scholarly journals BIOFABRICATION OF ZINC OXIDE NANOPARTICLES USING PTEROCARPUS MARSUPIUM AND ITS BIOMEDICAL APPLICATIONS

2019 ◽  
Vol 12 (1) ◽  
pp. 245
Author(s):  
Shymala Rajan Abhinaya ◽  
Ramakrishnan Padmini
Keyword(s):  
Lipid Peroxidation ◽  
Zinc Oxide ◽  
Ftir Spectroscopy ◽  
Zinc Acetate ◽  
Zinc Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Pterocarpus Marsupium ◽  
Uv Visible ◽  
Anti Inflammatory

Objective: The objective of the study is to perform the synthesis of zinc oxide nanoparticles using the bark extract of Pterocarpus marsupium and to evaluate its biomedical applications.Methods: Various concentrations of zinc acetate are used, and synthesis conditions were optimized to get a stable nanoparticle. The finest synthesis condition for zinc oxide nanoparticle production was at pH 7 with 20 ml extract, zinc acetate 10 mM, and 120 min of reaction time. The synthesized nanopowder was characterized using various analytical techniques, such as ultraviolet (UV)-visible spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The synthesized nanoparticles were tested for their antimicrobial, anti-inflammatory, inhibition of lipid peroxidation, and inhibition of amylase activity.Results: The size range of nanoparticles obtained was in the range of 10–32 nm as reported by SEM. The UV-visible absorption spectrum of the synthesized nanoparticle showed a peak at 340 nm, which confirmed the presence of nanoparticles. FTIR spectroscopy analysis indicated the presence of zinc oxide stretching at 666.22 cm-1. Further, the IR spectra indicated the presence of alcohols and acids, which can act as capping agents around the nanoparticles. XRD analysis confirmed the crystalline nature of nanoparticles.The synthesized nanoparticle showed appreciable antimicrobial activity. Zinc oxide nanoparticles at 40 μg/well were tested against phytopathogens, Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus flavus, and Aspergillus niger showed 16, 13, 15, and 16 mm zones of inhibition, respectively. The synthesized nanoparticle showed a considerable increase in inhibition of lipid peroxidation and amylase activity. The nanoparticle also exhibited appreciable anti-inflammatory activity measured by the inhibition of albumin denaturation.Conclusion: The study instigates the simple and convenient method of synthesizing zinc oxide nanoparticles using P. marsupium and its few biomedical applications.

scholarly journals BIOFABRICATION OF ZINC OXIDE NANOPARTICLES USING PTEROCARPUS MARSUPIUM AND ITS BIOMEDICAL APPLICATIONS

2019 ◽  
Vol 12 (1) ◽  
pp. 245
Author(s):  
Shymala Rajan Abhinaya ◽  
Ramakrishnan Padmini
Keyword(s):  
Lipid Peroxidation ◽  
Zinc Oxide ◽  
Ftir Spectroscopy ◽  
Zinc Acetate ◽  
Zinc Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Pterocarpus Marsupium ◽  
Uv Visible ◽  
Anti Inflammatory

Objective: The objective of the study is to perform the synthesis of zinc oxide nanoparticles using the bark extract of Pterocarpus marsupium and to evaluate its biomedical applications.Methods: Various concentrations of zinc acetate are used, and synthesis conditions were optimized to get a stable nanoparticle. The finest synthesis condition for zinc oxide nanoparticle production was at pH 7 with 20 ml extract, zinc acetate 10 mM, and 120 min of reaction time. The synthesized nanopowder was characterized using various analytical techniques, such as ultraviolet (UV)-visible spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The synthesized nanoparticles were tested for their antimicrobial, anti-inflammatory, inhibition of lipid peroxidation, and inhibition of amylase activity.Results: The size range of nanoparticles obtained was in the range of 10–32 nm as reported by SEM. The UV-visible absorption spectrum of the synthesized nanoparticle showed a peak at 340 nm, which confirmed the presence of nanoparticles. FTIR spectroscopy analysis indicated the presence of zinc oxide stretching at 666.22 cm-1. Further, the IR spectra indicated the presence of alcohols and acids, which can act as capping agents around the nanoparticles. XRD analysis confirmed the crystalline nature of nanoparticles.The synthesized nanoparticle showed appreciable antimicrobial activity. Zinc oxide nanoparticles at 40 μg/well were tested against phytopathogens, Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus flavus, and Aspergillus niger showed 16, 13, 15, and 16 mm zones of inhibition, respectively. The synthesized nanoparticle showed a considerable increase in inhibition of lipid peroxidation and amylase activity. The nanoparticle also exhibited appreciable anti-inflammatory activity measured by the inhibition of albumin denaturation.Conclusion: The study instigates the simple and convenient method of synthesizing zinc oxide nanoparticles using P. marsupium and its few biomedical applications.

