scholarly journals IMPROVEMENT OF ALOPECIA AND DECREASES IN HAIR CORTISOL AND DIHYDROTESTOSTERONE CONCENTRATIONS AFTER THE TOPICAL USE OF PLANT EXTRACTS IN MEN WITH ANDROGENETIC ALOPECIA

2021 ◽  
pp. 71-79
Author(s):  
SANG-HWAN DO ◽  
RYUN-SUP AHN ◽  
MYUNG-SUK NA ◽  
HYUNG-RUEL JU
Keyword(s):  
Plant Extracts ◽  
Hair Shaft ◽  
Androgenetic Alopecia ◽  
Hair Cortisol ◽  
Hair Density ◽  
Main Effect ◽  
Assessment Time ◽  
Single Blind ◽  
Single Time Point ◽  
Time Point

Objectives: Plant extracts possessing specific constituents with anti-inflammatory, antimicrobial, antioxidant, or 5α-reductase inhibitory properties are known to provide benefits against androgenetic alopecia (AGA) in men. A solid shampoo was formulated, and it contained a mixture of six different plant extracts that possess these beneficial properties against AGA. The improvement in AGA and changes in steroid concentrations were assessed after 4 months of formulated shampoo use. Methods: This study was conducted based on a randomized, placebo-controlled, and single-blind design. Hair-related variables and hair and saliva samples were collected bi-monthly in the treatment (n=48) and placebo (n=52) groups and at a single time point in the hairy controls (n=50). Results: The formulated shampoo was more effective on AGA than the placebo based on the hair shaft thickness and hair density in the receding hairline. The baseline hair cortisol and dihydrotestosterone (DHT) concentrations were significantly higher in the treatment and placebo groups than in the hairy controls. After 4 months, the hair steroid concentrations in the treatment group were reduced to those observed in the hairy controls, although the main effect of time on hair steroid concentrations was negligible in the placebo group. Salivary cortisol and DHT levels during the post-awakening period were comparable among the groups or assessment time points. Conclusion: The constituents of plant extracts included in the formulated shampoo would prevent hair loss, increase hair growth effects, and reduce hair cortisol and DHT concentrations without changes in the post-awakening salivary steroid levels in men with AGA.

scholarly journals The Effectiveness and Tolerability of Preformed Growth Factors Vehiculated Through Iontophoresis on Patients with Androgenetic Alopecia and Telogen Effluvium: A Clinical Study

2021 ◽  
pp. 2021082
Author(s):  
Aurora Maria Alessandrini ◽  
Francesca Bruni ◽  
Bianca Maria Piraccini ◽  
Michela Starace
Keyword(s):  
Growth Factors ◽  
Combined Therapy ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Treatment Modalities ◽  
Self Assessment ◽  
Hair Density ◽  
Pattern Distribution ◽  
Assessment Questionnaire

Background: Androgenetic alopecia is characterized by a progressive miniaturization of hair follicles in a pattern distribution in genetically predisposed individuals. The efficacy of conventional therapies is variable, therefore there is a need for adjuvant and newer treatment modalities to provide faster and better outcomes. Objectives: Evaluation of the efficacy and tolerability of a combined therapy: preformed growth factors vehiculated through iontophoresis in patients with androgenetic alopecia and associated telogen effluvium, to obtain faster hair regrowth. Materials and Methods: Treatment was performed between June 2018 and June 2019 on 60 patients with androgenetic alopecia and associated telogen effluvium. Each patient underwent 4 sessions in total, each session was performed every 3 weeks. Global photography and trichoscopy were collected at every session of therapy. All patients filed out a self-assessment questionnaire. Results: Results were very promising, with improvement of hair density and thickening of the hair shaft diameter in most of patients seen with both global photography and trichoscopy. All patients were satisfied of the clinical result and reported a complete reduction in hair loss. No serious adverse side effects were reported. Conclusions: The use of growth factors associated with iontophoresis technique is a useful treatment for treating and preventing androgenetic alopecia. In addition, in case of associated telogen effluvium, this technique allows for an early stop of hair shedding, especially when cosmetic procedures do not provide satisfactory results in patients.

Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

2021 ◽  
Vol 7 (2) ◽  
pp. 107-114
Author(s):  
Bela Padhiar ◽  
Sruthy Raveendran
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Androgenic Alopecia ◽  
Open Label ◽  
Hair Density ◽  
Convenience Sample ◽  
Double Spin ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

Androgenic alopecia (AGA) is a type of progressive hairloss, where there is androgen mediated conversion of susceptible terminal hairs into vellus hairs, in genetically predisposed individuals. To compare efficacy of Topical 5% Minoxidil alone versus Topical 5% Minoxidil with Autologous Platelet Rich Plasma (PRP) therapy in patients with Androgenetic Alopecia.This is aProspective study conducted in Department of Dermatology GMERS Medical College, Gandhinagar, Gujarat. A convenience sample of 62 men in the age group of 20-40 with Grade 2-5 AGA according to Hamilton- Norwood Grading were selected and was divided into 2 groups of 31 each. Presitting digital photographs and dermoscopic photos were taken. Autologous PRP was prepared using 18 ml of patients blood after double spin centrifugation and injected by Nappage technique. Results were assessed at the baseline and at the end of each sitting on the basis of change in hair density, photographic evaluation and patient’s self satisfaction. Highly significant increase in hair density was achieved after 4 months of treatment. At T4 (Fourth Session of treatment) Group B showed higher hair density (42.97± 8.96) as compared to Group A (36.94 ± 11.57) which was statistically significant at P = 0.03Group B showed better improvement as compared to Group A.PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects.

