scholarly journals A REVIEW ON TRANSDERMAL PATCHES USED AS AN ANTI-INFLAMMATORY AGENT

2021 ◽  
pp. 21-26
Author(s):  
DEIJY CHOUDHURY ◽  
KOUSHIK NANDAN DUTTA ◽  
RAMEN KALITA
Keyword(s):  
Side Effects ◽  
Oral Delivery ◽  
Antihypertensive Drugs ◽  
Diclofenac Sodium ◽  
Antiviral Agents ◽  
Extended Period ◽  
Transdermal Drug Delivery System ◽  
Non Invasive ◽  
Transdermal Patches ◽  
Anti Inflammatory

The transdermal drug delivery system is widely accepted due to its numerous advantages as it is a non-invasive drug administration process with prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance, and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs such as Diclofenac sodium, Lornoxicam, Aceclofenac, Ibuprofen, antihypertensive drugs, for example, Repaglinide, Atenolol, and Antiviral agents such as Stavudine, zidovudine represents the most commonly used medications for the treatment of pain and inflammatory reaction but various side effects can limit their use. Therefore, transdermal delivery of these drugs has advantages of avoiding hepatic first-pass effect, gastric irritation and delivering the drug for an extended period of time at a sustained level. The present article mainly focuses on the work been done on these drugs by formulated and delivered as transdermal patches to decrease the side effects related to the oral delivery.

scholarly journals Poisoning caused by diclofenac sodium

2017 ◽  
pp. 80-83
Author(s):  
Mykola Shevchuk ◽  
Viktor Bekar ◽  
Oksana Kharysh
Keyword(s):  
Side Effects ◽  
Diclofenac Sodium ◽  
Cardiovascular Disorders ◽  
Incident Case ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Medication Allergy

The death incident case caused by the continuous uncontrolled consuming of the non-steroidal anti-inflammatory drugs (diclofenac sodium) that resulted in developing of side effects of the organism - medication allergy and cardiovascular disorders is given.

Recent Advances in Non-Invasive Delivery of Macromolecules using Nanoparticulate Carriers System

2017 ◽  
Vol 23 (3) ◽  
pp. 440-453 ◽  
Author(s):  
Shadab Md. ◽  
Shadabul Haque ◽  
Ravi Sheshala ◽  
Lim Wei Meng ◽  
Venkata Srikanth Meka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Oral Delivery ◽  
The Body ◽  
Administration Routes ◽  
Non Invasive ◽  
Current Formulation ◽  
Delivery Routes ◽  
Systemic Side Effects ◽  
Rapid Clearance

Background: The drug delivery of macromolecules such as proteins and peptides has become an important area of research and represents the fastest expanding share of the market for human medicines. The most common method for delivering macromolecules is parenterally. However parenteral administration of some therapeutic macromolecules has not been effective because of their rapid clearance from the body. As a result, most macromolecules are only therapeutically useful after multiple injections, which causes poor compliance and systemic side effects. Methods: Therefore, there is a need to improve delivery of therapeutic macromolecules to enable non-invasive delivery routes, less frequent dosing through controlled-release drug delivery, and improved drug targeting to increase efficacy and reduce side effects. Result: Non-invasive administration routes such as intranasal, pulmonary, transdermal, ocular and oral delivery have been attempted intensively by formulating macromolecules into nanoparticulate carriers system such as polymeric and lipidic nanoparticles. Conclusion: This review discusses barriers to drug delivery and current formulation technologies to overcome the unfavorable properties of macromolecules via non-invasive delivery (mainly intranasal, pulmonary, transdermal oral and ocular) with a focus on nanoparticulate carrier systems. This review also provided a summary and discussion of recent data on non-invasive delivery of macromolecules using nanoparticulate formulations.

scholarly journals PREPARATION, CHARACTERIZATION AND OPTIMIZATION OF PRONIOSOMAL GEL OF ANTI-INFLAMMATORY AGENT

2020 ◽  
Vol 11 (10) ◽  
pp. 23-28
Author(s):  
Vamshi Krishna Lekkala ◽  
N Siva Subramanian ◽  
K Srikanth Gupta
Keyword(s):  
Diclofenac Sodium ◽  
Skin Irritation ◽  
Extended Period ◽  
Entrapment Efficiency ◽  
Therapeutic Index ◽  
Inflammatory Agent ◽  
Anti Inflammatory ◽  
Span 60 ◽  
Rat Paw

Proniosomal gel of anti-inflammatory agent (Diclofenac Sodium) was developed using two different non – ionic surfactants (Span 60 and Span 40) with an objective to develop stable, robust, controlled release gel of diclofenac sodium as it has short half-life and narrow therapeutic index. Various proniosomal gels were developed using different concentration of nonionic surfactants and one formulation was selected as optimized formulation based on the size, shape and % entrapment efficiency. FS603 was selected as an optimized formulation and was characterized further for zeta potential and stability and was found as stable at both refrigerated and room temperatures. No edema and erythema were observed in rats treated with formulation FS603 for four days and skin irritation index found as zero. In vivo anti-inflammatory activity with optimized formulation was carried out in rats against marketed preparation using carrageenan induced rat paw method and shown greater % inhibition of inflammation and extended period when compared with marketed preparation.

