scholarly journals A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION OF TYPE- II ANTIDIABETIC DRUGS IN PHARMACEUTICALS AND BIOLOGICAL MATRICES

2021 ◽  
pp. 69-76
Author(s):  
BADIKELA RAMAKRISHNA ◽  
SUMANTA MONDAL
Keyword(s):  
Prescription Drugs ◽  
K Channel ◽  
Type Ii ◽  
Biological Matrices ◽  
Food Material ◽  
Analogous Manner ◽  
Main Meal ◽  
Aggressive Liquid ◽  
Oral Symptom

Its a meglitinide analog is an oral symptom designed to common hour aldohexose excursions. Through not an antidiabetic, it acts in AN analogous manner by binding to antidiabetic receptor likewise on alternative one distinct receptor-» closure of adenosine triphosphate dependent K+ channel-» of depolarization-» internal secretion unharnesses. Repaglinide induces fast onset short-lasting internal secretion discharged. It is administered antero every main meal to stabilize postprandial hyperglycemia; the dose ought to be emitted if a food material is incomprehensible. Because of less permanent action, it perhaps had a lower risk of the seriousness of hypoglycemia. Repaglinide is indicated solely in type-II DM as another to sulfonylureas, or to supplement metformin/long internal secretion. It ought to be avoided in disease. This review delivers a detail description totally different of various analytical ways were printed for the estimation of repaglinide and its combination medicine in prescription drugs and biological matrices. This assessment encompasses different analytical ways such as chemical analysis ways, aggressive liquid activity (HPLC), superior thin-layer activity (HPTLC), liquid chromatography-mass spectroscopic analysis (LC-MS), and ultra-performance liquid activity (UPLC), GC-MS, [LC-ESI-MS-MS], capillary activity (CE), titrimetric and chemical science technique, and designation study for the estimation of repaglinide and together with a mixture.

µSPE followed by HPLC-MS/MS for the determination of series D and E resolvins in biological matrices

2021 ◽  
pp. 114181
Author(s):  
Federico Fanti ◽  
Eleonora Oliva ◽  
Daniel Tortolani ◽  
Camilla Di Meo ◽  
Marina Fava ◽  
...  
Keyword(s):  
Biological Matrices

An insight into the determination of size and number concentration of silver nanoparticles in blood using single particle ICP-MS (spICP-MS): Feasibility of application to samples relevant to in vivo toxicology studies

2021 ◽  
Author(s):  
Isabel Abad-Álvaro ◽  
Diego Leite ◽  
Dorota Bartczak ◽  
Susana Cuello ◽  
Beatriz Gomez-Gomez ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Single Particle ◽  
Number Concentration ◽  
Biological Matrices ◽  
Icp Ms ◽  
Toxicological Studies ◽  
Insight Into

Toxicological studies concerning nanomaterials in complex biological matrices usually require a carefully designed workflow that involves handling, transportation and preparation of a large number of samples without affecting the nanoparticle...

scholarly journals Analytical Methods for the Determination of Neuroactive Steroids

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 553
Author(s):  
Michal Kaleta ◽  
Jana Oklestkova ◽  
Ondřej Novák ◽  
Miroslav Strnad
Keyword(s):  
Nervous System ◽  
Steroid Hormone ◽  
Neuroactive Steroids ◽  
Physiological Changes ◽  
Biological Matrices ◽  
Pathological Conditions ◽  
Reliable Monitoring ◽  
Hormonal Steroids ◽  
Endocrine Tissues

Neuroactive steroids are a family of all steroid-based compounds, of both natural and synthetic origin, which can affect the nervous system functions. Their biosynthesis occurs directly in the nervous system (so-called neurosteroids) or in peripheral endocrine tissues (hormonal steroids). Steroid hormone levels may fluctuate due to physiological changes during life and various pathological conditions affecting individuals. A deeper understanding of neuroactive steroids’ production, in addition to reliable monitoring of their levels in various biological matrices, may be useful in the prevention, diagnosis, monitoring, and treatment of some neurodegenerative and psychiatric diseases. The aim of this review is to highlight the most relevant methods currently available for analysis of neuroactive steroids, with an emphasis on immunoanalytical methods and gas, or liquid chromatography combined with mass spectrometry.

Human Umbilical Cord Mesenchymal Stem Cells Induce into Chondrocytes in 3D Cultured System

2013 ◽  
Vol 749 ◽  
pp. 198-205
Author(s):  
Li Yu ◽  
Jing Liu ◽  
Chao Xu ◽  
Er Mei Luo ◽  
Ming Qiao Tang
Keyword(s):  
Real Time ◽  
Alcian Blue ◽  
Culture System ◽  
Type Ii Collagen ◽  
Human Umbilical Cord ◽  
Type Ii ◽  
Pellet Culture ◽  
Hla Dr

Objective: To investigate a better method of inducing hUC-MSCs into chondrocytes in different culture system in vitro. Method: hUC-MSCs were isolated and cultured by tissue block culture, and the cells surface antigens were identified by flow cytometry, hUC-MSCs were cultured with chondrogenic media and stained with Alcian Blue. The production of matrix was estimated from the determination of hydroxyproline content and Alcian Blue method. Expressions of glycosaminoglycan (GAG), type II collagen and Sox-9 were assayed by real-time fluorescence quantitative PCR. Results: The cultured hUC-MSCs phenotype was CD105+/CD29+/CD44+/ CD31-/CD34-/ CD40-/CD45-/HLA-DR-. hUC-MSCs weakly expressed chondrocyte marker, which strongly expressed GAG and type II collagen after chondrogenic induction, and the cells were incubated in pellet culture with higher expression. Real-time PCR results demonstrated that chondrogenic induction cells were expressed GAG, type II collagen and Sox-9, and the cells were incubated in pellet culture with higher expression. Conclusion: hUC-MSCs incubated in pellet culture is more conducive to differentiate into chondrocytes than those cultured in monolayer culture system.

scholarly journals Determination of free L-carnitine levels in type II diabetic women with and without complications

2007 ◽  
Vol 61 (7) ◽  
pp. 892-895 ◽  
Author(s):  
A Poorabbas ◽  
F Fallah ◽  
J Bagdadchi ◽  
R Mahdavi ◽  
A Aliasgarzadeh ◽  
...  
Keyword(s):  
Type Ii
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