scholarly journals Comprehensive Computer-Aided Decision Support Framework to Diagnose Tuberculosis From Chest X-Ray Images: Data Mining Study

10.2196/21790 ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. e21790
Author(s):  
Muhammad Owais ◽  
Muhammad Arsalan ◽  
Tahir Mahmood ◽  
Yu Hwan Kim ◽  
Kang Ryoung Park
Keyword(s):  
Diagnostic Performance ◽  
State Of The Art ◽  
Medical Condition ◽  
Area Under The Curve ◽  
Classification Model ◽  
Cad Tools ◽  
Descriptive Information ◽  
Computer Aided ◽  
Art Methods ◽  
Effective Diagnosis

Background Tuberculosis (TB) is one of the most infectious diseases that can be fatal. Its early diagnosis and treatment can significantly reduce the mortality rate. In the literature, several computer-aided diagnosis (CAD) tools have been proposed for the efficient diagnosis of TB from chest radiograph (CXR) images. However, the majority of previous studies adopted conventional handcrafted feature-based algorithms. In addition, some recent CAD tools utilized the strength of deep learning methods to further enhance diagnostic performance. Nevertheless, all these existing methods can only classify a given CXR image into binary class (either TB positive or TB negative) without providing further descriptive information. Objective The main objective of this study is to propose a comprehensive CAD framework for the effective diagnosis of TB by providing visual as well as descriptive information from the previous patients’ database. Methods To accomplish our objective, first we propose a fusion-based deep classification network for the CAD decision that exhibits promising performance over the various state-of-the-art methods. Furthermore, a multilevel similarity measure algorithm is devised based on multiscale information fusion to retrieve the best-matched cases from the previous database. Results The performance of the framework was evaluated based on 2 well-known CXR data sets made available by the US National Library of Medicine and the National Institutes of Health. Our classification model exhibited the best diagnostic performance (0.929, 0.937, 0.921, 0.928, and 0.965 for F1 score, average precision, average recall, accuracy, and area under the curve, respectively) and outperforms the performance of various state-of-the-art methods. Conclusions This paper presents a comprehensive CAD framework to diagnose TB from CXR images by retrieving the relevant cases and their clinical observations from the previous patients’ database. These retrieval results assist the radiologist in making an effective diagnostic decision related to the current medical condition of a patient. Moreover, the retrieval results can facilitate the radiologists in subjectively validating the CAD decision.

scholarly journals Comprehensive Computer-Aided Decision Support Framework to Diagnose Tuberculosis From Chest X-Ray Images: Data Mining Study (Preprint)

2020 ◽  
Author(s):  
Muhammad Owais ◽  
Muhammad Arsalan ◽  
Tahir Mahmood ◽  
Yu Hwan Kim ◽  
Kang Ryoung Park
Keyword(s):  
Diagnostic Performance ◽  
State Of The Art ◽  
Medical Condition ◽  
Area Under The Curve ◽  
Classification Model ◽  
Cad Tools ◽  
Descriptive Information ◽  
Computer Aided ◽  
Art Methods ◽  
Effective Diagnosis

