  
Chronic Hyperglycemia ◽  
Increased Risk

AbstractType 2 diabetes mellitus (T2DM) is a multifactorial chronic metabolic disease characterized by chronic hyperglycemia due to insulin resistance and a deficiency in insulin secretion. The global diabetes pandemic relates primarily to T2DM, which is the most prevalent form of diabetes, accounting for over 90% of all cases. Chronic low-grade inflammation, triggered by numerous risk factors, and the chronic activation of the immune system are prominent features of T2DM. Here we highlight the role of blood cells (platelets, and red and white blood cells) and vascular endothelial cells as drivers of systemic inflammation in T2DM. In addition, we discuss the role of microparticles (MPs) in systemic inflammation and hypercoagulation. Although once seen as inert by-products of cell activation or destruction, MPs are now considered to be a disseminated storage pool of bioactive effectors of thrombosis, inflammation, and vascular function. They have been identified to circulate at elevated levels in the bloodstream of individuals with increased risk of atherothrombosis or cardiovascular disease, two significant hallmark conditions of T2DM. There is also general evidence that MPs activate blood cells, express proinflammatory and coagulant effects, interact directly with cell receptors, and transfer biological material. MPs are considered major players in the pathogenesis of many systemic inflammatory diseases and may be potentially useful biomarkers of disease activity and may not only be of prognostic value but may act as novel therapeutic targets.

scholarly journals Diabetes Mellitus And Glycosylated Hemoglobin A1c

2018 ◽  
Vol 1 (2) ◽  
pp. 112-117
Author(s):  
Shiva Raj KC
Keyword(s):  
Diabetes Mellitus ◽  
Hemoglobin A1c ◽  
Glycosylated Hemoglobin ◽  
Time Frame ◽  
World Health ◽  
Chronic Hyperglycemia ◽  
Glycosylated Hemoglobin A1c ◽  
Health Organization ◽  
Global Health Problem

Diabetes mellitus is a global health problem in 21st century. The incidence of diabetes mellitus is in rise and is estimated to be more prevalent in coming years. It is becoming one of the most common non-infectious and non-neoplastic causes of morbidity and mortality. Various complications are associated with diabetes mellitus. With control of blood glucose level, complications of diabetes mellitus can be minimized. In different time frame, different parameters and level have been used to diagnose diabetes. Glycosylated hemoglobin A1c is one of the reliable indicator of chronic hyperglycemia. In 2011, World Health Organization has included HbA1c in the diagnostic criteria. Various methods are used to detect the level of HbA1c.  Glycosylated hemoglobin is being used in the management of diabetes mellitus. Various studies have shown its prognostic implication in micro and macrovascular complications. Here we discuss various methods of estimation of HbA1c, various role of HbA1c in the management of Diabetes Mellitus and limitation of the test.  

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