Studies on anti-inflammatory and analgesic properties of Lactobacillus rhamnosus in experimental animal models

2016 ◽  
Vol 13 (2) ◽  
Author(s):  
Sarika Amdekar ◽  
Vinod Singh
Keyword(s):  
Side Effects ◽  
Animal Models ◽  
Experimental Animal ◽  
Inflammatory Diseases ◽  
Diclofenac Sodium ◽  
Lactobacillus Rhamnosus ◽  
Standard Drug ◽  
Experimental Animal Models ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for the treatment of inflammatory diseases. However, constant use of NSAID may lead to some side effects like gastrointestinal ulcers, bleeding and renal disorders. This study evaluates analgesic and anti-inflammatory activities of: Diclofenac sodium was used as a standard drug for comparison.: Results showed that: The present study clearly suggests that

scholarly journals The effect of derivatives of tetrahydropyrido[2,1-b][1,3,5] thiadiazine on hematologic indices of rats with subacute parotitis

2018 ◽  
Vol 4 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Elena Bibik ◽  
Oksana Yaroshevskaya ◽  
Andrey Demenko ◽  
Konstantin Frolov ◽  
Viktor Dotsenko ◽  
...  
Keyword(s):  
Side Effects ◽  
Diclofenac Sodium ◽  
Rank Test ◽  
Control Group ◽  
Signed Rank ◽  
Short Period ◽  
Signed Rank Test ◽  
Anti Inflammatory ◽  
Nonparametric Statistical ◽  
Derivatives Of

Introduction: Regardless of belonging of NSAIDs to one or another chemical group, they all have common side effects that can occur when using these drugs for a long or short period. One type of toxicity in the spectrum of side effects of modern non-steroidal anti-inflammatory drugs is hematotoxicity. Objectives: to study the indices characterizing the red and white hematopoiesis in a clinical blood examination in animals with a simulated inflammation process against a background of pharmacocorrection with original thiadiazine derivatives. Methods: The experiments were carried out on 48 white pedigree mature rats of both sexes weighing 170–210 g. The tetrahydropyrido [2,1-b] [1,3,5] thiadiazine derivatives II, III and V were selected, since they showed the strongest anti-inflammatory, analgesic and antipyretic properties in the previous experiments. The animals were divided into eight groups: intact (rats without the pathology), control (with inlammation), referent 1 (inflammation+diclofenac sodium 0.5 mg/kg), referent 2 (inflammation+analgin 5 mg/kg), referent 3 (inflammation+indomethacin 5 mg / kg) and three test groups (with test substances administered at a dose of 5 mg/kg). Administration of the drugs was carried out for 14 days at the above doses. The standard methods were used to determine the number of erythrocytes, hemoglobin, color index, ESR, leukocytes and neutrophils. Results: In the analysis of the numerical results of the experiment, the valid ranges of values were determined for most parameters under study, which made it possible to use nonparametric statistical methods, including the Wilcoxon signed-rank test, to evaluate the reliability of differences. The use of tetrahydropyrido [2,1-b] [1,3,5] thiadiazine derivatives II, III, V in animals with experimental parotitis was accompanied by an increase in the number of erythrocytes in comparison with that in the control group. Conclusion: The studies of three derivatives of tetrahydropyrido [2.1-b] [1.3.5] thiadiazine, which have a high anti-inflammatory activity, proved that the compounds III and V have no hematotoxicity.

A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

2020 ◽  
Vol 24 (5) ◽  
pp. 473-486 ◽  
Author(s):  
Ligia S. da Silveira Pinto ◽  
Thatyana R. Alves Vasconcelos ◽  
Claudia Regina B. Gomes ◽  
Marcus Vinícius N. de Souza
Keyword(s):  
Side Effects ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Present Review ◽  
Pharmacological Properties ◽  
Important Group ◽  
Wide Range ◽  
Anti Inflammatory

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review

2020 ◽  
Vol 17 (4) ◽  
pp. 270-278
Author(s):  
Maha Nasr ◽  
Rawan Al-Karaki
Keyword(s):  
Side Effects ◽  
Therapeutic Efficacy ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Topical Delivery ◽  
Natural Compounds ◽  
Therapeutic Activity ◽  
Dermatological Diseases ◽  
Anti Inflammatory ◽  
Topical Applications

Nanotechnology is currently a hot topic in dermatology and nutraceutical/cosmeceutical delivery, owing to the advantages it provides in terms of enhancing the skin permeation of drugs, as well as increasing their therapeutic efficacy in the treatment of different dermatological diseases. There is also a great interest in the topical delivery of nutraceuticals; which are natural compounds with both therapeutic and cosmetic benefits, in order to overcome the side effects of topically applied chemical drugs. Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration. This review highlights the topical applications of quercetin, and summarizes the nanocarrier-based solutions to its percutaneous delivery challenges.

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