BACKGROUND Tuberculosis (TB) is one of the most infectious diseases that can be fatal. Its early diagnosis and treatment can significantly reduce the mortality rate. In the literature, several computer-aided diagnosis (CAD) tools have been proposed for the efficient diagnosis of TB from chest radiograph (CXR) images. However, the majority of previous studies adopted conventional handcrafted feature-based algorithms. In addition, some recent CAD tools utilized the strength of deep learning methods to further enhance diagnostic performance. Nevertheless, all these existing methods can only classify a given CXR image into binary class (either TB positive or TB negative) without providing further descriptive information. OBJECTIVE The main objective of this study is to propose a comprehensive CAD framework for the effective diagnosis of TB by providing visual as well as descriptive information from the previous patients’ database. METHODS To accomplish our objective, first we propose a fusion-based deep classification network for the CAD decision that exhibits promising performance over the various state-of-the-art methods. Furthermore, a multilevel similarity measure algorithm is devised based on multiscale information fusion to retrieve the best-matched cases from the previous database. RESULTS The performance of the framework was evaluated based on 2 well-known CXR data sets made available by the US National Library of Medicine and the National Institutes of Health. Our classification model exhibited the best diagnostic performance (0.929, 0.937, 0.921, 0.928, and 0.965 for F1 score, average precision, average recall, accuracy, and area under the curve, respectively) and outperforms the performance of various state-of-the-art methods. CONCLUSIONS This paper presents a comprehensive CAD framework to diagnose TB from CXR images by retrieving the relevant cases and their clinical observations from the previous patients’ database. These retrieval results assist the radiologist in making an effective diagnostic decision related to the current medical condition of a patient. Moreover, the retrieval results can facilitate the radiologists in subjectively validating the CAD decision.

scholarly journals Can a Computer-Aided Mass Diagnosis Model Based on Perceptive Features Learned From Quantitative Mammography Radiology Reports Improve Junior Radiologists’ Diagnosis Performance? An Observer Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Zilong He ◽  
Yue Li ◽  
Weixiong Zeng ◽  
Weimin Xu ◽  
Jialing Liu ◽  
...  
Keyword(s):  
Breast Imaging ◽  
Diagnostic Performance ◽  
Area Under The Curve ◽  
Breast Mass ◽  
Cad Model ◽  
Breast Masses ◽  
Radiology Reports ◽  
Computer Aided ◽  
Mass Lesions ◽  
The Impact

Radiologists’ diagnostic capabilities for breast mass lesions depend on their experience. Junior radiologists may underestimate or overestimate Breast Imaging Reporting and Data System (BI-RADS) categories of mass lesions owing to a lack of diagnostic experience. The computer-aided diagnosis (CAD) method assists in improving diagnostic performance by providing a breast mass classification reference to radiologists. This study aims to evaluate the impact of a CAD method based on perceptive features learned from quantitative BI-RADS descriptions on breast mass diagnosis performance. We conducted a retrospective multi-reader multi-case (MRMC) study to assess the perceptive feature-based CAD method. A total of 416 digital mammograms of patients with breast masses were obtained from 2014 through 2017, including 231 benign and 185 malignant masses, from which we randomly selected 214 cases (109 benign, 105 malignant) to train the CAD model for perceptive feature extraction and classification. The remaining 202 cases were enrolled as the test set for evaluation, of which 51 patients (29 benign and 22 malignant) participated in the MRMC study. In the MRMC study, we categorized six radiologists into three groups: junior, middle-senior, and senior. They diagnosed 51 patients with and without support from the CAD model. The BI-RADS category, benign or malignant diagnosis, malignancy probability, and diagnosis time during the two evaluation sessions were recorded. In the MRMC evaluation, the average area under the curve (AUC) of the six radiologists with CAD support was slightly higher than that without support (0.896 vs. 0.850, p = 0.0209). Both average sensitivity and specificity increased (p = 0.0253). Under CAD assistance, junior and middle-senior radiologists adjusted the assessment categories of more BI-RADS 4 cases. The diagnosis time with and without CAD support was comparable for five radiologists. The CAD model improved the radiologists’ diagnostic performance for breast masses without prolonging the diagnosis time and assisted in a better BI-RADS assessment, especially for junior radiologists.

scholarly journals Use of State-of-the-Art Methods in the Architectural Design Process

2019 ◽  
Vol 11 (1) ◽  
pp. 179-182
Author(s):  
Dorottya Szilágyi ◽  
Nándor Bakai
Keyword(s):  
Design Process ◽  
Computer Aided Design ◽  
Architectural Design ◽  
State Of The Art ◽  
Computer Aided ◽  
Art Methods ◽  
Aided Design ◽  
Two Sides ◽  
Source Of Information ◽  
Insight Into

Abstract The following article summarizes a research with the intention to demonstrate the challenges that architecture students need to face throughout their design tasks. The study is also meant to contribute to the cognition of state-of-the-art methods that can help students with these emerging problems. The main source of information was a questionnaire. Students were asked about the duties they accomplish when completing a design, about their adopted design methods and about their thoughts on a future profession. As a complement, Interviews were conducted with professional architects from local studios. This allowed a deeper insight into the requirements that the two sides lay down for each other. The research charts how computer aided design could affect the difficulties that appear in the architectural design process.

