scholarly journals Oral and Dental Manifestations of Fanconi Anemia

2021 ◽  
Vol 28 (3) ◽  
pp. E202132
Author(s):  
Vesna Ambarkova
Keyword(s):  
Oral Cancer ◽  
Fanconi Anemia ◽  
Dental Treatment ◽  
Cell Types ◽  
Urogenital System ◽  
Oral Diseases ◽  
Dental Anomalies ◽  
Gradual Development ◽  
Oncological Diseases ◽  
Close Cooperation

Fanconi anemia is a rare disease, which is characterized by decreased production of all blood cell types. Fanconi anemia is the most common inherited form of aplastic anemia. Congenital abnormalities of the eyes, ears, and heart, malformed or absent kidney, urogenital system involvement are common. There is a delay in physical development. Intelligence in patients with Fanconi anemia is usually normal. The most serious problems associated with Fanconi anemia include the gradual development of bone marrow disorders. Many patients with Fanconi anemia develop leukemia or myelodysplastic syndrome, as well as other oncological diseases. Oral manifestations in patients with Fanconi anemia can be classified as gingivitis, periodontitis, dental caries, dental anomalies, soft tissue lesions, oral cancer, and lesions of the tongue. Patients with Fanconi anemia have increased predisposition to squamous cell carcinoma of the head and neck and oral cancer. The interdisciplinary team of medical and dental specialists must be included in the medical and dental treatment of patients with Fanconi anemia. For proper dental care of patients with Fanconi anemia, the close cooperation of dental specialists, including orthodontists, pedodontists, prosthetists, oral surgeons, as well as specialists in periodontology and oral diseases, is of particular importance.

Challenges of Stem-cell-based Craniofacial Regeneration

2021 ◽  
Vol 16 ◽  
Author(s):  
Ruoshi Xu ◽  
Chenchen Zhou ◽  
Yuning Zhang ◽  
Shiwen Zhang ◽  
Jing Xie ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Dental Caries ◽  
Dental Treatment ◽  
Systemic Disease ◽  
Functional Restoration ◽  
Tissue Loss ◽  
Clinical Approach ◽  
Self Healing ◽  
Oral Diseases ◽  
Signal Molecule

Abstract: Oral diseases, such as dental caries, pulpitis, periodontitis, or craniofacial trauma, are common. Some individuals even suffer from oral cancer or congenital craniofacial defects. The oral-systemic disease link reveals that a dental disorder is not a minor problem. Tissue loss is an inevitable consequence of most oral diseases, and repairing the tissue loss and restoring craniofacial function are highly expected by patients and are terminal targets of dental treatment. The current clinical approach for tissue loss due to dental caries, pulpitis, periodontitis, oral cancer, trauma, and developmental diseases depends on the filling of corresponding material, allograft, or autograft bone after lesion removal. Repair of the tissue volume is expectedly followed by promising functional restoration using regenerative dental tissue or tissue engineering, which has currently aroused the interest of clinicians and researchers. This review focuses on the bold ideas and recent findings on newly identified skeletal stem cells (SSCs) as candidates for craniofacial regeneration, signaling regulation of SSCs extended from embryonic development, and signal molecule delivery for the repair of the craniofacial defect, sincerely hoping that the hypothesis of craniofacial self-healing is true in the future.

scholarly journals STUDI KASUS PATOLOGI GIGI: KARIES PADA RANGKA MANUSIA ST1, SONG TERUS, PACITAN, JAWA TIMUR ( Dental Pathology Case Study: Caries On ST1 Human Remains, Song Terus, Pacitan, East Java)

2018 ◽  
Vol 10 (2) ◽  
pp. 101-115
Author(s):  
Anita Tamu Ina ◽  
Dyah Prastiningtyas ◽  
Harry Widianto ◽  
Florent Détroit ◽  
Ferry Fredy Karwur ◽  
...  
Keyword(s):  
Dental Treatment ◽  
Human Remains ◽  
Oral Disease ◽  
Dietary Habit ◽  
Oral Diseases ◽  
Dental Pathology ◽  
Comparison Results ◽  
Depth Study ◽  
Macroscopic Observation ◽  
Song Terus