Bidirectional saturable transport of LHRH across the blood-brain barrier

1991 ◽  
Vol 261 (3) ◽  
pp. E312-E318 ◽  
Author(s):  
C. M. Barrera ◽  
A. J. Kastin ◽  
M. B. Fasold ◽  
W. A. Banks
Keyword(s):  
Blood Brain Barrier ◽  
Ovarian Function ◽  
Brain Barrier ◽  
Multiple Time ◽  
Blood Brain ◽  
Permeability Surface ◽  
Cerebrovascular Permeability ◽  
The Difference ◽  
Single Time Point ◽  
Time Point

Systemic administration of luteinizing hormone-releasing hormone (LHRH) in rats has been found to influence behavior independently of pituitary or ovarian function. A previous study has shown that LHRH can cross the blood-brain barrier in one direction, but it was not known whether this was due to a saturable transport system. The rate of entry of 125I-labeled LHRH from blood to brain was determined by two different single-pass methods of carotid perfusion. The first, a multiple time point method, measures Ki from the slope of the linear regression when brain-to-blood ratios of radioiodinated LHRH are plotted against time. Saturable transport was determined by the difference between the Ki of rats perfused with 125I-LHRH (12.51 X 10(-3) mg.g-1.min-1) vs. rats perfused with 125I-LHRH and unlabeled LHRH (10 nmol/ml; 2.20 X 10(-3) ml.g-1.min-1). The inhibition by the unlabeled peptide was statistically significant (P less than 0.001). The second method, a single time point technique, measures the cerebrovascular permeability-surface area coefficient (PA). Saturable transport was determined in rats by the competition of unlabeled LHRH with 125I-LHRH. The PA value for 125I-LHRH (20.00 X 10(-3) ml.g-1.min-1) was significantly greater (P less than 0.05) than for 125I-LHRH with the addition of 10 nmol/ml unlabeled LHRH (4.14 X 10(-3) ml.g-1.min-1). Saturable transport of LHRH from brain to blood in mice was also determined.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals The Utility of Functional Data Analyses to Reveal Between-Limbs Asymmetries in Those With a History of Anterior Cruciate Ligament Reconstruction

2021 ◽  
Author(s):  
McKenzie S. White ◽  
William Z. Horton ◽  
Julie P. Burland ◽  
Matthew K. Seeley ◽  
Lindsey K. Lepley
Keyword(s):  
Anterior Cruciate Ligament ◽  
Functional Data ◽  
Ligament Reconstruction ◽  
Cruciate Ligament ◽  
Cruciate Ligament Reconstruction ◽  
Data Analyses ◽  
History Of ◽  
Anterior Cruciate ◽  
Single Time Point ◽  
Time Point

Context Researchers have traditionally used motion capture to quantify discrete biomechanical data points (peak values) during hop testing. However, these analyses restrict the evaluation to a single time point (ie, certain percentage of stance) and provide only a narrow view of movement. Applying more comprehensive analyses may help investigators identify important characteristics that are masked by the discrete analyses often used to screen patients for activity. Objective To examine the utility of functional data analyses to reveal asymmetries that are undetectable using discrete (ie, single time point) evaluations in participants with a history of anterior cruciate ligament reconstruction (ACLR) who achieved clinical hop symmetry. Design Cross-sectional study. Setting Laboratory. Patients or Other Participants Fifteen participants with unilateral ACLR (age = 21 ± 3 years, time from surgery = 4 ± 3 years) and 15 control participants without ACLR (age = 23 ± 2 years). Intervention(s) Lower extremity biomechanics during the triple–hop-for-distance task for the ACLR and contralateral limbs of patients and a representative limb of control participants were measured. Main Outcome Measure(s) Peak sagittal-plane joint power, joint work, and power profiles were determined. Results Using discrete analyses, we identified lower peak knee power and work in the ACLR limb compared with the contralateral and control limbs (P < .05) but were unable to demonstrate differences at the ankle or hip. Using functional data analyses, we observed asymmetries at the ankle, knee, and hip between the ACLR and contralateral or control limbs throughout stance (P < .05) and revealed that these asymmetries stemmed from knee power deficits that were prominent during early loading. Conclusions Despite achieving hop-distance symmetry, the ACLR limbs absorbed less power. Although this information was revealed using the discrete analyses, underlying asymmetries at the ankle and hip were masked. Using functional data analyses, we found interlimb asymmetries at the ankle, knee, and hip throughout ground contact and more fully elucidated the extent and source of asymmetries that can be used by clinicians and researchers alike to guide clinical decision making.

A combination of different diagnostic tools allows identification of inactive hepatitis B virus carriers at a single time point evaluation

2016 ◽  
Vol 37 (3) ◽  
pp. 362-368 ◽  
Author(s):  
Sergio Maimone ◽  
Gaia Caccamo ◽  
Giovanni Squadrito ◽  
Angela Alibrandi ◽  
Francesca Saffioti ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Diagnostic Tools ◽  
Point Evaluation ◽  
Single Time ◽  
B Virus ◽  
Single Time Point ◽  
Time Point
Sign in / Sign up

Export Citation Format

Share Document