scholarly journals RELATIONSHIP OF SERUM DIPEPTIDYL PEPTIDASE-IV ACTIVITY AND ANTI-CASEIN ANTIBODIES TO GASTROINTESTINAL SYMPTOMS AMONG CHILDREN WITH AUTISM SPECTRUM DISORDER: AN EGYPTIAN STUDY

Author(s):  
Inas R El-alameey ◽  
Hanaa H Ahmed ◽  
Ihab M Eid ◽  
Ghada El-dory ◽  
Manal Gameel

 Objectives: The objectives of the study were to assess serum dipeptidyl peptidase-IV (DPP-IV) activity in autistic children suffering from severe gastrointestinal (GI) disorder and to examine the hypothesis that there is a link between DPP-IV activity in serum and GI disorder in a subgroup of children with autism spectrum disorder (ASD).Subjects and Methods: Serum levels of casein antibodies and DPP-IV enzyme activity from 40 autistic children with chronic GI symptoms, and 40 of age-matched children without autism or gastrointestinal (GI) symptoms were assayed using enzyme-linked immunosorbent assay kits.Results: In comparison with controls, developmental milestones were delayed among autistic children. The serum DPP-IV activity was significantly lower in the studied patients (p<0.05), while the mean serum levels of casein antibodies were statistically significantly higher in the studied patients (p<0.01). Multiple logistic regression analysis recorded significant association between the high serum level of antibodies to casein, food selectivity and recurrent attacks of abdominal pain (p<0.05), while the low serum DPP-IV enzyme activity was associated with recurrent attacks of abdominal pain in the studied patients with a prediction of 95% (p<0.05).Conclusions: Serum levels of casein antibodies were higher in children with ASD, and maybe contributes to their abdominal pain, and food selectivity. Serum DPP-IV enzyme activity was lower and associated with recurrent attacks of abdominal pain in the studied patients. They may benefit from a supplemental digestive enzyme formula.

Author(s):  
Inas R El-alameey ◽  
Hanaa H Ahmed ◽  
Ihab M Eid ◽  
Ghada El-dory ◽  
Manal Gameel

 Objectives: Gastrointestinal symptoms are major characteristic in children with autism spectrum disorder (ASD), drawing attention to a potent association with gluten sensitivity. The goal of this study was to evaluate anti-gliadin antibodies serum levels in a group of Egyptian children with ASDs and to address the potential link to gastrointestinal (GI) symptoms, behavioral, and social communications.Patients and Methods: This descriptive case–control study included 45 children diagnosed as ASD according to Diagnostic and Statistical Manual of Mental Disorders 5th Edition and a history of GI symptoms, compared with 45 apparently healthy children of matched age and sex. Serum anti-gliadin antibodies were measured using enzyme-linked immunosorbent assay kits.Results: Serum levels of IgM, IgA, and IgG class antibodies to gliadin showed a significant increase compared to healthy controls (p<0.000). Multiple logistic regression analysis showed a significant association between the high serum levels of IgA and IgM class antibodies to gliadin in the studied patients and GI symptoms (p<0.05). A significant association was detected between the high serum levels of IgG antibodies to gliadin and the behavior symptoms (p<0.05).Conclusions: The anti-gliadin antibody response and its association with GI symptoms indicated the involvement of abnormal immunologic intestinal permeability in affected children. Immune system of some autistic patients could be abnormally triggered by gluten assumption.


Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1024
Author(s):  
Laura Reche-Olmedo ◽  
Laura Torres-Collado ◽  
Laura María Compañ-Gabucio ◽  
Manuela Garcia-de-la-Hera

Food selectivity is common in children with autism spectrum disorder (ASD). It can be defined as the unwillingness to eat common or new foods, resulting in a lack of variety in the diet or limited food consumption for multiple reasons, such as inflexibility or sensory alterations. We conducted a peer scoping review to describe the interventions that are carried out from occupational therapy (OT) in children with ASD with food selectivity. Two authors independently searched the databases PubMed, Scopus, Web of Science, and EMBASE, as well as the OT journals indexed in Journal Citation Reports. Articles exploring OT interventions in children (≤12 years) with ASD and food selectivity, published in Spanish or English, with experimental design, and with full text available were included. Of the 1445 articles identified, 8 articles met the inclusion criteria. Three main intervention categories were identified: sensory–behavioral, family focused, and other interventions. Most of the interventions from OT were aimed at treating sensory–behavioral aspects. Only three articles described interventions led exclusively by occupational therapists, and the rest were led by a multidisciplinary team. Finally, although these interventions are not exclusive to OT, occupational therapists can participate together with other professionals as an essential component in the treatment of food selectivity in children with ASD.