Structural Analysis of Product and Computer-Aided Assembly Planning in AssemBL Software Package

2018 ◽  
pp. 11-33
Author(s):  
A. N. Bozhko
Keyword(s):  
Computer Aided Design ◽  
State Of The Art ◽  
Graph Model ◽  
Design System ◽  
Assembly Planning ◽  
Complex Products ◽  
Assembly Sequences ◽  
Computer Aided ◽  
Cad Cam ◽  
Aided Design

Computer-aided design of assembly processes (Computer aided assembly planning, CAAP) of complex products is an important and urgent problem of state-of-the-art information technologies. Intensive research on CAAP has been underway since the 1980s. Meanwhile, specialized design systems were created to provide synthesis of assembly plans and product decompositions into assembly units. Such systems as ASPE, RAPID, XAP / 1, FLAPS, Archimedes, PRELEIDES, HAP, etc. can be given, as an example. These experimental developments did not get widespread use in industry, since they are based on the models of products with limited adequacy and require an expert’s active involvement in preparing initial information. The design tools for the state-of-the-art full-featured CAD/CAM systems (Siemens NX, Dassault CATIA and PTC Creo Elements / Pro), which are designed to provide CAAP, mainly take into account the geometric constraints that the design imposes on design solutions. These systems often synthesize technologically incorrect assembly sequences in which known technological heuristics are violated, for example orderliness in accuracy, consistency with the system of dimension chains, etc.An AssemBL software application package has been developed for a structured analysis of products and a synthesis of assembly plans and decompositions. The AssemBL uses a hyper-graph model of a product that correctly describes coherent and sequential assembly operations and processes. In terms of the hyper-graph model, an assembly operation is described as shrinkage of edge, an assembly plan is a sequence of shrinkages that converts a hyper-graph into the point, and a decomposition of product into assembly units is a hyper-graph partition into sub-graphs.The AssemBL solves the problem of minimizing the number of direct checks for geometric solvability when assembling complex products. This task is posed as a plus-sum two-person game of bicoloured brushing of an ordered set. In the paradigm of this model, the brushing operation is to check a certain structured fragment for solvability by collision detection methods. A rational brushing strategy minimizes the number of such checks.The package is integrated into the Siemens NX 10.0 computer-aided design system. This solution allowed us to combine specialized AssemBL tools with a developed toolkit of one of the most powerful and popular integrated CAD/CAM /CAE systems.

Clinical Application of Computer-Aided Diagnosis According to S-Detect in Category 4 Breast Lesions: Prospective Single-Center Study (Preprint)

2020 ◽  
Author(s):  
Pengfei Sun ◽  
Chen Chen ◽  
Weiqi Wang ◽  
Lei Liang ◽  
Dan Luo ◽  
...  
Keyword(s):  
Clinical Management ◽  
Diagnostic Performance ◽  
Breast Biopsy ◽  
Computer Aided Diagnosis ◽  
Breast Lesions ◽  
Breast Masses ◽  
Computer Aided ◽  
Conventional Ultrasound ◽  
Us Findings ◽  
Aided Diagnosis

