scholarly journals SYNERGISTIC IMMUNOMODULATORY ACTIVITY OF AQUEOUS ROOT EXTRACT OF ASPARAGUS RACEMOSUS WILLD AND ETHANOL WHOLE PLANT EXTRACT OF BOERHAVIA DIFFUSA LINN

2021 ◽  
pp. 120-123
Author(s):  
AMRITA KUMARI ◽  
MAINAK CHAKRABORTY ◽  
NILANJAN SARKAR ◽  
SEKHAR KUMAR BOSE ◽  
KALYAN ROY ◽  
...  
Keyword(s):  
Plant Extract ◽  
Immunomodulatory Activity ◽  
Neutrophil Adhesion ◽  
Asparagus Racemosus ◽  
Blood Parameter ◽  
Polyherbal Formulation ◽  
Root Part ◽  
Whole Plant ◽  
Carbon Clearance ◽  
Boerhavia Diffusa

Objective: On the basis of traditional use and Ethno pharmacological evidences Boerhavia diffusa whole plant and root part of Asparagus racemosus (Shatavari) both are widely used to enhance the immunity. But in combination there is no scientific evidence so current study was designed. Methods: Laboratory based study, namely, carbon clearance, cyclophosphamide induced immune suppression and neutrophil adhesion was designed using mice as an experimental animals in different combination of aqueous whole plant extract of B. diffusa and methanol extract of root part of A. racemosus were used as a test drug in the ratio 1:1, 1:2, and 2:1 (100 mg/kg) against the established standard drug Ashwagandha. Results: The results revealed that animals treated with combined extract (1:1, 1:2, and 2:1) at a dose of 100 mg/kg increase rate of carbon clearance from blood, there is significance alternation in blood parameter in cyclophosphamide group and also improve the Neutrophil adhesion when treated with different combination of polyherbal formulation treated groups. Conclusion: The polyherbal formulation in different ratio showing good significant immunomodulatory activity as compare to standard.

Immunomodulatory activity of Alcoholic extracts of Tinospora cordifolia Stem

2021 ◽  
pp. 73-77
Author(s):  
Sanjiv Kumar Biradar ◽  
Chandra Kishore Tyagi
Keyword(s):  
Experimental Models ◽  
Tinospora Cordifolia ◽  
Delayed Type Hypersensitivity ◽  
Phagocytic Index ◽  
Immunomodulatory Activity ◽  
Neutrophil Adhesion ◽  
Cell Mediated Immunity ◽  
Medicinal Value ◽  
Carbon Clearance

Tinospora cordifolia is a plant well known for its medicinal value in Indian ayurveda and Indian traditional medicine system. However, to prove its efficiency for the clinical utilization, more experimental data will be beneficial. In the present investigation, evaluated the immunomodulatory activity of the alcoholic extracts of Tinospora cordifolia stem on various in-vivo experimental models such as neutrophil adhesion test, phagocytic index by carbon clearance test, Hemagglutinating antibody (HA) titre and delayed type hypersensitivity (DTH) responses. The evaluation of immunomodulatory potential by oral administration of alcoholic stem extracts (50, 100, 200 and 300mg/kg b.w, p.o) evoked a significant increase in percent neutrophil adhesion to nylon fibers as well as a dose dependent increased in antibody titre values, and potentiated delayed type hypersensitivity reaction induced by sheep red blood cells and significant response towards phagocytosis in carbon clearance assay (*p<0.05, *p<0.01, ***p<0.001). This may be due to concentrations of active phytochemicals present in particular plant extract. Hence, it was concluded that the plant extracts increased humoral as well as cell mediated immunity.

Chemical Constituents and Antibacterial Activity of Cissus Aralioides.

2020 ◽  
Vol 17 ◽  
Author(s):  
Balogun Olaoye Solomon ◽  
Ajayi Olukayode Solomon ◽  
Owolabi Temitayo Abidemi ◽  
Oladimeji Abdulkarbir Oladele ◽  
Liu Zhiqiang
Keyword(s):  
Plant Extract ◽  
Chemical Constituents ◽  
Ethyl Acetate Fraction ◽  
Antibacterial Activities ◽  
Sub Saharan Africa ◽  
Chromatographic Purification ◽  
Whole Plant ◽  
Sub Saharan ◽  
First Time

: Cissus aralioides is a medicinal plant used in sub-Saharan Africa for treatment of infectious diseases; however the chemical constituents of the plant have not been investigated. Thus, in this study, attempt was made at identifying predominant phytochemical constituents of the plant through chromatographic purification and silylation of the plant extract, and subsequent characterization using spectroscopic and GC-MS techniques. The minimum inhibitory concentration (MICs) for the antibacterial activities of the plant extract, chromatographic fractions and isolated compounds were also examined. Chromatographic purification of the ethyl acetate fraction from the whole plant afforded three compounds: β-sitosterol (1), stigmasterol (2) and friedelin (3). The phytosterols (1 and 2) were obtained together as a mixture. The GC-MS analysis of silylated extract indicated alcohols, fatty acids and sugars as predominant classes, with composition of 24.62, 36.90 and 26.52% respectively. Results of MICs indicated that friedelin and other chromatographic fractions had values (0.0626-1.0 mg/mL) comparable with the standard antibiotics used. Characterization of natural products from C. aralioides is being reported for the first time in this study.

