Clinical effect of porous titanium mesh with cross-linked collagen membrane for guided bone regeneration

Background and Objective: Guided bone regeneration allows new bone formation in anatomical sites showing defects preventing implant rehabilitation. Material and Methods: The present case series reported the outcomes of five patients treated with customized titanium meshes manufactured with a digital workflow for achieving bone regeneration at future implant sites. A significant gain in both width and thickness was achieved for all patients. Results: From a radiographic point of view (CBTC), satisfactory results were reached both in horizontal and vertical defects. An average horizontal gain of 3.6 ± 0.8 mm and a vertical gain of 5.2 ± 1.1 mm. Conclusions: The findings from this study suggest that customized titanium meshes represent a valid method to pursue guided bone regeneration in horizontal, vertical or combined defects. Particular attention must be paid by the surgeon in the packaging of the flap according to a correct method called the “poncho” technique in order to reduce the most frequent complication that is the exposure of the mesh even if a partial exposure of one mesh does not compromise the final outcome of both the reconstruction and the healing of the implants.

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Dentin-Derived-Barrier Membrane in Guided Bone Regeneration: A Case Report

Materials ◽

10.3390/ma14092166 ◽

2021 ◽

Vol 14 (9) ◽

pp. 2166

Author(s):

Jeong-Kui Ku ◽

In-Woong Um ◽

Mi-Kyoung Jun ◽

Il-hyung Kim

Keyword(s):

Case Report ◽

Bone Regeneration ◽

Guided Bone Regeneration ◽

Successful Outcome ◽

Collagen Membrane ◽

Type I ◽

Barrier Membrane ◽

Dentin Matrix ◽

Demineralized Dentin Matrix ◽

Demineralized Dentin

An autogenous, demineralized, dentin matrix is a well-known osteo-inductive bone substitute that is mostly composed of type I collagen and is widely used in implant dentistry. This single case report describes a successful outcome in guided bone regeneration and dental implantation with a novel human-derived collagen membrane. The authors fabricated a dentin-derived-barrier membrane from a block-type autogenous demineralized dentin matrix to overcome the mechanical instability of the collagen membrane. The dentin-derived-barrier acted as an osteo-inductive collagen membrane with mechanical and clot stabilities, and it replaced the osteo-genetic function of the periosteum. Further research involving large numbers of patients should be conducted to evaluate bone forming capacity in comparison with other collagen membranes.

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Biomimetic characteristics of mussel adhesive protein-loaded collagen membrane in guided bone regeneration of rabbit calvarial defects

Journal of Periodontal & Implant Science ◽

10.5051/jpis.2018.48.5.305 ◽

2018 ◽

Vol 48 (5) ◽

pp. 305 ◽

Cited By ~ 4

Author(s):

Woong-Kyu Song ◽

Joo-Hyun Kang ◽

Jae-Kook Cha ◽

Jung-Seok Lee ◽

Jeong-Won Paik ◽

...

Keyword(s):

Bone Regeneration ◽

Guided Bone Regeneration ◽

Collagen Membrane ◽

Adhesive Protein ◽

Mussel Adhesive Protein ◽

Calvarial Defects ◽

Mussel Adhesive

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Horizontal-guided Bone Regeneration using a Titanium Mesh and an Equine Bone Graft

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1653 ◽

2015 ◽

Vol 16 (2) ◽

pp. 154-162 ◽

Cited By ~ 12

Author(s):

Danilo Alessio Di Stefano ◽

Gian Battista Greco ◽

Lorenzo Cinci ◽

Laura Pieri

Keyword(s):

Bone Graft ◽

Bone Regeneration ◽

Guided Bone Regeneration ◽

Bone Sample ◽

Successful Outcome ◽

Autogenous Bone ◽

Titanium Mesh ◽

Ridge Augmentation ◽

Stereolithographic Model ◽

Equine Bone

ABSTRACT Aim The present work describes a horizontal ridge augmentation in which a titanium mesh was preshaped by adapting it to a stereolithographic model of the patient's jaw that was fabricated from CT scans. Background Guided bone regeneration (GBR) involves covering the augmentation site with a long-lasting barrier to protect it from the invasion of surrounding soft tissues. Among barriers, titanium meshes may provide a successful outcome, but the intraoperatory time needed to shape them is a disadvantage. Case description The 54-year-old patient, missing the right mandibular second bicuspid, first molar, and second molar, had her atrophic ridge augmented with a 30:70 mixture of autogenous bone and equine, enzyme-deantigenic collagenpreserved bone substitute. Two conical implants were inserted concomitantly in the second bicuspid and first molar positions, and the site was protected with the preshaped mesh. Four months later, the titanium mesh was retrieved, a bone sample was collected, and histological and histomorphometric analyses were performed. Provisional and definitive prostheses were then delivered, and follow-up controls were performed for up to 24 months. Conclusion Preshaping the mesh on a model of the patient's mandible shortened the surgical time and enabled faster mesh placement. Two years after surgery, the implants were perfectly functional, and the bone width was stable over time as shown by radiographic controls. Histological analysis of the bone sample showed the heterologous biomaterial to be biocompatible and undergoing advanced remodeling and replacement with newly formed bone. Clinical significance Preshaping a titanium mesh over a stereolithographic model of the patient's jaw allowed for a significant reduction of the intraoperative time and may be therefore, advisable in routine practice. How to cite this article Di Stefano DA, Greco GB, Cinci L, Pieri L. Horizontal-guided Bone Regeneration using a Titanium Mesh and an Equine Bone Graft. J Contemp Dent Pract 2015;16(2):154-162.