BACKGROUND Computer-aided diagnosis (CAD) is a useful tool that can provide a reference for the differential diagnosis of benign and malignant breast lesion. Previous studies have demonstrated that CAD can improve the diagnostic performance. However, conventional ultrasound (US) combined with CAD were used to adjust the classification of category 4 lesions has been few assessed. OBJECTIVE The objective of our study was to evaluate the diagnosis performance of conventional ultrasound combined with a CAD system S-Detect in the category of BI-RADS 4 breast lesions. METHODS Between December 2018 and May 2020, we enrolled patients in this study who received conventional ultrasound and S-Detect before US-guided biopsy or surgical excision. The diagnostic performance was compared between US findings only and the combined use of US findings with S-Detect, which were correlated with pathology results. RESULTS A total of 98 patients (mean age 51.06 ±16.25 years, range 22-81) with 110 breast masses (mean size1.97±1.38cm, range0.6-8.5) were included in this study. Of the 110 breast masses, 64/110 (58.18%) were benign, 46/110 (41.82%) were malignant. Compared with conventional ultrasound, a significant increase in specificity (0% to 53.12%, P<.001), accuracy (41.81% to70.19%, P<.001) were noted, with no statistically significant decrease on sensitivity(100% to 95.65% ,P=.48). According to S-Detect-guided US BI-RADS re-classification, 30 out of 110 (27.27%) breast lesions underwent a correct change in clinical management, 74of 110 (67.27%) breast lesions underwent no change and 6 of 110 (5.45%) breast lesions underwent an incorrect change in clinical management. The biopsy rate decreased from 100% to 67.27 % (P<.001).Benign masses among subcategory 4a had higher rates of possibly benign assessment on S-Detect for the US only (60% to 0%, P<.001). CONCLUSIONS S-Detect can be used as an additional diagnostic tool to improve the specificity and accuracy in clinical practice. S-Detect have the potential to be used in downgrading benign masses misclassified as BI-RADS category 4 on US by radiologist, and may reduce unnecessary breast biopsy. CLINICALTRIAL none

scholarly journals CoCoX: Generating Conceptual and Counterfactual Explanations via Fault-Lines

2020 ◽  
Vol 34 (03) ◽  
pp. 2594-2601
Author(s):  
Arjun Akula ◽  
Shuai Wang ◽  
Song-Chun Zhu
Keyword(s):  
Neural Network ◽  
State Of The Art ◽  
Input Image ◽  
Classification Model ◽  
Learning Models ◽  
Fault Line ◽  
Semantic Level ◽  
Explainable Ai ◽  
Fault Lines ◽  
Classification Category

We present CoCoX (short for Conceptual and Counterfactual Explanations), a model for explaining decisions made by a deep convolutional neural network (CNN). In Cognitive Psychology, the factors (or semantic-level features) that humans zoom in on when they imagine an alternative to a model prediction are often referred to as fault-lines. Motivated by this, our CoCoX model explains decisions made by a CNN using fault-lines. Specifically, given an input image I for which a CNN classification model M predicts class cpred, our fault-line based explanation identifies the minimal semantic-level features (e.g., stripes on zebra, pointed ears of dog), referred to as explainable concepts, that need to be added to or deleted from I in order to alter the classification category of I by M to another specified class calt. We argue that, due to the conceptual and counterfactual nature of fault-lines, our CoCoX explanations are practical and more natural for both expert and non-expert users to understand the internal workings of complex deep learning models. Extensive quantitative and qualitative experiments verify our hypotheses, showing that CoCoX significantly outperforms the state-of-the-art explainable AI models. Our implementation is available at https://github.com/arjunakula/CoCoX

scholarly journals Multi-hop assortativities for network classification

2018 ◽  
Vol 7 (4) ◽  
pp. 603-622 ◽  
Author(s):  
Leonardo Gutiérrez-Gómez ◽  
Jean-Charles Delvenne
Keyword(s):  
Machine Learning ◽  
Scientific Collaboration ◽  
State Of The Art ◽  
Medical Engineering ◽  
Research Field ◽  
Classification Task ◽  
Collaboration Network ◽  
Structural Patterns ◽  
Art Methods