Human remains found in Song Terus (Pacitan, East Java), known as ST1, presented an opportunity of in-depth study in reconstructing how human lived during Early Holocene period in the area. This article focuses on palaeopathological aspects by examining lesions of disease observable in bones and dentition of human remains found in archaeological context. The research done for this article focuses more on dental remains, as teeth are known to have durability and longevity as archaeological finds, and could also provide information on age-at-death, types of diet, and oral diseases which may occurred during a person’s life. Dental caries is one of the most common type of oral disease found in archaeological context. Research methods used are macroscopic observation and literature reference comparison.. Results showed there were nine dentition on this individual (from a total of 27 identified dentition) suffered from caries with various degree of severity. Other types of oral disease noted during observation and analysis were periodontal disease. ST1 might have been suffering from severe caries due to lack of oral hygiene, as well as minimum dental treatment towards emerging oral disease. Nevertheless, these diseases did not seem to be directly caused by ST1’s dietary habit during lifetime. ABSTRAK Temuan rangka manusia ST1 di Song Terus (Pacitan, Jawa Timur) memberikan peluang untuk menelusuri lebih jauh pola kehidupan manusia pada periode Holosen Awal di wilayah ini. Artikel ini berfokus pada aspek paleopatologi yang merupakan salah satu kajian ilmu dalam menelusuri jejak kehidupan manusia di masa lalu melalui penyakit pada tulang dan gigi manusia yang ditemukan dalam konteks arkeologi. Materi penelitian dalam artikel ini menitikberatkan pada gigi manusia yang merekam informasi mengenai masa hidup seseorang, termasuk aspek-aspek perkiraan usia saat mati, jenis makanan yang pernah dikonsumsi, dan penyakit yang pernah diderita. Kasus patologi berupa karies menarik untuk diteliti sebab penyakit ini merupakan salah satu kasus yang umum ditemukan pada sisa rangka manusia. Metode penelitian yang digunakan adalah observasi makroskopis dan metode pustaka. Hasil analisis menunjukkan bahwa dari 27 gigi tersisa pada individu ST1, terdapat sembilan gigi yang terdeteksi mengalami karies dan beberapa gigi lain yang menderita penyakit periodontal. Karies pada individu ini tampak disebabkan oleh mikro-organisme yang berkembang di dalam mulut akibat minimalnya perawatan kesehatan gigi dan mulut, serta tidak berhubungan langsung dengan asupan nutrisi yang dikonsumsi oleh individu ini pada masa hidupnya.

Oral cancer in Fanconi anemia: Review of 121 cases

2018 ◽  
Vol 125 ◽  
pp. 35-40 ◽  
Author(s):  
Camila Pinheiro Furquim ◽  
Allana Pivovar ◽  
José Miguel Amenábar ◽  
Carmem Bonfim ◽  
Cassius Carvalho Torres-Pereira
Keyword(s):  
Oral Cancer ◽  
Fanconi Anemia

Two enemies, one fight: An update of oral cancer in patients with Fanconi anemia

Cancer ◽  
2019 ◽  
Vol 125 (22) ◽  
pp. 3936-3946 ◽  
Author(s):  
José M. Amenábar ◽  
Cassius C. Torres‐Pereira ◽  
Kai D. Tang ◽  
Chamindie Punyadeera
Keyword(s):  
Oral Cancer ◽  
Fanconi Anemia

scholarly journals Factors Affecting Preventive Dental Treatment of Adolescents in Korea

2020 ◽  
Vol 17 (14) ◽  
pp. 4948
Author(s):  
Seon-Hui Kwak ◽  
Soo-Myoung Bae ◽  
Sun-Jung Shin ◽  
Bo-Mi Shin
Keyword(s):  
Oral Health ◽  
Health Education ◽  
Social Deprivation ◽  
Dental Treatment ◽  
Deprivation Index ◽  
Oral Diseases ◽  
Factors Affecting ◽  
Oral Health Education ◽  
Preventive Dental ◽  
The Government

We conducted a multilevel analysis to identify factors affecting adolescents’ preventive dental treatment experience in South Korea. We sampled 72,435 students who participated in the 9th Korea Youth Risk Behavior Web-based Survey. The individual-level variables were divided into demographic factors, socioeconomic factors, oral health behavioral factors, and oral symptom experience factors. The regional-level variables included oral health resources, rate of students receiving oral health education at school by region, social deprivation index, and the number of private educational institutions. A higher rate of receiving oral health education in school by region was associated with increased fluoride application (1.04 times, p = 0.003). However, the number of private educational institutes per 1000 people was negatively associated with fluoride application experienced by students (0.64 times, p = 0.039). Students underwent more scaling when there were more dentists per 10,000 individuals (1.14 times, p = 0.008) and less scaling in areas with a higher social deprivation index (0.88 times, p = 0.024). To increase the access to preventive care for oral diseases among adolescents, a preventive system should be established in schools, and a primary dental care system should be established through the cooperation of the government, private dental clinics, and schools.

scholarly journals ORAL CANCER SCREENING IN NON-INSTITUTIONALIZED OLDER ADULTS LIVING IN RURAL COMMUNITIES OF SOUTHEAST GEORGIA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S883-S884
Author(s):  
Swaha Pattanaik ◽  
Bettye Apenteng ◽  
Adrienne L Cohen ◽  
Georgia Dounis ◽  
Raymona Lawrence
Keyword(s):  
Older Adults ◽  
Cancer Screening ◽  
Rural Communities ◽  
Oral Cancer ◽  
Well Being ◽  
The United States ◽  
Oral Diseases ◽  
Key Informants ◽  
Oral Cancer Screening ◽  
Common Sign

