scholarly journals EVALUATION OF MEDICATION COMPLIANCE IN PATIENTS WITH CONGESTIVE HEART FAILURE IN YEMEN

Author(s):  
AL-ZAAZAAI ET AL ALI AHMED MOHAMMED AL-Z ◽  
MANSOUR A. AL-AMRANI ◽  
KHALID ALAKHALI ◽  
NOURADDEN ALJABER

Objective: Non-compliance with heart failure medication is related to the highest mortality, morbidity, and health-care costs. The objective of this study was to evaluate medication compliance with patients with congestive heart failure. Methods:Inpatients of the cardiac care unit and medical ward of Republican Hospital, German Hospital, Revolutionary Hospital, and Chinese–Yemeni Friendship Hospital were recruited for this study. The study was conducted on patients that were diagnosed as having congestive heart failure and were receiving treatment. Questionnaires were distributed and personal interviews to evaluate the patients’ compliance was conducted to determine the reasons for their non-compliance in taking drugs. Results: Of 86 patients, 44% (n = 38) reported compliance and 56% (n = 48) reported non-compliance. The distribution of the patients in terms of sex was as follows: among men, 41% (n = 24) were compliant and 59% (n = 35) were non-compliant; among women, 52% (n = 14) were compliant and 48% (n = 13) were non-compliant. In addition, smoking status was too significantly linked with non-compliance (P = 0.001). Furthermore, the status of chewing of khat tree leaves was also significantly associated with non-compliance (P = 0.007). Conclusion: This study indicates that the reasons for non-compliance with medications among patients can be attributed to lack of education, chewing of khat tree leaves, lack of health insurance, and cigarette smoking. Therefore, healthcare professionals should create strategies to address these reasons in order to increase medication compliance with patients in heart failure.

Author(s):  
Carlotta Sciaccaluga ◽  
Giulia Elena Mandoli ◽  
Chiara Nannelli ◽  
Francesca Falciani ◽  
Cosimo Rizzo ◽  
...  

2011 ◽  
Vol 10 (1_suppl) ◽  
pp. 32-32
Author(s):  
L. Brugnaro ◽  
N. Frizzarin ◽  
C. Marangon ◽  
M. Perazzolo ◽  
G. Boscaro ◽  
...  

2007 ◽  
Vol 12 (2) ◽  
pp. 92-97
Author(s):  
Michael Drafz

Abstract Clinicians working in a facility specializing in cardiac care have probably seen patients with decompensated congestive heart failure (CHF) and renal failure. As a vascular access specialist, chances are that clinicians have recently been asked to provide vascular access for a relatively new treatment procedure called peripherally inserted veno-venous ultrafiltration or aquapheresis. This treatment, pioneered between 2002 and 2003, was designed for patients suffering from decompensated CHF, leading to acute fluid overload and renal failure. These patients no longer respond to the traditional diuretic and sodium-depleting therapies and often have no other treatment choices left. This article discusses the vascular access side of this treatment and the associated challenges.


2021 ◽  
Vol 06 (01) ◽  
pp. 008-014
Author(s):  
Vijay Kumar Bodicherla ◽  
Kalyan Chakravarthy ◽  
Hemalatha Yellapragada

Abstract Background The get with the guidelines (GWTG) risk score was developed to predict in-hospital mortality in acute heart failure patients. We aimed to clarify the prognostic impacts of the GWTG risk score in the south Indian heart failure patients admitted to intensive cardiac care unit (ICCU) in our hospital. Aim Our primary aim was to see the applicability of predicted GWTG risk score of heart failure in the south Indian heart failure patients admitted to intensive cardiac care unit (ICCU) of our hospital. Our secondary aim was to see the event rates and correlate predicted GWTG risk score of heart failure with in-hospital complications. Materials and Methods We included all the patients admitted to ICCU with the diagnosis of either ischemic or dilated cardiomyopathy over 6 months (January 2018 to June 2018). Indication for admission was either symptomatic heart failure (HF) or to evaluate cause for heart failure. We recorded the demographic and clinical parameters along with the ECG, 2D echo features, and relevant laboratory investigations. The GWTG risk score was based on seven parameters. Race, age, systolic blood pressure, heart rate, blood urea nitrogen (BUN) level, sodium concentration, and presence of chronic obstructive pulmonary disease (COPD) were used to predict in-hospital all-cause mortality, and in-hospital complications were noted. Results Out of 130 patients, 97 patients fulfilled the inclusion criteria. Out of them, 65 were males, with most of the patients between 40 to 80 years of age. Half the patients were diabetic and had abnormal electrocardiogram (ECG), and more than half were hypertensive, had clinically left ventricular failure (LVF) and diagnosed with ischemic cardiomyopathy (ICMP). Very few were smokers, and < 30% were alcoholics, had abnormal liver function tests (LFT) and diagnosed with dilated cardiomyopathy (DCMP). Patients were divided into ICMP and DCMP patients, and all the variables were compared. Low systolic blood pressure (BP), abnormal ECG and the mean of GWTG score were greater in 22 patients afflicted with DCMP. However, abnormal renal functions with anemia and more NT-pro-brain natriuretic peptide (NT-proBNP) elevations were observed in ICMP HF patients. Out of 97 patients 70% patients had GTWG score of 34 to 50. There were no patients with score > 58 in our study. Eighteen patients showed in-hospital complications. Five patients died with mean GWTG score 45.00, and they experienced cardiogenic shock with tachycardia and severe LV dysfunction (ejection fraction [EF] < 15%), renal failure, hyponatremia, NT-proBNP levels > 25,000 pg/dl and hepatic derangement at admission. A total of 92 patients were discharged with 39.02 mean GWTG score. There was a significant difference between the mean GWTG scores of patients in their final status (discharged/death) (p = 0.040). Also, patients with in-hospital complications had higher GWTG values (on an average 7 scores higher) than without complications (p = 0.000). Conclusions GWTG scores were able to predict (with statistical significance) the true end results for both complications during hospitalization and final discharge/death in hospitalized Indian HF patients. Higher GWTG Scores were an indication of complications or death (39 for complications and 45 for death seems to be the possible average values).


Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 5589-5589
Author(s):  
Christopher Hollenbeak ◽  
Eldon Spackman ◽  
Matthew J. Page ◽  
Rami Ben-Joseph3 ◽  
Todd Williamson3

Abstract Metabolic syndrome (MetS) is a constellation of metabolic risk factors that can lead to diabetes, cardiovascular events, and other complications. MetS is recognized by several standards-setting bodies, including the National Cholesterol Education Program - Adult Treatment Panel III (NCEP-ATP III) and the International Diabetes Federation (IDF). In this study, we used a nationally representative set of data to create a model to predict the prevalence of MetS in a population from demographic information. Data for this study were from the National Health and Nutrition Examination Survey (NHANES) data set, a nationwide probability sample survey designed to collect information on the health and nutritional status of the U.S. population through interviews and direct physical examinations. NHANES 2001–2002 includes data for 11,039 persons, of which 2,605 had information necessary for identification of metabolic syndrome. A weighted logistic regression model was used to determine the effects of gender, age, ethnicity, and smoking status on the prevalence of MetS based on IDF and NCEP-ATP III criteria. Estimated coefficients were then used to predict the prevalence of MetS conditional on the demographic characteristics of the population. In addition, the model predicts the one-year risk of acute myocardial infarction and stroke as well as the prevalence of coronary heart disease, congestive heart failure, and type 2 diabetes among those with MetS. Values were calculated based on the population age 18 and over as reported by the U.S. Census combined with the NHANES 2001–2002 means for the other demographic variables (gender, mean age, ethnicity, smoking status). The model was validated using an earlier NHANES cohort (1999–2000). Table 1 presents the prevalence of MetS based on the two definitions and the percentage of each population exceeding the risk thresholds for each of the five MetS components. The estimated rate of metabolic syndrome in the U.S. is 25.0% according to the NCEP-ATP III definition and 41.3% according to the IDF definition, a difference most likely attributable to the smaller waist circumference listed by the IDF definition. The complications are not consistently higher for either group as defined by NCEP-ATP III or IDF. The model validation shows how well the model predicts MetS prevalence in the NHANES 1999–2000 data. The predicted prevalence using demographics from NHANES 1999–2000 and following the NCEP-ATP III definition was 24.7% compared to an actual prevalence of 23.1%. Using the IDF definition the prevalence was predicted to be 40.9% and the actual prevalence was 39.2%. For both definitions predictions were within the 95% probability range suggested by the model. In a disease where actual clinical measures are required for diagnosis, it is possible to model and predict the prevalence of MetS using fundamental demographic data. Therefore, this model will be useful for healthcare providers and decision makers in estimating the prevalence of MetS when clinical measures are absent. Table 1. Prevalence of Metabolic Syndrome and Its Components NCEP-ATP III IDF * Annual Risk, ** Prevalence Prevalence 25.0% 41.3% Components High Waist Circumference 88.5% 100% High Triglycerides 83.3% 65.5% Low HDL Cholesterol 82.0% 58.5% High Blood Pressure 62.7% 72.9% High Fasting Plasma Glucose 76.4% 66.0% Complications Acute Myocardial Infarction * 0.4% 0.8% Stroke * 0.8% 0.6% Coronary Heart Disease ** 4.8% 5.0% Congestive Heart Failure ** 4.0% 3.6% Diabetes ** 24.0% 20.6%


2011 ◽  
Vol 10 ◽  
pp. S32
Author(s):  
L. Brugnaro ◽  
N. Frizzarin ◽  
C. Marangon ◽  
M. Perazzolo ◽  
G. Boscaro ◽  
...  

1997 ◽  
Vol 272 (2) ◽  
pp. H884-H893 ◽  
Author(s):  
R. Sethi ◽  
K. S. Dhalla ◽  
R. E. Beamish ◽  
N. S. Dhalla

The status of beta-adrenergic receptors and adenylyl cyclase in crude membranes from both left and right ventricles was examined when the left coronary artery in rats was occluded for 4, 8, and 16 wk. The adenylyl cyclase activity in the presence of isoproterenol was decreased in the uninfarcted (viable) left ventricle and increased in the right ventricle subsequent to myocardial infarction. The density of beta1-adrenergic receptors, unlike beta2-receptors, was reduced in the left ventricle, whereas no change in the characteristics of beta1- and beta2-adrenergic receptors was seen in the right ventricle. The catalytic activity of adenylyl cyclase was depressed in the viable left ventricle but was unchanged in the right ventricle. In comparison to sham controls, the basal, as well as NaF-, forskolin-, and 5'-guanylyl imidodiphosphate [Gpp(NH)p]-stimulated adenylyl cyclase activities were decreased in the left ventricle and increased in the right ventricle of the experimental animals. Opposite alterations in the adenylyl cyclase activities in left and right ventricles from infarcted animals were also seen when two types of purified sarcolemmal preparations were employed. These changes in adenylyl cyclase activities in the left and right ventricles were dependent on the degree of heart failure. Furthermore, adenosine 3',5'-cyclic monophosphate contents were higher in the right ventricle and lower in the left ventricle from infarcted animals injected with saline, isoproterenol, or forskolin in comparison to the controls. The results suggest differential changes in the viable left and right ventricles with respect to adenylyl cyclase activities during the development of congestive heart failure due to myocardial infarction.


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