Abstract Several social, medical, engineering and biological challenges rely on discovering the functionality of networks from their structure and node metadata, when it is available. For example, in chemoinformatics one might want to detect whether a molecule is toxic based on structure and atomic types, or discover the research field of a scientific collaboration network. Existing techniques rely on counting or measuring structural patterns that are known to show large variations from network to network, such as the number of triangles, or the assortativity of node metadata. We introduce the concept of multi-hop assortativity, that captures the similarity of the nodes situated at the extremities of a randomly selected path of a given length. We show that multi-hop assortativity unifies various existing concepts and offers a versatile family of ‘fingerprints’ to characterize networks. These fingerprints allow in turn to recover the functionalities of a network, with the help of the machine learning toolbox. Our method is evaluated empirically on established social and chemoinformatic network benchmarks. Results reveal that our assortativity based features are competitive providing highly accurate results often outperforming state of the art methods for the network classification task.

scholarly journals Evaluation of the feasibility of explainable computer-aided detection of cardiomegaly on chest radiographs using deep learning

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mu Sook Lee ◽  
Yong Soo Kim ◽  
Minki Kim ◽  
Muhammad Usman ◽  
Shi Sub Byon ◽  
...  
Keyword(s):  
Deep Learning ◽  
Diagnostic Performance ◽  
Absolute Error ◽  
Training Dataset ◽  
Computer Aided Detection ◽  
Test Dataset ◽  
Cardiothoracic Ratio ◽  
Computer Aided ◽  
Chest X Ray ◽  
Public Datasets

AbstractWe examined the feasibility of explainable computer-aided detection of cardiomegaly in routine clinical practice using segmentation-based methods. Overall, 793 retrospectively acquired posterior–anterior (PA) chest X-ray images (CXRs) of 793 patients were used to train deep learning (DL) models for lung and heart segmentation. The training dataset included PA CXRs from two public datasets and in-house PA CXRs. Two fully automated segmentation-based methods using state-of-the-art DL models for lung and heart segmentation were developed. The diagnostic performance was assessed and the reliability of the automatic cardiothoracic ratio (CTR) calculation was determined using the mean absolute error and paired t-test. The effects of thoracic pathological conditions on performance were assessed using subgroup analysis. One thousand PA CXRs of 1000 patients (480 men, 520 women; mean age 63 ± 23 years) were included. The CTR values derived from the DL models and diagnostic performance exhibited excellent agreement with reference standards for the whole test dataset. Performance of segmentation-based methods differed based on thoracic conditions. When tested using CXRs with lesions obscuring heart borders, the performance was lower than that for other thoracic pathological findings. Thus, segmentation-based methods using DL could detect cardiomegaly; however, the feasibility of computer-aided detection of cardiomegaly without human intervention was limited.

scholarly journals Automatic Detection of Discrimination Actions from Social Images

Electronics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 325
Author(s):  
Zhihao Wu ◽  
Baopeng Zhang ◽  
Tianchen Zhou ◽  
Yan Li ◽  
Jianping Fan
Keyword(s):  
Action Recognition ◽  
State Of The Art ◽  
Automatic Detection ◽  
Experimental Results ◽  
Practical Approach ◽  
Detection And Identification ◽  
Art Methods ◽  
Image Set ◽  
Social Images ◽  
Relationship Identification

In this paper, we developed a practical approach for automatic detection of discrimination actions from social images. Firstly, an image set is established, in which various discrimination actions and relations are manually labeled. To the best of our knowledge, this is the first work to create a dataset for discrimination action recognition and relationship identification. Secondly, a practical approach is developed to achieve automatic detection and identification of discrimination actions and relationships from social images. Thirdly, the task of relationship identification is seamlessly integrated with the task of discrimination action recognition into one single network called the Co-operative Visual Translation Embedding++ network (CVTransE++). We also compared our proposed method with numerous state-of-the-art methods, and our experimental results demonstrated that our proposed methods can significantly outperform state-of-the-art approaches.

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