scholarly journals Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1662
Author(s):  
Mahadevamurthy Murali ◽  
Nataraj Kalegowda ◽  
Hittanahallikoppal G. Gowtham ◽  
Mohammad Azam Ansari ◽  
Mohammad N. Alomary ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Food Packaging ◽  
Biological Activities ◽  
Drug Loading ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Potential Candidate

Zinc oxide nanoparticles have become one of the most popular metal oxide nanoparticles and recently emerged as a promising potential candidate in the fields of optical, electrical, food packaging, and biomedical applications due to their biocompatibility, low toxicity, and low cost. They have a role in cell apoptosis, as they trigger excessive reactive oxygen species (ROS) formation and release zinc ions (Zn2+) that induce cell death. The zinc oxide nanoparticles synthesized using the plant extracts appear to be simple, safer, sustainable, and more environmentally friendly compared to the physical and chemical routes. These biosynthesized nanoparticles possess strong biological activities and are in use for various biological applications in several industries. Initially, the present review discusses the synthesis and recent advances of zinc oxide nanoparticles from plant sources (such as leaves, stems, bark, roots, rhizomes, fruits, flowers, and seeds) and their biomedical applications (such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, photocatalytic, wound healing, and drug delivery), followed by their mechanisms of action involved in detail. This review also covers the drug delivery application of plant-mediated zinc oxide nanoparticles, focusing on the drug-loading mechanism, stimuli-responsive controlled release, and therapeutic effect. Finally, the future direction of these synthesized zinc oxide nanoparticles’ research and applications are discussed.

scholarly journals Green Synthesis, Characterization of Zinc Oxide Nanoparticles and their Incorporation into Glass Ionomer Cement for Inhibition of Streptococcus mutans

2021 ◽  
Vol 33 (3) ◽  
pp. 515-520
Author(s):  
N. Ahalya ◽  
P. Dhamodhar ◽  
A.D. Vaishnavi
Keyword(s):  
Zinc Oxide ◽  
Antibacterial Activity ◽  
Streptococcus Mutans ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Glass Ionomer Cement ◽  
Oxide Nanoparticles ◽  
Glass Ionomer ◽  
Uv Visible ◽  
Ionomer Cement

In present study, zinc oxide nanoparticles were synthesised using Syzygium aromaticum and characterized using UV visible spectroscopy, SEM, XRD and FTIR techniques. The characteristic hexagonal structure of the ZnO nanoparticles was confirmed through XRD analysis. The UV-Visible spectrum showed a strong absorbance at 366 nm confirming the presence of ZnO and the peak at 496 cm-1 in FTIR indicated the Zn-O stretch bond. Average size of the zinc oxide nanoparticles obtained from SEM analysis was found to be 86 nm. The zinc oxide nanoparticles exhibited better antibacterial activity than clove extract, when tested against clinical isolates of Streptococcus mutans. The nanoparticles incorporated into the dental restorative material, glass ionomer cement (GIC) were tested against S. mutans and exhibited better antibacterial activity than clove extract. Glass ionomer cement (GIC) did not exhibit antibacterial activity alone, but the incorporation of ZnO nanoparticles into GIC significantly improved antibacterial activity. Hence, ZnO embedded GIC is a promising material in restorative dentistry for preventing the recurrence of dental caries.

Zinc Oxide Nanoparticles: A Biological and Pharmaceutical Review

2020 ◽  
Vol 10 ◽  
Author(s):  
Behin Sundara Raj ◽  
Punitha Isaac Samraj
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Photocatalytic Property ◽  
Zinc Ion ◽  
Ion Concentration ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Biological Aspects ◽  
Novel Therapeutic

: Zinc oxide (ZnO) is a metal oxide well known for its photocatalytic property and widely used in cosmetics. Lately, it has gained more importance in its biomedical applications, especially in cancer therapy. Scientific works have elucidated the efficiency of ZnO nanoparticles (NPs) against different cancer cell lines. There are safety concerns related to the usage of ZnO NPs, and the zinc ion concentration may lead to changes in the human body. This review covers the significant pharmaceutical and biological aspects of ZnO NPs. Besides, this review updates ZnO NPs revolutionary use in photodynamic therapy (PDT), where it can work wonders and pave the way for a novel therapeutic approach against cancer.

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