scholarly journals Frequency estimation of disease-causing mutations in the Belgian population of some dog breeds

2016 ◽  
Vol 85 (4) ◽  
pp. 185-196 ◽  
Author(s):  
E. Beckers ◽  
M. Van Poucke ◽  
L. Ronsyn ◽  
L. Peelman
Keyword(s):  
Frequency Estimation ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Labrador Retriever ◽  
Golden Retriever ◽  
Progressive Retinal Atrophy ◽  
Cavalier King Charles Spaniel ◽  
Low Genetic Diversity ◽  
Retinal Atrophy ◽  
Belgian Population ◽  
Degenerative Myelopathy

A Belgian population of ten breeds with a low to moderately low genetic diversity or which are relatively popular in Belgium, i.e. Bichon frise, Bloodhound, Bouvier des Flandres, Boxer, Cavalier King Charles spaniel, Irish setter, Papillon, Rottweiler, Golden retriever and Labrador retriever, was genotyped for all potentially relevant disease-causing variants known at the start of the study. In this way, the frequency was estimated for 26 variants in order to improve breeding advice. Disorders with a frequency high enough to recommend routine genotyping in breeding programs are (1) degenerative myelopathy for the Bloodhound, (2) arrhythmogenic right ventricular cardiomyopathy and degenerative myelopathy for Boxers, (3) episodic falling syndrome and macrothrombocytopenia for the Cavalier King Charles spaniel, (4) progressive retinal atrophy rod cone dysplasia 4 for the Irish setter (5) Golden retriever progressive retinal atrophy 1 for the Golden retriever and (6) exercise induced collapse and progressive rod-cone degeneration for the Labrador retriever. To the authors’ knowledge, in this study, the presence of a causal mutation for a short tail in the Bouvier des Flandres is described for the first time.

scholarly journals A novel mutation in TTC8 is associated with progressive retinal atrophy in the golden retriever

2014 ◽  
Vol 1 (1) ◽  
pp. 4 ◽  
Author(s):  
Louise M Downs ◽  
Berit Wallin-Håkansson ◽  
Tomas Bergström ◽  
Cathryn S Mellersh
Keyword(s):  
Novel Mutation ◽  
Golden Retriever ◽  
Progressive Retinal Atrophy ◽  
Retinal Atrophy

scholarly journals Frequency estimation of disease-causing mutations in the Belgian population of some dog breeds

2016 ◽  
Vol 85 (4) ◽  
pp. 175-184 ◽  
Author(s):  
E. Beckers ◽  
M. Van Poucke ◽  
L. Ronsyn ◽  
L. Peelman
Keyword(s):  
Genetic Diversity ◽  
Multidrug Resistance ◽  
Frequency Estimation ◽  
German Shepherd ◽  
Breeding Programs ◽  
German Shepherd Dog ◽  
Belgian Population ◽  
Degenerative Myelopathy ◽  
First Time

In light of improving breeding advice, the frequency was estimated for all the disease-causing mutations that were known at the start of the study and that are potentially relevant for a group of dog breeds, which are relatively popular or in which the genetic diversity in Belgium is low to moderately low. In this study, the results for the German shepherd dog, Malinois, Lakenois, Groenendael, Tervuren, Australian shepherd and Border collie are presented. Disorders with a frequency high enough to warrant routine genotyping for breeding programs are (1) multidrug resistance 1 and hereditary cataract for the Australian shepherd, (2) degenerative myelopathy for the German shepherd dog, Malinois and Groenendael and (3) collie eye anomaly for the Border collie. In addition, the hyperuricosuria mutation described in the German shepherd dog was not found in its Belgian population, but was, to the authors’ knowledge discovered for the first time in the Malinois.

scholarly journals A Frameshift Mutation in Golden Retriever Dogs with Progressive Retinal Atrophy Endorses SLC4A3 as a Candidate Gene for Human Retinal Degenerations

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e21452 ◽  
Author(s):  
Louise M. Downs ◽  
Berit Wallin-Håkansson ◽  
Mike Boursnell ◽  
Stefan Marklund ◽  
Åke Hedhammar ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Frameshift Mutation ◽  
Golden Retriever ◽  
Progressive Retinal Atrophy ◽  
Retinal Degenerations ◽  
Retinal Atrophy

Vergiftungen durch Aufnahme von Unrat bei Hunden (“Müllintoxikation”)