Abstract The older population in the United States is growing at an unprecedented rate. Oral diseases such as oral cancer can affect physical, psychological, and social well-being in older adults. Oral cancer screening can prevent development of the disease in high-risk individuals. The purpose of this research was to assess determinants of preventive oral health behavior including oral cancer screening in noninstitutionalized older adults living in rural/medically underserved communities of southeast Georgia. A mixed methods sequential explanatory design was used. Surveys were administered to 206 individuals aged 50 and older. Phone interviews were conducted with 22 individuals from the survey sample and 11 key informants. The majority of the participants (83.01%) said they had never been examined for oral cancer by a doctor or a dentist. Those who correctly recognized the most common sign of oral cancer were about three times more likely (OR=3.75; 95% CI: 1.04 – 13.50) to have had an exam for oral cancer (p=0.04). The survey participants who lived alone were more likely (OR = 4.39; 95% CI = 0.95 – 20.26) to have been examined for oral cancer (p = 0.05). During the interview, older adult participants rarely mentioned oral cancer with regards to an unhealthy mouth. The interview participants revealed that living alone gave them more time to pay attention to their health. For the older adults, prevention of oral diseases was grounded in the autonomy in their own behaviors, while the key informants saw more macro community and systems- level factors as the solution.

scholarly journals Anesthetic Management of a Patient With Fanconi Anemia

2019 ◽  
Vol 66 (4) ◽  
pp. 218-220
Author(s):  
Saki Nagano ◽  
Masanori Tsukamoto ◽  
Takeshi Yokoyama
Keyword(s):  
Fanconi Anemia ◽  
Platelet Transfusion ◽  
Autosomal Recessive ◽  
Dental Treatment ◽  
Bone Marrow Failure ◽  
Anesthetic Management ◽  
Bone Marrow Failure Syndrome ◽  
Hematopoietic Stem ◽  
Dental Surgery ◽  
Preoperative Examination

Fanconi anemia (FA) is a type of bone marrow failure syndrome based on an autosomal recessive inherited trait with increased predisposition for other cancers. It is extremely rare and is characterized by short stature, polydactyly, and pancytopenia. At present, the only effective treatment for FA is allogeneic hematopoietic stem cell transplantation (SCT). Chemotherapy is necessary prior to allogeneic SCT. Dental treatment is usually performed before chemotherapy to reduce potential infections. We experienced the anesthetic management of a 4-year-old boy diagnosed with FA, who underwent extensive dental extractions before chemotherapy for SCT. In the preoperative examination, the platelet count was decreased to less than 3.0 × 104 cells/μL because of chronic pancytopenia. The patient received 20 units of platelet transfusion over 3 days prior to anesthesia. Dental surgery and multiple dental extractions were successfully completed under general anesthesia with sevoflurane, fentanyl, and remifentanil, and chemotherapy started 3 days postoperatively.

Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease

2007 ◽  
Vol 86 (4) ◽  
pp. 306-319 ◽  
Author(s):  
T.A. Silva ◽  
G.P. Garlet ◽  
S.Y. Fukada ◽  
J.S. Silva ◽  
F.Q. Cunha
Keyword(s):  
Polymorphonuclear Leukocytes ◽  
Bone Cells ◽  
Inflammatory Diseases ◽  
Cell Types ◽  
Cellular Responses ◽  
Experimental Models ◽  
Periodontal Tissue ◽  
Oral Diseases ◽  
Specific Receptors

The inflammatory oral diseases are characterized by the persistent migration of polymorphonuclear leukocytes, monocytes, lymphocytes, plasma and mast cells, and osteoblasts and osteoclasts. In the last decade, there has been a great interest in the mediators responsible for the selective recruitment and activation of these cell types at inflammatory sites. Of these mediators, the chemokines have received particular attention in recent years. Chemokine messages are decoded by specific receptors that initiate signal transduction events, leading to a multitude of cellular responses, including chemotaxis and activation of inflammatory and bone cells. However, little is known about their role in the pathogenesis of inflammatory oral diseases. The purpose of this review is to summarize the findings regarding the role of chemokines in periapical and periodontal tissue inflammation, and the integration, into experimental models, of the information about the role of chemokines in human diseases.

scholarly journals FEATURES OF PROVIDING DENTAL CARE TO DRUG-ADDICTED PATIENTS

2018 ◽  
Vol 22 (1) ◽  
pp. 55-57
Author(s):  
Victoria V. Evstratenko ◽  
A. V Sevbitov ◽  
V. V Platonova
Keyword(s):  
Drug Addiction ◽  
Dental Care ◽  
Dental Treatment ◽  
Dental Health ◽  
Oral Diseases

Drug addiction of any kind is a serious threat to patients' dental health too. It has been found out that patients, who are drug addicted, have a significantly higher frequency and severity of oral diseases: increase in frequency of caries and its complications, inflammatory-and-dystrophic diseases of periodontitis, pathologies of mucous tunic of mouth. We examined 197 persons who had drug addiction. The conducted research revealed that all 100% examined patients needed dental care; preparation of drug-addicted patients for a dental treatment must be conducted under control of narcologist, anesthesiologist and dentist.

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