Author(s):  
Afnan Maatouk Al - Talhi

The current study aimed to develop a mobile application based on video modeling to improve and enhance self-protection skills for children with autism. Semi-experimental design of the two groups was adopted: the control, which received the self-protection skills in the traditional way, while these skills was provided to the experimental group through the application based on video modeling. The research sample was consisted of 16 students who met the criteria. The researcher was applied the self-protection skills scale on the sample. After the experiment was applied for five weeks, the data were analyzed statistically. The results showed the effectiveness of the application in the development of self-protection skills for autistic children. The researcher recommended the use of the preferences of children with autism and the use of applications that based on video modeling in their education.


2021 ◽  
Vol 2 (1) ◽  
pp. 29-41
Author(s):  
Mansour Mohammed Ali Bopaeda

Having a baby is a huge responsibility. It often happens that mothers, especially when they are having their first baby, feel stressed and incompetent in their role as mothers even as their children normally grows. The purpose of this article is to identify the general features of psychological stress among mothers of autism spectrum disorder and Down syndrome and to identify the differences and relationship in psychological stress between mothers of autism and down syndrome. In this study participated a group of mothers with children who have autism (n = 44) and mothers of children with Down syndrome (n = 44). The findings made proved that the general features of psychological stress are high Among mothers of autistic children, while it was low among mothers of Down syndrome, there were also statistically significant differences in the level of psychological stress between mothers of autism and Down syndrome, and a correlation was found between mothers of autism and Down syndrome at the level of significance (0.01).


2017 ◽  
Vol 48 (2) ◽  
pp. 583-591 ◽  
Author(s):  
Liem T. Chistol ◽  
Linda G. Bandini ◽  
Aviva Must ◽  
Sarah Phillips ◽  
Sharon A. Cermak ◽  
...  

2016 ◽  
Vol 47 (2) ◽  
pp. 439-446 ◽  
Author(s):  
Linda G. Bandini ◽  
Carol Curtin ◽  
Sarah Phillips ◽  
Sarah E. Anderson ◽  
Melissa Maslin ◽  
...  

Psichologija ◽  
2009 ◽  
Vol 39 ◽  
pp. 19-30
Author(s):  
Elena Mickevičienė ◽  
Liuda Šinkariova ◽  
Aidas Perminas