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Comparative In Vivo Analysis of the Integration Behavior and Immune Response of Collagen-Based Dental Barrier Membranes for Guided Bone Regeneration (GBR)

Membranes ◽

10.3390/membranes11090712 ◽

2021 ◽

Vol 11 (9) ◽

pp. 712

Author(s):

Milena Radenković ◽

Said Alkildani ◽

Ignacio Stoewe ◽

James Bielenstein ◽

Bernd Sundag ◽

...

Keyword(s):

Wound Healing ◽

Bone Regeneration ◽

Barrier Function ◽

Guided Bone Regeneration ◽

Collagen Membrane ◽

Cellular Infiltration ◽

Barrier Membranes ◽

Tissue Integration ◽

Tissue Reactions

Collagen-based resorbable barrier membranes have been increasingly utilized for Guided Bone Regeneration (GBR), as an alternative to non-resorbable synthetic membranes that require a second surgical intervention for removal. One of the most important characteristics of a resorbable barrier membrane is its mechanical integrity that is required for space maintenance and its tissue integration that plays a crucial role in wound healing and bone augmentation. This study compares a commercially available porcine-derived sugar-crosslinked collagen membrane with two non-crosslinked collagen barrier membranes. The material analysis provides an insight into the influence of manufacturing on the microstructure. In vivo subcutaneous implantation model provides further information on the host tissue reaction of the barrier membranes, as well as their tissue integration patterns that involve cellular infiltration, vascularization, and degradation. The obtained histochemical and immunohistochemical results over three time points (10, 30, and 60 days) showed that the tissue response to the sugar crosslinked collagen membrane involves inflammatory macrophages in a comparable manner to the macrophages observed in the surrounding tissue of the control collagen-based membranes, which were proven as biocompatible. The tissue reactions to the barrier membranes were additionally compared to wounds from a sham operation. Results suggest wound healing properties of all the investigated barrier membranes. However, the sugar-crosslinked membrane lacked in cellular infiltration and transmembraneous vascularization, providing an exclusive barrier function in GBR. Moreover, this membrane maintained a similar swelling ratio over examined timepoints, which suggests a very slow degradation pattern and supports its barrier function. Based on the study results, which showed biocompatibility of the sugar crosslinked membrane and its stability up to 60 days post-implantation, it can be concluded that this membrane may be suitable for application in GBR as a biomaterial with exclusive barrier functionality, similar to non-resorbable options.

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Guided bone regeneration in calvarial critical size bony defect using a double-layer resorbable collagen membrane covering a xenograft: a histological and histomorphometric study in rats

Oral and Maxillofacial Surgery ◽

10.1007/s10006-018-0694-x ◽

2018 ◽

Vol 22 (2) ◽

pp. 203-213 ◽

Cited By ~ 4

Author(s):

Roy Abou Fadel ◽

Rawad Samarani ◽

Carole Chakar

Keyword(s):

Bone Regeneration ◽

Double Layer ◽

Critical Size ◽

Guided Bone Regeneration ◽

Collagen Membrane ◽

Bony Defect ◽

Histomorphometric Study

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Buccal Fat Pad–Derived Stem Cells in Three-Dimensional Rehabilitation of Large Alveolar Defects: A Report of Two Cases

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-17-00215 ◽

2019 ◽

Vol 45 (1) ◽

pp. 45-54 ◽

Cited By ~ 5

Author(s):

Arash Khojasteh ◽

Sepanta Hosseinpour ◽

Maryam Rezai Rad ◽

Marzieh Alikhasi

Keyword(s):

Stem Cells ◽

Bone Regeneration ◽

Guided Bone Regeneration ◽

Collagen Membrane ◽

Bovine Bone ◽

Fat Pad ◽

Buccal Fat Pad ◽

Efficient Treatment ◽

Impacted Teeth ◽

Surgical Extraction

This case report seeks to describe efficient clinical application of adipose-derived stem cells (AdSCs) originated from buccal fat pad (BFP) in combination with conventional guided bone regeneration as protected healing space for reconstruction of large alveolar defects after extraction of multiple impacted teeth. The first case was a 19-year-old woman with several impacted teeth in the maxillary and mandibular regions, which could not be forced to erupt and were recommended for surgical extraction by the orthodontist. After this procedure, a large bone defect was created, and this space was filled by AdSC loaded natural bovine bone mineral (NBBM), which was protected with lateral ramus cortical plates, microscrews, and collagen membrane. After 6 months of post-guided bone regeneration, the patient received 6 and 7 implant placements, respectively, in the maxilla and mandible. At 10 months postoperatively, radiographic evaluation revealed thorough survival of implants. The second case was a 22-year-old man with the same complaint and large bony defects created after his teeth were extracted. After 6 months of post-guided bone regeneration, he received 4 dental implants in his maxilla and 7 implants in the mandible. At 48 months postoperatively, radiographs showed complete survival of implants. This approach represented a considerable amount of 3-dimensional bone formation in both cases, which enabled us to use dental implant therapy for rehabilitation of the whole dentition. The application of AdSCs isolated from BFP in combination with NBBM can be considered an efficient treatment for bone regeneration in large alveolar bone defects.

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