scholarly journals Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Patrick Amoateng ◽  
Samuel Adjei ◽  
Dorcas Osei-Safo ◽  
Kennedy Kwami Edem Kukuia ◽  
Irene Akwo Kretchy ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Plant Extract ◽  
Analgesic Effects ◽  
Whole Plant ◽  
Synedrella Nodiflora

scholarly journals Immunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay

2014 ◽  
Vol 4 (5) ◽  
pp. 398-400 ◽  
Author(s):  
Annie George ◽  
Sasikala Chinnappan ◽  
Yogendra Choudhary ◽  
Praveen Bommu ◽  
Murthy Sridhar
Keyword(s):  
Aqueous Extract ◽  
Immunomodulatory Activity ◽  
Swiss Albino Mice ◽  
Carbon Clearance ◽  
Polygonum Minus ◽  
Albino Mice

scholarly journals Preparation of Boerhaavia diffusa Mediated Selenium Based Mouthwash-A Comparative Microbial and Cytotoxic Effect

2021 ◽  
pp. 860-870
Author(s):  
Pravalika Arunkumar ◽  
R. V. Geetha ◽  
S. Rajesh Kumar
Keyword(s):  
Cytotoxic Activity ◽  
Plant Extract ◽  
Selenium Nanoparticles ◽  
Diffusion Method ◽  
Zone Of Inhibition ◽  
Hot Air ◽  
Brine Shrimp Lethality Assay ◽  
Boerhaavia Diffusa ◽  
Immunomodulatory Potential ◽  
Boerhavia Diffusa

Introduction: The extract of Boerhaavia diffusa root, a plant used in Indian traditional medicine, has significant immunomodulatory Potential. Selenium, a nutrient element that has a massive function in biological systems, is one of the interesting compounds to integrate with antibacterial agents. Recently several studies have pointed out the ability of selenium nanoparticles to exhibit anticancer, antioxidant, antibacterial and antibiofilm properties. Aim: To analyze the antimicrobial and cytotoxic activity of Boerhaavia diffusa mediated selenium nanoparticles based mouthwash. Materials and Methods:   1 g of Boerhavia diffusa was added in 100 ml of distilled water. It was boiled; the plant extract was filtered using Whatman’s no.1 filter paper. In 250 ml conical flask, 60 ml of 20 millimolar sodium selenite was prepared and 40 ml of the filtered plant extract was mixed. This flask was kept in a magnetic stirrer. The nanoparticle solution was centrifuged at 8000rpm to prepare nanoparticle pellets. The nanoparticle pellet was dried in a hot air oven at 80 degree celsius. The dried powder was sent for Characterization. A mouthwash is prepared. The prepared mouthwash was tested for cytotoxic activity by brine shrimp lethality assay and antimicrobial activity evaluated the zone of inhibition of agar well diffusion method. Results and Discussion: It was proved that cytotoxic activity of selenium bound mouthwash was less compared to the commercial mouthwash. The antibacterial activity of the selenium bound mouthwash against C. albicans and S. mutans was significant when compared to the standard antimicrobial agent. Conclusion: Based on the results, this mouthwash has the required qualities to be commercially be used. Therefore further studies can be done to prove that this mouthwash can be used commercially.

Cytotoxcity and in vivo Antimalarial Activity of Aqueous Whole Plant Extract of Munronia pinnata (Wall.) Theob. (Meliaceae) in Mice

2012 ◽  
Vol 6 (3) ◽  
pp. 267-273 ◽  
Author(s):  
R.M. Dharmadasa ◽  
G.A.S. Premakumar ◽  
P.L. Hettiarach ◽  
W.D. Ratnasoori
Keyword(s):  
Plant Extract ◽  
Antimalarial Activity ◽  
Whole Plant

Sub-acute toxicity of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L) Gaertn in rats

2014 ◽  
Vol 8 (4) ◽  
pp. 271 ◽  
Author(s):  
Patrick Amoateng ◽  
Dorcas Osei-Safo ◽  
Clement Sasu ◽  
BenoitBanga N′guessan ◽  
Phyllis Addo ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Plant Extract ◽  
Whole Plant ◽  
Synedrella Nodiflora

scholarly journals New ent–Kaurane type Diterpene Glycoside, Pulicaroside-B, from Pulicaria Undulata L

2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Nasir Rasool ◽  
Viqar Uddin Ahmad ◽  
Naseem Shahzada ◽  
Muhammad A. Rashida ◽  
Aman Ullah ◽  
...  
Keyword(s):  
Spectral Data ◽  
Plant Extract ◽  
Soluble Fraction ◽  
2D Nmr ◽  
Spectroscopic Techniques ◽  
Spectral Evidence ◽  
Whole Plant ◽  
Derivatives Of ◽  
Related Compounds

Investigation of the n-butanol-soluble fraction of the whole plant extract of Pulicaria undulata yielded a new ent–kaurane type diterpene glycoside, pulicaroside-B (1), together with three known compounds, paniculoside-IV (2), roseoside (3), and corchoionol C (4). Compounds 3 and 4 are derivatives of α-ionol. The structures of the new and known compounds were elucidated by 1D- and 2D-NMR spectroscopic techniques, along with other spectral evidence, and by comparison of the spectral data with those of closely related compounds.

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