Straipsnyje pateikiami abiejų tėvų, kurie augina vaiką, turintį autizmo sindromą, ir kontrolinės grupės tėvų, auginančių normalios raidos vaiką, depresyvumo ypatumai. Analizuodami depresyvumą, kalbame apie tam tikrą ikiklinikinių nuotaikos būsenų intensyvumą, pasireiškiantį liūdesiu, pesimizmu ir aktyvumo sumažėjimu.Tyrimo tikslas – palyginti tėvų ir motinų, auginančių vaikus, kuriems diagnozuotas autizmas, depresyvumo raiškos skirtumus atsižvelgiant į socialinius demografinius veiksnius. Tyrime dalyvavo motinos ir tėvai, auginantys vaikus, turinčius autizmo sindromą. Kontrolinė grupė atrinkta atitinkamai pagal autizmo sindromą turinčio vaiko ir jo tėvų lytį bei amžių – tai motinos ir tėvai, auginantys normalios raidos vaikus. Tyrime depresyvumo lygiui įvertinti buvo naudojama Zungo depresijos (Zung-SRD) skalė. Papildomai buvo pateikiami klausimai apie socialinius demografinius veiksnius: tiriamojo amžių, išsilavinimą, užimtumą, šeimos sudėtį bei vaiko, kuriam diagnozuotas autizmas, amžių, lytį, užimtumą, autizmo sutrikimo sunkumo laipsnį.Buvo nustatyta, kad šeimoje, auginančioje vaiką, kuriam būdingas autizmo sindromas, motinų ir tėvų depresyvumas pasireiškia vienodai. Tėvų ir motinų, auginančių autizmo sindromą turintį vaiką, depresyvumas yra didesnis nei normalios raidos vaiko tėvų ir motinų. Abiejų tėvų, auginančių vaiką, kuriam būdingas autizmo sindromas, depresyvumas nėra susijęs su amžiumi ir išsilavinimu. Autizmo sindromą turinčio vaiko amžius skirtingai siejasi su abiejų tėvų depresyvumo lygiu: tėvų depresyvumas didesnis, kai autizmo sindromą turintis vaikas yra 8–11 metų, o motinų depresyvumas didesnis šį sutrikimą turinčio vaiko paauglystės laikotarpiu (12–18 m.).Pagrindiniai žodžiai: vaikai, turintys autizmo sindromą, tėvas, motina, depresyvumas.Depression in fathers and mothers of children with autism spectrum disorderElena Mickevičienė, Liuda Šinkariova, Aidas Perminas SummaryParenting a child with autism spectrum disorder is stressful for many reasons: difficulty with diagnosis, lack of information about autism and its treatment, deficit of social support, etc. It is impossible to review all the problems experienced by parents, so our study focused on depression in both parents of an autistic child.The purpose of this work was to compare depression in fathers and mothers of children with autism spectrum disorder and to compare our findings with results of the control group, i.e. parents of a normally developing child. Depression in our study indicates the intensity of the preclinical state of mind, manifested by sadness, pessimism and a decrease of activity.120 persons participated in the study, 72 (60%) of them being mothers and 48 (40%) fathers of autistic children raging from 3 to 18 years of age. Control group consisted of 69 mothers (57.5%) and 51 fathers (42.5%) of normally developing children of the same age, selected in accordance with the gender and age of autistic children as well as the gender and age of their parents. The age of the participants ranged from 25 to 60 years (mean 39, SD 6.55).For evaluation of depression, we employed Cung’s depression scale. Additional questions on social-demographic factors were also included: age, education and employment status of participants; family composition; age and gender of child with diagnosed autism and occupation.The results showed that depression in mothers and fathers with autistic children did not differ. Both parents of an autistic child had a higher depression than both parents of normally developing children (p = 0,001). The age and education of parents with autistic children did not correlate with depression. The age of the autistic child correlated with depression of both parents differently: when an autistic child was 3–7 years old, depression in fathers and mothers did not differ; when an autistic child was 8–11 years old, depression in fathers was higher than in mothers; during adolescence of an autistic child, the difference of depression persised, but its direction was opposite, mothers showing a higher depression than fathers.There are several limitations to this study. We should note that the sample does not represent the population of families with autistic children. Also, Cung’s depression scale might not be the best scale to evaluate depression in these families. Another limitation is that we did not consider all circumstances, such as marital status, gender of children, occupation of parents and children, individual characteristics, social support and the degree of severity of autism. Findings of this study require further researche. However, the results indicate that parents of an autistic child need special understanding and support.Keywords: autistic child, mother, father, depression.


2019 ◽  
Vol 8 (3) ◽  
pp. 5995-5999

This study aims to explain on the development of an Android based application using a serious games technique, which known as Autism Kits. It's a built mobile application that functions as an autism spectrum disorder learning application. The model was followed by the ADDIE methodology. In the meantime, respondents, including autism students, educators and parents, were tested. After the application was completed, a survey was performed. Results have demonstrated that teachers and parents are willing to use the application for autistic children that has been found to be very useful.


Author(s):  
Md. Arif Uddin Khan

Autism Spectrum Disorders are increasingly known in developing countries like Bangladesh. The children with autism exhibit significant deficits in social communication, including delayed language development and imitation skills. This disorder is different from other disorders and its characteristics and functions are also different. Families having children with autism spectrum disorder play important role in their socialization and face many challenges as the disorder is associated with disruptive antisocial behavior. The main objective of this research is to know the role of family in socializing autistic children. This research was conducted though survey method by using a semi-structured questionnaire. The data of this study was collected from 78 parents having children with autism spectrum disorder. In our country autism newly introduced and research on autism especially role of the family of the autistic children in socialization are very few. So, this study discusses the role of family in socializing autistic children.


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