2008 ◽  
Vol 36 (S 01) ◽  
pp. S67-S72
Author(s):  
J. Jensen ◽  
I. Nolte
Keyword(s):  
Labrador Retriever ◽  
Golden Retriever ◽  
Klinische Relevanz

Zusammenfassung Gegenstand und Ziel: Die Aufnahme von Abfällen oder Kadavern durch Hunde als Aasfresser ist nicht ungewöhnlich. Bisher wurden in diesem Zusammenhang vor allem akute gastrointestinale Symptome beschrieben. In der neueren Literatur finden sich jedoch auch Berichte über zum Teil schwere neurologische Störungen. Die Zielsetzung der vorliegenden Untersuchung war die Beschreibung von Rassen-, Altersund Geschlechtsverteilung sowie Symptomen und Prognose bei durch die Aufnahme von Unrat hervorgerufenen Intoxikationen. Untersuchungsgut, Material und Methode: Daten von im Zeitraum Dezember 2003 bis Juli 2007 stationär aufgenommenen Patienten wurden retrospektiv auf Hinweise für eine durch Aufnahme von Unrat ausgelöste Intoxikation untersucht. Ergebnisse: Insgesamt konnten 26 Hunde mit einer “Müllintoxikation” identifiziert werden. Achtzehn Hunde waren weiblich und nur acht männlich. Das mittlere Alter lag bei 4,4 Jahren (6 Monate bis 14 Jahre). Die am häufigsten vertretenen Rassen waren Labrador Retriever (n = 5), Golden Retriever und Jack Russell Terrier (je n = 3). 17 Hunde (65%) zeigten zentralnervöse Veränderungen. Bei 10 dieser Hunde war die Aufnahme von Unrat anamnestisch gesichert. Schlussfolgerungen: Neurologische Störungen konnten bei über der Hälfte der untersuchten Hunde festgestellt werden. In zukünftigen Untersuchungen sollte deshalb zur Identifizierung möglicher auslösender Substanzen besonderer Wert auf eine umfangreiche toxikologische Abklärung solcher Fälle gelegt werden. Klinische Relevanz: Bei plötzlichem Auftreten von zentralnervösen Symptomen sollte auch an Intoxikationen durch die Aufnahme von Unrat gedacht werden. Die Therapie erfolgt soweit möglich durch Dekontamination sowie symptomatisch. Die Prognose ist in der Regel gut.

scholarly journals A CNGB1 Frameshift Mutation in Papillon and Phalène Dogs with Progressive Retinal Atrophy

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72122 ◽  
Author(s):  
Saija J. Ahonen ◽  
Meharji Arumilli ◽  
Hannes Lohi
Keyword(s):  
Frameshift Mutation ◽  
Progressive Retinal Atrophy ◽  
Retinal Atrophy

scholarly journals Avaliação fisiológica e comportamental de cães utilizados em terapia assistida por animais (TAA)

2012 ◽  
Vol 64 (3) ◽  
pp. 568-576
Author(s):  
K.C.M. Yamamoto ◽  
E.Y.T Silva ◽  
K.N Costa ◽  
M.S. Souza ◽  
M.L.M. Silva ◽  
...  
Keyword(s):  
Labrador Retriever ◽  
Golden Retriever

Realizou-se a observação comportamental de nove cães terapeutas (oito da raça Labrador Retriever e um Golden Retriever), dosaram-se cortisol sérico e salivar, aferiram-se a temperatura retal, a pressão arterial sistólica e as frequências cardíaca e respiratória nos seguintes momentos: M0 (média de três avaliações do cão em repouso) e em M1, M2 e M3 (imediatamente antes, imediatamente após e decorridas 24h das atividades de terapia assistida por animais - TAA), respectivamente. Não houve diferença significativa quanto às características estudadas (P>0,05), exceto pela temperatura, que foi mais elevada em M1 e M2 do que em M0 (P=0,009). A avaliação comportamental, realizada de maneira descritiva, não apresentou alteração negativa. Houve diferença significativa quanto à concentração de cortisol sérico entre os momentos M1 e M3 (P=0,071), e não ocorreu diferença da concentração do cortisol salivar entre os quatro momentos (P=0,746). As alterações observadas foram atribuídas à contenção e à manipulação dos animais e não desencadearam desconforto físico ou estresse dignos de nota em cães.

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